Abstract:
PURPOSE:The purpose of this study was to evaluate the efficiency of biologic augmentation of rotator cuff repair with iliac crest bone marrow-derived mesenchymal stem cells (MSCs). The prevalence of healing and prevention of re-tears were correlated with the number of MSCs received at the tendon-to-bone interface. METHODS:Forty-five patients in the study group received concentrated bone marrow-derived MSCs as an adjunct to single-row rotator cuff repair at the time of arthroscopy. The average number of MSCs returned to the patient was 51,000 ± 25,000. Outcomes of patients receiving MSCs during their repair were compared to those of a matched control group of 45 patients who did not receive MSCs. All patients underwent imaging studies of the shoulder with iterative ultrasound performed every month from the first postoperative month to the 24th month. The rotator cuff healing or re-tear was confirmed with MRI postoperatively at three and six months, one and two years and at the most recent follow up MRI (minimum ten-year follow-up). RESULTS:Bone marrow-derived MSC injection as an adjunctive therapy during rotator cuff repair enhanced the healing rate and improved the quality of the repaired surface as determined by ultrasound and MRI. Forty-five (100 %) of the 45 repairs with MSC augmentation had healed by six months, versus 30 (67 %) of the 45 repairs without MSC treatment by six months. Bone marrow concentrate (BMC) injection also prevented further ruptures during the next ten years. At the most recent follow-up of ten years, intact rotator cuffs were found in 39 (87 %) of the 45 patients in the MSC-treated group, but just 20 (44 %) of the 45 patients in the control group. The number of transplanted MSCs was determined to be the most relevant to the outcome in the study group, since patients with a loss of tendon integrity at any time up to the ten-year follow-up milestone received fewer MSCs as compared with those who had maintained a successful repair during the same interval. CONCLUSION:This study showed that significant improvement in healing outcomes could be achieved by the use of BMC containing MSC as an adjunct therapy in standard of care rotator cuff repair. Furthermore, our study showed a substantial improvement in the level of tendon integrity present at the ten-year milestone between the MSC-treated group and the control patients. These results support the use of bone marrow-derived MSC augmentation in rotator cuff repair, especially due to the enhanced rate of healing and the reduced number of re-tears observed over time in the MSC-treated patients.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Hernigou P,Flouzat Lachaniette CH,Delambre J,Zilber S,Duffiet P,Chevallier N,Rouard Hdoi
10.1007/s00264-014-2391-1subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1811-8issue
9eissn
0341-2695issn
1432-5195journal_volume
38pub_type
杂志文章abstract::Postoperative infection is a regular complication in coccygectomy. The authors propose the use of a topical skin adhesive on the postoperative wound as a contribution to the prevention of this complication. It was used on the first 56 patients in this study. The rate of infection was 3.6% compared with the 14% rate of...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-010-1058-9
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abstract::The aim of this prospective study was to measure bone density changes and to assess adaptive bone remodelling after uncemented total hip arthroplasty with a taper-design femoral component using quantitative computer-tomography-assisted osteodensitometry. This method is able to differentiate cortical and cancellous bon...
journal_title:International orthopaedics
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doi:10.1007/s00264-007-0389-7
更新日期:2008-10-01 00:00:00
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journal_title:International orthopaedics
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-016-3293-1
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journal_title:International orthopaedics
pub_type: 杂志文章
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journal_title:International orthopaedics
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析,评审
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journal_title:International orthopaedics
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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journal_title:International orthopaedics
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更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-12-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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更新日期:2019-12-01 00:00:00
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journal_title:International orthopaedics
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更新日期:2018-12-01 00:00:00
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