Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis.

abstract：:Interleukin (IL)-35 is the latest member of IL-12 family, which plays an important role in other autoimmune diseases. Bone marrow mononuclear cells Coombs test‑positive hemocytopenia, also termed immunorelated hemocytopenia (IRH) is a type of autoimmune-associated diseases. The present study investigated the relations...

journal_title：Molecular medicine reports

authors： Li Y,Wang Y,Liu H,Ding K,Hao S,Shao Y,Wang H,Chen J,Huang L,Shao Z,Fu R

更新日期：2018-02-01 00:00:00

abstract：:Metabolic syndrome is a combination of medical disorders including hypertension, dyslipidemia, hyperglycemia, insulin resistance and increased waist circumference, and is associated with a higher risk of cardiovascular disease. An increase in adipose tissue mass is associated with t...

journal_title：Molecular medicine reports

authors： Pérez PM,Moore-Carrasco R,González DR,Fuentes EQ,Palomo IG

更新日期：2012-05-01 00:00:00

abstract：:Mineralized bone matrix constituted with collagenous and non-collagenous proteins was synthesized by osteoblasts differentiated from mesenchymal stem cells. Secretory leukocyte protease inhibitor (SLPI), a serine protease inhibitor, promotes cell migration and proliferation, and suppresses the inflammatory response. R...

journal_title：Molecular medicine reports

authors： Choi BD,Lee SY,Jeong SJ,Lim DS,Cha HJ,Chung WG,Jeong MJ

更新日期：2016-08-01 00:00:00

abstract：:B7-H4 is a co‑inhibitory molecule of the B7 family, which is expressed on antigen‑presenting cells (APCs) and is able to limit the T‑cell immune response. Macrophages act as professional APCs and are important for immunoregulation of the tumor microenvironment in breast cancer. In order to identify the association bet...

journal_title：Molecular medicine reports

authors： Liu L,Li D,Chen S,Zhao R,Pang D,Li D,Fu Z

更新日期：2016-09-01 00:00:00

abstract：:MicroRN-143 (miR‑143) has been previously reported to be downregulated in specific types of cancer, including colorectal, bladder, oral squamous cell, pituitary, cervical, nasopharyngeal, lymphoma and prostate cancer. In the present study, the effects of miR-143 on prostate cancer cell migration and invasion were exam...

journal_title：Molecular medicine reports

authors： Wu D,Huang P,Wang L,Zhou Y,Pan H,Qu P

更新日期：2013-08-01 00:00:00

abstract：:The activation of the (pro)renin receptor (PRR) may be potentially active in the development of atherosclerotic plaques independent of angiotensin II. Our previous studies demonstrated that high glucose was able to induce the activation of PRR. The present study was designed to determine the function of oxidized low‑d...

journal_title：Molecular medicine reports

authors： Cheng Y,Liu X,Zhang L,Zhang Y,Liu Y,Lu Y,Jiang Y

更新日期：2015-06-01 00:00:00

abstract：:The von Hippel‑Lindau (VHL) gene is a tumor suppressor gene, which is widely expressed in the kidney, lung, breast, eye, ovary and cervix. Mutations of the VHL gene are able to induce VHL disease and tumorigenesis. However, it has yet to be evaluated whether the VHL gene is expressed in the human endometrium. The obje...

journal_title：Molecular medicine reports

authors： Lu YY,Zhu WJ,Xie BG

更新日期：2014-04-01 00:00:00

abstract：:Physical exercise is beneficial for the functional recovery of neurons after stroke. It has been suggested that exercise regulates proliferation and differentiation of endogenous neural stem cells (NSCs); however, the underlying molecular mechanisms are still largely unknown. In the present study, the aim was to inves...

journal_title：Molecular medicine reports

authors： Liu W,Wu W,Lin G,Cheng J,Zeng Y,Shi Y

更新日期：2018-08-01 00:00:00

abstract：:Dehydrocostuslactone is a sesquiterpene lactone derived from Saussurea lappa, a plant used in traditional herbal medicines. The anti-proliferative activity of dehydrocostuslactone was investigated in human breast cancer (MDA-MB-231, MDA-MB-453 and SK-BR-3) and ovarian cancer (SK-OV-3 and OVCAR3) cell lines using the m...

