High proportion of PD-1-expressing CD4+ T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence.

abstract：:Th cells can adopt a number of different phenotypes. We performed microarray-assisted mRNA profiling on antigen-stimulated, TCR transgenic murine splenocytes that were cultured in the presence of cytokines. Transcriptome snapshots of Th cells differentiating into Th1 and Th2 phenotypes were obtained at various time po...

journal_title：European journal of immunology

authors： van den Ham HJ,de Waal L,Zaaraoui-Boutahar F,Bijl M,van Ijcken WF,Osterhaus AD,de Boer RJ,Andeweg AC

更新日期：2013-04-01 00:00:00

abstract：:In the murine system, we tested in vivo the immunogenicity of different preparations of the yeast-derived surface antigen (S-antigen or S-protein) of hepatitis B virus (HBV). Native S-protein molecules self-assemble into stable 22-nm particles. BALB/c mice immunized with low doses of native S-particles without adjuvan...

journal_title：European journal of immunology

authors： Schirmbeck R,Melber K,Mertens T,Reimann J

更新日期：1994-05-01 00:00:00

abstract：:A small dose of the IgG1 fraction of anti-idiotypic antibody (aId1) raised in guinea pigs against a strain A/J antibody specific for streptococcal Group A carbohydrate sensitizes A/J mice against Group A streptococci. This is opposed to the previously established suppressive function of anti-idiotypic antibody of the ...

journal_title：European journal of immunology

authors： Eichmann K,Rajewsky K

更新日期：1975-10-01 00:00:00

abstract：:Constitutive expression of CD25, the IL-2 receptor alpha-chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in vivo. IL-2 has been implicated in the generation and maintenance of Treg, however, a functional contribution of the IL-2 receptor during suppression is thus far...

journal_title：European journal of immunology

authors： de la Rosa M,Rutz S,Dorninger H,Scheffold A

更新日期：2004-09-01 00:00:00

abstract：:A panel of closely and distantly related lysozymes and lysozyme-peptide fragments were utilized in assessing the specificity repertoire of murine anti-hen egg white lysozyme hybridomas. The 44 monoclonal antibodies could be divided into a minimum of 18 fine specificity groups in tests using the lysozyme panel. Two hyb...

journal_title：European journal of immunology

authors： Metzger DW,Ch'ng LK,Miller A,Sercarz EE

更新日期：1984-01-01 00:00:00

abstract：:Mucosal boosting of BCG-immunised individuals with a subunit tuberculosis (TB) vaccine would be highly desirable, considering that the lungs are the principal port of entry for Mycobacterium tuberculosis (MTB) and the site of the primary infection and reactivation. However, the main roadblock for subunit TB vaccine de...

journal_title：European journal of immunology

authors： Stylianou E,Diogo GR,Pepponi I,van Dolleweerd C,Arias MA,Locht C,Rider CC,Sibley L,Cutting SM,Loxley A,Ma JK,Reljic R

更新日期：2014-02-01 00:00:00

abstract：:Th2 lymphocytes deliver essential signals for induction of asthmatic airway inflammation. We previously found that airway antigen challenge induces recruitment of Gr-1(+) neutrophils prior to the recruitment of Th2 cells. We examined, therefore, whether Gr-1(+) cells contribute to the development of Th2-dependent airw...

journal_title：European journal of immunology

authors： Jung YW,Zindl CL,Lai JF,Weaver CT,Chaplin DD

更新日期：2009-08-01 00:00:00

abstract：:Th1 and Th2 cells, which produce distinct sets of cytokines, differentially express several chemokine receptors that may regulate their tissue-specific localization. Although the expression pattern and regulation of chemokines are likely to play a critical role in many immunopathological processes, they remain largely...

journal_title：European journal of immunology

authors： Iellem A,Colantonio L,Bhakta S,Sozzani S,Mantovani A,Sinigaglia F,D'Ambrosio D

更新日期：2000-04-01 00:00:00

abstract：:The development and the differentiation of CD8(+) T cells are dependent on IL-15. Here, we have studied the source and mechanism of how IL-15 modulates CD8(+) T cell-mediated Th1 immune responses by employing two delayed-type hypersensitivity (DTH) models. IL-15-deficient (IL-15(-/-)) mice or mice treated with soluble...

journal_title：European journal of immunology

authors： Rückert R,Brandt K,Bulanova E,Mirghomizadeh F,Paus R,Bulfone-Paus S

更新日期：2003-12-01 00:00:00

abstract：:The expression of HLA class II genes is under the control of a transcriptional activator, CIITA, encoded by the AIR-1 locus. Here we show that CIITA inhibits HIV-1 LTR transactivation mediated by Tat. The inhibition occurred when CIITA and Tat were transiently expressed in cells after transfection and, most importantl...

