Abstract：
:Rough titanium surfaces enhance cell response to activation of Wnt canonical signalling, a pathway required for osteoblast differentiation. The present study investigated the effects of GSK3β-inhibitors SB216763 and SB415286 on osteoblastic differentiation on titanium surfaces with different topography and wettability. Osteoblastic MC3T3 cells were plated on smooth (Pickled), sand-blasted/acid-etched (SLA) or hyper hydrophilic SLA (modSLA) titanium discs and transfected with a reporter vector sys-tem for Wnt canonical signalling. Cells were also seeded in the presence or in the absence of GSK3b-inhibitors SB216763 or SB415286 and their viability, morphology and the expression of Wnt target and osteoblast specific genes was assessed by Real Time PCR. Inhibitors altered cell morphology and mostly reduced cell viability at high concentration. SB415286 markedly increased the expression of ALP in MC3T3 cells on rough surfaces at the concentration of 100 nM before decreasing its expression at higher concentrations. OCN expression was unaffected. Increasing concentrations of SB216763 increased the expression of ALP in MC3T3 cells on rough surfaces but OCN expression was not changed at any con-centration. SB216763 and SB415286 inhibitors should be further investigated as potential tools to improve cell differentiation on titanium surfaces for endosseous implants.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Lumetti S,Calciolari E,Parisi L,Toffoli A,Mazzotta S,Ferrillo S,Ierardo G,Macaluso GM,Galli C,Manfredi Esubject
Has Abstractpub_date
2017-07-01 00:00:00pages
579-587issue
3eissn
0393-974Xissn
1724-6083journal_volume
31pub_type
杂志文章abstract：:Anxiety and worry are important components that affect the patients behaviour during dental sessions and influence the effectiveness of dental treatment. Psychological approach and hypnotic approach (HA) have in recent years assumed increasing prominence as effective treatment regimes. Dentists have used a number of ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:B cell antigen receptor (BCR) engagement results in the assembly of a multimolecular complex at the cytosolic side of the plasma membrane, known as signalosome. Here we briefly review the current knowledge on the molecules which participate in the BCR signalosome and on the response modulators which control the final ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:In the last few years, different tissue engineering strategies have been developed for the repair of osteochondral lesions. When the osteochondral scaffold is implanted on the femoral condyle, the meniscus might be affected by the implant and might undergo a progressive degeneration. The aim of our study is to analyze...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2017-10-01 00:00:00
abstract：:To investigate percutaneous exposures to HIV in the highly active antiretroviral therapy (HAART) era, we performed an analysis of all percutaneous exposures reported from January 1994 to December 1998 in 18 Italian acute-care hospitals. Frequency and rate per 100 prevalent AIDS cases of HIV exposures decreased by 40% ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:Protein hydrolysates (PH) are rich sources of proteins that supply the need of exercising muscles. PHs are enriched in di- and tripeptides and are better than free amino acids or intact proteins when muscle anabolic effect is considered. Digestion, absorption and muscle uptake of amino acids are faster and more effici...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
更新日期：2017-01-01 00:00:00
abstract：:The early detection of genomic biomarkers (e.g. RNAs) through analysis of circulating blood cells could have a substantial impact on biomedicine, particularly in monitoring clinical trials, drug toxicity and doping in athletes. To achieve this goal, it is essential to develop methods that are sufficiently sensitive to...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：:Long non-coding ribonucleic acids (lncRNAs) have been recognized as markers in several cancers and play important roles in glioblastoma (GBM). But the role of lncRNA X inactive-specific transcript (XIST) in GBM and its possible mechanisms are rarely studied in depth. This study was conducted to explore the detailed ro...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：10.23812/20-558-L
更新日期：2020-11-01 00:00:00
abstract：:Measured resection and ligament balancing techniques are the most used in TKA; both require, in the majority of knee arthroplasty systems, a femoral intramedullary canal referencing for the distal femoral cut. Fat embolism, activation of coagulation and bleeding may occur from the reamed canal; this can be avoided wit...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-11-01 00:00:00
abstract：:End-stage renal diseases requiring chronic dialysis are rare in childhood and adolescence, but they are associated with high mortality and impaired quality of life (1, 2). The most common disease that causes chronic kidney disease (CKD) is primary glomerular disease (GD), followed by congenital abnormalities of the ki...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 临床试验
doi：
更新日期：2019-09-01 00:00:00
abstract：:The relationship between allergic diseases and cancer is a very controversial topic, widely discussed in the last decades. Many studies have demonstrated inverse association between allergy and cancer, but others have reached neutral conclusions or have indicated a positive role of allergy in the development of cancer...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论
doi：10.23812/19-418-63-E
更新日期：2020-03-01 00:00:00
abstract：:Acupuncture is an integral part of ancient Chinese medical practice. The technique has been used extensively in pain relief and is being tried for many other chronic conditions. Industrial development and affluence lead to the increase in the prevalence of many endocrine disorders such as diabetes, obesity, and polycy...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件,评审
doi：
更新日期：2016-10-01 00:00:00
abstract：:We report the case of a young girl (17-year-old) wounded by an accidental gunshot. The bullet entered through the skin midline over the navel area, passed through the stomach perforating the vena cava and, by breaking the right pedicle of L4, moved inside the vertebral canal (bridging the cauda equina) stopping just i...
