Presence of interleukin-17C in the tissue around aseptic loosened implants.

Abstract:

PURPOSE:The most common long-term complication of joint arthroplasty is aseptic loosening. The proinflammatory cytokines secreted by macrophages are involved in aseptic loosening. Recently, a novel proinflammatory cytokine IL-17C was reported to participate in inflammatory diseases by synergising with proinflammatory cytokines. However, the relationship between IL-17C and the aseptic loosening is unclear. METHODS:The tissues around aseptic loosened implants were collected during revision surgery and handled by formalin fixation and embedded in paraffin. The presence of IL-17C in the tissues around the aseptic loosened implants was investigated in 12 aseptic loosening patients using immunofluorescence. RESULTS:The presence of IL-17C protein in the tissues around aseptic loosened implants was detected by immunofluorescence. There are no statistical differences between optical density of IL-17C in aseptic loosening samples and in rheumatoid arthritis samples (positive control). CONCLUSIONS:These results suggest the presence of IL-17C in aseptic loosening. Interleukin-17C was related to the inflammation of aseptic loosening, possibly by contributing to the inflammation and osteolysis in the tissues surrounding aseptic loosened implants.

journal_name

Int Orthop

authors

Hou C,Zhang Y,Yu S,Li Z,Zhai Q,Li Z,Zhang X,Xiao J,Sheng P

doi

10.1007/s00264-013-1812-x

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

953-9

issue

5

eissn

0341-2695

issn

1432-5195

journal_volume

37

pub_type

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