当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione inhibits the growth and metastasis of breast carcinoma in mice.

2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione inhibits the growth and metastasis of breast carcinoma in mice.

Abstract：

:Metastasis causes approximately 90% of breast cancer-related deaths in women. Previously, we have demonstrated that 2-dodecyl-6-methoxycyclohexa-2,5-diene- 1,4-dione (DMDD) remarkably inhibited the growth of human breast cancer cells with little toxicity. In this study, we investigated the toxicity and efficacy of DMDD to treat metastatic breast tumors using an in vivo mouse model of the 4T1 mammary carcinoma. DMDD caused no observable toxicity and significantly extended the survival of 4T1 tumor-bearing mice. DMDD effectively inhibited the growth of 4T1 cells in vitro, and suppressed the growth and metastasis of mammary tumor in vivo. The levels of inflammatory cytokines in the serum (TNF-α, IL-6, IL-12, TGF-β, and VEGF) were down regulated by DMDD. Immunohistochemical analysis demonstrated that the inhibition of tumor growth and metastasis was associated with activation of Bax, cleaved caspases-3 and -9, and down-regulation of Bcl-2, MMP-2 and -9, NF-κB and IκBα. We speculate that DMDD inhibits cytokine production in the tumor cells in mice, which leads to deactivation of NF-κB pathway, and consequently inhibits the expression of many anti-apoptosis and metastasis-promoting genes, such as Bcl-2 and MMPs. Collectively, our results demonstrate the potential of DMDD as a safe and effective antitumor agent in the treatment of late-stage breast cancer.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Chen C,Nong Z,Xie Q,He J,Cai W,Tang X,Chen X,Huang R,Gao Y

doi

10.1038/s41598-017-07162-3

subject

Has Abstract

pub_date

2017-07-27 00:00:00

pages

6704

issue

1

issn

2045-2322

pii

10.1038/s41598-017-07162-3

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Effects of enzymatic browning reaction on the usability of tobacco leaves and identification of components of reaction products.

    abstract：:The enzyme browning reaction results in grey speckles on tobacco leaves, which impairs the value and industrial usability of tobacco leaves. To demonstrate the influences of different browning degrees (BDs) of tobacco leaves on the usability of different cultivars and positions and identified structure of brown (grey)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54360-2

    authors： Chen Y,Zhou J,Ren K,Zou C,Liu J,Yao G,He J,Zhao G,Huang W,Hu B,Chen Y,Xiong K,Jin Y

    更新日期：2019-11-28 00:00:00

  • Fabrication of copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2-2-aminobenzohydrazide and investigation of its catalytic application in the synthesis of 1,2,3-triazole compounds.

    abstract：:In the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2 modified by isatoic anhydride. The structure of the catalyst has been determined by ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81632-7

    authors： Rajabi-Moghaddam H,Naimi-Jamal MR,Tajbakhsh M

    更新日期：2021-01-22 00:00:00

  • Low resistance to chytridiomycosis in direct-developing amphibians.

    abstract：:Host-generalist pathogens sporadically infect naive hosts, potentially triggering epizootics. The waterborne fungus Batrachochytrium dendrobatidis (Bd) is linked to declines of hundreds of amphibian species with aquatic larvae. Although several population declines and extinctions attributed to Bd have been reported am...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16425-y

    authors： Mesquita AFC,Lambertini C,Lyra M,Malagoli LR,James TY,Toledo LF,Haddad CFB,Becker CG

    更新日期：2017-11-30 00:00:00

  • A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells.

    abstract：:Harnessing complement-mediated cytotoxicity by therapeutic antibodies has been limited because of dependency on size and density of antigen, structural constraints resulting from orientation of antibody binding, and blockade of complement activation by inhibitors expressed on target cells. We developed a modular bispe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48461-1

    authors： Cruz JW,Damko E,Modi B,Tu N,Meagher K,Voronina V,Gartner H,Ehrlich G,Rafique A,Babb R,Aneja P,Potocky TB,D' Orvilliers A,Coppi A,E SY,Qiu H,Williams CM,Bennett BL,Chen G,Macdonald L,Olson W,Lin JC,Stahl N,Mu

    更新日期：2019-08-19 00:00:00

  • Nanofiber-expanded human CD34+ cells heal cutaneous wounds in streptozotocin-induced diabetic mice.