journal_title：Journal of biological regulators and homeostatic agents
pub_type：
doi：
更新日期：2020-07-01 00:00:00
abstract：:The introduction of highly purified natural and recombinant single allergenic molecules represented an important improvement in the diagnosis of IgE sensitization. The identification of specific IgE against cross-reacting molecules such as profilin, lipid transfer proteins, calcium binding proteins or against genuine...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
更新日期：2018-01-01 00:00:00
abstract：:Cytokine proteins may have important roles during different human physiological and pathological processes. In the oral cavity, the bone loss and periodontal tissue pathology was related to inflammatory process activation. The aim of the present study was to assess the effects of etiological periodontal therapy with a...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件,多中心研究,随机对照试验
doi：
更新日期：2018-03-01 00:00:00
abstract：:The pseudoarthrosis (PSA) of scaphoid leads to alteration in load transfer in the wrist joint. Its treatment aims to achieve consolidation to improve clinical complaints and prevent post-traumatic arthritis. The indication for using vascularized bone grafts is still controversial. This prospective comparative study ai...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 临床试验
doi：
更新日期：2020-05-01 00:00:00
abstract：:Acute ST-segment elevation myocardial infarction (STEMI) is one of the most common cardiovascular emergencies. With the improvement of living standards, the incidence and mortality rate of STEMI has shown a significant growth trend. ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2019-03-01 00:00:00
abstract：:Microscopic satellites (microsatellites) in primary melanoma are defined as one or more discontinuous nests of neoplastic melanocytes measuring more than 0.05 mm in diameter that are clearly separated by normal dermis (i.e., no fibrosis or inflammation) from the main invasive component of the melanoma by a distance of...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:Vertebral fusion is performed in order to stabilize the spine in the presence of degenerative, traumatic or oncological pathologies that alter its stability. The autologous bone, harvested from the patient’s iliac crest or from the lamina during surgery, is still considered the “gold standard” for spine fusion due to ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2017-10-01 00:00:00
abstract：:Aim of this retrospective study was to evaluate the one-year clinical and radiographic outcomes of implants with a triangular shaped neck inserted immediately after tooth extraction in esthetic zones. Patients in which immediate postextraction implants were placed and restored in the anterior maxilla, who underwent a ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2019-11-01 00:00:00
abstract：:This study aimed to investigate the effectiveness of perioperative nursing intervention on patients undergoing laparoscopic gastric stromal tumor resection. Sixty patients with gastric stromal tumor were selected from our hospital and evenly divided into group A and group B. Patients in both groups underwent laparosco...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2018-01-01 00:00:00
abstract：:Within the immune system homeostasis is maintained by a myriad of mechanisms that include the regulation of immune cell activation and programmed cell death. The breakdown of immune homeostasis may lead to fatal inflammatory diseases. We set out to identify genes of tumor necrosis factor-alpha-induced protein 8 (TNFAI...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论
doi：
更新日期：2013-07-01 00:00:00
abstract：:This case report presents the technique of deep infiltration for the treatment of hypomineralized enamel lesions in a patient affected by molar incisor hypomineralization (MIH) with the purpose of obtaining an aesthetic improvement in the affected vestibular enamel. Deep infiltration treatment involves a sequence of s...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-05-01 00:00:00
abstract：:Oral mucosa is constantly under the influence of various internal and external stimuli, therefore it is interested by a range of developmental disorders, irritation, inflammation, and neoplastic conditions. Traumatic fibroma is one of these lesions. The aim of this work is to obtain an ultrasound characterization of a...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2017-04-01 00:00:00
abstract：:The purpose of this study was to concomitantly determine oxidative DNAdamage and bone resorption following a rapid body mass reduction in association with energy restriction and exercise training, considering 17β-estradiol level, in female collegiate judokas. Eighteen nationally ranked university female judokas were e...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-07-01 00:00:00
abstract：:STAT3 signaling pathway is related to the proliferation, apoptosis and metastasis of tumor cells. The relationship between STAT3 and drug resistance is still unknown. We studied the inhibitors in STAT3 pathway and its downstream molecules to analyze the unique effects in drug-resistant bladder cancer cells. qRT-PCR an...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：10.23812/19-68-A
更新日期：2019-09-01 00:00:00
abstract：:Bisphosphonates are antiresorptive pharmacological agents used in the treatment of osteoporosis. Recently, osteonecrosis of the jaw has been recognized as a potential side effect in patients on long-term bisphosphonate therapy. This condition, popularly called bisphosphonate-related osteonecrosis of the jaw (BRONJ), h...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 临床试验,杂志文章
doi：
更新日期：2017-07-01 00:00:00
abstract：:To compare the effectiveness of Doctor Tecar TherapyTM with that of laser therapy in the management of low back pain (LBP), a total of 60 patients with LBP were enrolled. The participants were randomly divided into two groups: a Tecar group (experimental group, 30 subjects), and a laser group (control group, 30 subjec...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2017-04-01 00:00:00
abstract：:Activated T-cells are susceptible to induction of apoptosis or programmed cell death in response to ligation of several cell surface structures, including CD2, CD3, and CD95/Fas. These mechanisms may be important in the regulation of immune responses and in prevention of autoimmunity. We used flow cytometric quantitat...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：:Glycoprotein Ia (GPIa), also known as integrin alpha 2 (ITGA2), together with GPIIa (ITGB1), form the heterodimer integrin α2β1. This complex is a major collagen receptor on the membrane of platelets, which is involved in thrombus formation through platelet adhesion and activation. ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2019-05-01 00:00:00
abstract：:A number of studies have shown that vitamin D has a protective effect against the development of cancer, which may also be related to prostate cancer. Low serum vitamin D concentration has also been demonstrated in benign prostate hyperplasia. We compared serum vitamin D concentration in two groups of Polish men with ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2015-01-01 00:00:00
