Abstract：
:This study was carried out by varying both graphene oxide (GO) concentration (10 μg/mL, 50 μg/mL, 100 μg/mL) and flakes sizes of 1320 nm and 130 nm. Characterization by scanning electron microscopy and Raman spectroscopy demonstrate that the area of GO flakes varies of one order of magnitude but their chemical structure remains unmodified. A 24-h cytotoxicity test showed, for A549, a loss in the viability, while the test exhibits overall a positive increase in the viability for CaCo2 and Vero. A 24-h comet assay shows a marked GO genotoxicity: for micrometer-sized GO flakes the genotoxicity is in positive correlation with the concentration, while for nanometer-sized GO flakes there was a high degree of genotoxicity at the lowest concentration tested.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
De Marzi L,Ottaviano L,Perrozzi F,Nardone M,Santucci S,De Lapuente J,Borras M,Treossi E,Palermo V,Poma Asubject
Has Abstractpub_date
2014-04-01 00:00:00pages
281-9issue
2eissn
0393-974Xissn
1724-6083pii
12journal_volume
28pub_type
杂志文章abstract：:HAART is the cornerstone of HIV therapy, and has significantly reduced morbidity and mortality associated with HIV disease. The institution of HAART during the primary HIV-1 infection has a more profound influence on the ultimate pattern and rate of disease progression than therapy commenced later on. However, it also...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Pig weaning involves radical changes, which affect health, behavior and performance. Weaning stress dramatically impacts the porcine immune system. This study aimed to evaluate the expression of different cytokines and nuclear factor kappa B (NF-kB) in growing postweaning pigs. Forty piglets weaned at 28 days of age, ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：10.23812/19-342-A
更新日期：2019-11-01 00:00:00
abstract：:Inflammatory responses are operationally characterized by pain, redness, heat and swelling at the site of infection and trauma. Mast cells reside near small blood vessels and, when activated, release potent mediators involved in allergy and inflammation. Vitamin D modulates contraction, inflammation and remodeling tis...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论
doi：
更新日期：2013-04-01 00:00:00
abstract：:Bisphosphonates are antiresorptive pharmacological agents used in the treatment of osteoporosis. Recently, osteonecrosis of the jaw has been recognized as a potential side effect in patients on long-term bisphosphonate therapy. This condition, popularly called bisphosphonate-related osteonecrosis of the jaw (BRONJ), h...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 临床试验,杂志文章
doi：
更新日期：2017-07-01 00:00:00
abstract：:Cerebral small vessel disease (CSVD) is a leading cause of progressive decline of cognition and a major risk factor for stroke. Thymoquinone (TQ) is the major biological component of Nigella sativa (N. sativa) and its extracts. We explored the possible protective effect of TQ against CSVD in strokeprone spontaneously ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-03-01 00:00:00
abstract：:Present data about hormonal regulation of haemostasis are often contradictory and are mostly based on clinical observations. The aim of the current research is to study the effects of the hormones of hypothalamic-pituitary-thyroid (HPT) axis on plasma levels (i.e. on the synthesis and secretion) of vitamin K-dependent...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:The aim of this study is to investigate the expression of mTOR in breast cancer and observe the effect of CCI-779 on proliferation and apoptosis of MDA-MB-231 cells. Immunohistochemical staining was used to detect the expression of mTOR protein in breast cancer tissues and MDA-MB-231 cells. MTT assay was used to asses...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2015-10-01 00:00:00
abstract：:Establishment of Leishmania infection inside macrophages requires deactivation of various signaling pathways that are dispensable for effective immune responses against the parasite. In the present study, we provide evidence that Leishmania infantum promastigotes attachment on the surface of peritoneal macrophages, in...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:We here describe a new technique for making a definitive impression that we refer to as the two-step impression/injection technique. This technique initially follows the classical one-step putty/ light-body impression technique with the polymerization of the putty and the light-body compound. This is then followed by ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：:Percutaneous techniques for treatment of thoraco-lumbar fractures type A2 and A3 are widely used. These techniques are considered temporary fixations and instrumentation must be removed with fracture healing. The aim of the study is to analyze clinical results, motility of treated segments and any loss of correction a...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:The purpose of this study was to concomitantly determine oxidative DNAdamage and bone resorption following a rapid body mass reduction in association with energy restriction and exercise training, considering 17β-estradiol level, in female collegiate judokas. Eighteen nationally ranked university female judokas were e...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-07-01 00:00:00
abstract：:There is increasing concern about the impact on public health of methicillin-resistant Staphylococcus aureus (MRSA) associated with animal food products. MRSA remains a serious problem because of the high incidence and multidrug resistance of the strains, even for strains isolated from foods, food environments and foo...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：:Dental pulp stem cells (DPSCs) are multipotent stem cells with the potential to differentiate into various cell types. For this reason, they have been proposed as an alternative source for mesenchymal stem cells. Somatostatin is a peptide hormone with an inhibitory effect on several endogenous hormones. The aim of our...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-07-01 00:00:00
