Abstract:
PURPOSE:The purpose of this study was to identify risk factors for the development of infection after open fracture fixation. METHODS:A comprehensive search in all scientific literature of the last 30 years was performed in order to identify patient-, trauma-, diagnosis- and treatment-related risk factors. Studies were included when infectious complications were assessed in light of one or more risk factors. A meta-analysis was performed. Risk ratios (RR) or risk differences (RD) with 95% confidence intervals were calculated. RESULTS:A total of 116 manuscripts were included. Male gender (RR 1.42), diabetes mellitus (DM) (RR 1.72), smoking (RR1.29), a lower extremity fracture (RR 1.94), Gustilo-Anderson grade III open fracture (RR 3.01), contaminated fracture (RR 7.85) and polytrauma patients (RR 1.49) were identified as statistically significant risk factors for the development of infectious complications. Of the treatment-related risk factors, only pulsatile lavage was associated with a higher infectious complication rate (RR 2.70). CONCLUSION:A number of risk factors for the development of infections after open fractures have been identified in the available literature. These factors should still be tested for independence in a multivariable model. Prospective, observational studies are needed to identify and quantify individual risk factors for infection after open fracture fixation.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Kortram K,Bezstarosti H,Metsemakers WJ,Raschke MJ,Van Lieshout EMM,Verhofstad MHJdoi
10.1007/s00264-017-3556-5subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1965-1982issue
10eissn
0341-2695issn
1432-5195pii
10.1007/s00264-017-3556-5journal_volume
41pub_type
杂志文章,meta分析,评审abstract::In vitro and in vivo studies have demonstrated the possibility that cancellous bone could be used as a carrier of antibiotics for local delivery. However, the release of antibiotics from the loaded cancellous bone is too rapid and uncertain. We hypothesised that demineralisation of cancellous bone would increase the a...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-002-0384-y
更新日期:2003-01-01 00:00:00
abstract::Fractures around a femoral prosthesis have been treated with plating and additional cement, but this leads to further reduction of bone stock in the proximal femur. Since February 1992, we have dealt with this problem in 12 patients by revision using a long uncemented stem and distal interlocking combined with homolog...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050112
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Ankle sprains are the most common athletic injury. One of five chronic lateral ankle instability patients will require surgery, making operative outcomes crucial. The purpose of this study is to determine if operative method influences failure and complication rates in chronic lateral ankle ligament repair surg...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3617-9
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:The longest follow-up dual mobility series from inventor Gilles Bousquet focussing on implant survival and the incidence of dislocation. METHODS:This was a retrospective study from 1985 to 1990, on 240 hips using a PF® modular femoral stem and a dual mobility Novae® tripodal socket (SERF). RESULTS:The 22-year...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-011-1289-4
更新日期:2012-03-01 00:00:00
abstract::The effect of a low dose of diclofenac sodium, administered locally, on heterotopic bone formation in rats was investigated. Heterotopic bone was induced by implantation of demineralised bone matrix into the gluteal muscles. Diclofenac was released continuously for 2 weeks from micro-osmotic pumps for each demineralis...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00178357
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to examine the effect of subperiosteal injection of chondroinductive growth factors on the histological and biomechanical outcome of autologous osteoperiosteal grafts. METHODS:Thirty six standardised osteochondral defects were created in the trochlear groove of 18 Göttinger Minipi...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-013-1827-3
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:The management of calcaneal fractures remains challenging and often controversial. Open reduction and internal fixation with a lateral plate has been established as a standard therapy for displaced articular fractures. However, accurate subtalar joint reduction, while mandatory, is difficult to achieve, require...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-011-1249-z
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:Leg-length changes at total hip arthroplasty (THA) may result from too proximal position of the femoral component, i.e. not being sunk deep enough into the femoral canal due to the size and shape of both medullary canal and implant. Some femoral implants are designed to achieve such fixation in the mediolateral...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-020-04671-1
更新日期:2020-06-22 00:00:00
abstract:INTRODUCTION:Although consensus has been reached regarding the main aspects of intralesional surgery for giant cell tumour of the bone (GCTB), debates continue about the most effective combination of local adjuvants. The purpose of study was to analyze the previous experience and determine the most effective curettage ...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-020-04860-y
更新日期:2020-10-22 00:00:00
abstract:PURPOSE:The review aims to provide a summary of the current literature regarding common medications prescribed in orthopaedic surgery and their potential implications in COVID-19 patients. METHODS:A systematic review was performed using the PRISMA guidelines. All clinical studies, reviews, consensus and guidelines rel...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04643-5
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Residual feeling of leg length discrepancy (LLD) is a common cause of patient dissatisfaction following total hip arthroplasty (THA). The purpose of this study is to propose a method for determining an optimal leg length correction goal in THA. METHODS:We conducted a retrospective study of 132 patients to exam...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-019-04411-0
更新日期:2020-03-01 00:00:00
abstract::High tibial wedge osteotomies are often followed by transient neurological complications. From a retrospective study of 132 patients it appears that the incidence of this troublesome complication can be reduced after osteotomy with external fixation by using a technique of making consecutive drill holes of increasing ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00178347
更新日期:1995-01-01 00:00:00
abstract::To evaluate the effects of aggressive early rehabilitation on the clinical outcome of anterior cruciate ligament reconstruction using semitendinosus (and gracilis) tendon, 103 of 110 consecutive patients who underwent ACL reconstruction using multistrand semitendinosus tendon (ST) or the central one-third of patellar ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050276
