Oncogenic miR-23a-5p is associated with cellular function in RCC.

abstract：:Gastric cancer has become a serious disease in the past decade. It has the second highest mortality rate among the four most common cancer types, leading to ~700,000 mortalities annually. Previous studies have attempted to elucidate the underlying biological mechanisms of gastric cancer. The present study aimed to obt...

journal_title：Molecular medicine reports

authors： Qi W,Sun L,Liu N,Zhao S,Lv J,Qiu W

更新日期：2018-10-01 00:00:00

abstract：:The present study aimed to investigate the clinical significance of histone methylation in sepsis. A total of 43 blood samples from trauma and esophageal cancer patients with or without sepsis were collected. Immunofluorescence staining of isolated peripheral white blood cells (WBCs) was conducted. Co‑stained 293T cel...

journal_title：Molecular medicine reports

authors： Jiang L,Wang Y,Zhu D,Xue Z,Mao H

更新日期：2016-12-01 00:00:00

abstract：:Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is convers...

journal_title：Molecular medicine reports

authors： Rizos E,Siafakas N,Skourti E,Papageorgiou C,Tsoporis J,Parker TH,Christodoulou DI,Spandidos DA,Katsantoni E,Zoumpourlis V

更新日期：2016-12-01 00:00:00

abstract：:The aim of the present study was to identify potential key genes associated with the progression and prognosis of colorectal cancer (CRC). Differentially expressed genes (DEGs) between CRC and normal samples were screened by integrated analysis of gene expression profile datasets, including the Gene Expression Omnibus...

journal_title：Molecular medicine reports

authors： Yu C,Chen F,Jiang J,Zhang H,Zhou M

更新日期：2019-08-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) comprise a sizeable class of non‑coding RNAs with a length of over 200 base pairs. Little is known about their biological function, although over 20,000 lncRNAs have been annotated in the human genome. Through a diverse range of mechanisms, their primary function is in the regulation of ...

journal_title：Molecular medicine reports

authors： Kołat D,Hammouz R,Bednarek AK,Płuciennik E

更新日期：2019-08-01 00:00:00

abstract：:Cisplatin-induced heart damage is associated with enzymes and protein alterations. The purpose of this study was to investigate cisplatin-induced alterations in cardiac endothelin (ET)-1 and type III collagen following administration of cisplatin. Male Wistar rats were randomly divided into two groups: a control and a...

journal_title：Molecular medicine reports

authors： Huang QY,Li XF,Liu SP

更新日期：2012-03-01 00:00:00

abstract：:Interleukin (IL)-35 is the latest member of IL-12 family, which plays an important role in other autoimmune diseases. Bone marrow mononuclear cells Coombs test‑positive hemocytopenia, also termed immunorelated hemocytopenia (IRH) is a type of autoimmune-associated diseases. The present study investigated the relations...

journal_title：Molecular medicine reports

authors： Li Y,Wang Y,Liu H,Ding K,Hao S,Shao Y,Wang H,Chen J,Huang L,Shao Z,Fu R

更新日期：2018-02-01 00:00:00

abstract：:Aldose reductase (AR) is involved in the pathogenesis of nonalcoholic steatohepatitis. This study aimed to determine the mechanism by which AR affects the development of murine diet-induced nonalcoholic steatohepatitis. Steatohepatitis was induced in C57BL/6 mice by administration of a methionine-choline-deficient (MC...

journal_title：Molecular medicine reports

authors： Chen T,Shi D,Chen J,Yang Y,Qiu M,Wang W,Qiu L

更新日期：2015-01-01 00:00:00

abstract：:In the present study, optically active cis and trans α-hydroxy-β-lactams were prepared by Baker's yeast reduction of a racemic α-keto-β-lactam and by the hydrolysis of a racemic α-acetoxy β-lactam with the resting cells of Bacillus Subtilis. ...

journal_title：Molecular medicine reports

authors： Banik BK,Negi M,Manhas MS,Bose AK

更新日期：2010-03-01 00:00:00

abstract：:Increasing evidence has indicated that the generation of reactive oxygen species (ROS) contributes to H2O2‑induced nerve injury. This may result in oxidative stress that leads to cell damage or death. Dietary or pharmaceutical augmentation of the endogenous antioxidant defense capacity is a potential means by which to...

journal_title：Molecular medicine reports

authors： Lin P,Tian XH,Yi YS,Jiang WS,Zhou YJ,Cheng WJ

更新日期：2015-11-01 00:00:00

abstract：:Skeletal stem cells (SSCs) are a population of progenitor cells which give rise to postnatal skeletal tissues including bone, cartilage and bone marrow stroma, however not to adipose, haematopoietic or muscle tissue. Growth plate chondrocytes exhibit the ability of continuous proliferation and differentiation, which c...

