Abstract:
PURPOSE:The purpose of this study was to evaluate the efficiency of biologic augmentation of rotator cuff repair with iliac crest bone marrow-derived mesenchymal stem cells (MSCs). The prevalence of healing and prevention of re-tears were correlated with the number of MSCs received at the tendon-to-bone interface. METHODS:Forty-five patients in the study group received concentrated bone marrow-derived MSCs as an adjunct to single-row rotator cuff repair at the time of arthroscopy. The average number of MSCs returned to the patient was 51,000 ± 25,000. Outcomes of patients receiving MSCs during their repair were compared to those of a matched control group of 45 patients who did not receive MSCs. All patients underwent imaging studies of the shoulder with iterative ultrasound performed every month from the first postoperative month to the 24th month. The rotator cuff healing or re-tear was confirmed with MRI postoperatively at three and six months, one and two years and at the most recent follow up MRI (minimum ten-year follow-up). RESULTS:Bone marrow-derived MSC injection as an adjunctive therapy during rotator cuff repair enhanced the healing rate and improved the quality of the repaired surface as determined by ultrasound and MRI. Forty-five (100 %) of the 45 repairs with MSC augmentation had healed by six months, versus 30 (67 %) of the 45 repairs without MSC treatment by six months. Bone marrow concentrate (BMC) injection also prevented further ruptures during the next ten years. At the most recent follow-up of ten years, intact rotator cuffs were found in 39 (87 %) of the 45 patients in the MSC-treated group, but just 20 (44 %) of the 45 patients in the control group. The number of transplanted MSCs was determined to be the most relevant to the outcome in the study group, since patients with a loss of tendon integrity at any time up to the ten-year follow-up milestone received fewer MSCs as compared with those who had maintained a successful repair during the same interval. CONCLUSION:This study showed that significant improvement in healing outcomes could be achieved by the use of BMC containing MSC as an adjunct therapy in standard of care rotator cuff repair. Furthermore, our study showed a substantial improvement in the level of tendon integrity present at the ten-year milestone between the MSC-treated group and the control patients. These results support the use of bone marrow-derived MSC augmentation in rotator cuff repair, especially due to the enhanced rate of healing and the reduced number of re-tears observed over time in the MSC-treated patients.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Hernigou P,Flouzat Lachaniette CH,Delambre J,Zilber S,Duffiet P,Chevallier N,Rouard Hdoi
10.1007/s00264-014-2391-1subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1811-8issue
9eissn
0341-2695issn
1432-5195journal_volume
38pub_type
杂志文章abstract:PURPOSE:The purpose of this study was to find a suitable method of labelling cartilage samples for the measurement of distraction distances in biomechanical testing. METHODS:Samples of bovine cartilage were labelled using five different methods: hydroquinone and silver nitrate (AgNO3), potassium permanganate (KMnO4) w...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-011-1468-3
更新日期:2012-07-01 00:00:00
abstract::In 1975 we carried out a survey in Hong Kong to locate Chinese children with congenital dislocation of the hip. Analysis of the available records between 1960 and 1975 gave an observed incidence which was at least 10 times less than found in Caucasians. The age and sex distribution, radiographic findings and the left-...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266064
更新日期:1981-01-01 00:00:00
abstract::A case of bilateral habitual dislocation of the patella associated with cleft lip and palate, and short metatarsals, metacarpals and phalanges is reported. The possible cause of habitual dislocation is discussed in the light of 20 cases which have been seen by the author. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00183358
更新日期:1990-01-01 00:00:00
abstract::Five cases of fracture of the lateral tibial condyle of the split-depression type were treated by elevation of the depressed fragment, bone grafting and cancellous bone screws. During the operation, tantalum markers were inserted into the depressed fragment and the tibial metaphysis for radiographic stereophotogrammet...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00192467
更新日期:1994-06-01 00:00:00
abstract::This transtrochanteric approach to the hip maintains continuity between the greater trochanter and the vastus lateralis muscle, thereby preventing the gross displacement of the greater trochanter and preserving the branches of the lateral circumflex vessels to it. The procedure offers the advantages of easy exposure a...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00265739
更新日期:1988-01-01 00:00:00
