Measurement of exhaled nitric oxide concentration in patients with obstructive sleep apnea: A meta-analysis.

Abstract:

BACKGROUND:Exhaled nitric oxide (eNO) has been proposed as a noninvasive measure of airway inflammation. However, its value in patients with obstructive sleep apnea (OSA) is still controversial. The authors aim to assess the difference in eNO levels between patients with OSA and controls by a meta-analysis. METHODS:A systematic search was performed in the PubMed, EMBASE, the Cochrane Library, and MEDLINE databases to collect relevant studies published from 1996 to 2016. Eligible studies that reported eNO levels in patients with OSA were included. STATA (version 12.0) was used for data analysis. RESULTS:Two hundred eighty-four studies were reviewed for inclusion, with 16 studies pooled for analysis (16 studies for fractional exhaled nitric oxide [FENO], 5 for alveolar nitric oxide [CANO], and 4 for the maximum airway wall flux of nitric oxide [J'awNO]). The FENO levels were significantly higher in patients with OSA compared with that in the control groups (6.32 ppb, 95% confidence interval [CI] 4.46-8.33, P < 0.001). Furthermore, FENO was significantly increased (4.00 ppb, 95% CI 1.74-6.27, P = 0.001) after overnight sleep in patients with OSA, but not in healthy controls. Additionally, long-term continuous positive airway pressure (CPAP) therapy reduced FENO levels (-5.82 ppb, 95% CI -9.6 to -2.01, P < 0.001). However, the CANO (-0.01 ppb, 95% CI -1.66 to 1.64, P = 0.989) and J'awNO levels (220.32 pl/s, 95% CI -49.31 to 489.94, P = 0.109) were not significantly different between the OSA groups and non-OSA groups. CONCLUSION:The results of the meta-analysis suggest that OSA is significantly associated with airway inflammation and elevated FENO levels can be modified by long-term CPAP therapy. J'awNO and CANO levels were not significantly different between the OSA groups and control groups.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Zhang D,Luo J,Qiao Y,Xiao Y,Huang R,Zhong X

doi

10.1097/MD.0000000000006429

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

e6429

issue

12

eissn

0025-7974

issn

1536-5964

pii

00005792-201703240-00053

journal_volume

96

pub_type

杂志文章,meta分析

相关文献

MEDICINE文献大全
  • Dabrafenib plus trametinib for compassionate use in metastatic melanoma: A STROBE-compliant retrospective observational postauthorization study.

    abstract::The main objective of the study was to evaluate the efficacy and safety of dabrafenib alone or combined with trametinib for compassionate use in patients with metastatic melanoma.This retrospective, observational study involved 135 patients with unresectable stage IIIC or stage IV melanoma from an expanded-access prog...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009523

    authors: Martín Algarra S,Soriano V,Fernández-Morales L,Berciano-Guerrero MÁ,Mujika K,Manzano JL,Puértolas Hernández T,Soria A,Rodríguez-Abreu D,Espinosa Arranz E,Medina Martínez J,Márquez-Rodas I,Rubió-Casadevall J,Ortega ME,Jurado G

    更新日期:2017-12-01 00:00:00

  • The catalase C-262T gene polymorphism and cancer risk: a systematic review and meta-analysis.

    abstract::Many studies suggest that catalase C-262T gene polymorphism is associated with cancer risk, but with inconsistent results. This study aimed to summarize the overall association between catalase C-262T polymorphism and cancer risk. Literature search was performed in PubMed, Embase, and other databases, studies regardin...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000000679

    authors: Shen Y,Li D,Tian P,Shen K,Zhu J,Feng M,Wan C,Yang T,Chen L,Wen F

    更新日期:2015-04-01 00:00:00

  • Cisplatin-induced cardiotoxicity with midrange ejection fraction: A case report and review of the literature.