journal_title：Molecular medicine reports

authors： Choi EJ,Kim GH

更新日期：2010-01-01 00:00:00

abstract：:Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects in several types of cancer. The present study aimed to examine the anticancer effects of caffeine on gastric cancer (GC) cells (MGC‑803 and SGC‑7901) in vitro, and to determine whether the apoptosis‑relat...

journal_title：Molecular medicine reports

authors： Liu H,Zhou Y,Tang L

更新日期：2017-09-01 00:00:00

abstract：:The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway. Male albino Wistar rats were injected subcutaneously with isoproterenol (100 ...

journal_title：Molecular medicine reports

authors： Jia G,Zao M,Liu X

更新日期：2017-08-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are involved in diverse biological processes, including cell proliferation, differentiation and apoptosis. Results from the MTT assay revealed that BMP-2 significantly inhibited the proliferation of MDA-MB‑231 and MCF-7 breast cancer cells. The flo...

journal_title：Molecular medicine reports

authors： Chen A,Wang D,Liu X,He S,Yu Z,Wang J

更新日期：2012-09-01 00:00:00

abstract：:In order to provide an abundant source of specimen and to reveal the correlation between the overexpression of urokinase plasminogen activator receptor isoform uPAR (D1D2) and hepatic cell malignant transformation, the optimal liver cell culture method was selected from three cell culture methods to culture and separa...

journal_title：Molecular medicine reports

authors： Zhou Y,Lǚ X,Li S,Zhan L

更新日期：2014-05-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effect of sorafenib combined with silencing of activating transcription factor 2 (ATF2) in hepatocellular carcinoma (HCC) cells and to assess the underlying molecular mechanisms. Huh‑7 HCC cell line was selected for the present study. Small interfering RNA (siRNA)‑...

journal_title：Molecular medicine reports

authors： Luo L,Cai L,Luo L,Tang Z,Meng X

更新日期：2018-06-01 00:00:00

abstract：:Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long...

journal_title：Molecular medicine reports

authors： Xie Z,Xia W,Hou M

更新日期：2018-02-01 00:00:00

abstract：:Brain metabolism is closely associated with neuronal activity and enables the accurate synthesis and function of neurotransmitters. Although previous studies have demonstrated that chronic stress is associated with the overproduction of reactive oxygen species (ROS), which leads to oxidative stress and the disruption ...

journal_title：Molecular medicine reports

authors： Herbet M,Natorska-Chomicka D,Korga A,Ostrowska M,Izdebska M,Gawrońska-Grzywacz M,Piątkowska-Chmiel I,Pawłowski K,Ślaska B,Poleszak E,Dudka J

更新日期：2019-03-01 00:00:00

abstract：:Matrilin-2 (matn2) contains a unique domain, between the second von Willebrand factor A (vWFA) domain and the C-terminal coiled-coil domain, with no sequence homology with other family members. Complementary DNA (cDNA) sequence analysis of matn2 expression in both mice and humans re...

journal_title：Molecular medicine reports

authors： Li L,Zhang L,Shao Y,Wang G,Gong R,Wang Z,Peng J,Wang S,Genochio D,Zhao B,Luo J

更新日期：2012-11-01 00:00:00

abstract：:Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescu...

journal_title：Molecular medicine reports

authors： Han YH,Kim SH,Kim SZ,Park WH

更新日期：2009-03-01 00:00:00

abstract：:Magnesium, an important inorganic mineral component in bones, enhances osteoblast adhesion and osteogenic gene expression. Mg2+‑containing hydroxyapatite promotes mouse mesenchymal stem cell (MMSC) osteogenic differentiation. In the present study, MMSCs were cultured in media containing different concentrations of MgC...

journal_title：Molecular medicine reports

authors： Ni S,Xiong XB,Ni XY

更新日期：2020-11-01 00:00:00

abstract：:Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), is a traditional Chinese medicine widely used for the treatment of various diseases. In the present study, we examined the antiproliferative effect and apoptosis-inducing activity of paeonol and the crude total glycosides (CTG) extracted from ...

journal_title：Molecular medicine reports

authors： Xing G,Zhang Z,Liu J,Hu H,Sugiura N

更新日期：2010-01-01 00:00:00

abstract：:The present study aimed to identify the mutation causing an atypical syndrome. High-resolution single nucleotide polymorphism (SNP) arrays are considered to be a major detection method for submicroscopic chromosomal rearrangements smaller than 5 Mb in size. Genomic DNA samples of the patient and his parents were conve...