    abstract：:Despite advances in diabetic wound care, the significant number of amputations that occur every year demands more effective therapeutics. Herein, we offer an aminated polyethersulfone nanofiber-expanded human umbilical cord blood-derived CD34+ cells (henceforth CD34+ cells) effective therapy, tested in cutaneous wound...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44932-7

    authors： Kanji S,Das M,Joseph M,Aggarwal R,Sharma SM,Ostrowski M,Pompili VJ,Mao HQ,Das H

    更新日期：2019-06-10 00:00:00

  • Mating and blood-feeding induce transcriptome changes in the spermathecae of the yellow fever mosquito Aedes aegypti.

    abstract：:Aedes aegypti mosquitoes are the primary vectors of numerous viruses that impact human health. As manipulation of reproduction has been proposed to suppress mosquito populations, elucidation of biological processes that enable males and females to successfully reproduce is necessary. One essential process is female sp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71904-z

    authors： Camargo C,Ahmed-Braimah YH,Amaro IA,Harrington LC,Wolfner MF,Avila FW

    更新日期：2020-09-10 00:00:00

  • Surgical treatment in Paget's disease with invasive ductal carcinoma: an observational study based on SEER.

    abstract：:The aim is to analyse the clinical presentation, treatment and outcomes in patients with Paget's disease with invasive ductal carcinoma (PD-IDC), with special emphasis on the role of surgical treatment. Using data obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2013, we investigate...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45510

    authors： Wu Q,Ding X,Li J,Sun S,Zhu S,Wu J,Liu Q,Yao F,Sun S

    更新日期：2017-04-19 00:00:00

  • Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry.

    abstract：:Immunoaffinity enrichment of proteotypic peptides, coupled with selected reaction monitoring, enables indirect protein quantification. However the lack of suitable antibodies limits its widespread application. We developed a method in which multi-specific antibodies are used to enrich groups of peptides, thus facilita...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08759

    authors： Weiß F,Schnabel A,Planatscher H,van den Berg BH,Serschnitzki B,Nuessler AK,Thasler WE,Weiss TS,Reuss M,Stoll D,Templin MF,Joos TO,Marcus K,Poetz O

    更新日期：2015-03-04 00:00:00

  • An experimental study of network effects on coordination in asymmetric games.

    abstract：:Network structure has often proven to be important in understanding the decision behavior of individuals or agents in different interdependent situations. Computational studies predict that network structure has a crucial influence on behavior in iterated 2 by 2 asymmetric 'battle of the sexes' games. We test such beh...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43260-0

    authors： Broere J,Buskens V,Stoof H,Sánchez A

    更新日期：2019-05-02 00:00:00

  • Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: the different roles of FGF21.

    abstract：:Increased fibroblast growth factor 21 (FGF21) levels have been found in patients with metabolic syndrome (MetS). MetS is also associated with cognitive decline. However, the correlation between FGF21 and cognitive decline in elderly and nonelderly MetS patients has not been investigated. 116 non-elderly patients (age ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23550-9

    authors： Phrommintikul A,Sa-Nguanmoo P,Sripetchwandee J,Vathesatogkit P,Chattipakorn N,Chattipakorn SC

    更新日期：2018-03-26 00:00:00

  • Disadvantageous associations: Reversible spatial cueing effects in a discrimination task.

    abstract：:Current theories describe learning in terms of cognitive or associative mechanisms. To assess whether cognitive mechanisms interact with automaticity of associative processes we devised a shape-discrimination task in which participants received both explicit instructions and implicit information. Instructions further ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16156

    authors： Nico D,Daprati E

    更新日期：2015-11-04 00:00:00

  • A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo.

    abstract：:The complement system is the first line of defense against foreign intruders, and deregulation of this system has been described in multiple diseases. In age-related macular degeneration (AMD), patients have higher complement activation levels compared to controls. Recently, a combination of three single nucleotide po...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26568

    authors： Paun CC,Lechanteur YTE,Groenewoud JMM,Altay L,Schick T,Daha MR,Fauser S,Hoyng CB,den Hollander AI,de Jong EK

    更新日期：2016-05-31 00:00:00

  • Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET.

    abstract：:We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67197-x

    authors： Trudzinski FC,Jörres RA,Alter P,Kahnert K,Waschki B,Herr C,Kellerer C,Omlor A,Vogelmeier CF,Fähndrich S,Watz H,Welte T,Jany B,Söhler S,Biertz F,Herth F,Kauczor HU,Bals R,COSYCONET consortium.

