Abstract:
:The aims of this study were to assess the development of heart failure in patients with congenitally corrected transposition of the great arteries in a medium-term follow-up, to identify the impact of tricuspid regurgitation on the development of heart failure, and to determine the most reliable marker for its identification. The prospective 6-year follow-up study included 19 adult patients. All patients were evaluated clinically by the determination of N-terminal pro-hormone brain natriuretic peptide levels, exercise stress testing, echocardiography magnetic resonance, or CT. Among them, two patients died of heart failure. There was a decline in exercise capacity and systolic systemic ventricular function (p=0.011). Systemic ventricular ejection fraction decreased (48.3±13.7 versus 42.7±12.7%, p=0.001). Tissue Doppler imaging showed a decline in peak tricuspid systolic annular velocity (10.3±2.0 versus 8.3±2.5 cm/second, p=0.032) and peak tricuspid early diastolic annular velocity (14.6±4.3 versus 12.0±4.5 cm/second, p=0.048). The tricuspid regurgitation did not increase significantly. N-terminal pro-hormone brain natriuretic peptide levels increased (127.0 ng/L(82.3-305.8) versus 226.0 ng/L(112.5-753.0), p=0.022). Progressive exercise intolerance in congenitally corrected transposition of the great arteries appears to be driven mainly by a progression in systemic right ventricular dysfunction. Tricuspid regurgitation is likely to play a role, especially in patients with structural abnormalities of the tricuspid valve - Ebstein anomaly. The N-terminal pro-hormone brain natriuretic peptide levels and tissue Doppler parameters appear sensitive in detecting changes over time and may guide management.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Koželj M,Cvijić M,Berden P,Podnar Tdoi
10.1017/S1047951114002479subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1332-9issue
7eissn
1047-9511issn
1467-1107pii
S1047951114002479journal_volume
25pub_type
杂志文章abstract::IntroductionDiagnostic and interventional catheter angiography of the heart is frequently used in paediatric cardiology. It is also possible to detect urinary system anomalies with cineurography images that may be obtained during angiocardiography. In this study, the aim was to determine the frequency, distribution, a...
journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Cardiology in the young
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doi:10.1017/s1047951100009227
更新日期:2000-05-01 00:00:00
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journal_title:Cardiology in the young
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doi:10.1017/s104795110000963x
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journal_title:Cardiology in the young
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doi:10.1017/S1047951106000461
更新日期:2006-06-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951119000921
更新日期:2019-05-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112000947
更新日期:2013-06-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111001107
更新日期:2012-04-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951107000352
更新日期:2007-04-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001346
更新日期:2015-06-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100008854
更新日期:2000-11-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951109991892
更新日期:2009-12-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111800063X
更新日期:2018-08-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951108002990
更新日期:2008-12-01 00:00:00
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951119000088
更新日期:2019-04-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111000072
更新日期:2011-06-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100009732
更新日期:2000-10-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S1047951107001795
更新日期:2008-02-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100008957
更新日期:2000-11-01 00:00:00
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更新日期:2015-10-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113002400
更新日期:2015-01-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120004321
更新日期:2020-12-14 00:00:00