    abstract:RATIONALE:Cisplatin monotherapy-induced cardiotoxicity is rare, and the prevalence remains unknown. It's extremely important to stop cisplatin when cardiotoxicity is considered. PATIENT CONCERNS:A 53-year-old woman developed cervical cancer. She was administered cisplatin (37 mg/m/wk) for 3 weeks, but the left ventric...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000013807

    authors: Hu Y,Sun B,Zhao B,Mei D,Gu Q,Tian Z

    更新日期:2018-12-01 00:00:00

  • Rituximab in treatment of anti-GBM antibody glomerulonephritis: A case report and literature review.

    abstract:RATIONALE:Anti-glomerular basement membrane (GBM) disease is a T cell-mediated disease that has a poor prognosis with conventional therapy. We tested rituximab as a primary therapy to reduce anti-GBM antibody produced by B cells. PATIENT CONCERNS:A 53-year old woman with complaints of a fever, headache and abdominal d...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000017801

    authors: Uematsu-Uchida M,Ohira T,Tomita S,Satonaka H,Tojo A,Ishimitsu T

    更新日期:2019-11-01 00:00:00

  • Acupotomy for third lumbar vertebrae transverse process syndrome: A protocol for systematic review.

    abstract:BACKGROUND:Acupotomy has been widely used clinically to relieve low back pain. However, the efficacy of acupotomy for the third lumbar vertebrae transverse process syndrome is still uncertain. The aim of this study is to determine the effectiveness and safety of acupotomy therapy for the third lumbar vertebrae transver...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021072

    authors: Jiao L,Xiao Y,Chi Z,Zhu D,Ouyang X,Xu W,You J,Luo Z,Yuan F

    更新日期:2020-07-17 00:00:00

  • Nocardiosis of the central nervous system: experience from a general hospital and review of 84 cases from the literature.

    abstract::Central nervous system (CNS) nocardiosis is a rare disease entity caused by the filamentous bacteria Nocardia species. We present a case series of 5 patients from our hospital and a review of the cases of CNS nocardiosis reported in the literature from January 2000 to December 2011. Our results indicate that CNS nocar...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000000012

    authors: Anagnostou T,Arvanitis M,Kourkoumpetis TK,Desalermos A,Carneiro HA,Mylonakis E

    更新日期:2014-01-01 00:00:00

  • A case report of a child with sepsis induced multiorgan failure and massive complement consumption treated with a short course of Eculizumab: A case of crosstalk between coagulation and complement?

    abstract:RATIONALE:This article describes a child with a life-threatening multiorgan failure with disseminated intravascular coagulation (DIC) and massive complement consumption. To our knowledge this therapeutic approach was for the first time effectively applied in a pediatric patient. PATIENT CONCERNS:A 14-month-old boy was...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014105

    authors: Galic S,Csuka D,Prohászka Z,Turudic D,Dzepina P,Milosevic D

    更新日期:2019-01-01 00:00:00

  • Worse clinical outcomes following percutaneous coronary intervention with a high SYNTAX score: A systematic review and meta-analysis.

    abstract:BACKGROUND:The synergy between percutaneous coronary intervention (PCI) with TAXUS and Cardiac Surgery (SYNTAX) score is an angiographic tool which is used to determine the complexity of coronary artery disease (CAD). We aimed to compare PCI versus coronary artery bypass surgery (CABG) in patients with a high SYNTAX sc...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000007140

    authors: Bundhun PK,Bhurtu A,Huang F

    更新日期:2017-06-01 00:00:00

  • Circulating D-dimer level correlates with disease characteristics in hepatoblastoma patients.

    abstract:OBJECTIVES:Hepatoblastoma (HB) is the most common pediatric liver malignancy, typically affecting children within the first 4 years of life. However, only a few validated blood biomarkers are used in clinical evaluation. The current study explored the clinical application and significance of D-dimer levels in patients ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008798

    authors: Zhang B,Liu G,Liu X,Zheng S,Dong K,Dong R

    更新日期:2017-11-01 00:00:00

  • A meta-analytic review of prevalence for Brugada ECG patterns and the risk for death.

