Human urine-derived stem cells contribute to the repair of ischemic acute kidney injury in rats.

abstract：:The proliferation of cardiac fibroblasts (CFs) and excessive deposition of extracellular matrix are the predominant pathological characteristics of cardiac fibrosis. As the largest member of the nucleotide‑binding domain and leucine‑rich repeat (NLR) family, NLRC5 has been shown to be pivotal in the development of hep...

journal_title：Molecular medicine reports

authors： Zhou H,Yu X,Zhou G

更新日期：2017-09-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity. MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of numerous cerebrovascular diseases, including ICH. miR‑222 has been revealed to play important roles in various physiological and pathological process...

journal_title：Molecular medicine reports

authors： Bai YY,Niu JZ

更新日期：2020-03-01 00:00:00

abstract：:Roux-en-Y gastric bypass (RYGB) has become an effective treatment for type 2 diabetes mellitus (T2DM). However, the blood glucose mechanism involved remains unclear. In this study, 60 male Goto-Kakizaki (GK) rats were randomly divided into 6 groups (each with 10 rats): the GB1/2 gro...

journal_title：Molecular medicine reports

authors： Li J,Wang Y,Zhou Y,Liu J

更新日期：2012-11-01 00:00:00

abstract：:Angiogenesis is the formation of new vessels starting from pre-existing vasculature. Tumour environment is characterized by 'aberrant angiogenesis', whose main features are tortuous and permeable blood vessels, heterogeneous both in their structure and in efficiency of perfusion and very different from normal vessels....

journal_title：Molecular medicine reports

authors： Caporarello N,Lupo G,Olivieri M,Cristaldi M,Cambria MT,Salmeri M,Anfuso CD

更新日期：2017-10-01 00:00:00

abstract：:Icariside II is a flavonoid extracted from Epimedium that has antioxidant, anti‑inflammatory and antiapoptotic effects. The aim of the present study was to evaluate the effects icariside II on diabetic cardiomyopathy in streptozotocin-induced diabetic rats. Icariside II treatment improved body weight, heart/body weigh...

journal_title：Molecular medicine reports

authors： Yang L,Peng C,Xia J,Zhang W,Tian L,Tian Y,Yang X,Cao Y

更新日期：2018-03-01 00:00:00

abstract：:Ginsenosides exhibit various neuroprotective effects against oxidative stress. However, which ginsenoside provides optimal effects for the treatment of neurological disorders as a potent antioxidant remains to be elucidated. Therefore, the present study investigated and compared the neuroprotective effects of the Rb1,...

journal_title：Molecular medicine reports

authors： Ye J,Yao JP,Wang X,Zheng M,Li P,He C,Wan JB,Yao X,Su H

更新日期：2016-04-01 00:00:00

abstract：:Scutellarin (SC), mainly extracted from the Chinese herb Erigeron breviscapus (vant.), has been reported to possess various pharmacological activities; however, its effects on Alzheimer's disease (AD) have not been systemically reported. The protective effects of SC on AD were investigated using an L‑glutamic acid (L‑...

journal_title：Molecular medicine reports

authors： Hu X,Teng S,He J,Sun X,Du M,Kou L,Wang X

更新日期：2018-11-01 00:00:00

abstract：:MicroRNA (miR)-22 has previously been reported to be frequently downregulated in certain types of cancer. The present study examined the expression and effects of miR-22 in renal cell carcinoma (RCC). The results indicated that miR‑22 was downregulated in tumor tissue from patients with RCC. In addition, lower miR‑22 ...

journal_title：Molecular medicine reports

authors： Fan W,Huang J,Xiao H,Liang Z

更新日期：2016-06-01 00:00:00

abstract：:The aim of the present study was to evaluate the protective effect and mechanism of Astragaloside IV (ASIV) on myocardial injury induced by type 2 diabetes, with a focus on energy metabolism. Blood glucose, the hemodynamic index, left ventricular weight/heart weight (LVW/HW), the left ventricular systolic pressure (LV...

journal_title：Molecular medicine reports

authors： Zhang Z,Wang J,Zhu Y,Zhang H,Wang H

更新日期：2019-11-01 00:00:00

abstract：:microRNAs (miRNAs) have been reported to be involved in various human diseases. They may have uses in diagnosis and as therapeutic targets, thus the discovery of novel miRNAs has the potential to provide clinical tools or shed light on novel mechanisms. In the current study, miR‑107 was revealed to be downregulated in...

journal_title：Molecular medicine reports

authors： Ruan J,Liu X,Xiong X,Zhang C,Li J,Zheng H,Huang C,Shi Q,Weng Y

更新日期：2015-02-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) is considered to have a critical role in the occurrence and development of atherosclerosis in atherosclerosis-prone mice; however, it remains uncertain whether treatment with a TLR4 inhibitor may attenuate atherosclerosis. The present study aimed to determine the vascular protective effects...