abstract：:Peripheral nerve injury in surgical trauma patients is very common. The femoral nerve can be divided into two branches: one regarding the quadricep muscles, and one the skin. After nerve transection and suture, the motor axons have an equal opportunity to regenerate into the original muscle branch, or regenerate into ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2017-04-07 00:00:00
abstract：:Microscopic satellites (microsatellites) in primary melanoma are defined as one or more discontinuous nests of neoplastic melanocytes measuring more than 0.05 mm in diameter that are clearly separated by normal dermis (i.e., no fibrosis or inflammation) from the main invasive component of the melanoma by a distance of...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:The aim of this work was to study the effects of micro ribonucleic acid (miR)-20a on acute kidney injury (AKI) in sepsis rats and its key molecular mechanism. Sprague-Dawley rats were randomly divided into healthy rat group (H group, n=3), sham group (S group, n=3), sepsis rat group (D group, n=3), sepsis rat + negati...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：10.23812/20-174-A
更新日期：2020-07-01 00:00:00
abstract：:Aim of this retrospective study was to evaluate the one-year clinical and radiographic outcomes of implants with a triangular shaped neck inserted immediately after tooth extraction in esthetic zones. Patients in which immediate postextraction implants were placed and restored in the anterior maxilla, who underwent a ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2019-11-01 00:00:00
abstract：:T cell subsets in the synovial fluid (SF) and peripheral blood (PB) of RA patients and controls suffering from different forms of chronic synovitis have been investigated. The immunological evaluation showed a reduction of CD4 subsets in RA-SF compared to RA-PB (p less than 0.001), and an almost complete absence of th...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:Orofaciodigital syndrome (OFD) is a group of hereditary disorders identified by malformations of the mouth (oris), face (facies), hands and feet (digitus=finger and toe). Although there are several different types reported in the literature, there is a great overlap in their clinical presentation. The full spectrum of...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:This study highlights the close link between upper and lower airways and the relevance of bronchodilation test in patients presenting with moderate-severe persistent allergic rhinitis and mild persistent asthma. ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2008-10-01 00:00:00
abstract：:Acute ST-segment elevation myocardial infarction (STEMI) is one of the most common cardiovascular emergencies. With the improvement of living standards, the incidence and mortality rate of STEMI has shown a significant growth trend. ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2019-03-01 00:00:00
abstract：:DNA holds genetic information in the nucleus of eukaryotic cells; and has three different functions: replication, storage of hereditary information, and regulation of cell division. Most studies described the association of single nucleotide polymorphism (SNP) to common orthopaedics diseases and the susceptibility to ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Aerobic exercise is associated with the sympathetic activation evoking adaptive responses to sustain muscle engagement. Physical exercise can cause alterations in the cardiovascular activity and cellular stress may occur which could be marked by either heart rate (HR), or galvanic skin response (GSR). Moderate plasma ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2019-03-01 00:00:00
abstract：:Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children. Recently, treatment with intranasal corticosteroids has been suggested to decrease the size of AH. The aim of the study is to evaluate the long-term effect of intranasal flunisolide on AH during a 12-month follow-up. On...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-04-01 00:00:00
abstract：:The state of sleep/wakefulness is well known to influence esophageal acid exposure and the number of acid refluxes whereas it is uncertain whether the same is true of the non-acid refluxes that predominate in the newborns. To investigate the relationship between sleep/wakefulness and refluxes 45 newborns with gastroes...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:There is a great hazard of mercury intoxication in the third world for artisanal miners using mercury as amalgam for extracting and refining gold. In developing countries, there is the possibility of risk regarding exposure to Hg from amalgam tooth fillings, ethyl-Hg (thimerosal) added as antiseptic to vaccines and me...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论,评审
doi：
更新日期：2009-10-01 00:00:00
abstract：:Given the pathological incidence of metastases or radioiodine-refractory papillary thyroid carcinoma (PTC) is increasing worldwide, patients have little alternatives when choosing effective drugs. Therefore, it is necessary to develop new therapeutic targets for PTC treatment. CDK7 is a member of the cyclindependent p...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-11-01 00:00:00
abstract：:A number of studies have shown that vitamin D has a protective effect against the development of cancer, which may also be related to prostate cancer. Low serum vitamin D concentration has also been demonstrated in benign prostate hyperplasia. We compared serum vitamin D concentration in two groups of Polish men with ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2015-01-01 00:00:00
abstract：:Patients with submassive pulmonary embolism (PE) resulting in right heart strain (RHS) have an increased risk of mortality compared to those with a preserved right ventricular function. This study aimed to investigate the predictive value of computed tomography pulmonary angiogram (CTPA) findings of right heart strain...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2018-03-01 00:00:00
abstract：:Allergic rhinitis (AR) is caused by an IgE-mediated inflammatory reaction. Non-allergic rhinitis (NAR) is characterized by a non-IgE-mediated pathogenesis. Frequently, patients have the two disorders associated: such as mixed rhinitis (MR). Hyaluronic acid (HA) is a fundamental component of the human connective tissue...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2016-01-01 00:00:00
