Abstract：
:The precise etiology of Inflammatory Bowel Disease (IDB) remains unclear and several factors are believed to play a role in its development and progression, including the composition of microbial communities resident in the gastrointestinal tract. Human intestinal microbiota are extensive with at least 15,000-36,000 bacterial species. However, thanks to the new development in sequencing and molecular taxonomic methodologies, our understanding of the microbiota population composition, dynamics, and ecology has greatly increased. Intestinal microbiota play a critical role in the maintenance of the host intestinal barrier homeostasis, while dysbiosis, which involves reduction in the microbiome diversity, can lead to progression of inflammatory disorders, such as IBD and colorectal cancer. It is hypothesized that fingerprinting characterization of the microbiota community composition is the first step in the study of this complex bacterial ecosystem and a crucial step in the targeted therapy. Molecular fingerprinting of human gastrointestinal tract microbiota could be performed by different techniques including the semi quantitation, 16SrRNA, the DNA- microarray as well as other relatively new methods which were developed to study many complex bacterial ecosystems. These techniques provide individual data and profiles, using fast and sensitive tools for the high taxonomic level fingerprint of the human intestinal microbiota and provide estimation of the relative presence of the microbial target groups within each individual. Such personalized information serves as a remarkable and unprecedented opportunity to improve targeted medical treatment and probably develop strategies to prevent disease.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Tomasello G,Mazzola M,Jurjus A,Cappello F,Carini F,Damiani P,Gerges Geagea A,Zeenny MN,Leone Asubject
Has Abstractpub_date
2017-01-01 00:00:00pages
245-249issue
1eissn
0393-974Xissn
1724-6083pii
37journal_volume
31pub_type
杂志文章abstract：:Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children. Recently, treatment with intranasal corticosteroids has been suggested to decrease the size of AH. The aim of the study is to evaluate the long-term effect of intranasal flunisolide on AH during a 12-month follow-up. On...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-04-01 00:00:00
abstract：:This study was carried out by varying both graphene oxide (GO) concentration (10 μg/mL, 50 μg/mL, 100 μg/mL) and flakes sizes of 1320 nm and 130 nm. Characterization by scanning electron microscopy and Raman spectroscopy demonstrate that the area of GO flakes varies of one order of magnitude but their c...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2014-04-01 00:00:00
abstract：:Free radical damage to many cellular components has been proposed as the main mechanism underlying the aging process. In the liver, NO can be generated by iNOS, but also by the constitutively expressed endothelial NOS (eNOS). iNOS enzyme appears to be expressed in liver disease such as cirrhosis and fulminant hepatiti...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Clicking may appear in the initial, middle, or final phase of mandibular opening. Magnetic Resonance Imaging (MRI) is the most appropriate diagnostic imaging for diagnosing disc position. With anterior repositioning splint (ARS), disc recapture is achieved through a change in the position of the condyle to encourage a...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:A potential role of Helicobater Pylori (HP) infection in several extra-intestinal pathologies has been recently suggested. The aim of our study was to assess the role of serology positive for HP in atopic and non atopic infants and children affected by atopic dermatitis, urticaria, rhinitis and asthma. We included 615...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:7, 12- Dimethylbenz-(a)-anthracene (DMBA) has been used for a long time to induce rat mammary gland carcinogenesis. In a previous paper we described the effects of diet, of non-steroidal anti-inflammatory drugs and the combination of these two factors on breast cancer. We also pointed out that DMBA tumor generating pr...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：:The correct functionality (sensitivity and receptivity) of endometrial tissue is regulated by paracrine and endocrine pathways that activate several mediators or metabolic pathways and gene cascades. This study aimed to investigate the influence of E2 and P4 on progesterone receptor (PGR) and progesterone receptor mem...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:Upper respiratory infections are widespread in clinical practice. Antibiotics are frequently used in the management of patients with airways infection. However, antibiotics can induce intestinal and respiratory dysbiosis that, in turn, worsens respiratory symptoms. Moreover, respiratory infections per se can cause dys...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
更新日期：2020-11-01 00:00:00
abstract：:Within the immune system homeostasis is maintained by a myriad of mechanisms that include the regulation of immune cell activation and programmed cell death. The breakdown of immune homeostasis may lead to fatal inflammatory diseases. We set out to identify genes of tumor necrosis factor-alpha-induced protein 8 (TNFAI...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论
doi：
更新日期：2013-07-01 00:00:00
abstract：:Despite a wide range of available antidepressants, the effect of the treatment is often suboptimal and there is a need for more effective and better tolerated drugs. Unlike other antidepressants, agomelatine represents a new approach to depression with an innovative mechanism of action. It is an agonist of melatoniner...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：2011-01-01 00:00:00
abstract：:Pro-inflammatory cytokines, i.e., IL-1 mediate the inflammatory response and are genetically regulated in periodontal diseases. Strong association was found between the composite genotype allele 2 of IL-1β+3954 and IL-1α-889 and severe chronic periodontitis. The aim of this study is to determine the prevalence of IL-1...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：:The repair of complex craniofacial bone defects is challenging and a successful result depends on the defect size, the quality of the soft tissue covering the defect and the choice of reconstructive method. Autologous bone grafts are the gold standard for bone replacement. Tissue engineered constructs are temporary su...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-07-01 00:00:00
abstract：:To study the cytology profile of cervical smears and the respective prevalence and incidence of certain cervico-vaginal infections detectable by routine Pap smear cytology in Lebanese women from 2002 to 2006. Pap smear cytology results were compiled from the archives of the Institut National de Pathologie for the peri...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 临床试验,信件,多中心研究
