Abstract:
:Skin tests and measurement of serum levels of immunoglobulin E do not accurately identify foods for elimination from the diets of patients with eosinophilic esophagitis (EoE). We investigated whether an esophageal prick test, in which the esophageal mucosa is challenged by local injection of allergen extracts, could identify individuals with esophageal sensitization. During endoscopy, 6 allergens were injected in the esophagus of 8 patients with EoE and 3 patients without EoE (controls). A second endoscopy was performed after 24 hours to evaluate delayed responses. Five of the 8 patients with EoE had evidence for an acute response (luminal obstruction and mucosal blanching); 2 other patients had a delayed wheal or flare reaction. No responses were observed in controls. We conclude that esophageal mucosal food allergen injections induce acute and/or delayed responses in patients with EoE but not controls. The esophageal prick test deserves further exploration because it may guide elimination diets.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Warners MJ,Terreehorst I,van den Wijngaard RM,Akkerdaas J,van Esch BCAM,van Ree R,Versteeg SA,Smout AJPM,Bredenoord AJdoi
10.1053/j.gastro.2017.08.062subject
Has Abstractpub_date
2018-01-01 00:00:00pages
57-60.e2issue
1eissn
0016-5085issn
1528-0012pii
S0016-5085(17)36095-Xjournal_volume
154pub_type
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