    更新日期：2020-06-29 00:00:00

  • Biomimetic cellular vectors for enhancing drug delivery to the lungs.

    abstract：:Despite recent advances in drug delivery, the targeted treatment of unhealthy cells or tissues continues to remain a priority. In cancer (much like other pathologies), delivery vectors are designed to exploit physical and biological features of unhealthy tissues that are not always homogenous across the disease. In so...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55909-x

    authors： Evangelopoulos M,Yazdi IK,Acciardo S,Palomba R,Giordano F,Pasto A,Sushnitha M,Martinez JO,Basu N,Torres A,Hmaidan S,Parodi A,Tasciotti E

    更新日期：2020-01-13 00:00:00

  • Enhanced optoelectronic performances of vertically aligned hexagonal boron nitride nanowalls-nanocrystalline diamond heterostructures.

    abstract：:Field electron emission (FEE) properties of vertically aligned hexagonal boron nitride nanowalls (hBNNWs) grown on Si have been markedly enhanced through the use of nitrogen doped nanocrystalline diamond (nNCD) films as an interlayer. The FEE properties of hBNNWs-nNCD heterostructures show a low turn-on field of 15.2 ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29444

    authors： Sankaran KJ,Hoang DQ,Kunuku S,Korneychuk S,Turner S,Pobedinskas P,Drijkoningen S,Van Bael MK,D' Haen J,Verbeeck J,Leou KC,Lin IN,Haenen K

    更新日期：2016-07-11 00:00:00

  • Author Correction: A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-62766-6

    authors： Sheu JR,Chen ZC,Jayakumar T,Chou DS,Yen TL,Lee HN,Pan SH,Hsia CH,Yang CH,Hsieh CY

    更新日期：2020-04-06 00:00:00

  • Noncoding RNA-regulated gain-of-function of STOX2 in Finnish pre-eclamptic families.

    abstract：:The familial forms of early onset pre-eclampsia and related syndromes (HELLP) present with hypertension and proteinuria in the mother and growth restriction of the fetus. Genetically, these clinically similar entities are caused by different founder-dependent, placentally-expressed paralogous genes. All susceptibility...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32129

    authors： Oudejans CB,Poutsma A,Michel OJ,Thulluru HK,Mulders J,van de Vrugt HJ,Sistermans EA,van Dijk M

    更新日期：2016-08-24 00:00:00

  • New limits of secondary β-relaxation.

    abstract：:Glass is an ultraviscous liquid that ceases to flow on a laboratory timescale but continues to relax on a geological timescale. Quintessentially, it has become hopeless for humans to explore the equilibrium behavior of glass, although the technology of glass making witness a remarkable advance. In this work, we propos...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43091

    authors： Tripathy SN,Rams-Baron M,Wojnarowska Z,Knapik-Kowalczuk J,Paluch M

    更新日期：2017-02-22 00:00:00

  • Author Correction: Antibiotic drug-resistance as a complex system driven by socio-economic growth and antibiotic misuse.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-50846-1

    authors： Malik B,Bhattacharyya S

    更新日期：2019-10-18 00:00:00

  • Computational geometric tools for quantitative comparison of locomotory behavior.

    abstract：:A fundamental challenge for behavioral neuroscientists is to accurately quantify (dis)similarities in animal behavior without excluding inherent variability present between individuals. We explored two new applications of curve and shape alignment techniques to address this issue. As a proof-of-concept we applied thes...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52300-8

    authors： Stamps MT,Go S,Mathuru AS

    更新日期：2019-11-12 00:00:00

  • Transcriptomic Analysis of mRNA-lncRNA-miRNA Interactions in Hepatocellular Carcinoma.

    abstract：:Fully elucidating the molecular mechanisms of non-coding RNAs (ncRNAs), including micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs), underlying hepatocarcinogenesis is challenging. We characterized the expression profiles of ncRNAs and constructed a regulatory mRNA-lncRNA-miRNA (MLMI) network based on transcripto...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52559-x

    authors： Tang X,Feng D,Li M,Zhou J,Li X,Zhao D,Hao B,Li D,Ding K

    更新日期：2019-11-06 00:00:00

  • Size distribution of magnetic charge domains in thermally activated but out-of-equilibrium artificial spin ice.

    abstract：:A crystal of emerging magnetic charges is expected in the phase diagram of the dipolar kagomé spin ice. An observation of charge crystallites in thermally demagnetized artificial spin ice arrays has been recently reported by S. Zhang and coworkers and explained through the thermodynamics of the system as it approaches...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05702

    authors： Montaigne F,Lacour D,Chioar IA,Rougemaille N,Louis D,Mc Murtry S,Riahi H,Burgos BS,Menteş TO,Locatelli A,Canals B,Hehn M