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:Total hip arthroplasty with a dual mobility cup (DMC) is a proposed alternative to the widely performed bipolar hemiarthroplasty (BHA) for treating displaced intracapsular femoral neck fractures (DFNF) in the elderly. However, the comparison between the two modalities has not been extensively conducted thus far...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-3767-4
更新日期:2018-06-01 00:00:00
abstract::The Mennen plate has been used for osteosynthesis of 5 femoral fractures, 4 of which were at the tip of a prosthesis stem. Union was achieved in 2 fractures, and loss of fixation of the plate in three. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050234
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To analyse the results of the Ponseti method in the treatment of non-idiopathic clubfeet and compare them with idiopathic clubfeet in a programme-based setting using a standardized protocol METHODS: We reviewed two groups of 782 children treated prospectively in our programme-based Clubfoot Clinic: group I comp...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04677-9
更新日期:2021-01-01 00:00:00
abstract::The objective of this study was to determine whether BMP-2 and -14, noggin, and chordin could be detected in human fractures and to assess their regional and cellular distribution. The expression of these proteins was detected by immunohistochemistry in an archive of human fractures. BMP-2 and BMP-14 expression was st...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-008-0691-z
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:To evaluate the influence of stem offset and neck shaft angles on the range of motion before component impingement (ROMCI) and bony impingement (ROMBI), and the types of impingement in total hip arthroplasty (THA). METHODS:Using the computed tomography data of 101 patients who underwent THA, three-dimensional ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2826-3
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the impact of a preoperative myocardial infarction (MI) on outcomes of inpatient orthopaedic operations. METHODS:The National Surgical Quality Improvement Program database was used to identify patients who underwent common orthopaedic operations from 2006 to 2010. Pati...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-013-2001-7
更新日期:2013-12-01 00:00:00
abstract::Between 1993 and 1998, 49 consecutive patients with impending or complete pathological fractures of the femur due to metastatic bone disease were treated with intramedullary nailing. Twenty-four were treated with a long Gamma nail and 32 with an AO nail with a cephalomedullary spiral blade. Both implants gave a good f...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640000114
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:Several recent studies have reported accurate and reliable use of patient-specific cutting guides (PSCG) for medial opening-wedge high tibial osteotomy (OW-HTO); however, a majority of these are small cases series or ex-vivo reports. The hypothesis of this study was that performing an OW-HTO with PSCG resu...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-019-04372-4
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Diagnosing periprosthetic infection remains a challenge. Multiplex-PCR and biomarkers such as alpha-defensin are potentially useful and fast methods for detecting periprosthetic infection. This study compared these new methods with clinical assessment, conventional microbiological methods and histo-pathological...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3412-7
更新日期:2017-07-01 00:00:00
abstract::Percutaneous bone grafting with a specially devised milling cutter was used in 21 patients with nonunion or delayed union of fractures of the tibial shaft. Union was obtained in 18. The technique is safe, simple and can be done under local anaesthesia. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00181707
更新日期:1993-11-01 00:00:00
abstract::In 1975 we carried out a survey in Hong Kong to locate Chinese children with congenital dislocation of the hip. Analysis of the available records between 1960 and 1975 gave an observed incidence which was at least 10 times less than found in Caucasians. The age and sex distribution, radiographic findings and the left-...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266064
更新日期:1981-01-01 00:00:00
abstract::Over 10 years, 842 consecutive autopsies on patients dying from a malignant neoplasm were evaluated microscopically to determine the incidence of spinal and skeletal metastases. Vertebral wedging, sclerosis and areas of osteolysis were defined as features of spinal metastases. The incidence was 30.6%, 65% of which aro...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00181116
更新日期:1995-01-01 00:00:00
abstract::The objective was to assess whether time to diagnosis is influenced by patient/tumour-related factors and whether or not duration of symptoms has any impact on survival in soft tissue sarcoma. The study was an analysis of prospectively collected data for patients treated at our centre over a 20-year period. Risk facto...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-007-0319-8
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:The transfer of the pectoralis major in cases of irreparable rupture of the subscapularis has been described through different techniques. The aim of this prospective study was to compare the clinical results of transferring the clavicular or the sternal head of the pectoralis major tendon underneath the conjoi...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-014-2566-9
更新日期:2015-03-01 00:00:00
abstract:PURPOSES:Post arthroplasty gait analysis has up till now been performed on subjects walking slowly on flat ground rather than challenging them at faster speeds or walking uphill. We therefore asked: (1) Is there a measurable difference in the performance of hip resurfacing arthroplasty (HRA) and total hip arthroplasty ...
journal_title:International orthopaedics
pub_type: 临床试验,杂志文章
doi:10.1007/s00264-013-1819-3
更新日期:2013-05-01 00:00:00
abstract::This experimental study was undertaken in mice to investigate the procedures for storage of allogenic cancellous bone. Cancellous grafts were were stored at -80 degrees C, -196 degrees C or freeze dried. Grafts were implanted into a defect in the recipient's femur and after one week the cellular kinetic activity was a...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00178753
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:Antibiotic prophylaxis is routinely used in the surgical management of proximal femur fractures. The role of bacterial colonization of the skin and urine in the development of deep surgical site infections (SSI) is yet to be elucidated. This study aimed to evaluate the role of previous skin and urine colonizati...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04525-w
更新日期:2020-06-01 00:00:00