Abstract：
INTRODUCTION:While adherence to medication in smoking cessation clinical trials is strongly associated with clinical outcome, very few studies have evaluated the validity of pill count as a measure of adherence relative to a biological assay, and evaluated a broad range of correlates of adherence. METHODS:In a smoking cessation clinical trial of varenicline, we compared pill counts collected over 4 different time periods to varenicline salivary levels taken after 2weeks of treatment, as well as evaluated predictors of adherence to varenicline. RESULTS:Using a binary measure of adherence based on salivary varenicline levels, adherence was higher among older, white, and more educated participants. Relative to 3, 7, and 14-day pill count, 12-week pill count was the only significant measure able to discriminate adherence as defined by salivary varenicline levels (assessed by area under the receiver operating characteristic curve; AUC=0.59, p=0.004). Seventy-two percent of participants who indicated adherence on 12-week pill count were classified as adherent based on varenicline saliva levels (sensitivity=0.80; specificity=0.40). There was modest variability in the relationship between 12-week pill count and varenicline levels across race and rate of nicotine metabolism. Lastly, General Estimating Equation models demonstrated that longitudinal changes in withdrawal, craving, negative and positive affect, and side effect count and severity were not related to adherence based on salivary varenicline levels. CONCLUSIONS:These results indicate that 12-week pill count was the best, albeit a relatively weak, measure of varenicline adherence; additional factors associated with treatment adherence need to be identified.
journal_name
Addict Behavjournal_title
Addictive behaviorsauthors
Peng AR,Morales M,Wileyto EP,Hawk LW Jr,Cinciripini P,George TP,Benowitz NL,Nollen NL,Lerman C,Tyndale RF,Schnoll Rdoi
10.1016/j.addbeh.2017.07.006subject
Has Abstractpub_date
2017-12-01 00:00:00pages
122-129eissn
0306-4603issn
1873-6327pii
S0306-4603(17)30251-4journal_volume
75pub_type
杂志文章abstract：:The relationship between heroin-related attentional bias (AB) and a proxy for dependence severity (monthly frequency of heroin use-injecting or inhaling) was measured in individuals attending a heroin harm reduction service. A flicker change blindness paradigm was employed in which change detection latencies were meas...
journal_title：Addictive behaviors
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journal_title：Addictive behaviors
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journal_title：Addictive behaviors
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journal_title：Addictive behaviors
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journal_title：Addictive behaviors
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journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Addictive behaviors
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journal_title：Addictive behaviors
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journal_title：Addictive behaviors
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journal_title：Addictive behaviors
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journal_title：Addictive behaviors
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