FastGT: an alignment-free method for calling common SNVs directly from raw sequencing reads.

abstract：:As an important method for building blocks synthesis, whole cell biocatalysis is hindered by some shortcomings such as unpredictability of reactions, utilization of opportunistic pathogen, and side reactions. Due to its biological and extensively studied genetic background, Pseudomonas putida KT2440 is viewed as a pro...

journal_title：Scientific reports

authors： Wang Y,Lv M,Zhang Y,Xiao X,Jiang T,Zhang W,Hu C,Gao C,Ma C,Xu P

更新日期：2014-11-06 00:00:00

abstract：:Bark beetles often serve as forest damaging agents, causing landscape-level mortality. Understanding the biology and ecology of beetles are important for both, gathering knowledge about important forest insects and forest protection. Knowledge about the bark beetle gut-associated bacteria is one of the crucial yet sur...

journal_title：Scientific reports

authors： Chakraborty A,Ashraf MZ,Modlinger R,Synek J,Schlyter F,Roy A

更新日期：2020-10-29 00:00:00

abstract：:Colon cancer stem cells have been attributed to poor prognosis, therapeutic resistance and aggressive nature of the malignancy. Recent reports associated CD44v6 expression with relapse, metastasis and reduced 5-year survival of colon cancer patients, thereby making it a potential therapeutic target. Thus, in this stud...

journal_title：Scientific reports

authors： Patel S,Waghela B,Shah K,Vaidya F,Mirza S,Patel S,Pathak C,Rawal R

更新日期：2018-11-19 00:00:00

abstract：:Macroscopic rhythms are often signatures of healthy functioning in living organisms, but they are still poorly understood on their microscopic bases. Globally interacting oscillators with heterogeneous couplings are here considered. Thorough theoretical and numerical analyses indicate the presence of multiple phase tr...

journal_title：Scientific reports

authors： Qiu T,Bonamassa I,Boccaletti S,Liu Z,Guan S

更新日期：2018-08-28 00:00:00

abstract：:Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here w...

journal_title：Scientific reports

authors： Hansen J,Timmers S,Moonen-Kornips E,Duez H,Staels B,Hesselink MK,Schrauwen P

更新日期：2016-10-19 00:00:00

abstract：:Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required whic...

journal_title：Scientific reports

authors： Jiang M,Jin Y,Yang H,Fu H

更新日期：2016-05-17 00:00:00

abstract：:Humans interact with the oceans in diverse and profound ways. The scope, magnitude, footprint and ultimate cumulative impacts of human activities can threaten ocean ecosystems and have changed over time, resulting in new challenges and threats to marine ecosystems. A fundamental gap in understanding how humanity is af...

journal_title：Scientific reports

authors： Halpern BS,Frazier M,Afflerbach J,Lowndes JS,Micheli F,O'Hara C,Scarborough C,Selkoe KA

更新日期：2019-08-12 00:00:00

abstract：:Blockage of pores by particles is found in many processes, including filtration and oil extraction. We present filtration experiments through a linear array of ten channels with one dimension which is sub-micron, through which a dilute dispersion of Brownian polystyrene spheres flows under the action of a fixed pressu...

journal_title：Scientific reports

authors： Liot O,Singh A,Bacchin P,Duru P,Morris JF,Joseph P

更新日期：2018-08-20 00:00:00

abstract：:The importance of metallurgy for social and economic development is indisputable. Although copper (Cu) was essential for the wealth of pre- and post-colonial societies in the Andes, the onset of extensive Cu metallurgy in South America is still debated. Comprehensive archaeological findings point to first sophisticate...

journal_title：Scientific reports

authors： Eichler A,Gramlich G,Kellerhals T,Tobler L,Rehren T,Schwikowski M

更新日期：2017-01-31 00:00:00

abstract：:Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh environments including flooded habitats and varying temperature changes. To survive these environments, fruit flies have adapted mechanisms of tolerance that allow them to thrive. During exposure to anoxic stress, fruit flies and oth...

journal_title：Scientific reports

authors： Benasayag-Meszaros R,Risley MG,Hernandez P,Fendrich M,Dawson-Scully K

更新日期：2015-03-17 00:00:00

abstract：:In community ecology, it is important to understand the distribution of communities along environmental and spatial gradients. However, it is common for the residuals of models investigating those relationships to be very high (> 50%). It is believed that species' intrinsic characteristics such as rarity can contribut...

