Structural features of absorptive cell and microvillus membrane preparations from rat small intestine.

abstract：BACKGROUND & AIMS:Simeprevir (TMC435) is an oral NS3/4 protease inhibitor in phase III trials for chronic hepatitis C virus (HCV) infection. We performed a phase IIb, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of the combination of simeprevir, peginterferon-α2a (PegIFN), and ...

journal_title：Gastroenterology

authors： Zeuzem S,Berg T,Gane E,Ferenci P,Foster GR,Fried MW,Hezode C,Hirschfield GM,Jacobson I,Nikitin I,Pockros PJ,Poordad F,Scott J,Lenz O,Peeters M,Sekar V,De Smedt G,Sinha R,Beumont-Mauviel M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND & AIMS:CD8(+) T cells that produce interleukin (IL)-17 (Tc17 cells) promote inflammation and have been identified in tumors. We investigated their role in the pathogenesis of gastric cancer. METHODS:We used flow cytometry analyses to determine levels and phenotype of Tc17 cells in blood and tumor samples fr...

journal_title：Gastroenterology

authors： Zhuang Y,Peng LS,Zhao YL,Shi Y,Mao XH,Chen W,Pang KC,Liu XF,Liu T,Zhang JY,Zeng H,Liu KY,Guo G,Tong WD,Shi Y,Tang B,Li N,Yu S,Luo P,Zhang WJ,Lu DS,Yu PW,Zou QM

更新日期：2012-10-01 00:00:00

abstract：:Severe cholestasis associated with long-term home parenteral nutrition is rare, and no treatment is known to be effective. This study shows a case of a patient who developed jaundice while receiving long-term home parenteral nutrition. Causes of jaundice, other than the patient's parenteral feedings, were excluded. Th...

journal_title：Gastroenterology

authors： Lindor KD,Burnes J

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:Dilutional hyponatremia is a frequent complication of cirrhosis partly because of nonosmotic vasopressin release. No effective therapy exists for this complication. Therefore, we investigated the effects of VPA-985, an orally active vasopressin V2 receptor antagonist, in patients with cirrhosis and di...

journal_title：Gastroenterology

authors： Gerbes AL,Gülberg V,Ginès P,Decaux G,Gross P,Gandjini H,Djian J,VPA Study Group.

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND & AIMS:Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase-C receptor that stimulates intestinal fluid secretion and transit and reduces pain in animal models. We assessed the safety and efficacy of a range of linaclotide doses in patients with chronic constipation. METHODS:We perfo...

journal_title：Gastroenterology

authors： Lembo AJ,Kurtz CB,Macdougall JE,Lavins BJ,Currie MG,Fitch DA,Jeglinski BI,Johnston JM

更新日期：2010-03-01 00:00:00

abstract：:A number of minimally invasive methods have been tested for the thermal ablation of liver tumors as an alternative to surgical resection. The use of focused ultrasound transducers to ablate deep tumors offers the first completely noninvasive alternative to these techniques. By increasing the flexibility of this techno...

journal_title：Gastroenterology

authors： Jolesz FA,Hynynen K,McDannold N,Freundlich D,Kopelman D

更新日期：2004-11-01 00:00:00

abstract：:Excretion of hydrogen in breath commonly persists despite an overnight fast. Although elevation of hydrogen concentration above the fasting value after administration of a test sugar is evidence of malabsorption, the significance of the fasting value itself is unknown. We determined the normal limits of fasting breath...

journal_title：Gastroenterology

authors： Perman JA,Modler S,Barr RG,Rosenthal P

更新日期：1984-12-01 00:00:00

abstract：:A monoclonal antibody to bromodeoxyuridine was used in tissue specimens previously incubated with bromodeoxyuridine to show S-phase cells by immunohistochemical technique. Biopsy specimens of normal mucosa (n = 10), hyperplastic polyps (n = 10), adenomas with low-grade dysplasia (n = 20), adenomas with high-grade dysp...

journal_title：Gastroenterology

authors： Risio M,Coverlizza S,Ferrari A,Candelaresi GL,Rossini FP

更新日期：1988-04-01 00:00:00

abstract：:Among the components of dietary fiber, the soluble polysaccharides, primarily guaran and pectin, have been found to impair intestinal absorption. Little is known, however, about the mechanism of this effect. The direct action of guaran on small intestinal absorption was evaluated by a single-pass perfusion technique. ...

journal_title：Gastroenterology

authors： Elsenhans B,Zenker D,Caspary WF

更新日期：1984-04-01 00:00:00

abstract：:Three generations of a kindred comprising 50 individuals are described in which recurrent intrahepatic cholestasis of pregnancy has occurred with high frequency. A uniform expression and complete penetrance of the trait in the women of a limited "affected" portion of the kindred (6 affected of 10 women), along with th...

