Abstract：
PURPOSE:We have previously reported that a cylindrical bioabsorbable synthetic polymer scaffold made of poly (DL-lactide-co-glycolide) (PLG) can be used to repair osteochondral defects without using cultured cells in a rabbit model. This cylindrical scaffold has a solid and pre-formed design, which limits its widespread application. Therefore, we created a cotton-textured PLG scaffold, which would be superior to other scaffolds in terms of plastic property and operability. The purpose of the present study was to examine the efficacy of the cotton-textured PLG scaffold in the repair of osteochondral defects. METHODS:Cotton-textured PLG scaffolds were prepared using the electrospinning method and used to repair osteochondral defects produced on the right femoral condyle in 36 rabbits. As a control, the defect was left untreated. The outcomes of repair were examined histologically at postoperative weeks four, eight, and 12. RESULTS:In the untreated control group, the surface of the defect remained concave and the regenerated cartilaginous tissue partially covered the articular surface even at postoperative week 12. In the scaffold group, cartilaginous tissue covered the surface of the defect at postoperative week four, and the surface was smooth and the cartilaginous tissue was well regenerated and integrated with the native cartilage at postoperative week 12. CONCLUSIONS:The cotton-textured PLG scaffold could repair the osteochondral defect with good outcomes similar to those previously reported for the cylindrical scaffold, with its characteristic advantages of better plasticity and operability. We conclude that the cotton-textured PLG scaffold has potential for clinical application in comminuted osteochondral injury.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Sakata R,Kokubu T,Mifune Y,Inui A,Nishimoto H,Fujioka H,Kuroda R,Kurosaka Mdoi
10.1007/s00264-013-2253-2subject
Has Abstractpub_date
2014-11-01 00:00:00pages
2413-20issue
11eissn
0341-2695issn
1432-5195journal_volume
38pub_type
杂志文章abstract：PURPOSE:Our aim was to evaluate the results of short-segment pedicle instrumentation with screw insertion in the fracture level and find factors predicting kyphosis recurrence in thoracolumbar burst fractures. METHODS:We retrospectively analysed 122 patients with thoracolumbar burst fracture who were divided into two ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-016-3180-9
更新日期：2016-06-01 00:00:00
abstract：:Joint arthroplasty registries show an increased rate of aseptic loosening in uncemented acetabular components as compared to cemented acetabular components. Since loosening is associated with particulate wear debris, we postulated that uncemented acetabular components demonstrate a higher polyethylene wear rate than c...
journal_title：International orthopaedics
pub_type： 杂志文章,评审
doi：10.1007/s00264-012-1738-8
更新日期：2013-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-014-2369-z
更新日期：2014-10-01 00:00:00
abstract：:The purpose of the study was to analyse the clinical results of an open Bankart repair for anterior instability in patients with a glenoid defect and those without a glenoid defect, and to identify factors related to the glenoid defect associated with anterior instability. The prospective study involved 20 patients wi...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-006-0234-4
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journal_title：International orthopaedics
pub_type： 杂志文章,meta分析
doi：10.1007/s00264-011-1228-4
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-010-0995-7
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-012-1731-2
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00182984
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pub_type： 杂志文章
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journal_title：International orthopaedics
pub_type： 杂志文章
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journal_title：International orthopaedics
pub_type： 杂志文章,评审
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journal_title：International orthopaedics
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doi：10.1007/s002640050112
更新日期：1997-01-01 00:00:00
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journal_title：International orthopaedics
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journal_title：International orthopaedics
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doi：10.1007/BF00180180
更新日期：1994-02-01 00:00:00
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journal_title：International orthopaedics
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更新日期：1984-01-01 00:00:00
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journal_title：International orthopaedics
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更新日期：2009-12-01 00:00:00
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journal_title：International orthopaedics
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更新日期：1991-01-01 00:00:00
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pub_type： 杂志文章,已发布勘误
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更新日期：2018-07-01 00:00:00
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journal_title：International orthopaedics
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更新日期：1998-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 临床试验,杂志文章
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journal_title：International orthopaedics
pub_type： 临床试验,杂志文章,随机对照试验
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