当前位置： SCI文献检索 > JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS期刊下所有文献 > Caveolin-1 improves lung injury in rats with chronic obstructive pulmonary disease partially through Wnt/β-catenin signaling pathway.

Caveolin-1 improves lung injury in rats with chronic obstructive pulmonary disease partially through Wnt/β-catenin signaling pathway.

Abstract：

:The aim of this study was to explore the effects of Caveolin-1 on lung injury in rats with chronic obstructive pulmonary disease (COPD). The forced expiratory volume in 0.3 s/forced vital capacity (FEV0.3/ FVC) and peak expiratory flow (PEF) were determined. The total white blood cells (WBC), neutrophil ratio (NEUT%), mononuclear macrophage ratio (MNM%), lymphocyte ratio (LY%) and protein concentration in bronchoalveolar lavage fluid (BALF) were measured. Both FEV0.3/FVC and PEF significantly declined in the COPD group compared with those in the Control group, while they significantly rose in the IWR-1 group and Daidzin group compared with those in the COPD group. HE staining showed that there were alveolar dilatation and enlargement with obviously increased intercept in the COPD group, while there were basically no changes in the alveoli in the IWR-1 group and Daidzin group. Massive apoptosis of alveolar tissues was observed in COPD group, and there was only a little apoptosis in IWR-1 group and Daidzin group. In COPD group, WBC, NEUT% and protein concentration in BALF were obviously increased, MNM% was obviously decreased, and there was no obvious difference in LY% compared with those in the Control group. In the the IWR-1 group and Daidzin group, WBC, NEUT%, protein concentration, MNM% and LY% in BALF had no obvious differences compared with those in the Control group. In the IWR-1 group and Daidzin group, WBC, NEUT% and protein concentration evidently declined, MNM% evidently rose, and there was no obvious difference in LY% compared with those in the COPD group. Caveolin-1, Wnt-1 and β-catenin in lung tissues were remarkably higher in the COPD group than those in the Control group. Caveolin-1 was remarkably higher in the IWR-1 group than that in the Control group. And Wnt-1 and β-catenin were higher in the Daidzin group than those in the Control group. In addition, Wnt-1 and β-catenin in lung tissues markedly declined in the IWR-1 group compared with those in the COPD group. Caveolin-1, Wnt-1 and β-catenin in lung tissues also markedly declined in the Daidzin group compared with those in the COPD group. Caveolin-1 can improve lung injury in COPD rats through the Wnt/β-catenin signaling pathway.

journal_name

J Biol Regul Homeost Agents

journal_title

Journal of biological regulators and homeostatic agents

authors

Guan P,Cai WT,Jiang F,Li W,Zeng M,Wu J

doi

10.23812/20-71-A-37

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

457-465

issue

2

eissn

0393-974X

issn

1724-6083

pii

37

journal_volume

34

pub_type

信件

相关文献

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS文献大全
  • Covid-19 and cardiac involvement in childhood: state of the art.

    abstract：:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first described in a cluster of patients in Wuhan, China, in December of 2019. Over the past few months, COVID-19 has rapidly spread worldwide becoming the first pandemic of the 21st century. COVID-19 resul...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章,评审

    doi：

    authors： SPECIAL ISSUE: FOCUS ON PEDIATRIC CARDIOLOGY.,Cuppari C,Ceravolo G,Ceravolo MD,Sestito S,Nicocia G,Chimenz R,Salpietro C,Calabrò MP

    更新日期：2020-07-01 00:00:00

  • Real-time PCR detection of the effect of postweaning on the expression of cytokines and NF-kB in piglets.

    abstract：:Pig weaning involves radical changes, which affect health, behavior and performance. Weaning stress dramatically impacts the porcine immune system. This study aimed to evaluate the expression of different cytokines and nuclear factor kappa B (NF-kB) in growing postweaning pigs. Forty piglets weaned at 28 days of age, ...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：10.23812/19-342-A

    authors： Turin L,Torinesi R,Pastorelli G

    更新日期：2019-11-01 00:00:00

  • Expression of poly(ADP-ribose) polymerase in bone regeneration.