    更新日期：2014-07-16 00:00:00

  • Discrimination of three Ephedra species and their geographical origins based on multi-element fingerprinting by inductively coupled plasma mass spectrometry.

    abstract：:Discrimination of species and geographical origins of traditional Chinese medicine (TCM) is essential to prevent adulteration and inferior problems. We studied Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A.Mey. and Ephedra przewalskii Bge. to investigate the relationship between inorganic element content and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28558-9

    authors： Ma X,Fan L,Mao F,Zhao Y,Yan Y,Tian H,Xu R,Peng Y,Sui H

    更新日期：2018-07-06 00:00:00

  • Early alterations in a mouse model of Rett syndrome: the GABA developmental shift is abolished at birth.

    abstract：:Genetic mutations of the Methyl-CpG-binding protein-2 (MECP2) gene underlie Rett syndrome (RTT). Developmental processes are often considered to be irrelevant in RTT pathogenesis but neuronal activity at birth has not been recorded. We report that the GABA developmental shift at birth is abolished in CA3 pyramidal neu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45635-9

    authors： Lozovaya N,Nardou R,Tyzio R,Chiesa M,Pons-Bennaceur A,Eftekhari S,Bui TT,Billon-Grand M,Rasero J,Bonifazi P,Guimond D,Gaiarsa JL,Ferrari DC,Ben-Ari Y

    更新日期：2019-06-25 00:00:00

  • Amelioration of diabetic nephropathy in db/db mice treated with tibetan medicine formula Siwei Jianghuang Decoction Powder extract.

    abstract：:Siwei Jianghuang Decoction Powder (SWJH) documented originally in the Four Medical Tantras-Blue Glaze exhibited beneficial effects on diabetic nephropathy (DN) via combined synergistically action of multiple formula components including Curcumae longae Rhizoma, Berberidis dictyophyllae Cortex, Phyllanthi Fructus and T...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35148-2

    authors： Lai X,Tong D,Ai X,Wu J,Luo Y,Zuo F,Wei Z,Li Y,Huang W,Wang W,Jiang Q,Meng X,Zeng Y,Wang P

    更新日期：2018-11-12 00:00:00

  • MicroPattern: a web-based tool for microbe set enrichment analysis and disease similarity calculation based on a list of microbes.

    abstract：:The microbiota colonized on human body is renowned as "a forgotten organ" due to its big impacts on human health and disease. Recently, microbiome studies have identified a large number of microbes differentially regulated in a variety of conditions, such as disease and diet. However, methods for discovering biologica...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40200

    authors： Ma W,Huang C,Zhou Y,Li J,Cui Q

    更新日期：2017-01-10 00:00:00

  • Author Correction: Dogs and humans respond to emotionally competent stimuli by producing different facial actions.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-28651-z

    authors： Caeiro C,Guo K,Mills D

    更新日期：2018-07-05 00:00:00

  • Erratum: At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody.

    abstract：:This corrects the article DOI: 10.1038/srep20029. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/srep46385

    authors： Yu C,Gao K,Zhu L,Wang W,Wang L,Zhang F,Liu C,Li M,Wormald MR,Rudd PM,Wang J

    更新日期：2017-06-30 00:00:00

  • The interaction of asbestos and iron in lung tissue revealed by synchrotron-based scanning X-ray microscopy.

    abstract：:Asbestos is a potent carcinogen associated with malignant mesothelioma and lung cancer but its carcinogenic mechanisms are still poorly understood. Asbestos toxicity is ascribed to its particular physico-chemical characteristics, and one of them is the presence of and ability to adsorb iron, which may cause an alterat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01123

    authors： Pascolo L,Gianoncelli A,Schneider G,Salomé M,Schneider M,Calligaro C,Kiskinova M,Melato M,Rizzardi C

    更新日期：2013-01-01 00:00:00

  • Haptoglobin polymorphism and prostate cancer mortality.

    abstract：:Prostate cancer is a common malignancy in men worldwide and it is known that oxidative stress is a risk factor for cancer development. A common functional haptoglobin (Hp) polymorphism, originating from a duplication of a gene segment spanning over two exons, results in three distinct phenotypes with different anti-ox...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69333-z

    authors： Kaiser M,Thurner EM,Mangge H,Herrmann M,Semeraro MD,Renner W,Langsenlehner T

    更新日期：2020-08-04 00:00:00