abstract::One hundred fractures of the tibial shaft were treated by early weight-bearing in a below knee patellar tendon bearing plaster cast. The rate of union, and the range of knee and ankle motion were assessed. Ninety-five per cent had good or excellent results. This method of treatment is particularly valuable in the thir...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00268506
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:Extracorporeal shockwave therapy (ESWT) has become a common practice for treating knee osteoarthritis (OA). However, the effectiveness and safety of this treatment are still questionable. This meta-analysis is aimed at determining the degree of pain reduction and functional outcome after ESWT for knee OA. METH...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-020-04489-x
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:Empirical broad-spectrum antibiotic treatment for orthopaedic implant infections after surgical lavage is common practice while awaiting microbiological results, but lacks evidence. METHODS:This was a single-centre cohort study from 1996 to 2010 with a follow-up of two years. RESULTS:We retrieved 342 implant ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-013-1924-3
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Treatment of open fractures is complex and controversial. The purpose of the present study is to add evidence to the management of open tibial fractures, where tissue loss necessitates cover with a free flap. We identified factors that increase the risk of complications. We questioned whether early flap coverag...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2712-z
更新日期:2015-06-01 00:00:00
abstract::There is currently an increased interest in the use of electro surgery in arthroscopy. Since the introduction of the bipolar arthroscopic radiofrequency (RF) wand, it has started to replace the classic Bovie monopolar probe on the assumption that the new technology provides multifunctional devices, combining both tiss...
journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00264-008-0541-z
更新日期:2009-02-01 00:00:00
abstract::The aim of this investigation was to examine the effect of short-term immobilization on subchondral cortical and trabecular bone tissue in the rat tibia and to determine whether there was any difference when the knee was immobilized in extension or flexion. Thirty-six male rats were used in this study, and in 18 the k...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266984
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:Occult intra-operative periprosthetic acetabular fracture is a seldom-reported complication of primary total hip arthroplasty (THA). It may potentially be associated with cup instability and implant loosening. The present study aimed to investigate clinical consequences of this complication. METHODS:Between 20...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-4084-7
更新日期:2019-07-01 00:00:00
abstract::Since 1975 we have treated 36 infected hip replacements by a two stage procedure in which the prosthesis and cement were first removed. Gentamicin impregnated beads were left at the sites of the prosthesis. Not less than 45 days later a fresh prosthesis was inserted into the hip. In two hips revision was not undertake...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00181860
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Previous reports revealed a correlation between psychological problems and spinal surgery. There is a lack of knowledge on the effect of anxiety on the percutaneous transforaminal endoscopic discectomy (PTED) outcome at the two year follow-up. The purpose of this study is to investigate changes in anxiety after...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04656-0
更新日期:2020-11-01 00:00:00
abstract::Synovial oedema is a frequent complication in arthroscopic procedures performed with normal saline as the irrigating fluid. The authors have studied the effect of saline solution, Ringer lactate, 5% Dextran and 10% Dextran in normal saline on 12 specimens of human synovial membrane. They found that 10% Dextran in norm...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:Forty patients were enrolled in a prospective randomised study using conventional method or "Trabecular Metal Cone" (TM Cone) (Zimmer inc., Warsaw, USA) for reconstruction of bone loss of the proximal tibia during revision total knee arthroplasty (rTKA). The aim was to evaluate changes in bone mineral density (...
journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00264-012-1601-y
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Osteoarthritis (OA) is one of the most common causes of disability and a prevalent chronic disease. The use of collagen is growing due to the satisfactory results in the treatment of OA. However, the possible beneficial effects of collagen for the treatment of OA are currently controversial. The aim of the pres...