    abstract：:Poly(ADP-ribose) polymerase (PARP) is a 116kDa enzyme catalysing the synthesis of ADP-ribose polymers from NAD+. PARP is activated in response to DNA strand breaks and plays a critical role in the maintenance of genomic integrity. However, considering its role also in transcription, proliferation as well as apoptosis ...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 信件

    doi：

    authors： Lo Muzio L,Pannone G,Santarelli A,Lo Russo L,De Lillo A,Rubini C,Bambini F,Bufo P,Dioguardi M,Procaccini M

    更新日期：2014-10-01 00:00:00

  • Time course of the upper limb motor recovery in subacute stroke patients undergoing conventional or robotic rehabilitation. A preliminary report.

    abstract：:Upper limb recovery is a complex process and a strong challenge in the rehabilitation of patients after stroke. Several studies have been conducted to compare the efficacy of conventional and robotic rehabilitation to restore the upper limb motor impairment following a stroke. However, the evolution of the upper limb ...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type：

    doi：

    authors： Germanotta M,Cruciani A,Galli C,Cattaneo D,Spedicato A,Aprile I

    更新日期：2020-09-01 00:00:00

  • Short term efficacy of capacitive-resistive diathermy therapy in patients with low back pain: a prospective randomized controlled trial.

    abstract：:To compare the effectiveness of Doctor Tecar TherapyTM with that of laser therapy in the management of low back pain (LBP), a total of 60 patients with LBP were enrolled. The participants were randomly divided into two groups: a Tecar group (experimental group, 30 subjects), and a laser group (control group, 30 subjec...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Notarnicola A,Maccagnano G,Gallone MF,Covelli I,Tafuri S,Moretti B

    更新日期：2017-04-01 00:00:00

  • PRESBYOPIA OPTOMETRY METHOD BASED ON DIOPTER REGULATION AND CHARGE COUPLE DEVICE IMAGING TECHNOLOGY.

    abstract：:With the development of photoelectric technology and single-chip microcomputer technology, objective optometry, also known as automatic optometry, is becoming precise. This paper proposed a presbyopia optometry method based on diopter regulation and Charge Couple Device (CCD) imaging technology and, in the meantime, d...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 社论,评审

    doi：

    authors： Zhao Q,Wu XX,Zhou J,Wang X,Liu RF,Gao J

    更新日期：2015-07-01 00:00:00

  • Occult sinusitis may be a key feature for non-controlled asthma in children.

    abstract：:Sinusitis is frequently associated with asthma. The diagnosis and management of patients with asthma associated with sinusitis are often challenging, though sometimes unsatisfactory. Detection and treatment of sinusitis in asthmatics may lead to a better control of asthma symptoms. Most of the studies regarding the re...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Marseglia GL,Caimmi S,Marseglia A,Pagella F,Ciprandi G,La Rosa M,Leonardi S,Miraglia Del Giudice M,Caimmi D

    更新日期：2012-01-01 00:00:00

  • NeuroAIDS: virological aspects of HIV infection.

    abstract：:NeuroAIDS is one of the main complications of chronic HIV-infection. The Central Nervous System is an immunologic sanctuary for HIV and allows the persistence of the virus despite an efficient antiretroviral therapy. HIV-1 could promote the neurodegeneration through the induction of inflammation by the release of neur...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Surdo M,Cortese MF,Perno CF,Aquaro S

    更新日期：2013-04-01 00:00:00

  • CLINICAL DIAGNOSIS OF CAROTID ATHEROSCLEROSTIC PLAQUE IN HYPERTENSIVE PATIENTS WITH HIGH RESOLUTION MAGNETIC RESONANCE ANGIOGRAPHY.

    abstract：:As the incidence of ischemic cerebrovascular disease increases continuously over the years, carotid atherosclerosis as an important dangerous factor has drawn a lot of attention from many experts and scholars. To explore the clinical significance of high resolution magnetic resonance angiography (MRA) in carotid ather...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 信件

    doi：

    authors： Zhang L,Tian CM,Liu QY,Wang SS,Wang X,Chen L,Feng Y,Guo LT

    更新日期：2015-04-01 00:00:00

  • A novel technique to prevent sinus membrane collapse during maxillary sinus floor augmentation without bone graft: technical note.