    abstract:BACKGROUND:The prevalence of Brugada ECG pattern (BrEP) is different in different regions, and its mean prevalence over the world is unknown. The risk of people with BrEP for death remains unknown. We performed a meta-analysis to determine the prevalence of BrEP and risk ratio (RR) for death. METHODS:Relevant studies ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000005643

    authors: Quan XQ,Li S,Liu R,Zheng K,Wu XF,Tang Q

    更新日期:2016-12-01 00:00:00

  • Neonatal pulmonary sequestration (PS) with rhabdomyomas-like hyperplasia: A case report.

    abstract:INTRODUCTION:Pulmonary sequestration (PS) is a rare pulmonary congenital malformation characterized by disconnection with the tracheobronchial tree or the pulmonary arterial blood supply thus impeding the connection to the arterial blood supply from systemic circulation, ultimately resulting in a non-functional lung. ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020052

    authors: Liu XM,Yuan LM,Wu YR,Zhou CJ

    更新日期:2020-05-01 00:00:00

  • Metastatic spread of solid subtype lung adenocarcinoma to the small intestine with anemia and melena: A case report.

    abstract:RATIONALE:Metastasis to the small intestine from a primary lung cancer is rare, and is associated with a poor prognosis. Early diagnosis of small intestine metastasis is difficult because of the low incidence of clinically apparent symptoms. PATIENT CONCERNS:Clinical data and treatment of a 59-year-old man with small ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007768

    authors: Ying X,Wang M,Verma V,Wang M,Ye S,Bi J,Zhou X,Han G,Zhen W

    更新日期:2017-08-01 00:00:00

  • Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with urologic tumors: A PRISMA-compliant meta-analysis.

    abstract:BACKGROUND:The prognostic value of pretreatment lymphocyte to monocyte ratio (LMR) in patients with urologic tumors remains controversial. Therefore, we herein conducted a meta-analysis to systematically assess the prognostic value of LMR in patients with urologic tumors. METHODS:We comprehensively searched PubMed, EM...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000014091

    authors: Li J,Cheng Y,Ji Z

    更新日期:2019-01-01 00:00:00

  • Efficacy and Safety of Zoledronic Acid and Pamidronate Disodium in the Treatment of Malignant Skeletal Metastasis: A Meta-Analysis.

    abstract::Solid tumors frequently metastasize to bone. Two bisphosphonates have been investigated for bone metastases including pamidronate disodium and zoledronic acid.By searching the PubMed, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases, we conducted a meta-analysis to determine the efficacy a...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000001822

    authors: Yang L,Du S

    更新日期:2015-10-01 00:00:00

  • Comparative efficacy of low volume versus traditional standard volume PEG on bowel preparation before colonoscopy: Protocol for an updated meta-analysis with trial sequential analysis.

    abstract:INTRODUCTION:Polyethylene glycol (PEG) has been considered as the first recommendation for bowel preparation prior to colonoscopy. A previous meta-analysis suggested that low volume PEG may improve the acceptability of ingesting bowel preparation solution. However, several limitations impaired the power of findings fro...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000010599

    authors: Yi LJ,Tian X,Pi YP,Feng L,Chen H,Liu XL,Chen WQ

    更新日期:2018-04-01 00:00:00

  • Cinobufotalin injection combined with chemotherapy for the treatment of advanced NSCLC in China: A PRISMA-compliant meta-analysis of 29 randomized controlled trials.

    abstract:BACKGROUND AND OBJECTIVE:Cinobufotalin injection (CFI), a kind of Chinese medicine, has been considered as a promising complementary therapy option for advanced non-small cell lung cancer (NSCLC), but their efficacy and safety remain controversial. This study aimed to systematically evaluate the efficacy and safety of ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000016969

    authors: Zhang F,Yin Y,Xu T

    更新日期:2019-08-01 00:00:00

  • Bisphenol A and hormone-associated cancers: current progress and perspectives.

