De novo aortopathy and cardiovascular outcomes in paediatric liver transplant recipients.

Abstract:

:With the increase in long-term survival of post-transplant children, there is a paradigm shift in the emphasis of post-transplant care. We describe de novo cardiovascular abnormalities, which occurred in otherwise asymptomatic paediatric liver transplant recipients, who received liver allografts between 1991 and 2014 at the National University Hospital, Singapore, detected during routine post-transplant monitoring. A total of 96 paediatric liver transplants were performed in 90 children. After transplant, 7/90 (7.8%) recipients were identified with new-onset aortopathy. Glycogen storage disease type I (42.9% versus 2.4%; p<0.001) and recipient Epstein-Barr virus seropositivity (85.7 versus 31.0%, p=0.004) were significant risk factors for aortopathy on univariate analysis. On multivariate analysis, only glycogen storage disease type I remained as the significant risk factor (odds ratio 51.3 [95% confidence intervals: 1.1-2498.1, p=0.047]). Liver transplant is a double-edged sword that reverses certain cardiopulmonary complications of end-stage liver disease but may induce de novo structural cardiac injury in the form of aortic dilation.

journal_name

Cardiol Young

journal_title

Cardiology in the young

authors

Huang JG,Lim T,Quek SC,Quak SH,Aw MM

doi

10.1017/S104795111800063X

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

986-994

issue

8

eissn

1047-9511

issn

1467-1107

pii

S104795111800063X

journal_volume

28

pub_type

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