    abstract：:Different surgical techniques have been developed to reconstruct the posterior maxilla without bone graft. A barrier membrane usually placed internal to the sinus, without stabilizer or bone window, pushed inside the sinus cavity as the ''roof'' of the sinus cavity to preserve the space and help bone regeneration has ...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 信件

    doi：

    authors： Scarano A,Murmura G,Mastrangelo F,Lorusso F,Greco Lucchina A,Carinci F

    更新日期：2018-11-01 00:00:00

  • Flow cytometric enumeration and immunophenotyping of hematopoietic stem and progenitor cells.

    abstract：:Flow cytometric enumeration of CD34+ hematopoietic stem and progenitor cells (HPC) is widely used for evaluation of graft adequacy of peripheral blood stem cell grafts, and is also useful in planning the apheresis sessions necessary to obtain these grafts. The state-of-the-art method to enumerate CD34+ cells makes use...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章,评审

    doi：

    authors： Gratama JW,Sutherland DR,Keeney M,Papa S

    更新日期：2001-01-01 00:00:00

  • Inhibition of the differentiation of 3T3-L1 cells by interferon-beta and difluoromethyl ornithine.

    abstract：:Both mouse interferon-beta (MuIFN-beta) and the inhibitor of ornithine decarboxylase (ODC), alpha-difluoromethyl ornithine (DFMO), inhibited the differentiation of mouse 3T3-L1 fibroblasts into adipocytes in a dose-dependent manner. DFMO and MuIFN-beta added together to cultures that were induced to differentiate prod...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Taylor JL,Turo KA,McCann PP,Grossberg SE

    更新日期：1988-01-01 00:00:00

  • T lymphocyte dependence of the immune response to immunosuppressive neoantigen-exposing Fc fragments of IgG.

    abstract：:We recently identified a rheumatoid factor associated with autoimmune disease resistance and remission, and have named it regulatory rheumatoid factor (regRF). Epitopes recognized by regRF can be induced in papain Fc fragments of IgG. Immunization of arthritic rats with homologous Fc fragments that expose neoepitopes ...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 信件

    doi：

    authors： Stolyarova E,Beduleva L,Menshikov I,Sidorov A,Khramova T

    更新日期：2019-05-01 00:00:00

  • Comparative analysis of cleaning ability of two rotary instrument systems: Mtwo and ProTaper® universal. An in vitro scanning electron microscopic study.

    abstract：:This study is to compare the cleaning effectiveness of two Ni-Ti files systems. Thirty single-rooted human teeth were selected and two NiTi rotary systems were used. Group A: canal shaping with ProTaper® Universal (Dentsply Tulsa Dental Specialties, Tulsa, OK) (PTU); Group B: (n=15) canal shaping with Mtwo Ni-Ti instr...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： DENTAL SUPPLEMENT.,Severino M,Libonati A,Di Taranto V,Montemurro E,Campanella V

    更新日期：2019-05-01 00:00:00

  • Hyperbilirubinemia and management of breastfeeding.

    abstract：:Hyperbilirubinemia and jaundice are natural, physiological phenomena which are only to be expected in the neonatal period, within certain limits. The highest percentage of jaundice in breastfed newborns should be evaluated in connection with inadequate management of breastfeeding rather than a direct effect of breast ...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章,评审

    doi：

    authors： Soldi A,Tonetto P,Chiale F,Varalda A,Peila C,Sabatino G,Occhi L,Giuliani F,Perathoner C,Prandi G

    更新日期：2012-07-01 00:00:00

  • Kawasaki disease and cardiac involvement: an update on the state of the art.