journal_title：European journal of immunology

authors： Accolla RS,Mazza S,De Lerma Barbaro A,De Maria A,Tosi G

更新日期：2002-10-01 00:00:00

abstract：:The expression of the Pit-1/GHF-1 transcription factor (hereafter Pit-1), which controls the expression of growth hormone (GH) and prolactin (PRL) in the pituitary gland, has been documented in human and rat hemopoietic and lymphoid tissues and cell lines. Pit-1 mRNA was detected by in situ hybridization in about 1% o...

journal_title：European journal of immunology

authors： Delhase M,Vergani P,Malur A,Hooghe-Peters EL,Hooghe RJ

更新日期：1993-04-01 00:00:00

abstract：:Stimulation of T cells via the T cell receptor (TCR) leads to an increase intracellular in free Ca2+ levels ([Ca2+]i) and the activation of the MAP kinase signaling pathway. This study analyzes for the first time Ca2+ fluxes in naive cytotoxic T cells stimulated with full agonists, partial agonists, or antagonists. Fo...

journal_title：European journal of immunology

authors： Bachmann MF,Mariathasan S,Bouchard D,Speiser DE,Ohashi PS

更新日期：1997-12-01 00:00:00

abstract：:Stilbene disulfonates are known to competitively inhibit Cl-/HCO3- flux through Band 3-related anion exchange (AE) proteins. To study the role of AE in lymphocyte activation, stilbene disulfonates were added to cultures of rat splenocytes (SPL). Four different stilbene derivatives were tested and each directly stimula...

journal_title：European journal of immunology

authors： Deane KH,Mannie MD

更新日期：1992-05-01 00:00:00

abstract：:Using limiting dilution analysis, we investigated proliferative responses of UCHL1+ and UCHL1- T cell populations to compare the precursor cell frequencies following recall and alloantigen stimulation, and the complexity of cellular interactions within UCHL1+ and UCHL1- populations. We find high frequencies of recall ...

journal_title：European journal of immunology

authors： Merkenschlager M,Terry L,Edwards R,Beverley PC

更新日期：1988-11-01 00:00:00

abstract：:Regulatory T (Treg) cells are critically important for the maintenance of immunological tolerance. Both centrally arising natural nTreg cells and those emerging in the periphery in response to TGF-β, iTreg cells, play a role in the control of unwanted immune responses. Treg cells adopt multiple mechanisms to inhibit e...

journal_title：European journal of immunology

authors： Chen Y,Adams E,Regateiro FS,Vaux DJ,Betz AG,Andersen KG,Waldmann H,Howie D

更新日期：2012-06-01 00:00:00

abstract：:The zinc-finger transcription factor GATA3 serves as a master regulator of T-helper-2 (Th2) differentiation by inducing expression of the Th2 cytokines IL-4, IL-5 and IL-13 and by suppressing Th1 development. Here, we investigated how GATA3 affects Th17 differentiation, using transgenic mice with enforced GATA3 expres...

journal_title：European journal of immunology

authors： van Hamburg JP,de Bruijn MJ,Ribeiro de Almeida C,van Zwam M,van Meurs M,de Haas E,Boon L,Samsom JN,Hendriks RW

更新日期：2008-09-01 00:00:00

abstract：:In an effort to derive monoclonal antibodies (mAb) which can induce production of macrophage-activating factor (MAF) by cloned murine cytolytic T lymphocyte (CTL) lines, we have fused spleen cells from a rat immunized with a CTL clone with the nonsecreting mouse myeloma X63-Ag8.653. Three mAb (designated I-22, III-5 a...

journal_title：European journal of immunology

authors： MacDonald HR,Bron C,Rousseaux M,Horvath C,Cerottini JC

更新日期：1985-05-01 00:00:00

abstract：:B cells have multiple functions in adaptive immunity, including antibody production, antigen presentation and regulation of T-cell responses. Recent evidences indicate that B cells have more subsets than previously thought and may have non-classical functions, such as involvement in innate immunity and immune regulati...

journal_title：European journal of immunology

authors： Bao Y,Han Y,Chen Z,Xu S,Cao X

更新日期：2011-03-01 00:00:00

abstract：:T cells from human peripheral blood were enriched in T4+ cells by lysis of T8+ cells with the monoclonal antibody OKT8 plus complement. The T4+ subset was separated into 4 fractions differing in avidity for the lectin Helix pomatia A hemagglutinin (HP). The fractions were studied for their capacity to help autologous ...

journal_title：European journal of immunology

authors： Wikén M,Hellström U,Perlmann P

更新日期：1984-11-01 00:00:00

abstract：:Local graft-vs.-host reaction (GVHR) was induced in rats by injecting parental cells into young F1 recipients. As a consequence of antigenic stimulation in the course of developing GVHR in the responding lymph nodes, the number of interleukin 2-receptor (IL 2R)-bearing T cells increased from less than 1% up to 10% of ...

