Abstract:
:Synovial fluid from a loose prosthesis may act as a vehicle for factors that regulate bone turnover. The effect of such synovial fluid on osteoblasts has been studied. Synovial fluid obtained from patients who underwent revision hip arthroplasty because of aseptic prosthesis loosening was studied regarding the effect on protein synthesis, procollagen I mRNA expression, the secretion of procollagen I carboxyterminal propeptide (PICP) and osteocalcin in MG63 osteoblasts. Protein synthesis was increased and procollagen I mRNA expression was decreased by synovial fluid from patients with prosthesis loosening. Synovial fluid stimulated the total PICP in cell medium, but there was no change after correction for cell protein content in the cells. Synovial fluid in patients with prosthesis loosening has a general stimulatory effect on collagen formation and osteoblast proliferation because of a stimulatory effect on cell growth. Aseptic prosthesis loosening may be associated with an increase in bone formation.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Tsai JA,Andersson MK,Ivarsson M,Granberg B,Stark Adoi
10.1007/s00264-008-0533-zsubject
Has Abstractpub_date
2009-06-01 00:00:00pages
873-7issue
3eissn
0341-2695issn
1432-5195journal_volume
33pub_type
杂志文章abstract::Lesions produced by splinters of wood in the soft tissues and bones of the limbs are not uncommon and may be difficult to diagnose. A detailed history and a high index of suspicion are the key to making the correct diagnosis. Investigations are usually inconclusive. Complete excision results in prompt resolution. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00183364
更新日期:1990-01-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
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更新日期:2015-05-01 00:00:00
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journal_title:International orthopaedics
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journal_title:International orthopaedics
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journal_title:International orthopaedics
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journal_title:International orthopaedics
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journal_title:International orthopaedics
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更新日期:2018-09-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266603
更新日期:1980-01-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00264-012-1563-0
更新日期:2012-08-01 00:00:00
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journal_title:International orthopaedics
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更新日期:2020-08-01 00:00:00
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journal_title:International orthopaedics
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doi:10.1007/s00264-013-2253-2
更新日期:2014-11-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-007-0359-0
更新日期:2008-08-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-012-1622-6
更新日期:2012-09-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3477-3
更新日期:2017-06-01 00:00:00
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journal_title:International orthopaedics
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更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050158
更新日期:1997-01-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-016-3301-5
更新日期:2017-01-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050356
更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章,评审
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更新日期:2019-04-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00