Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling.

abstract：:Malignant glioma is the most common type of cancer in the central nervous system, with highly invasive characteristics. The Rho-associated protein kinase (ROCK1) has been found to act as key regulator of actin cytoskeleton reorganization, a process closely associated with cancer cell invasion. microRNA-145 (miRNA-145)...

journal_title：Molecular medicine reports

authors： Wan X,Cheng Q,Peng R,Ma Z,Chen Z,Cao Y,Jiang B

更新日期：2014-05-01 00:00:00

abstract：:The present study aimed to investigate the mechanism underlying the effects of minocycline on diabetic retinopathy‑associated cellular apoptosis. A total of 40 Sprague Dawley (SD) rats were used as a diabetic retinopathy model following injection with streptozotocin. Among the 34 rats in which the diabetes model was s...

journal_title：Molecular medicine reports

authors： Wu Y,Chen Y,Wu Q,Jia L,Du X

更新日期：2015-10-01 00:00:00

abstract：:Although the etiology of intervertebral disc degeneration is poorly understood, one approach to prevent this process may be to inhibit apoptosis. In the current study, the anti‑apoptotic effects of carboxymethylated chitosan (CMCS) in nucleus pulposus (NP) cells were investigated with the aim to enhance disc cell surv...

journal_title：Molecular medicine reports

authors： He B,Tao H,Liu S,Wei A

更新日期：2015-03-01 00:00:00

abstract：:The aim of the present study was to report on a complete synthetic approach, namely benzylation-hydrolysis-acylation‑hydrogenation, to the synthesis of regioselectively acylated quercetin analogues using low‑cost rutin as a starting material. Three quercetin analogues, quercetin‑3‑O‑propionate (Q‑pr), quercetin‑3‑O‑bu...

journal_title：Molecular medicine reports

authors： Duan Y,Sun N,Xue M,Wang X,Yang H

更新日期：2017-12-01 00:00:00

abstract：:Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. The present study aimed to elucidate the protective effect of magnolol (MG) on the progression of LN, via inhibition of key signaling pathways. The results of the present study demonstrated that administration of MG caused inhibition of the...

journal_title：Molecular medicine reports

authors： Huang F,Zhang RY,Song L

更新日期：2017-10-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity. MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of numerous cerebrovascular diseases, including ICH. miR‑222 has been revealed to play important roles in various physiological and pathological process...

journal_title：Molecular medicine reports

authors： Bai YY,Niu JZ

更新日期：2020-03-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) is known to increase the survival of skin flaps by promoting neovascularization; however, the detailed mechanisms involved are not fully understood. In the present study, we aimed to characterize the effects of HBO treatment on neovascularization and skin flap survival. We also analyzed the mec...

journal_title：Molecular medicine reports

authors： Liu X,Liang F,Yang J,Li Z,Hou X,Wang Y,Gao C

更新日期：2013-10-01 00:00:00

abstract：:Prolonged treatment with tyrosine kinase inhibitors (TKI) including imatinib (IMA) or nilotinib (NIL), induces severe disturbances of bone metabolism in patients with chronic myeloid leukaemia. As vitamin D3 (VD3) is involved in the complex cycle of bone remodelling, the present study investigated in vitro, the influe...

journal_title：Molecular medicine reports

authors： Kroschwald L,Suttorp M,Tauer JT,Zimmermann N,Günther C,Bauer A

更新日期：2018-01-01 00:00:00

abstract：:E-cadherin, β-catenin and N‑cadherin serve key roles in the epithelial‑to‑mesenchymal transition (EMT) that leads to human lens epithelial cell (LEC) transdifferentiation and subsequent cataract formation. The present study aimed to investigate the role of E‑cadherin in LEC transdifferentiation. SRA01/04 human LECs we...

journal_title：Molecular medicine reports

authors： Huang L,Jiang J,Guo Q,Yang H

更新日期：2017-10-01 00:00:00

abstract：:Colorectal cancer (CRC) remains a primary contributor to cancer‑associated mortality. The Lin28/let‑7 axis has previously been verified to participate in numerous pathophysiological processes involved in CRC. However, the potential roles and underlying mechanisms of this axis in apoptosis during CRC remain to be fully...

journal_title：Molecular medicine reports

authors： Zhang H,Zong Y,Qiu G,Jia R,Xu X,Wang F,Wu D

更新日期：2018-04-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. RGS9‑2, a brain‑specific splice variant of the RGS9 gene, is highly expressed in the striatum but lowly expressed in the periaqueductal gray and spinal cord, which mediate various act...