doi：
更新日期：2011-07-01 00:00:00
abstract：:To study the effect and related mechanism of IL-21 alone and in combination with 5-Fluorouracil on the proliferation and growth, transferability, and apoptosis of gastric cancer cells, we cultivated gastric cancer cell SGC-7901 and created four experimental groups with varying concentrations of IL-21 and 5-Fluorouraci...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2018-05-01 00:00:00
abstract：:The aim of this review was to collect available evidence and evaluate accuracy outcomes of dental implant impression techniques, and to compare the accuracy of conventional implant impression versus digital implant impression. Inclusion and exclusion criteria were defined by the authors before the start of the study. ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
更新日期：2020-01-01 00:00:00
abstract：:Protein hydrolysates (PH) are rich sources of proteins that supply the need of exercising muscles. PHs are enriched in di- and tripeptides and are better than free amino acids or intact proteins when muscle anabolic effect is considered. Digestion, absorption and muscle uptake of amino acids are faster and more effici...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
更新日期：2017-01-01 00:00:00
abstract：:Bronchial asthma is a chronic inflammatory disease characterized by bronchial obstruction, usually reversible spontaneously or after therapy, bronchial hyperreactivity and accelerated decrease of lung function that may possibly evolve into irreversible obstruction of the respiratory tract. Bronchial provocation tests ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-04-01 00:00:00
abstract：:The aim of this study was to investigate the value of Gd-EOB-DTPA-enhanced MRI on hepatobiliary phase (HBP) imaging and T1 mapping sequence in the differentiation of hepatocellular carcinoma (HCC). A total of 45 patients with HCC who were to undergo a resection were enrolled in this study. Gd-EOB-DTPA-enhanced magneti...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2017-10-01 00:00:00
abstract：:The aim of this study was to explore the effects of Caveolin-1 on lung injury in rats with chronic obstructive pulmonary disease (COPD). The forced expiratory volume in 0.3 s/forced vital capacity (FEV0.3/ FVC) and peak expiratory flow (PEF) were determined. The total white blood cells (WBC), neutrophil ratio (NEUT%),...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：10.23812/20-71-A-37
更新日期：2020-03-01 00:00:00
abstract：:Diabetic nephropathy (DN) is a severe and life-threatening complication of long-standing diabetes. As one of the main causes of end-stage renal disease, the prevention and treatment of DN in early stage, and the slowing down of DN progression are of utmost importance and are topics of several ongoing research studies....
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Scleroderma is a chronic systemic autoimmune disease (primarily of the skin) characterized by fibrosis (or hardening), vascular alterations and autoantibodies production.There are currently no effective therapies against this devastating and often lethal disorder. Despite the interest for the immunomodulatory effects ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Acute lung injury (ALI) is a disease with high incidence and no effective therapeutic treatments. miR- 145-5p has been reported to be aberrantly expressed in lung injury tissues, suggesting a potential role in the progression and development of ALI. To validate this hypothesis and explore the underlying mechanism, a m...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2019-07-01 00:00:00
abstract：:The aim of this study was to evaluate the periodontal healing of the distal sites of the mandibular second molars, comparing the extraction therapy of the third molar with and without PRF adjunct into the postextraction alveolus. The study sample was composed by 40 consecutive patients who underwent extraction of mand...
journal_title：Journal of biological regulators and homeostatic agents
pub_type：
doi：
更新日期：2020-09-01 00:00:00
abstract：:Various hematopoietic malignant disorders have been shown to bear chromosome abnormalities of the 11q23 band, which can be rearranged with many different chromosomal regions in a wide variety of different leukemia subtypes. Several laboratories have identified a trithorax-related gene that is involved in most of the 1...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：:Rough titanium surfaces enhance cell response to activation of Wnt canonical signalling, a pathway required for osteoblast differentiation. The present study investigated the effects of GSK3β-inhibitors SB216763 and SB415286 on osteoblastic differentiation on titanium surfaces with different topography and wettability...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2017-07-01 00:00:00
abstract：:Vitamin and mineral disturbances may interfere with glucose metabolism. Elderly persons with diabetes type 2 (T2DM) are more prone to mineral disturbances and vitamin deficiencies. The aim of this study was to analyze concentrations of vitamins B12 and D and macro- and microelements among diabetic elderly patients. Th...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2019-03-01 00:00:00
abstract：:Persistent shoulder pain is a highly prevalent problem, due to different pathologies, that is frequently associated with limited range of motion and decreased function. The correct diagnosis can lead to the best treatment for each pathology. In this study we tried to understand what could be the role of hyaluronic aci...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2015-10-01 00:00:00
abstract：:IL-32, a newly-discovered proinflammatory cytokine that activates the p38MAPK and NF-kappaB pathways, is an important player in innate and adaptive immune response. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the productio...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论,评审
doi：
更新日期：2009-07-01 00:00:00
abstract：:This study aimed to evaluate the efficacy of T-cell immune function and L-dopamine (L-DOPA) in patients with Parkinsons disease (PD). Sixty subjects (included in the study group) with PD who were patients of the Neurology Department of The Affiliated Hospital of Hangzhou Normal University from July 2015 to March 2017...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2018-05-01 00:00:00
abstract：:Degenerative osteoarthropathy, a kind of arthrosis induced by various factors, mainly affects articular cartilage and causes syndesmophyte formation. Its morbidity increases year by year, tending to occur more among young people than previously. This paper mainly discusses the clinical effects of iontophoresis of the ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件,随机对照试验
doi：
更新日期：2015-01-01 00:00:00
