Abstract：
BACKGROUND:Insufficient levels of serum 25-hydroxyvitamin D (25-OHD) influence the knee joint cartilage and lead to development and progression of knee osteoarthritis (OA). The purpose of this study was to determine the status of serum 25-OHD levels in patients with knee OA compared with controls. METHODS:A total of 148 patients with knee OA and 150 controls were studied. Serum 25-OHD was measured by the ELISA method and concentrations <20 ng/ml were considered as deficient levels. Mann-Whitney U test was used for comparisons of means and logistic regression analysis with calculation of odds ratio (OR) was applied to determine association. RESULTS:The mean ages of patients and controls were 60.2 ± 12.9 and 60.1 ± 10.2 years, respectively (P = 0.23). In the entire population the mean serum 25-OHD in OA patients was not significantly lower than controls (P = 0.28), but in subgroup analysis the mean 25-OHD in OA patients aged <60 years was significantly lower than controls (23.8 ± 18.8 vs. 34.5. ± 29.6 ng/ml, P = 0.01). In this age group knee OA was significantly associated with serum 25-OHD deficiency which remained significant after adjusting for age and sex (adjusted OR = 2.26, 95% CI 1.15-4.4, P = 0.018). A greater association was observed in patients aged < 55 years (OR = 2.63, 95% CI 1.16-5.95, P = 0.01); whereas the association between OA and serum 25-OHD deficiency in patients aged ≥60 years did not reach a significant level. CONCLUSION:These findings indicate a significant association between serum 25-OHD deficiency and knee OA in patients aged < 60 years and suggest serum 25-OHD measurement in any patient with symptoms suggestive of knee OA particularly at the initial stage of disease.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Heidari B,Heidari P,Hajian-Tilaki Kdoi
10.1007/s00264-010-1186-2subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1627-31issue
11eissn
0341-2695issn
1432-5195journal_volume
35pub_type
杂志文章abstract：:Between 1991 and 2002, we treated 21 patients with tibial bone loss using a conventional external fixator. Nine patients had an infected open fracture and 12 patients an infected nonunion. After corticotomy, the bone was distracted at the rate of 1 mm (1 mm/step) on alternate days or every 48 h. The mean follow-up per...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-004-0553-2
更新日期：2004-06-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
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journal_title：International orthopaedics
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doi：10.1007/s00264-016-3295-z
更新日期：2017-02-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
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journal_title：International orthopaedics
pub_type： 杂志文章
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journal_title：International orthopaedics
pub_type： 杂志文章,评审
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更新日期：2009-04-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
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journal_title：International orthopaedics
pub_type： 杂志文章
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journal_title：International orthopaedics
pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
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journal_title：International orthopaedics
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更新日期：2008-10-01 00:00:00
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journal_title：International orthopaedics
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00178347
更新日期：1995-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章,评审
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journal_title：International orthopaedics
pub_type： 杂志文章
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更新日期：2013-10-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章,评审
doi：10.1007/BF00266367
更新日期：1989-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s002640000209
更新日期：2001-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00178764
更新日期：1990-01-01 00:00:00
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journal_title：International orthopaedics
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00183550
更新日期：1993-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00267036
更新日期：1985-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-016-3395-9
更新日期：2017-08-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章,随机对照试验
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更新日期：2011-07-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章,随机对照试验
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更新日期：2015-05-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
