Abstract:
INTRODUCTION:Dilatation of the ascending aorta is described in Turner's syndrome with variable prevalence (6.8-32%). Reported series typically include patients with associated cardiac anomalies. OBJECTIVE:To characterise the prevalence, age of onset, and the progress of dilatation of the ascending aorta in Turner's syndrome patients free of structural cardiac anomalies. Potential risk factors such as karyotype and growth hormone therapy were analysed for correlation with aortic dilatation. METHODS:We carried out a retrospective study with data collected from medical records and echocardiography studies. Patients with Tuner's syndrome followed-up between 1992 and 2010 with at least two echocardiography studies were eligible. Patients with previous cardiac surgery or under anti-hypertensive medication were excluded. Ascending aorta diameter measurements were adjusted for body surface area, and dilatation was defined as Z-score>2. RESULTS:The study population consisted of 44 patients, aged 11.9±7.4 years at the first echocardiogram and 17.9±7.3 years at the last follow-up, with a follow-up duration of 6.0±3.7 years. A total of 13 (29.5%) patients exhibited aortic dilatation during follow-up, suggesting an actuarial estimate of the freedom from aortic dilatation dropping from 86 to 70% and then to 37% at 10, 20, and 30 years of age, respectively. There was no statistically significant impact of karyotype or growth hormone therapy on aortic Z-score progression. CONCLUSION:The prevalence of dilatation of the ascending aorta in Turner's syndrome patients free of structural aortic anomalies is comparable with published data with associated lesions. Growth hormone therapy and karyotype had no significant impact; however, longitudinal follow-up is warranted.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Alami Laroussi N,Dahdah N,Dallaire F,Thérien J,Fournier Adoi
10.1017/S1047951115000682subject
Has Abstractpub_date
2016-03-01 00:00:00pages
539-46issue
3eissn
1047-9511issn
1467-1107pii
S1047951115000682journal_volume
26pub_type
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pub_type: 杂志文章
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journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110000375
更新日期:2010-08-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 社论
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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doi:10.1017/S1047951110000090
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journal_title:Cardiology in the young
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doi:10.1017/S1047951117001846
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journal_title:Cardiology in the young
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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更新日期:2018-12-26 00:00:00
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pub_type: 杂志文章
doi:10.1017/S1047951114000298
更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1017/S1047951114001656
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journal_title:Cardiology in the young
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pub_type: 杂志文章,多中心研究
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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