journal_title：Scientific reports

authors： Brasil LS,Vieira TB,Andrade AFA,Bastos RC,Montag LFA,Juen L

更新日期：2020-11-13 00:00:00

abstract：:Hyperspectral imaging technique was employed to determine spatial distributions of chlorophyll (Chl), and carotenoid (Car) contents in cucumber leaves in response to angular leaf spot (ALS). Altogether, 196 hyperspectral images of cucumber leaves with five infection severities of ALS were captured by a hyperspectral i...

journal_title：Scientific reports

authors： Zhao YR,Li X,Yu KQ,Cheng F,He Y

更新日期：2016-06-10 00:00:00

abstract：:The bald eagle (Haliaeetus leucocephalus) once experienced near-extinction but has since rebounded. For decades, bald eagles near the Wisconsin River, USA, have experienced a lethal syndrome with characteristic clinical and pathological features but unknown etiology. Here, we describe a novel hepacivirus-like virus (F...

journal_title：Scientific reports

authors： Goldberg TL,Sibley SD,Pinkerton ME,Dunn CD,Long LJ,White LC,Strom SM

更新日期：2019-10-18 00:00:00

abstract：:FGF10 is a member of fibroblast growth factors (FGFs). We previously showed that FGF10 protects neuron against oxygen-glucose deprivation injury in vitro; however, the effect of FGF10 in ischemic stroke in vivo is unknown. In the present study, we showed that FGF10 was mainly expressed in neurons but not astrocytes, a...

journal_title：Scientific reports

authors： Li YH,Fu HL,Tian ML,Wang YQ,Chen W,Cai LL,Zhou XH,Yuan HB

更新日期：2016-01-27 00:00:00

abstract：:Open algal cultivation platforms often suffer crop losses to herbivorous grazers that have potential to devastate biomass production within a few days. While a number of studies suggest synthetic chemicals as control agents for voracious algal grazers, environmental and safety concerns associated with the use of these...

journal_title：Scientific reports

authors： Yun JH,Cho DH,Lee B,Kim HS,Chang YK

更新日期：2018-03-29 00:00:00

abstract：:Hemodialysis patients are a special group of patients with higher mortality rates. Hemodialysis patients with vitamin D deficiency {plasma levels of 25-hydroxyvitamin D [25(OH)D] below 20 ng/mL} are associated with even higher mortality rates. The prognostic importance of vitamin D deficiency in hemodialysis patients ...

journal_title：Scientific reports

authors： Hsu HJ,Wu IW,Hsu KH,Sun CY,Chen CY,Lee CC

更新日期：2020-05-05 00:00:00

abstract：:Mutations at positions 70 and/or 91 in the core protein of genotype-1b, hepatitis C virus (HCV) are associated with hepatocellular carcinoma (HCC) risk in Asian patients. To evaluate this in a US population, the relationship between the percentage of 70 and/or 91 mutant HCV quasispecies in baseline serum samples of ch...

journal_title：Scientific reports

authors： El-Shamy A,Pendleton M,Eng FJ,Doyle EH,Bashir A,Branch AD

更新日期：2016-06-01 00:00:00

abstract：:The Tcf/Lef family of transcription factors mediates the Wnt/β-catenin pathway that is involved in a wide range of biological processes, including vertebrate embryogenesis and diverse pathogenesis. Post-translational modifications, including phosphorylation, sumoylation and acetylation, are known to be important for t...

journal_title：Scientific reports

authors： Han W,Lee H,Han JK

更新日期：2017-02-15 00:00:00

abstract：:Orbital angular momentum (OAM) multiplexing technique has recently emerged and generated widespread interests since the OAM was discovered as a property of electromagnetic wave and acoustic wave. It was widely acknowledged that OAM multiplexing can achieve very high effective degrees of freedom (EDOF) and improve the ...

journal_title：Scientific reports

authors： Li Z,Qu F,Wei Y,Yang G,Xu W,Xu J

更新日期：2020-03-23 00:00:00

abstract：:Somatostatin (SST)-positive interneurons in the anterior cingulate cortex (ACC) play important roles in neuronal diseases, memory and cognitive functions. However, their development in the ACC remains unclear. Using postnatal day 3 (P3) to P45 GIN mice, we found that most of the intrinsic membrane properties of SST in...

journal_title：Scientific reports

authors： Pan G,Yang JM,Hu XY,Li XM

更新日期：2016-06-20 00:00:00

abstract：:Craniosynostosis must often be corrected using surgery, by which the affected bone tissue is remodeled. Nowadays, surgical reconstruction relies mostly on the subjective judgement of the surgeon to best restore normal skull shape, since remodeled bone is manually placed and fixed. Slight variations can compromise the ...