journal_title：Molecular medicine reports

authors： Hu S,Yang Y,Liu L,Tan Z,Zhao T

更新日期：2017-05-01 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to be important in the establishment and progression of colon cancer. However the underlying molecular mechanisms remain to be fully elucidated. Polypeptide N‑acetylgalactosaminyltransferase4 (GALNT4) participates in numerous cellular processes, including tumorigenesis. The pres...

journal_title：Molecular medicine reports

authors： Qu JJ,Qu XY,Zhou DZ

更新日期：2017-10-01 00:00:00

abstract：:It has been suggested that survivin, a member of the inhibitor of apoptosis protein (IAP) family, is an attractive novel target for anticancer therapy. The present study investigated the expression of survivin during the early stages of hepatocellular carcinoma (HCC) and associated hepatitis, and attempted to elucidat...

journal_title：Molecular medicine reports

authors： Mamori S,Matsushima M,Matsuura T,Tajiri H

更新日期：2009-11-01 00:00:00

abstract：:Advances in the treatment of nasopharyngeal carcinoma (NPC) have significantly improved the local control rate; however, distant metastasis remains a principal cause of mortality. Previous studies have demonstrated that the expression levels of amyloid β precursor protein (APP) are increased in NPC. The present study ...

journal_title：Molecular medicine reports

authors： Xu J,Ying Y,Xiong G,Lai L,Wang Q,Yang Y

更新日期：2019-07-01 00:00:00

abstract：:Numerous studies have shown that N-nitrosamines and their precursors are probable etiological factors for esophageal cancer. Certain N-nitrosamines have been shown to induce esophageal cancer in animal models. However, the molecular mechanisms by which N-nitrosamines promote esophageal carcinogenesis remain poorly und...

journal_title：Molecular medicine reports

authors： Xie Y,Tang E,Ren B,Feng L

更新日期：2010-05-01 00:00:00

abstract：:Various studies have investigated hepatic carcinoma cachexia, however, there is little published information regarding the effect of Chinese Medicine carcinoma cachexia. The present study was performed to investigate the effect of modified Chinese herbal compound jianpijiedu (MJPJD) on a mouse model of ascites‑induced...

journal_title：Molecular medicine reports

authors： Sun B,Luo H,Deng L,Zhang S,Chen Z

更新日期：2016-10-01 00:00:00

abstract：:The costs of spinal cord injury and its complications are high in personal, social and financial terms. Complications include bladder cancer, for which the risk is 16-28 times higher than that of the general population, There is currently little consensus regarding the cause of this discrepancy. As microRNAs are stabl...

journal_title：Molecular medicine reports

authors： Wang T,Liu Y,Yuan W,Zhang L,Zhang Y,Wang Z,Zhou X,Zhou H,Chu T,Hao Y,Liu B,Zhao X,Lu L,Feng S,Kong X

更新日期：2015-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Although numerous studies have suggested the potentially oncogenic roles of wild‑type or mutant hepatitis B virus X (HBx) protein in hepatocarcinogenesis, their exact mechanism remains unclear. Increasing evidence suggests that microRNAs ...

journal_title：Molecular medicine reports

authors： Fu X,Tan D,Hou Z,Hu Z,Liu G,Ouyang Y,Liu F

更新日期：2013-02-01 00:00:00

abstract：:Heat shock proteins (HSPs) are molecular chaperones that were initially identified as proteins expressed following exposure of cells to environmental stress. However, the function of HSPs in epithelial‑to‑mesenchymal transition (EMT) of peritoneal mesothelial cells remains unknown. In the present study, the regulation...

journal_title：Molecular medicine reports

authors： Liu J,Bao J,Hao J,Peng Y,Hong F

更新日期：2014-08-01 00:00:00

abstract：:Growing evidence suggests that the elevation of free fatty acids, including palmitic acid (PA), are associated with inflammation and oxidative stress, which may be involved in endothelial dysfunction, characterized by the reduced bioavailability of nitric oxide (NO) synthesized from endothelial NO synthase (eNOS). Hem...

journal_title：Molecular medicine reports

authors： Jeong SO,Son Y,Lee JH,Cheong YK,Park SH,Chung HT,Pae HO

更新日期：2015-07-01 00:00:00