journal_title：Molecular medicine reports

authors： Wang XQ,Wan HQ,Wei XJ,Zhang Y,Qu P

更新日期：2016-07-01 00:00:00

abstract：:Circular RNAs (circRNAs) are non-coding RNAs forming closed-loop structures, and their aberrant expression may lead to disease. However, the potential network of circRNA‑associated competing endogenous RNA (ceRNA) involved in nonvalvular persistent atrial fibrillation (NPAF) has not been previously reported. In the pr...

journal_title：Molecular medicine reports

authors： Zhang Y,Ke X,Liu J,Ma X,Liu Y,Liang D,Wang L,Guo C,Luo Y

更新日期：2019-01-01 00:00:00

abstract：:The silent information regulator 2 related enzyme 2 (SIRT2) has been reported to have an important role in tumorigenesis. Although two distinct effects of SIRT2 have recently been revealed, which explain opposing expression patterns in different types of cancer, the specific function of SIRT2 in ovarian cancer remains...

journal_title：Molecular medicine reports

authors： Du Y,Wu J,Zhang H,Li S,Sun H

更新日期：2017-04-01 00:00:00

abstract：:Macrophages can be polarized into the inflammatory M1 lineage or the immunomodulatory M2 lineage, depending on the differential tissue microenvironment signaling, specific pathogens or cytokine stimulation. Tumor necrosis factor α‑induced protein 8‑like protein 2 (TIPE2) has been demonstrated to negatively regulate in...

journal_title：Molecular medicine reports

authors： Jiang Y,Li Q,Zhang Y,Gao Y,Jiang L,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:Hepatitis C virus (HCV)‑encoded protein p7 is a viroporin that acts as an ion channel and is indispensable for HCV particle production. Although the main target of HCV p7 is the endoplasmic reticulum, it also targets mitochondria. HCV‑infected cells show mitochondrial depolarization and ATP depletion; however, the fun...

journal_title：Molecular medicine reports

authors： You DG,Lee HR,Kim WK,Kim HJ,Lee GY,Yoo YD

更新日期：2017-12-01 00:00:00

abstract：:Human keratinocytes are located in the outermost skin layer and thus particularly vulnerable to ultraviolet B (UVB) radiation exposure. Previous studies have focused on the cellular and molecular perspectives of UVB-induced keratinocyte damage. In the present study, it was demonstrated that pretreatment with the phyto...

journal_title：Molecular medicine reports

authors： Cha HJ,Lee GT,Lee KS,Lee KK,Hong JT,Lee NK,Kim SY,Lee BM,An IS,Hahn HJ,Ahn KJ,Lee SJ,An S,Bae S

更新日期：2014-09-01 00:00:00

abstract：:Pancreatic cancer (PC) is associated with high mortality rates and poor prognoses. Pancreatic adenocarcinoma is the most common type of PC, and almost all cases of pancreatic adenocarcinoma are pancreatic ductal adenocarcinoma (PDAC). The aim of the current study was to reveal the genes involved in the prognosis of PD...

journal_title：Molecular medicine reports

authors： Zheng B,Peng J,Mollayup A,Bakri A,Guo L,Zheng J,Xu H

更新日期：2018-01-01 00:00:00

abstract：:Colorectal cancer has become a disease with one of the highest incidence rates worldwide, and liver metastasis threatens the prognosis of colorectal cancer. MicroRNA (miR)‑200 and miR‑141 have been confirmed to be aberrantly expressed in colorectal cancer, however, whether miR‑200 and miR‑141 are involved in the progr...

journal_title：Molecular medicine reports

authors： Ding M,Zhang T,Li S,Zhang Y,Qiu Y,Zhang B

更新日期：2017-11-01 00:00:00

abstract：:The autoimmune regulator (Aire) protein is a transcriptional activator that is essential in central immune tolerance, as it regulates the ectopic expression of many tissue‑restricted antigens in medullary thymic epithelial cells. Aire expression has also been described in hematopoietic cells, such as monocytes/macroph...

journal_title：Molecular medicine reports

authors： Li H,Li D,Sun J,Li Y,Yang W,Li Y

更新日期：2016-01-01 00:00:00

abstract：:Abnormal expression of matrix metalloproteinase 9 (MMP9) is correlated with podocyte epithelial-to---mesenchymal transition (EMT) in diabetic nephropathy (DN). However, the mechanisms underlying this process are not well defined. Site‑specific demethylation may sustain high expression levels of target genes. In the pr...

