Abstract：
:The well-known pleiotropic health benefits of green tea are mainly attributed to epigallocatechin-3-gallate (EGCG), a polyphenolic compound from the group of catechins. EGCG's poor stability and intestinal permeability, however, can strongly impair its biological activities. In this work, EGCG-loaded nanostructured lipid carriers (NLC) functionalized with folic acid were optimized through a Box-Behnken design intended to provide an enhanced oral absorption and increased bioavailability of EGCG. Size, zeta potential and encapsulation efficiency (EE) of the produced spherical nanoparticles were evaluated. NLC were further characterized by Differential Scanning Calorimetry (DSC). An in vitro release study in simulated gastric and intestinal fluids was conducted and the storage stability of the nanoparticles was evaluated over a period of 8weeks. The overall results demonstrated the suitability of the developed formulation for the oral delivery of EGCG and its potential for applications in food industry.
journal_name
Food Chemjournal_title
Food chemistryauthors
Granja A,Vieira AC,Chaves LL,Nunes C,Neves AR,Pinheiro M,Reis Sdoi
10.1016/j.foodchem.2017.06.019subject
Has Abstractpub_date
2017-12-15 00:00:00pages
803-810eissn
0308-8146issn
1873-7072pii
S0308-8146(17)31000-2journal_volume
237pub_type
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