    abstract：:Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology. It has a self-limiting course and so far, represents the most common cause of coronary heart disease acquired in children aged between 6 months and 5 years. The inflammatory process can involve the coronary arteries with the formation of aneury...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： SPECIAL ISSUE: FOCUS ON PEDIATRIC CARDIOLOGY.,Conti G,Giannitto N,De Luca FL,Salpietro A,Oreto L,Viola I,Ceravolo A,Nicocia G,Sio A,Romeo M,Ceravolo G,Cuppari C,Calabrò MP,Chimenz R

    更新日期：2020-07-01 00:00:00

  • Management of gunshot wound to the lumbosacral spine in a 17-year-old girl without neurological impairment.

    abstract：:We report the case of a young girl (17-year-old) wounded by an accidental gunshot. The bullet entered through the skin midline over the navel area, passed through the stomach perforating the vena cava and, by breaking the right pedicle of L4, moved inside the vertebral canal (bridging the cauda equina) stopping just i...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type：

    doi：

    authors： Bassani R,Morselli C,Agnoletto M,Brambilla L,Peretti GM

    更新日期：2020-07-01 00:00:00

  • Effects of two different anesthetic methods on cellular immunity of patients after liver cancer resection.

    abstract：:This study aims to investigate the effects of epidural block in combination with general anesthesia and general anesthesia alone on the immune function of patients undergoing primary liver cancer resection. Twenty-four patients with liver cancer who received treatment in the Third Hospital of Harbin Medical University...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 信件,随机对照试验

    doi：

    authors： Xu Y,Sun Y,Chen H,Wang Y,Wang GN

    更新日期：2016-10-01 00:00:00

  • Articular capsule repair in initial artificial hip replacement via anterolateral approach to the hip joint.

    abstract：:This study was carried out to explore articular capsule repair in first artificial hip replacement (AHR) via anterolateral approach and its influence on postoperative dislocation. A total of 292 patients who received AHR via anterolateral approach and had the articular capsule repaired in People’s Hospital of Zhengzho...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Zhang BL,Wang F,Tian MB,Yin WL,You XY,Li D,Ma LG,Xing LQ

    更新日期：2016-04-01 00:00:00

  • Ultrasound imaging of oral fibroma: a case report.

    abstract：:Oral mucosa is constantly under the influence of various internal and external stimuli, therefore it is interested by a range of developmental disorders, irritation, inflammation, and neoplastic conditions. Traumatic fibroma is one of these lesions. The aim of this work is to obtain an ultrasound characterization of a...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Di Stasio D,Lauritano D,Paparella R,Franco R,Montella M,Serpico R,Lucchese A

    更新日期：2017-04-01 00:00:00

  • Ticagrelor for patients with ST-segment elevation myocardial infarction after emergency percutaneous coronary intervention.

    abstract：:Acute ST-segment elevation myocardial infarction (STEMI) is one of the most common cardiovascular emergencies. With the improvement of living standards, the incidence and mortality rate of STEMI has shown a significant growth trend. ...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 信件

    doi：

    authors： Han L,Zhang JJ,Jing HF,Qin L

    更新日期：2019-03-01 00:00:00

  • The use of hyaluronic acid in the treatment of shoulder capsulitis: a systematic review.

    abstract：:Adhesive capsulitis (AC) is a common pathological condition of the shoulder characterized by painful restriction of range of motion (ROM) of the glenohumeral joint. Currently, no consensus has been reached regarding the best treatment. Hyaluronic acid (HA) injection is a safe procedure that can result in significant i...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Papalia R,Tecame A,Vadalà G,Russo F,Perna M,Papalia G,Bressi F,Sterzi S,Denaro V

    更新日期：2017-12-27 00:00:00

  • Overexpression of miR-145-5p alleviated LPS-induced acute lung injury.

    abstract：:Acute lung injury (ALI) is a disease with high incidence and no effective therapeutic treatments. miR- 145-5p has been reported to be aberrantly expressed in lung injury tissues, suggesting a potential role in the progression and development of ALI. To validate this hypothesis and explore the underlying mechanism, a m...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Yu YL,Yu G,Ding ZY,Li SJ,Fang QZ