journal_title：Molecular medicine reports

authors： Wu YX,Jing XZ,Sun Y,Ye YP,Guo JC,Huang JM,Xiang W,Zhang JM,Guo FJ

更新日期：2017-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are important regulators of a variety of biological processes and their dysregulation is closely related to cancer formation and progression. Therefore, examination of aberrantly expressed miRNAs in oral squamous cell carcinoma (OSCC) may provide important clues for the diagnosis and treatment of pa...

journal_title：Molecular medicine reports

authors： Wang Q,Lv L,Li Y,Ji H

更新日期：2018-09-01 00:00:00

abstract：:The presence of excess glutamate in the brain interstitial fluid characterizes several acute pathological conditions of the brain, including traumatic brain injury and stroke. It has been demonstrated that it is possible to eliminate excess glutamate in the brain by decreasing blood glutamate levels and, accordingly, ...

journal_title：Molecular medicine reports

authors： Li Y,Hou X,Qi Q,Wang L,Luo L,Yang S,Zhang Y,Miao Z,Zhang Y,Wang F,Wang H,Huang W,Wang Z,Shen Y,Wang Y

更新日期：2014-01-01 00:00:00

abstract：:Chronic periodontitis, a common oral disease, usually results in irreversible bone resorption. Bone regeneration is a complex process between bone‑forming activity of osteoblasts and bone‑resorbing activity of osteoclasts, and still remains a challenge for physicians clinically. A previous study demonstrated that the ...

journal_title：Molecular medicine reports

authors： Li X,Chang B,Wang B,Bu W,Zhao L,Liu J,Meng L,Wang L,Xin Y,Wang D,Tang Q,Zheng C,Sun H

更新日期：2017-12-01 00:00:00

abstract：:G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventric...

journal_title：Molecular medicine reports

authors： Delbeck M,Golz S,Vonk R,Janssen W,Hucho T,Isensee J,Schäfer S,Otto C

更新日期：2011-01-01 00:00:00

abstract：:Hepatic glycoprotein (gp78), a membrane-anchored E3 ubiquitin ligase, has been reported to be involved in regulating lipid and energy metabolism in animals, and cell death‑inducing DFFA‑like effector c (cidec) has emerged as an important regulator of metabolism, which has been implicated in the process of fat differen...

journal_title：Molecular medicine reports

authors： Li J,Liu G,Zhang F,Zhang Z,Xu Y,Li Q

更新日期：2017-08-01 00:00:00

abstract：:Taraxacum coreanum Nakai is a dandelion that is native to Korea, and is widely used as an edible and medicinal herb. The present study revealed the neuroprotective effect of this plant against glutamate-induced oxidative stress in HT22 murine hippocampal neuronal cells. Ethanolic extracts from the aerial (TCAE) and th...

journal_title：Molecular medicine reports

authors： Yoon CS,Ko W,Lee DS,Kim DC,Kim J,Choi M,Beom JS,An RB,Oh H,Kim YC

更新日期：2017-04-01 00:00:00

abstract：:The present study aimed to evaluate the silencing effect of artificial microRNAs (amiRNAs) against the hepatitis C virus (HCV) 1b (HCV1b) genotype core (C) and non-structural protein 4B (NS4B) genes. pDsRed-monomer-Core and pDsRed-monomer-NS4B plasmids, containing the target genes were constructed. A total of eight ar...

journal_title：Molecular medicine reports

authors： Jiang XH,Xie YT,Jiang B,Tang MY,Ma T,Peng H

更新日期：2015-08-01 00:00:00

abstract：:Macrophages can be polarized into the inflammatory M1 lineage or the immunomodulatory M2 lineage, depending on the differential tissue microenvironment signaling, specific pathogens or cytokine stimulation. Tumor necrosis factor α‑induced protein 8‑like protein 2 (TIPE2) has been demonstrated to negatively regulate in...

journal_title：Molecular medicine reports

authors： Jiang Y,Li Q,Zhang Y,Gao Y,Jiang L,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:Down syndrome (DS) is the most common birth defect in children. To investigate the mechanisms of DS, the present study analyzed the bisulfite‑sequencing (seq) data GSE42144, which was downloaded from the Gene Expression Omnibus. GSE42144 included DNA methylation data of three DS samples and three control samples, and ...