    abstract::Bisphenol A (BPA), a carbon-based synthetic compound, exhibits hormone-like properties and is present ubiquitously in the environment and in human tissues due to its widespread use and biological accumulation. BPA can mimic estrogen to interact with estrogen receptors α and β, leading to changes in cell proliferation,...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000211

    authors: Gao H,Yang BJ,Li N,Feng LM,Shi XY,Zhao WH,Liu SJ

    更新日期:2015-01-01 00:00:00

  • The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report.

    abstract:RATIONALE:Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with great mortality rates. The prognosis of advanced HCC is very poor. PATIENT CONCERNS:Here, we report a HCC patient with a big paraspinal metastasis with 10 cm in diameter who failed the treatment of sorafenib. DIAGNOSES:Sorafenib refr...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009598

    authors: Zhu H,Zhao Y,Wang X

    更新日期:2018-01-01 00:00:00

  • What Do Stroke Patients Look for in Game-Based Rehabilitation: A Survey Study.

    abstract::Stroke is one of the most common causes of physical disability, and early, intensive, and repetitive rehabilitation exercises are crucial to the recovery of stroke survivors. Unfortunately, research shows that only one third of stroke patients actually perform recommended exercises at home, because of the repetitive a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003032

    authors: Hung YX,Huang PC,Chen KT,Chu WC

    更新日期:2016-03-01 00:00:00

  • Microcirculation function assessed by adenosine triphosphate stress myocardial contrast echocardiography and prognosis in patients with nonobstructive coronary artery disease.

    abstract:BACKGROUND:Recent studies have demonstrated that coronary microcirculation dysfunction (CMVD) is closely correlated with adverse clinical outcomes. In this study, quantitative stress myocardial contrast echocardiography (MCE) was used to evaluate the CMVD and to investigate its association with the prognosis of patient...

    journal_title:Medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/MD.0000000000015990

    authors: Yang N,Su YF,Li WW,Wang SS,Zhao CQ,Wang BY,Liu H,Guo M,Han W

    更新日期:2019-07-01 00:00:00

  • HIV prevalence and sexual behavior among young male conscripts in the Brazilian army, 2016.

    abstract::Since 1996, the Brazilian Department of Sexually Transmitted Infections (STI), AIDS and Viral Hepatitis (Departamento de Vigilância, Prevenção e Controle das IST, do HIV, AIDS e Hepatites Virais, Secretaria de Vigilância em Saúde, Ministério da Saúde) in collaboration with the Brazilian Ministry of Defense has conduct...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009014

    authors: Sperhacke RD,da Motta LR,Kato SK,Vanni AC,Paganella MP,Oliveira MCP,Pereira GFM,Benzaken AS

    更新日期:2018-05-01 00:00:00

  • Survival time and prognostic factors of patients with initial noncurative colorectal liver metastases.

    abstract::The true survival benefit of different curative strategies involving type of operative procedure and timing for patients with initial noncurative colorectal liver metastases remains uncertain. The goal of this study was to examine the effect of primary tumor resection on patients' survival and to clarify the predictiv...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008831

    authors: Liu Q,Hao L,Lou Z,Gao X,Gong H,Hong Y,Fu C,Zhang W

    更新日期:2017-12-01 00:00:00

  • Three inherited disorders of calcium sensing.

    abstract::Three distinct disorders of calcium homeostasis can result from mutations in the gene encoding the human calcium-sensing receptors (CASR; MIM 145980). One form of autosomal dominant familial hypocalciuric hypercalcemia results from the heterozygous state of inactivating mutations in the CASR gene. Neonatal severe hype...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00005792-199605000-00001

    authors: Pollak MR,Seidman CE,Brown EM

    更新日期:1996-05-01 00:00:00

  • Impact of thyroid ultrasonography combined ultrasound-guided fine-needle aspiration biopsy in detection thyroid microcarcinoma: A protocol of systematic review.

    abstract:BACKGROUND:This study aims to explore the accuracy of thyroid ultrasonography (TUS) combined ultrasound-guided fine-needle aspiration biopsy (UGFNAB) for detection of thyroid microcarcinoma (TMC). METHODS:A comprehensive search in PUBMED, EMBASE, Cochrane Library, Web of Science, Scopus, Chinese Biomedical Literature ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021712

    authors: Han ZN,Liu Z,Wang J

    更新日期:2020-08-14 00:00:00

  • Long-term outcomes of surgery alone versus surgery following preoperative chemoradiotherapy for early T3 rectal cancer: A propensity score analysis.

    abstract::Recently, a few studies have raised the question of whether preoperative chemoradiotherapy (PCRT) is essential for all T3 rectal cancers. This case-matched study aimed to compare the long-term outcomes of surgery alone with those of PCRT + surgery for magnetic resonance imaging (MRI)-assessed T3ab (extramural depth of...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006362

    authors: Cho SH,Choi GS,Kim GC,Seo AN,Kim HJ,Kim WH,Shin KM,Lee SM,Ryeom H,Kim SH

    更新日期:2017-03-01 00:00:00

  • Full-term pregnancy in a rudimentary horn with a live fetus: A case report.

    abstract:INTRODUCTION:Rudimentary horns and unicornuate uteri, 2 types of Mullerian duct abnormalities, often lack obvious symptoms. Ultrasonography (US) and magnetic resonance imaging (MRI) are alternative examinations but have low accuracy. Full-term rudimentary horn pregnancies are rather rare but life-threatening. PATIENT ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021604

    authors: Zhang Y,Pang Y,Zhang X,Zhao Z,Liu P

    更新日期:2020-08-21 00:00:00

  • Study protocol for a pilot randomized controlled trial on a smartphone application-based intervention for subthreshold depression: Study protocol clinical trial (SPIRIT Compliant).

    abstract:INTRODUCTION:Interventions aimed at addressing subthreshold depression (StD) are important to prevent the onset of major depressive disorder. Our video playback application (SPSRS) is designed to reduce depressive symptoms by presenting positive words in videos, shedding new light on the treatment of StD. However, no r...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018934

    authors: Kato Y,Kageyama K,Mesaki T,Uchida H,Sejima Y,Marume R,Takahashi K,Hirao K

    更新日期:2020-01-01 00:00:00

  • Magnetic resonance imaging-guided targeted biopsy in risk classification among patients on active surveillance: A diagnostic meta-analysis.

    abstract:BACKGROUND:The aim of this study was to assess the sensitivity and accuracy of magnetic resonance imaging-guided targeted biopsy (MRI-TB) in patients undergoing active surveillance (AS) procedure. METHODS:We searched databases to identify relevant studies which compared MRI-TB with systemic biopsy for diagnosing prost...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000016122

    authors: Xue W,Huang Y,Li T,Tan P,Liu L,Yang L,Wei Q

    更新日期:2019-06-01 00:00:00

  • Intravenous versus topical tranexamic acid in primary total hip replacement: A meta-analysis.

    abstract:BACKGROUND:As the prevalence of total hip arthroplasty (THA) is increasing, it is usually associated with considerable blood loss. Tranexamic acid (TXA) has been reported to reduce perioperative blood loss in hip joint arthroplasty. But the best route of TXA administration continues to be controversial. So, we conducte...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000005573

    authors: Zhang P,Liang Y,Chen P,Fang Y,He J,Wang J

    更新日期:2016-12-01 00:00:00

  • Effect of cancer characteristics and oncological outcomes associated with laparoscopic colorectal resection converted to open surgery: A meta-analysis.

    abstract:BACKGROUND:Although laparoscopic colorectal cancer resection is an oncologically safe procedure equivalent to open resection,the effects of conversion of a laparoscopic approach to an open approach remain unclear.This study evaluated the cancer characteristic and oncological outcomes associated with conversion of lapar...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013317

    authors: Wu B,Wang W,Hao G,Song G

    更新日期:2018-12-01 00:00:00