当前位置： SCI文献检索 > CARDIOLOGY IN THE YOUNG期刊下所有文献 > Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants.

Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants.

Abstract：

BACKGROUND:In very low birth weight infants, persistence of a patent ductus arteriosus results in morbidity and mortality. Therapies to close the ductus are effective, but clinical outcomes may depend on the accuracy of diagnosis and the timing of administration. The objective of the present study was to characterise the association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants. METHODS:This retrospective cohort study used electronic health record data on inborn infants of gestational age ⩽28 weeks and birth weight <1500 g who were discharged after day of life 7 from 362 neonatal ICU from 1997 to 2013. The primary outcome was death between day of life 7 and discharge. Secondary outcomes included bronchopulmonary dysplasia, necrotising enterocolitis, and grade 3 or 4 intraventricular haemorrhage. RESULTS:This study included a total of 48,551 infants with a median gestational age of 27 weeks (interquartile range 25, 28) and birth weight 870 g (706, 1050). Early echocardiography - that is, performed during days of life 2 to 6 - was performed in 15,971/48,551 (33%) infants, and patent ductus arteriosus was diagnosed in 31,712/48,551 (65%). The diagnosis was more common in infants who had undergone early echocardiography (14,549/15,971 [91%] versus 17,163/32,580 [53%], p<0.001). In multivariable analysis, early echocardiography was not associated with reduced mortality (odds ratio 0.97, 95% CI 0.89-1.05). Results were similar in the subset of infants who received therapy for patent ductus arteriosus (odds ratio 1.01, 95% CI 0.90-1.15). CONCLUSIONS:Early echocardiography was associated with an increased diagnosis of patent ductus arteriosus, but not with decreased mortality.

journal_name

Cardiol Young

journal_title

Cardiology in the young

authors

Lee JH,Greenberg RG,Quek BH,Clark RH,Laughon MM,Smith PB,Hornik CP

doi

10.1017/S1047951117001081

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1732-1739

issue

eissn

1047-9511

issn

1467-1107

pii

S1047951117001081

journal_volume

pub_type

杂志文章

在线工具

Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants.