Abstract:
:In vitro and in vivo studies have demonstrated the possibility that cancellous bone could be used as a carrier of antibiotics for local delivery. However, the release of antibiotics from the loaded cancellous bone is too rapid and uncertain. We hypothesised that demineralisation of cancellous bone would increase the amount of antibiotic adsorbed, and coating of the freeze-dried antibiotic-impregnated cancellous bone with bio-compatible material would prolong antibiotic release. Bovine cancellous bone blocks of equal size were demineralised using a 0.5 N HCl solution and loaded with vancomycin solution under vacuum. The loaded bone blocks were then freeze-dried. To obtain a bio-compatible coating, the vancomycin-impregnated bone blocks were soaked in fresh human venous blood for 3 h. The release of impregnated antibiotic from the bone blocks was evaluated in phosphate-buffered saline and foetal bovine serum. It was found that significantly larger amounts of vancomycin were adsorbed into the demineralised bone blocks than into the un-demineralised blocks. The blood coating was found to increase the duration of vancomycin release from the blocks. With demineralisation and blood coating, the blocks eluted vancomycin higher than therapeutic concentration for a 5-week period.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Rhyu KH,Jung MH,Yoo JJ,Lee MC,Seong SC,Kim HJdoi
10.1007/s00264-002-0384-ykeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
53-5issue
1eissn
0341-2695issn
1432-5195journal_volume
27pub_type
杂志文章abstract::The aim of our study was to evaluate clinical, radiological and functional outcomes of selected cases of percutaneous fixation of scaphoid fractures via a dorsal approach. Percutaneous fixation by dorsal approach was done in 32 patients (mean age 32.2 years) involving both fresh and late scaphoid fracture presentation...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-009-0891-1
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:This study describes a case series of 15 patients with radial head fractures who underwent radial head excision using an arthroscopic technique. METHODS:Over a four year period, 15 patients (average age 49.6 years) who had sustained a radial head or radial neck fracture underwent an arthroscopic excision of th...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-012-1667-6
更新日期:2012-12-01 00:00:00
abstract::The purpose of the study was to analyse the clinical results of an open Bankart repair for anterior instability in patients with a glenoid defect and those without a glenoid defect, and to identify factors related to the glenoid defect associated with anterior instability. The prospective study involved 20 patients wi...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-006-0234-4
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:Total knee arthroplasty (TKA) as a treatment for end-stage osteoarthritis of the knee shows good results in terms of patient satisfaction. For the assessment of outcome and revision rate after total joint arthroplasty, there are two major data sources: clinical studies and national arthroplasty registers. The p...
journal_title:International orthopaedics
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00264-011-1255-1
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:The benefits of minimally invasive surgical techniques in total hip arthroplasty (THA) are well known, but concerns about applying those techniques in obese patients are controversial. We prospectively compared patients with increased body mass index (BMI ≥ 30) undergoing THA with normal weight patients. METHO...
journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00264-013-1833-5
更新日期:2013-06-01 00:00:00
abstract:INTRODUCTION:We hypothesised that the use of a polyaxial locking plate design offers the same clinical benefits as a monoaxial locking plate system following distal femoral osteoporotic/periprosthetic fracture fixation. METHOD:A multicentre prospective randomised pilot trial was conducted. Inclusion criteria were pati...
journal_title:International orthopaedics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00264-018-4061-1
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To evaluate the influence of stem offset and neck shaft angles on the range of motion before component impingement (ROMCI) and bony impingement (ROMBI), and the types of impingement in total hip arthroplasty (THA). METHODS:Using the computed tomography data of 101 patients who underwent THA, three-dimensional ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2826-3
更新日期:2016-02-01 00:00:00
abstract::In Japan, the main reason for osteoarthritis of the hip joint is caused by dysplastic deformities. The implantation technique of cementless press-fit cup with multi-screw fixation and acetabular bone graft to reconstruct the true acetabular center is described. In addition, special design aspects of the BiCONTACT-N st...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Twenty three patients with lumbar spondylolisthesis (6 Grade I, 14 Grade II and 3 Grade III) with low back pain, and radicular pain in 14, were treated surgically when they failed to respond to conservative treatment. Their average age was 33.2 years. Bilateral posterolateral spinal fusions with autologous iliac bone ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050249
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To evaluate the safety and efficacy of a novel technique of preconditioning autologous blood with gold particles (GOLDIC®) and injection in patients with moderate to severe knee osteoarthritis (KOA). METHODS:During this phase 2a, proof-of-concept (PoC) open label study, 83 consecutive patients that 64 patients...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04870-w
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate whether femoral antetorsion affects the range of motion (ROM) following total hip arthroplasty (THA) using 3D dynamic analysis. METHODS:Using 3D computed tomography (CT) data of 71 patients (71 hips) who underwent THA, we calculated antetorsion of the femoral neck, fle...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-014-2452-5
更新日期:2015-01-01 00:00:00
abstract::Osteofibrous dysplasia of the tibia in children will commonly recur after surgical resection. The use of a leg brace until puberty offers a useful method of conservative management. Seven female patients, age three months to nine years at the time of brace treatment, have been followed for 3.5 to 18 years, an average ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00180213
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:The goal of total hip endoprosthesis is to achieve painless and functional hip for long term. Accurate reconstruction of hip anatomy largely depends on the implant design. In order to select an implant in correspondence with the native hip, the proximal femoral morphology has been in focus of many studies in th...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-021-04942-5
更新日期:2021-01-13 00:00:00
abstract::Proliferating cell nuclear antigen (PCNA) is one of the cell cycle-related proteins directly involved in DNA synthesis. It is a marker of cellular proliferation and has been shown to correlate with ploidy and proliferative activity of cells. Its expression has been used to estimate the growth fraction of human cancer ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640000147
更新日期:2000-01-01 00:00:00
abstract::From September 1995 to August 2001, we treated 25 patients with chronic osteomyelitis of long bones by a two-stage technique. This consisted of the radical removal of all infected bone and soft tissue and immediate provision of soft-tissue cover. This was supplemented when necessary with delayed autogenous bone grafti...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-002-0416-7
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:Restoring a neutral mechanical axis in total knee arthroplasty (TKA) (within ±3° of varus/valgus) is associated with superior functional outcome and reduced early implant failure. Using conventional alignment jigs results in malalignment in >20 % of cases. In this study, we investigated the reduction of outlier...
journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00264-014-2529-1
更新日期:2015-03-01 00:00:00
abstract::Extraskeletal osteosarcoma is very rare and is difficult to diagnose histologically. We report a case of a 63 year old women who had such a tumour in her thigh. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00182646
更新日期:1990-01-01 00:00:00
abstract::The articular cartilage and synovial membrane of immature and mature chicken knee joints were studied by light, scanning and transmission microscopy. The findings differed from human articular cartilage and we conclude that the chicken knee joint is not suitable as a model for human joint degeneration. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00183553
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:Management of proximal humeral tumours remains a surgical challenge. No study to date has assessed the quality of life scores following the composite reverse shoulder arthroplasty for this indication. We, therefore, evaluated function and quality of life following reconstruction with allograft for malignant tum...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3538-7
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:Surgical treatment of acetabular fractures with plate fixation is challenging for orthopaedic surgeons because of variations of the surface curvature and complex fracture patterns of the acetabulum. We present our experience with pre-operative computer-assisted virtual simulation and three-dimensional (3D) prin...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-4111-8
更新日期:2019-08-01 00:00:00
abstract::To measure the strength of the juxta-articular trabecular bone in knee replacement, an osteopenetrometer was developed. The principle of its function is tha a needle penetrates the bony tissue and during this penetration the pressure on and the displacement of the needle is registered. The instrument was tested on cad...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00271079
更新日期:1981-01-01 00:00:00
abstract::Three different lateral approaches for a Charnley total hip replacement were studied in 264 operations. The transtrochanteric approach was used in 94, the Liverpool in 88 and the Hardinge in 82. The mean follow up was 2.6 years (range 2 to 3 years). The clinical result was the same in each group. Radiographs showed th...
journal_title:International orthopaedics
pub_type: 临床试验,杂志文章
doi:10.1007/s002640050193
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Surgical treatment of an acute Achilles tendon rupture can effectively reduce the risk of re-rupture, but it increases the probability of surgical complications. We postulated that a minimally invasive surgical treatment might reduce the number of complications related to open surgery and improve the functional...
journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00264-012-1737-9
更新日期:2013-04-01 00:00:00
abstract::We report the outcome of 50 patients with degenerative lumbar spinal stenosis who were treated surgically by spinal decompression between 1984 and 1995. Their mean age at the time of surgery was 59.9 (45-77) years and the mean follow-up was 11.6 (6.1-17.2) years. Five patients had a concomitant spinal fusion. The preo...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-005-0030-6
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:Traditionally and since Neer, the humeral side of shoulder arthroplasty consisted of a stemmed component but the real need for stem fixation in total shoulder arthroplasty (TSA) has barely been investigated. The current study evaluated the clinical and radiological outcomes with a stemless TSA. METHODS:Forty-s...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-016-3371-4
更新日期:2017-05-01 00:00:00
abstract:INTRODUCTION:Several recent studies have reported accurate and reliable use of patient-specific cutting guides (PSCG) for medial opening-wedge high tibial osteotomy (OW-HTO); however, a majority of these are small cases series or ex-vivo reports. The hypothesis of this study was that performing an OW-HTO with PSCG resu...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-019-04372-4
更新日期:2019-12-01 00:00:00
abstract::In 1975 we carried out a survey in Hong Kong to locate Chinese children with congenital dislocation of the hip. Analysis of the available records between 1960 and 1975 gave an observed incidence which was at least 10 times less than found in Caucasians. The age and sex distribution, radiographic findings and the left-...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266064
更新日期:1981-01-01 00:00:00
abstract::A woman aged 31 had an ameloblastoma of the inferior part of the maxilla treated by excision and a bone graft from the iliac crest. Nine years later she presented with a metastasis from the tumour at the donor site. Metastases from an ameloblastoma are rarely encountered. In this case there might have been contaminati...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00180180
更新日期:1994-02-01 00:00:00
abstract::In 16 patients with ulnar wrist pain, we performed primary arthroscopic or open repair of the peripheral rim tears of the triangular fibrocartilage complex (TFCC) (14 ulnar, 4 volar, and 3 radial tears). The wrist function was assessed before and 1 year after the repair using the Mayo-modified wrist score. The average...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640100285
更新日期:2001-01-01 00:00:00
abstract::Synovial fluid from a loose prosthesis may act as a vehicle for factors that regulate bone turnover. The effect of such synovial fluid on osteoblasts has been studied. Synovial fluid obtained from patients who underwent revision hip arthroplasty because of aseptic prosthesis loosening was studied regarding the effect ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-008-0533-z
更新日期:2009-06-01 00:00:00