journal_title：Molecular medicine reports

authors： Zhu Y,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Osteopetrosis is a monogenic condition with various inheritance patterns, including autosomal dominant, autosomal recessive and X‑linked. Several disease‑causing genes have been identified and three distinguished types of osteopetrosis have been reported. In the present study, a family with osteopetrosis was investiga...

journal_title：Molecular medicine reports

authors： Yang Y,Ye W,Guo J,Zhao L,Tu M,Zheng Y,Li L

更新日期：2019-01-01 00:00:00

abstract：:Recent advances in the treatment of non-small cell lung cancer (NSCLC) with new agents require accurate histological subtyping at diagnosis to avoid the higher risk of an adverse response and to obtain the maximum therapeutic response. However, interobserver variability, tumor heterogeneity and the degree of different...

journal_title：Molecular medicine reports

authors： Hamamoto J,Soejima K,Yoda S,Naoki K,Nakayama S,Satomi R,Terai H,Ikemura S,Sato T,Yasuda H,Hayashi Y,Sakamoto M,Takebayashi T,Betsuyaku T

更新日期：2013-08-01 00:00:00

abstract：:Oxidative stress is known to play a key role in the progression of liver disease, including non-alcoholic steatohepatitis (NASH), which is often accompanied by hyperglycemia. This study examined the influence of high glucose on oxidative stress-induced hepatic cell death. Hc cells, a normal human hepatocyte-derived ce...

journal_title：Molecular medicine reports

authors： Shibata H,Ichikawa T,Nakao K,Miyaaki H,Takeshita S,Akiyama M,Fujimoto M,Miuma S,Kanda S,Yamasaki H,Eguchi K

更新日期：2008-05-01 00:00:00

abstract：:Numerous studies have shown that N-nitrosamines and their precursors are probable etiological factors for esophageal cancer. Certain N-nitrosamines have been shown to induce esophageal cancer in animal models. However, the molecular mechanisms by which N-nitrosamines promote esophageal carcinogenesis remain poorly und...

journal_title：Molecular medicine reports

authors： Xie Y,Tang E,Ren B,Feng L

更新日期：2010-05-01 00:00:00

abstract：:Bladder cancer (BCa) is the most common tumor of the urinary system. Chronic inflammation in the papillary urothelial neoplasm of low malignant potential (PUNLMP)may contribute to carcinogenesis, including that of BCa, via poorly understood mechanisms. In this study, we show that the lymphotoxin β receptor (LTβR) is u...

journal_title：Molecular medicine reports

authors： Shen M,Duan X,Zhou P,Zhou W,Wu X,Xu S,Chen Y,Tao Z

更新日期：2015-02-01 00:00:00

abstract：:In recent years, accumulating evidence has demonstrated that microRNAs (miRs, miRNAs) may serve an important role in the occurrence and development of tumors. miR‑23a‑5p has been confirmed as an oncogene in numerous diseases through gene chip analysis. However, as the most common type of renal tumor, the expression an...

journal_title：Molecular medicine reports

authors： Quan J,Jin L,Pan X,He T,Lai Y,Chen P,Lin C,Yang S,Zeng H,Lai Y

更新日期：2017-08-01 00:00:00

abstract：:Osteoclasts (OCs) are resorptive cells responsible for bone erosion in diseases, including osteoporosis, periodontitis and rheumatoid arthritis. Montelukast is a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist clinically used for the treatment of asthma. In the present study, the role of CysLTR1 on OC formation ...

journal_title：Molecular medicine reports

authors： Kang JH,Lim H,Lee DS,Yim M

更新日期：2018-08-01 00:00:00

abstract：:A type of aplastic anemia (AA), non-severe aplastic anemia (NSAA) is defined as AA that does not meet the diagnostic criteria of severe aplastic anemia (SAA). Complement component 1q (C1q) has an important role in the pathogenesis of various autoimmune diseases; however, the role of C1q in the immune pathogenesis of N...

journal_title：Molecular medicine reports

authors： Ding S,Liu C,Li Y,Liu H,Liu Z,Chen T,Zhang T,Shao Z,Fu R

更新日期：2019-02-01 00:00:00

abstract：:Patients with skull base chordomas have a poor prognosis, and the role of the protein expression of brachyury in chordomas remains to be fully elucidated. The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients. The results demonstrated tha...

journal_title：Molecular medicine reports

authors： Wang K,Tian K,Wang L,Wu Z,Ren C,Hao S,Feng J,Li J,Wan H,Jia G,Zhang L,Zhang J