journal_title：Gastroenterology

authors： Holzbach RT,Sivak DA,Braun WE

更新日期：1983-07-01 00:00:00

abstract：:In the search for novel therapeutic approaches to treat patients with colorectal carcinoma, anticancer vaccination holds promise. A large body of preclinical and clinical evidence has demonstrated that the immune system can be polarized against malignant cells by means of several active specific immunotherapy strategi...

journal_title：Gastroenterology

authors： Mocellin S,Rossi CR,Lise M,Nitti D

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND/AIMS:The role of cholecystokinin (CCK) in the regulation of gastric acid secretion is still controversial. This study examined the effect of the CCK-A receptor antagonist loxiglumide (lox) on gastrin- or CCK-induced gastric acid secretion and meal-stimulated plasma gastrin levels in a placebo-controlled stud...

journal_title：Gastroenterology

authors： Schmidt WE,Schenk S,Nustede R,Holst JJ,Fölsch UR,Creutzfeldt W

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND & AIMS:Reduced generation of all-trans retinoic acid (RA) by CD103(+) intestinal dendritic cells (DCs) is linked to intestinal inflammation in mice. However, the role of RA in intestinal inflammation in humans is unclear. We investigated which antigen-presenting cells (APCs) produce RA in the human intestine...

journal_title：Gastroenterology

authors： Sanders TJ,McCarthy NE,Giles EM,Davidson KL,Haltalli ML,Hazell S,Lindsay JO,Stagg AJ

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND & AIMS:Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about the molecules involved in mechanosensation from the gastrointestinal tract. We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK...

journal_title：Gastroenterology

authors： Sakurai J,Obata K,Ozaki N,Tokunaga A,Kobayashi K,Yamanaka H,Dai Y,Kondo T,Miyoshi K,Sugiura Y,Matsumoto T,Miwa H,Noguchi K

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND & AIMS:Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of patients with ulcerative colitis (UC). In a phase 1b trial of patients with UC, we evaluated the safety and efficacy of SER-287, an oral formulation...

journal_title：Gastroenterology

authors： Henn MR,O'Brien EJ,Diao L,Feagan BG,Sandborn WJ,Huttenhower C,Wortman JR,McGovern BH,Wang-Weigand S,Lichter DI,Chafee M,Ford CB,Bernardo P,Zhao P,Simmons S,Tomlinson AD,Cook DN,Pomerantz RJ,Misra BK,Auninš JG,Truc

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND/AIMS:Capillarization of the hepatic sinusoid occurs in alcoholic liver disease. Because endothelial cell proliferation is relevant to capillarization, we used the intragastric feeding rat model to evaluate the relationship between pathological liver injury and endothelial cell proliferation. METHODS:Male Wi...

journal_title：Gastroenterology

authors： Nanji AA,Tahan SR,Wei Y,Sadrzadeh SM

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND & AIMS:Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 (belapectin) is an inhibitor of galectin 3 that reduces liver fibrosis and portal hypertension in rats and was safe and well tolerated in phase ...

journal_title：Gastroenterology

authors： Chalasani N,Abdelmalek MF,Garcia-Tsao G,Vuppalanchi R,Alkhouri N,Rinella M,Noureddin M,Pyko M,Shiffman M,Sanyal A,Allgood A,Shlevin H,Horton R,Zomer E,Irish W,Goodman Z,Harrison SA,Traber PG,Belapectin (GR-MD-02) Stud

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND & AIMS:Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are potent antiviral agents that might have additive or synergistic antiviral activity in treatment of patients with chronic hepatitis B (CHB). We compared the efficacy and safety of ETV monotherapy with those of a combination of ETV and TDF. ME...

journal_title：Gastroenterology

authors： Lok AS,Trinh H,Carosi G,Akarca US,Gadano A,Habersetzer F,Sievert W,Wong D,Lovegren M,Cohen D,Llamoso C

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND & AIMS:High-carbohydrate diets with a high glycemic response may exacerbate the metabolic consequences of the insulin-resistance syndrome. The effect on the incidence of gallstone disease is not clear. METHODS:We examined the associations between high-carbohydrate diets with a high glycemic response and the...

journal_title：Gastroenterology

authors： Tsai CJ,Leitzmann MF,Willett WC,Giovannucci EL

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with colorectal tumors with microsatellite instability (MSI) have better prognoses than patients with tumors without MSI, but have a poor response to 5-fluorouracil–based chemotherapy. A dominant-negative form of heat shock protein (HSP)110 (HSP110DE9) expressed by cancer cells with MSI, via ...

journal_title：Gastroenterology

authors： Collura A,Lagrange A,Svrcek M,Marisa L,Buhard O,Guilloux A,Wanherdrick K,Dorard C,Taieb A,Saget A,Loh M,Soong R,Zeps N,Platell C,Mews A,Iacopetta B,De Thonel A,Seigneuric R,Marcion G,Chapusot C,Lepage C,Bouvier