journal_title：European journal of immunology

authors： Volk HD,Brocke S,Osawa H,Diamantstein T

更新日期：1986-10-01 00:00:00

abstract：:We isolated immunoglobulin (Ig) VH4 genes that were rearranged in the genomic DNA of 160 day human fetal spleen. Productively rearranged VH 4-21 genes were cloned into pRTM1, a human IgM expression vector. This allowed us to generate IgM kappa-expressing transfectomas by co-transfecting each of these constructs with p...

journal_title：European journal of immunology

authors： Parr TB,Johnson TA,Silberstein LE,Kipps TJ

更新日期：1994-12-01 00:00:00

abstract：:The tendency of isolated germinal center (GC) B cells to undergo apoptosis was suppressed by recombinant cell-bound CD40 ligand (CD40L): after 2 days at 37 degrees C, > 80% of cells remained viable in the presence of CD40L as compared to < 1% in control cultures. CD40L sustained a high rate of DNA synthesis in GC cell...

journal_title：European journal of immunology

authors： Holder MJ,Wang H,Milner AE,Casamayor M,Armitage R,Spriggs MK,Fanslow WC,MacLennan IC,Gregory CD,Gordon J

更新日期：1993-09-01 00:00:00

abstract：:Oxidant stress can initiate or enhance inflammatory responses during tissue injury, possibly through activation of redox-sensitive chemokines. Because the transcription factor Nrf2 (NF-E2-related factor 2) is responsive to oxidative stress, and induces expression of cytoprotective and antioxidant genes that attenuate ...

journal_title：European journal of immunology

authors： Zhang X,Chen X,Song H,Chen HZ,Rovin BH

更新日期：2005-11-01 00:00:00

abstract：:A method is described for achieving the efficient production of proteins of biological interest by the establishment of hybridomas from lymphocytes of transgenic animals carrying a fusion gene having promoter-regulatory sequences functional in lymphocytes fused to the coding sequences of the protein to be produced. Wh...

journal_title：European journal of immunology

authors： Babinet C,Morello D,Rougeot C,Rouyre S

更新日期：1986-08-01 00:00:00

abstract：:It is well established that therapeutic impairment of Foxp3+ Treg in mice and humans favors immune rejection of solid tumors. Less explored is the impact Foxp3 allelic variants may have on tumor incidence, progression and therapy. In this work, we tested and demonstrate that the Foxp3fgfp reporter allele, found previo...

journal_title：European journal of immunology

authors： Almeida-Santos J,Bergman ML,Amendoeira Cabral I,Correia V,Caramalho Í,Demengeot J

更新日期：2020-03-01 00:00:00

abstract：:Autoimmune diseases including multiple sclerosis (MS) are the result of an imbalanced immune tolerance network. Dendritic cells (DCs) are key players in both initiating immunity (immunogenic DCs) and regulating immune responses (tolerogenic DCs = tolDCs) and are potential targets for the treatment of MS. While the imm...

journal_title：European journal of immunology

authors： Gross CC,Jonuleit H,Wiendl H

更新日期：2012-03-01 00:00:00

abstract：:Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils. ...

journal_title：European journal of immunology

authors： Samadi N,Polak D,Kitzmüller C,Steinberger P,Zlabinger GJ,Jahn-Schmid B,Bohle B

更新日期：2019-09-01 00:00:00

abstract：:Leishmaniasis is currently classified as category 1 disease, i.e. emerging and uncontrolled. Since the importance of persistent infection for maintaining an effective long-lasting protective response is controversial, the present study asks whether immunisation with non-persistent parasites leads to protection against...

journal_title：European journal of immunology

authors： Kedzierski L,Curtis JM,Doherty PC,Handman E,Kedzierska K

更新日期：2008-11-01 00:00:00

abstract：:A monoclonal antibody, termed 3-2F1, is specific for the rabbit VH al allotypic marker. This antibody appears to recognize a common al determinant since it reacts with all of the a1 immunoglobulin (Ig) that is bound by polyclonal rabbit anti-a1, and completely inhibits the binding of polyclonal anti-a1 to a1 Ig. When ...

journal_title：European journal of immunology

authors： Metzger DW

更新日期：1984-04-01 00:00:00

abstract：:The present study demonstrates that the C3b receptor CR1 (CD35) and the C3dg/Epstein-Barr virus receptor CR2 (CD21) are expressed by 25% and 70% of normal human thymocytes, respectively. The expression of CR2 extends to both CD1+ and CD1- cells in the thymus. Two subsets of CR2+ thymocytes were defined expressing low ...

journal_title：European journal of immunology

authors： Delibrias CC,Mouhoub A,Fischer E,Kazatchkine MD

更新日期：1994-11-01 00:00:00