journal_title:International orthopaedics
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00264-018-4211-5
更新日期:2019-03-01 00:00:00
abstract::The aim of this study was to compare the safety and efficacy of OsteoSet®2 DBM with autologous cancellous bone in free vascularised fibular grafting for the treatment of large osteonecrotic lesions of the femoral head. Twenty-four patients (30 hips) with large osteonecrotic lesions of the femoral head (stage IIC in si...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-009-0915-x
更新日期:2011-04-01 00:00:00
abstract::A description is given of the vertical and horizontal components of the forces applied to the floor by the foot in walking. Information about the characteristics of the normal force pattern was obtained from the analysis of the gait of 214 normal subjects (108 young adults, 63 elderly people and 43 children). It is su...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266460
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:The purpose of this systematic review and meta-analysis of randomised controlled trials is to assess the effectiveness of no drainage when compared to drainage in total knee arthroplasty, in terms of recovery of knee flexion, reduction in swelling, length of hospital stay and haemoglobin levels following TKA. ...
journal_title:International orthopaedics
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00264-014-2455-2
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Intercondylar humerus fractures (AO type 13C), though less common (less than 1%), are increasing over the last few years. Open reduction and internal fixation (ORIF) of these fractures are now well recognised and preferred management. These fractures are principally approached from posterior side and various...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04785-6
更新日期:2020-12-01 00:00:00
abstract::The Mennen plate has been used for osteosynthesis of 5 femoral fractures, 4 of which were at the tip of a prosthesis stem. Union was achieved in 2 fractures, and loss of fixation of the plate in three. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050234
更新日期:1998-01-01 00:00:00
abstract::We treated 19 patients with piriformis muscle syndrome. All patients complained of pain in the buttocks and the posterior thigh. Clinically the buttock was tender and passive stretching increased the pain. In ten patients skin sensation was reduced and three had a limp. All patients were treated with tenotomy. At foll...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-001-0319-z
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:The management of calcaneal fractures remains challenging and often controversial. Open reduction and internal fixation with a lateral plate has been established as a standard therapy for displaced articular fractures. However, accurate subtalar joint reduction, while mandatory, is difficult to achieve, require...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-011-1249-z
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:Trochleoplasty is a relatively rare operation with few published results and it remains a technically demanding procedure which requires careful patient selection. The ideal candidate for surgery remains to be elucidated, and some authors consider it as a good revision option in cases of previous unsuccessful o...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-012-1746-8
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:There remains controversy as to whether computer-navigated total knee replacement (TKR) improves the overall prosthesis alignment and patient function. The aim of this study was to determine whether computer-assisted total knee arthroplasty provides superior prosthesis positioning when compared to a conventiona...
journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00264-013-1996-0
更新日期:2014-02-01 00:00:00
abstract::This study investigated the relationship of bone porosity and bone-cement interface shear strength. One hundred forty-six samples were taken from the distal metaphysis of 20 bovine femora. After cementation, the shear strength of the bone-cement interface was tested. According to the porosity, the samples were divided...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-008-0558-3
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:Degenerative disc disease involves sequential events that lead to the loss of cells, a decrease in disc matrix production, disc dehydration, and alteration of its biomechanical properties. The aim of this study was to determine whether cryoinjury of the nucleus pulposus performed through endplate perforation co...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-3971-2
更新日期:2018-09-01 00:00:00
abstract::The normal characteristics of the hallux sesamoid bones were studied in 200 toes (100 dissections and 100 radiographs from patients with hallux valgus), and pathological changes were recorded. Normally each sesamoid articulated with a separate groove on the plantar surface of the first metatarsal head. A bony ridge on...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00267743
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Synovial haemangioma is a rare type of tumour for which only around 200 cases have been reported worldwide. It usually occurs in the female population during the second decade of life and most commonly affects the knee joint. Patients can complain of pain, recurrent knee swelling and limitation of motion. Si...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2930-4
更新日期:2015-10-01 00:00:00