更新日期：2015-09-01 00:00:00

abstract：:Embryonic stem cells (ESCs) are pluripotent stem cells derived from early stage embryos. It remains unclear whether inhibiting the Wnt/β‑catenin signaling pathway using dickkopf Wnt signaling pathway inhibitor 1 (DKK1) impacts on the differentiation potential of mouse ESCs in vitro and in vivo. In the present study, i...

journal_title：Molecular medicine reports

authors： Ou L,Fang L,Tang H,Qiao H,Zhang X,Wang Z

更新日期：2016-01-01 00:00:00

abstract：:Severe invasive aspergillosis infection occurs when human immune function is impaired. The interaction between Aspergillus fumigatus (A. fumigatus) conidia and type II lung epithelial cells serves an important role in disease progression. The present study compared the proteomes of A549 human lung epithelial cells wit...

journal_title：Molecular medicine reports

authors： Zhang X,He D,Gao S,Wei Y,Wang L

更新日期：2020-12-01 00:00:00

abstract：:Following the publication of the above article, an interested reader drew to the authors' attention that a pair of the data panels shown in Fig. 4 contained overlapping data. After having consulted their original data, the authors realized that a total of three panels featured in Figs. 4 and 6 had been erroneously sel...

journal_title：Molecular medicine reports

authors： Xu F,Wu H,Zhang K,Lv P,Zheng L,Zhao J

更新日期：2020-09-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to be significant in numerous biological processes. Hypertension is a form of cardiovascular disease with at least one billion cases worldwide. The present study sought to compare the differential expression profiles of lncRNAs in the renal cortex of spontaneously ...

journal_title：Molecular medicine reports

authors： Hou L,Lin Z,Ni Y,Wu Y,Chen D,Song L,Huang X,Hu H,Yang D

更新日期：2016-01-01 00:00:00

abstract：:Osteosarcoma is the most common type of primary malignant tumor of the bone. However, mechanisms underlying osteosarcoma cell proliferation are poorly understood. The present study shows that RBEL1, a newly identified Rab-like GTPase, may be a key regulator of osteosarcoma cell proliferation. Knockdown of RBEL1 in ost...

journal_title：Molecular medicine reports

authors： Tang H,Ji F,Sun J,Xie Y,Xu Y,Yue H

更新日期：2016-02-01 00:00:00

abstract：:Macrophage cholesterol efflux is important in maintaining cellular lipid homeostasis and preventing the formation of lipid‑laden foam cells. Although radioactive [3H]‑cholesterol is widely used as a tracer in cholesterol efflux assays, the lengthy and labor‑intensive assay procedure, and the radioactivity disposal pro...

journal_title：Molecular medicine reports

authors： Song W,Wang W,Wang Y,Dou L,Chen L,Yan X

更新日期：2015-10-01 00:00:00

abstract：:Minimally invasive aesthetic and cosmetic procedures have increased in popularity. Injectable dermal fillers provide soft tissue augmentation, improve facial rejuvenation and wrinkles, and correct tissue defects. To investigate the use of adipose‑derived stem cells integrated with a hyaluronic acid based gel as a derm...

journal_title：Molecular medicine reports

authors： Guo J,Guo S,Wang Y,Yu Y

更新日期：2017-10-01 00:00:00

abstract：:Neisseria meningitidis is the pathogen of epidemic encephalomyelitis and is responsible for permanent damage to the brain and nervous system. In the present study, the prokaryotic expression vector pGEX-6p-1/neisseria surface protein A (NspA) was constructed and the immune protective effect was investigated with the p...

journal_title：Molecular medicine reports

authors： Ying S,He J,Yu M,Zhang Y,Deng S,Zhang L,Xie M,Hu S

更新日期：2014-09-01 00:00:00

abstract：:Ehlers-Danlos syndrome type IV is an autosomal dominant connective tissue disease. Mutations in COL3A1 have been identified to underlie this disease; however, to the best of our knowledge, no COL3A1 mutations have been reported in Ehlers-Danlos syndrome type IV patients with an ascending aortic aneurysm. In order to d...

journal_title：Molecular medicine reports

authors： Deng Y,Wei S,Hu S,Chen J,Tan Z,Yang Y

更新日期：2015-07-01 00:00:00

abstract：:The aim of the present study was to evaluate the protective effect and mechanism of Astragaloside IV (ASIV) on myocardial injury induced by type 2 diabetes, with a focus on energy metabolism. Blood glucose, the hemodynamic index, left ventricular weight/heart weight (LVW/HW), the left ventricular systolic pressure (LV...

journal_title：Molecular medicine reports

authors： Zhang Z,Wang J,Zhu Y,Zhang H,Wang H

更新日期：2019-11-01 00:00:00