更新日期：2014-02-01 00:00:00

abstract：:A pancreatic somatostatinoma metastatized to the liver was detected in a 70-yr-old woman presenting with chronic diarrhea, steatorrhea, pancreatic insufficiency, diabetes mellitus, and achlorhydria. At immunocytochemistry, most tumor cells stored both somatostatin and calcitoninlike substances. Chromatography of acid ...

journal_title：Gastroenterology

authors： Galmiche JP,Chayvialle JA,Dubois PM,David L,Descos F,Paulin C,Ducastelle T,Colin R,Geffroy Y

更新日期：1980-06-01 00:00:00

abstract：BACKGROUND & AIMS:Small intestinal carcinomas are rare but occur with increased incidence in Crohn's disease. The aim of this study was to elucidate the genetic alterations. METHODS:Mutations and deletions involved in colorectal carcinoma were studied in sporadic and Crohn's-associated intestinal carcinomas and precur...

journal_title：Gastroenterology

authors： Rashid A,Hamilton SR

更新日期：1997-07-01 00:00:00

abstract：:Specimens of the sigmoid colon were obtained from male and female patients (n = 11) with carcinoma of the colon or rectum and studied immunohistochemically for vasoactive intestinal polypeptide-, somatostatin-, substance P-, neuropeptide Y-, calcitonin gene-related peptide-, met- and leu-enkephalin-, 5-hydroxytryptami...

journal_title：Gastroenterology

authors： Crowe R,Kamm MA,Burnstock G,Lennard-Jones JE

更新日期：1992-02-01 00:00:00

abstract：:To determine the frequency and significance of alpha-fetoprotein elevation in severe hepatitis B surface antigen-negative chronic active hepatitis, 558 serum samples obtained from 83 patients were tested by an immunoenzymometric assay. All patients received corticosteroids and sampling occurred at 6-12-mo intervals du...

journal_title：Gastroenterology

authors： Czaja AJ,Beaver SJ,Wood JR,Klee GG,Go VL

更新日期：1987-10-01 00:00:00

abstract：:Intracerebroventricular prostaglandin E2 (PGE2) inhibits stimulated gastric acid secretion; however, the central site of action is unknown. Specific PGE2 binding sites have been localized to the ventromedial hypothalamic nucleus and central amygdala (A). The nuclear accumbens has been shown to play a role in central n...

journal_title：Gastroenterology

authors： Barocelli E,Impicciatore M,Seaton J,Conter R,Kauffman G

更新日期：1991-02-01 00:00:00

abstract：:Thyrotropin-releasing hormone transiently increased resting tension and spontaneous contraction amplitude more potently in longitudinal muscle than in circular muscle. The frequency of the contraction did not change. Excitation was enhanced by eserine, and blocked by atropine and tetrodotoxin; this excitation was, the...

journal_title：Gastroenterology

authors： Oouchi M,Ichikawa S

更新日期：1985-05-01 00:00:00

abstract：:One hundred symptomatic patients with radiolucent gallbladder stones were treated with a new piezoelectric lithotripter and oral chemolitholytic agents. Stone disintegration was achieved in 99 of these patients (99%) with a mean (+/- SD) maximum fragment size of 5.1 +/- 4.1 mm. Significant differences were found when ...

journal_title：Gastroenterology

authors： Ell C,Kerzel W,Schneider HT,Benninger J,Wirtz P,Domschke W,Hahn EG

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND & AIMS:Fish is a rich source of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Although consumption of fish and n-3 PUFA has been reported to protect against the development of some types of cancer, little is known ab...

journal_title：Gastroenterology

authors： Sawada N,Inoue M,Iwasaki M,Sasazuki S,Shimazu T,Yamaji T,Takachi R,Tanaka Y,Mizokami M,Tsugane S,Japan Public Health Center-Based Prospective Study Group.

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND & AIMS:SPD476 (LIALDA in the US; MEZAVANT in the EU; otherwise known as MMX mesalamine; Shire Pharmaceuticals Inc., Wayne, PA, under license from Giuliani SpA, Milan, Italy) is a novel, once-daily, high-strength (1.2 g/tablet) formulation of mesalamine, utilizing MMX Multi Matrix System (MMX) technology desi...

journal_title：Gastroenterology

authors： Kamm MA,Sandborn WJ,Gassull M,Schreiber S,Jackowski L,Butler T,Lyne A,Stephenson D,Palmen M,Joseph RE

更新日期：2007-01-01 00:00:00

abstract：:The kinetics of cholesterol and bile acid was determined from a 10-week analysis of the biliary lipids after a single injection of labeled cholesterol in parallel with a conventional 1-week study of primary bile acid kinetics. Six healthy controls and 6 patients with cholesterol cholelithiasis were studied. Two of the...

journal_title：Gastroenterology

authors： Hepner GW,Quarfordt SH

更新日期：1975-08-01 00:00:00