journal_title：Molecular medicine reports

authors： Ling L,Chen L,Zhang C,Gui S,Zhao H,Li Z

更新日期：2018-04-01 00:00:00

abstract：:Accumulating evidence has revealed that the mammalian heart possesses a measurable capacity for renewal. Neonatal mice retain a regenerative capacity over a short time-frame (≤6 days), but this capacity is lost by 7 days of age. In the present study, differential gene expression profiling of mouse cardiac tissue was p...

journal_title：Molecular medicine reports

authors： Liu M,Zhu JG,Yu ZB,Song GX,Shen YH,Liu YQ,Zhu C,Qian LM

更新日期：2014-06-01 00:00:00

abstract：:Tilianin, the main effective flavonoid monomer enriched from Dracocephalum moldavuca L., has been shown to have cardioprotective effects. However, the mechanism of tilianin cardioprotection remains largely unknown. The present study aimed to investigate the effects of tilianin preconditioning on myocardial ischemia/re...

journal_title：Molecular medicine reports

authors： Guo X,Cao W,Yao J,Yuan Y,Hong Y,Wang X,Xing J

更新日期：2015-03-01 00:00:00

abstract：:In contrast with mature brain‑derived neurotrophic factor (mBDNF), proBDNF induces cell apoptosis. However, the function of proBDNF in oligodendrocytes remains unclear. In the present study, the OLN‑93 oligodendroglia cell line was utilized as an in vitro model to analyse the functions of proBDNF in oligodendroglia. p...

journal_title：Molecular medicine reports

authors： Liu S,Guo W,Zhou H,Tang L,Feng S,Zhong JH,Zhou XF

更新日期：2018-10-01 00:00:00

abstract：:Purple sweet potato color (PSPC) is a natural anthocyanin pigment that is derived from purple sweet potato storage roots. PSPC possesses a variety of biological activities, including antioxidant, anti‑inflammatory and neuroprotective effects; however, the detailed effects of PSPC on high‑fat diet (HFD)‑induced neuroin...

journal_title：Molecular medicine reports

authors： Li J,Shi Z,Mi Y

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present study was to investigate the combination of certain serological markers (Forns' index; FI), FibroScan® and acoustic radiation force impulse elastography (ARFI) in the assessment of liver fibrosis in patients with hepatitis B, and to explore the impact of inflammatory activity and steatosis on th...

journal_title：Molecular medicine reports

authors： Dong DR,Hao MN,Li C,Peng Z,Liu X,Wang GP,Ma AL

更新日期：2015-06-01 00:00:00

abstract：:A 12‑year‑old Chinese girl presented with gradual vision loss and insulin‑dependent diabetes mellitus and was suspected to suffer from Wolfram syndrome (WFS). A series of clinical examinations were performed, as well as direct DNA sequencing to screen the entire coding region of the...

journal_title：Molecular medicine reports

authors： Xu Q,Qu H,Wei S

更新日期：2013-03-01 00:00:00

abstract：:Disruption of the intestinal mucosal barrier integrity is a pathogenic process in inflammatory bowel disease (IBD) development, and is therefore considered a drug discovery target for IBD. The well‑known traditional Chinese formulation Qing Hua Chang Yin (QHCY) has been suggested as a potential therapeutic agent for t...

journal_title：Molecular medicine reports

authors： Fang W,Zhao P,Shen A,Liu L,Chen H,Chen Y,Peng J,Sferra TJ,Sankararaman S,Luo Y,Ke X

更新日期：2021-03-01 00:00:00

abstract：:Viral myocarditis (VM), a severe clinical condition characterized by cardiac inflammation, is most frequently induced as a result of coxsackievirus infection. Evidence suggests that microRNAs may have significant roles in the progression of cardiac injury during coxsackievirus infection. Concurrently, microRNA (miR)-2...

journal_title：Molecular medicine reports

authors： Chen ZG,Liu H,Zhang JB,Zhang SL,Zhao LH,Liang WQ

更新日期：2015-07-01 00:00:00

abstract：:Formononetin (Form), a phytoestrogen extracted from the roots of Astragalus membranaceus, is one of the fundamental herbs used in traditional Chinese medicine because of its protective effects against certain malignant tumors. However, its role in colon carcinoma cells and the underlying molecular mechanisms have not ...

journal_title：Molecular medicine reports

authors： Wang AL,Li Y,Zhao Q,Fan LQ

更新日期：2018-06-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are endogenous transcribed RNA molecules without protein-coding potential, ranging between 200 and 100,000 nt in length. LncRNAs regulate the expression of specific genes in several ways, including guiding chromatin-remodeling, and affecting splicing, transcription or translation. The mut...

journal_title：Molecular medicine reports

authors： Li Y,Wang X

更新日期：2016-02-01 00:00:00