Molecular abnormalities in leukemia: the 11q23 story so far.

Abstract:

:Various hematopoietic malignant disorders have been shown to bear chromosome abnormalities of the 11q23 band, which can be rearranged with many different chromosomal regions in a wide variety of different leukemia subtypes. Several laboratories have identified a trithorax-related gene that is involved in most of the 11q23 abnormalities. Although some patterns and associations between the partner genes are beginning to emerge, it is not yet possible to frame a single unifying hypothesis for 11q23 leukaemic transformation. The aim of this review is to summarise the recent data concerning these 11q23 rearrangements and the understanding of their consequences.

authors

Gregorini A,Cinti C,Young BD

keywords:

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

95-105

issue

4

eissn

0393-974X

issn

1724-6083

journal_volume

12

pub_type

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