journal_title：Molecular medicine reports

authors： Zhang J,Zhou W,Liu Y,Li N

更新日期：2016-11-01 00:00:00

abstract：:Core2 β-1,6-N-acetylglucosaminyltransferase (C2GnT) forms an N-acetylglucosamine branch in the O-glycans (core2 O-glycans) of cell surface glycoproteins. We previously revealed that the expression of C2GnT is positively correlated with poor prognosis in prostate cancer patients. However, the detailed mechanisms underl...

journal_title：Molecular medicine reports

authors： Okamoto T,Yoneyama MS,Hatakeyama S,Mori K,Yamamoto H,Koie T,Saitoh H,Yamaya K,Funyu T,Fukuda M,Ohyama C,Tsuboi S

更新日期：2013-02-01 00:00:00

abstract：:The aim of the current study was to investigate the biological effect on T24 cells and human umbilical vein endothelial cells (HUVECs) of transfection with brain-specific angiogenesis inhibitor-1 (BAI-1). The recombinant plasmid pReceiver-M61-BAI-1 was transfected into human superficial bladder tumor cells (T24) and H...

journal_title：Molecular medicine reports

authors： Tian DW,Hu HL,Sun Y,Tang Y,Lei MD,Liu LW,Han RF,Wu CL

更新日期：2016-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) negatively regulate the expression of the target genes by binding to 'seed sequences' in the 3'‑untranslated region (3'‑UTR) mRNA transcripts, and the variants within or nearby 'seed sequences' may compromise or enhance miRNA/mRNA interaction leading to either 'loss‑of‑function' or 'gain‑of‑function...

journal_title：Molecular medicine reports

authors： Zhao Y,Li X,Zhu S

更新日期：2016-09-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1), a traditional Chinese herb extracted from Bolbostemma paniculatum (Maxim.), induces apoptosis in a number of human cancer cell lines. TBMS1 has been reported to induce apoptosis in human glioma cells, however the mechanism remains to be elucidated. The present study explored TBMS1‑induced PI3K/A...

journal_title：Molecular medicine reports

authors： Cao LJ,Xie HT,Chu ZX,Ma Y,Wang MM,Shi Z

更新日期：2020-08-01 00:00:00

abstract：:microRNAs have been shown to be stable and detectable in circulating blood, and circulating microRNAs are specifically expressed in numerous diseases. However, to date, the association between microRNAs and osteonecrosis of the femoral head (ONFH) has remained elusive. It was hypothesized that specific microRNAs in th...

journal_title：Molecular medicine reports

authors： Wang X,Qian W,Wu Z,Bian Y,Weng X

更新日期：2014-12-01 00:00:00

abstract：:An increasing amount of evidence indicates that the inhibition of β adrenergic signaling can result in the inhibition of tumor growth. However, the role of propranolol in liver cancer and the underlying mechanism remain to be elucidated. The present study aimed to investigate the role of propranolol in liver cancer ce...

journal_title：Molecular medicine reports

authors： Wang F,Liu H,Wang F,Xu R,Wang P,Tang F,Zhang X,Zhu Z,Lv H,Han T

更新日期：2018-04-01 00:00:00

abstract：:Small‑cell lung cancer (SCLC) is a type of lung cancer with early metastasis, and high recurrence and mortality rates. The molecular mechanism is still unclear and further research is required. The aim of the present study was to examine the pathogenesis and potential molecular markers of SCLC by comparing the differe...

journal_title：Molecular medicine reports

authors： Mao Y,Xue P,Li L,Xu P,Cai Y,Chu X,Jiang P,Zhu S

更新日期：2019-09-01 00:00:00

abstract：:Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragal...

journal_title：Molecular medicine reports

authors： Lee CY,Yang CY,Lin CC,Yu MC,Sheu SJ,Kuan YH

更新日期：2018-06-01 00:00:00

abstract：:LL‑37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL‑37 may modulate various inflammatory reactions. The authors previously revealed that LL‑37 improves the survival of a murine cecal ligation and puncture (CLP)...

journal_title：Molecular medicine reports

authors： Hosoda H,Nakamura K,Hu Z,Tamura H,Reich J,Kuwahara-Arai K,Iba T,Tabe Y,Nagaoaka I

更新日期：2017-10-01 00:00:00

abstract：:Cardiac stem cells (CSCs) can differentiate into cardiac muscle‑like cells; however, it remains unknown whether CSCs may possess the ability to differentiate into pacemaker cells. The aim of the present study was to determine whether angiotensin II (Ang II) could promote the specialization of CSCs into pacemaker‑like ...

journal_title：Molecular medicine reports

authors： Xue C,Zhang J,Lv Z,Liu H,Huang C,Yang J,Wang T

更新日期：2015-05-01 00:00:00