journal_title：Scientific reports

authors： García-Mato D,Ochandiano S,García-Sevilla M,Navarro-Cuéllar C,Darriba-Allés JV,García-Leal R,Calvo-Haro JA,Pérez-Mañanes R,Salmerón JI,Pascau J

更新日期：2019-11-27 00:00:00

abstract：:Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana. The molecular bases for low affinity transport however remained unknown. Since IRT1 and NRAMP1 have a broad range of subst...

journal_title：Scientific reports

authors： Castaings L,Caquot A,Loubet S,Curie C

更新日期：2016-11-16 00:00:00

abstract：:Urban climate is determined by a variety of factors, whose knowledge can help to attenuate heat stress in the context of ongoing urbanization and climate change. We study the influence of city size and urban form on the Urban Heat Island (UHI) phenomenon in Europe and find a complex interplay between UHI intensity and...

journal_title：Scientific reports

authors： Zhou B,Rybski D,Kropp JP

更新日期：2017-07-06 00:00:00

abstract：:Acquisition of the lower jaw (mandible) was evolutionarily important for jawed vertebrates. In humans, syndromic craniofacial malformations often accompany jaw anomalies. The basic helix-loop-helix transcription factor Hand2, which is conserved among jawed vertebrates, is expressed in the neural crest in the mandibula...

journal_title：Scientific reports

authors： Funato N,Kokubo H,Nakamura M,Yanagisawa H,Saga Y

更新日期：2016-06-22 00:00:00

abstract：:The freshwater snail Oncomelania hupensis is the unique intermediate host of the blood fluke Schistosoma japonicum, which is the major cause of schistosomiasis. The snail inhabits two contrasting environments: the hilly and marshland regions. The hilly snails are smaller in size and have the typical smooth shell, wher...

journal_title：Scientific reports

authors： Zhao JS,Wang AY,Zhao HB,Chen YH

更新日期：2017-11-17 00:00:00

abstract：:The present study evaluated the effects of exposing liquid-stored boar semen to different red light LED regimens on sperm quality and reproductive performance. Of all of the tested photo-stimulation procedures, the best pattern consisted of 10 min light, 10 min rest and 10 min of further light (10-10-10 pattern). This...

journal_title：Scientific reports

authors： Yeste M,Codony F,Estrada E,Lleonart M,Balasch S,Peña A,Bonet S,Rodríguez-Gil JE

更新日期：2016-03-02 00:00:00

abstract：:DDX3, a subunit of CK1ε, phosphorylates Dvl2 to promote β-catenin activation. Overexpression of the Dvl2 protein results in potent activation of β-catenin/TCF signaling in colorectal cancer. Therefore, we hypothesized that DDX3 might promote tumor invasion via the CK1ε/Dvl2 axis due to β-catenin/TCF activation. Wester...

journal_title：Scientific reports

authors： He TY,Wu DW,Lin PL,Wang L,Huang CC,Chou MC,Lee H

更新日期：2016-02-19 00:00:00

abstract：:To evaluate crop rotation effects on maize seedling performance and its associated microbiome, maize plants were grown in the greenhouse in soils preceded by either maize, pea, soybean or sunflower. Soils originated from a replicated field experiment evaluating different four-year rotation combinations. In the greenho...

journal_title：Scientific reports

authors： Benitez MS,Osborne SL,Lehman RM

更新日期：2017-11-16 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that regulate a variety of biological processes. Recently, human liver-specific miRNA miR-122 has been reported to facilitate hepatitis C virus (HCV) replication in liver cells. HCV is one of the leading causes of liver diseases worldwide. In Pakistan, the estimated preval...

journal_title：Scientific reports

authors： Butt AM,Raja AJ,Siddique S,Khan JS,Shahid M,Tayyab GU,Minhas Z,Umar M,Idrees M,Tong Y

更新日期：2016-02-22 00:00:00

abstract：:The presence of non-poplar extracts, cutin, and wax layer in the wheat straw outer surface (WOS) greatly limit its application in bio-composite preparation. In this study, a dielectric-barrier-discharge plasma using water vapor as feeding gas was used to fast modify the WOS. The morphology, free radical concentrations...

journal_title：Scientific reports

authors： Chen W,Xu Y,Shi S,Cao Y,Chen M,Zhou X

更新日期：2018-02-02 00:00:00