    更新日期：2019-07-01 00:00:00

  • The tumor necrosis factor-alpha-induced protein 8 family in immune homeostasis and inflammatory cancer diseases.

    abstract：:Within the immune system homeostasis is maintained by a myriad of mechanisms that include the regulation of immune cell activation and programmed cell death. The breakdown of immune homeostasis may lead to fatal inflammatory diseases. We set out to identify genes of tumor necrosis factor-alpha-induced protein 8 (TNFAI...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 社论

    doi：

    authors： Luan YY,Yao YM,Sheng ZY

    更新日期：2013-07-01 00:00:00

  • Reactive phenotypes after acute and chronic NK-cell activation.

    abstract：:Several phenotypic changes have been shown to occur after NK-cell stimulation, involving molecules that have been proved to regulate NK-cell migration into tissues and NK-cell activation and proliferation as well as target cell recognition and killing. Here, we review the reactive phenotypes observed in vivo after acu...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Lima M,Almeida J,Teixeira MA,Santos AH,Queirós ML,Fonseca S,Moura J,Gonçalves M,Orfão A,Pinto Ribeiro AC

    更新日期：2004-07-01 00:00:00

  • Drug-induced gingival overgrowth: an in vitro study on cyclosporine and human gingival fibroblasts.

    abstract：:Gingival overgrowth is a serious side-effect that accompanies the use of cyclosporine. Up to 97% of the patients submitted to immunosuppressant drugs have been reported to suffer from this side-effect. Several conflicting theories have been proposed to explain the fibroblast's function in gingival overgrowth. To deter...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 临床试验

    doi：

    authors： DENTAL SUPPLEMENT.,Candotto V,Baj A,Beltramini G,Scarano A,Palmieri A

    更新日期：2019-12-10 00:00:00

  • Concomitant assessment of DNA oxidation and bone resorption over a rapid body mass reduction period in female judokas.

    abstract：:The purpose of this study was to concomitantly determine oxidative DNAdamage and bone resorption following a rapid body mass reduction in association with energy restriction and exercise training, considering 17β-estradiol level, in female collegiate judokas. Eighteen nationally ranked university female judokas were e...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Yasuda N,Yano T

    更新日期：2018-07-01 00:00:00

  • Magnesium alginate in children with uncontrolled asthma.

    abstract：:Gastroesophageal reflux disease (GERD) may be frequently associated with asthma in children and may affect asthma control. Proton pump inhibitors (PPI) are commonly prescribed in asthmatic children, despite uncertain efficacy on respiratory symptoms and risk of relevant adverse effects. ...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 信件

    doi：

    authors： Miraglia Del Giudice M,Indolfi C,Ciprandi G,Decimo F,Campana G,Umano GR,Giannetti E,Maglione M

    更新日期：2019-03-01 00:00:00

  • Entero-colpo-defecography vs supine entero-MRI: which one is the best tool in the differentiation of enterocele, elytrocele and edrocele?

    abstract：:Pelvic floor disorders represent a significant cause of morbidity associated with a severe reduction of quality of life. It represents a very common clinical problem that afflicts women three to seven time more often than men. The purpose of this study was to assess the diagnostic tools available to define the imaging...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Faggian A,Alabiso ME,Serra N,Pizza NL,Iasiello F,Tecame M,Somma F,Rossi C,Di Grezia G,Feragalli B,Iacomino A,Grassi R

    更新日期：2013-07-01 00:00:00

  • Human T lymphocyte cell line (Mo) and its subclone (J) produce colony stimulating activity on normal and malignant T cell precursors.

    abstract：:Conditioned medium from a T-lymphoblastic cell line (Mo) is known to produce factors promoting CFU-GM, BFU-E and CFU-MK. In our study we investigated the potential CSA of conditioned media obtained from Mo and its subclone J on normal and malignant lymphoid progenitors of both T and B lineage. Both cell lines release ...

    journal_title：Journal of biological regulators and homeostatic agents

    pub_type： 杂志文章

    doi：

    authors： Legitimo A,Consolini R,Bason C,Balleari E,Macchia P

    更新日期：1995-10-01 00:00:00