当前位置： SCI文献检索 > CARDIOLOGY IN THE YOUNG期刊下所有文献 > Cardiac strain findings in children with latent rheumatic heart disease detected by echocardiographic screening.

Cardiac strain findings in children with latent rheumatic heart disease detected by echocardiographic screening.

Abstract：

BACKGROUND:Identification of patients with latent rheumatic heart disease by echocardiography presents a unique opportunity to prevent disease progression. Myocardial strain is a more sensitive indicator of cardiac performance than traditional measures of systolic function. OBJECTIVE:The objective of this study was to test the hypothesis that abnormalities in myocardial strain may be present in children with latent rheumatic heart disease. METHODS:Standard echocardiography images with electrocardiogram gating were obtained from Ugandan children found to have latent rheumatic heart disease as well as control subjects. Traditional echocardiography measures of systolic function were obtained, and offline global longitudinal strain analysis was performed. Comparison between groups was performed using strain as a continuous (Mann-Whitney U-test) and categorical (cut-off 5th percentile for age) variable. RESULTS:Our study included 14 subjects with definite rheumatic heart disease, 13 with borderline rheumatic heart disease, and 112 control subjects. None of the subjects had abnormal left ventricular size or ejection fraction. Global longitudinal strain was lower than the 5th percentile in 44% of the subjects with any rheumatic heart disease (p=0.002 versus controls) and 57% of the subjects with definite rheumatic heart disease (p=0.03). The mean absolute strain values were significantly lower when comparing subjects with any rheumatic heart disease with controls (20.4±3.95 versus 22.4±4.35, p=0.025) and subjects with definite rheumatic heart disease with controls (19.9±4.25 versus 22.4±4.35, p=0.033). CONCLUSION:Global longitudinal strain is decreased in subjects with rheumatic heart disease in the absence of abnormal systolic function. Larger studies with longer-term follow-up are required to determine whether there is a role for strain to help better understand the pathophysiology of latent rheumatic heart disease.

journal_name

Cardiol Young

journal_title

Cardiology in the young

authors

Beaton A,Richards H,Ploutz M,Gaur L,Aliku T,Lwabi P,Ensing G,Sable C

doi

10.1017/S1047951116002778

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

1180-1185

issue

eissn

1047-9511

issn

1467-1107

pii

S1047951116002778

journal_volume

pub_type

杂志文章

在线工具

Cardiac strain findings in children with latent rheumatic heart disease detected by echocardiographic screening.