Abstract:
:Serotonin is implicated in mood and affective disorders. However, growing evidence suggests that a core endogenous role is to promote flexible adaptation to changes in the causal structure of the environment, through behavioral inhibition and enhanced plasticity. We used long-term photometric recordings in mice to study a population of dorsal raphe serotonin neurons, whose activity we could link to normal reversal learning using pharmacogenetics. We found that these neurons are activated by both positive and negative prediction errors, and thus report signals similar to those proposed to promote learning in conditions of uncertainty. Furthermore, by comparing the cue responses of serotonin and dopamine neurons, we found differences in learning rates that could explain the importance of serotonin in inhibiting perseverative responding. Our findings show how the activity patterns of serotonin neurons support a role in cognitive flexibility, and suggest a revised model of dopamine-serotonin opponency with potential clinical implications.
journal_name
Elifejournal_title
eLifeauthors
Matias S,Lottem E,Dugué GP,Mainen ZFdoi
10.7554/eLife.20552subject
Has Abstractpub_date
2017-03-21 00:00:00issn
2050-084Xjournal_volume
6pub_type
杂志文章相关文献
eLife文献大全abstract::Atopic dermatitis can result from loss of structural proteins in the outermost epidermal layers, leading to a defective epidermal barrier. To test whether this influences tumour formation, we chemically induced tumours in EPI-/- mice, which lack three barrier proteins-Envoplakin, Periplakin, and Involucrin. EPI-/- mic...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01888
更新日期:2014-05-05 00:00:00
abstract::MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals. Although specific features of MarR family function have been described, the role of atomic motions in MarRs remains unexplored thus limiting insights int...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37268
更新日期:2018-10-17 00:00:00
abstract::Phenazines are natural bacterial antibiotics that can protect crops from disease. However, for most crops it is unknown which producers and specific phenazines are ecologically relevant, and whether phenazine biodegradation can counter their effects. To better understand their ecology, we developed and environmentally...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59726
更新日期:2020-09-15 00:00:00
abstract::Animals seek out relevant information by moving through a dynamic world, but sensory systems are usually studied under highly constrained and passive conditions that may not probe important dimensions of the neural code. Here, we explored neural coding in the barrel cortex of head-fixed mice that tracked walls with th...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12559
更新日期:2015-12-23 00:00:00
abstract::Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi. In natural populations of Podospora anserina, seven spore killer types (Psks) have been identified through classical genetic analyses. Here we show that the S...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46454
更新日期:2019-07-26 00:00:00
abstract::Group B Streptococcus (GBS) is the leading cause of invasive bacterial neonatal infections. Late-onset diseases (LOD) occur between 7 and 89 days of life and are largely due to the CC17 GBS hypervirulent clone. We studied the impact of estradiol (E2) and progesterone (P4), which impregnate the fetus during pregnancy, ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.48772
更新日期:2019-11-11 00:00:00
abstract::Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS). We hypothesized that TMAO exerts beneficial effects on the circulatory system and pr...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57028
更新日期:2020-06-08 00:00:00
abstract::The vascular pathogen Verticillium dahliae infects the roots of plants to cause Verticillium wilt. The molecular mechanisms underlying V. dahliae virulence and host resistance remain elusive. Here, we demonstrate that a secretory protein, VdSCP41, functions as an intracellular effector that promotes V. dahliae virulen...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34902
更新日期:2018-05-14 00:00:00
abstract::Junín virus (JUNV) is one of five New World mammarenaviruses (NWMs) that causes fatal hemorrhagic disease in humans and is the etiological agent of Argentine hemorrhagic fever (AHF). The pathogenesis underlying AHF is poorly understood; however, a prolonged, elevated interferon-α (IFN-α) response is associated with a ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55352
更新日期:2020-05-26 00:00:00
abstract::The rhythm generating network for breathing must continuously adjust to changing metabolic and behavioral demands. Here, we examined network-based mechanisms in the mouse preBötzinger complex using substance P, a potent excitatory modulator of breathing frequency and stability, as a tool to dissect network properties ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51350
更新日期:2019-12-05 00:00:00
abstract::Studies of the performance of individuals with dyslexia in perceptual tasks suggest that their implicit inference of sound statistics is impaired. Previously, using two-tone frequency discrimination, we found that the effect of previous trials' frequencies on the judgments of individuals with dyslexia decays faster th...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30018
更新日期:2018-02-28 00:00:00
abstract::Some anaerobic bacteria use insoluble minerals as terminal electron acceptors and discovering the ways in which electrons move through the membrane barrier to the exterior acceptor forms an active field of research with implications for both bacterial physiology and bioenergy. A previous study suggested that Shewanell...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.48054
更新日期:2019-06-24 00:00:00
abstract::Hawaiian isolates of the nematode species Caenorhabditis elegans have long been known to harbor genetic diversity greater than the rest of the worldwide population, but this observation was supported by only a small number of wild strains. To better characterize the niche and genetic diversity of Hawaiian C. elegans a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50465
更新日期:2019-12-03 00:00:00
abstract::Faithful chromosome segregation in all eukaryotes relies on centromeres, the chromosomal sites that recruit kinetochore proteins and mediate spindle attachment during cell division. The centromeric histone H3 variant, CenH3, is the defining chromatin component of centromeres in most eukaryotes, including animals, fung...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03676
更新日期:2014-09-23 00:00:00
abstract::Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers. Technical advances in cryo-electron microscopy brought a slew of full-length structu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40548
更新日期:2018-12-06 00:00:00
abstract::In humans, large conductance voltage- and calcium-dependent potassium (BK) channels are regulated allosterically by transmembrane voltage and intracellular Ca2+. Divalent cation binding sites reside within the gating ring formed by two Regulator of Conductance of Potassium (RCK) domains per subunit. Using patch-clamp ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40664
更新日期:2018-12-11 00:00:00
abstract::The IFNλ family of interferons controls the spread of viruses in the upper respiratory tract and transmission between mice. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.37552
更新日期:2018-05-24 00:00:00
abstract::We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell growth, and androgen sensitivity. We have now uncovered that the AR directly interacts with CHK2 and ionizing radiation (IR) increases this int...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51378
更新日期:2020-06-24 00:00:00
abstract::While specific mutations allow organisms to adapt to stressful environments, most changes in an organism's DNA negatively impact fitness. The mutation rate is therefore strictly regulated and often considered a slowly-evolving parameter. In contrast, we demonstrate an unexpected flexibility in cellular mutation rates ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22939
更新日期:2017-05-02 00:00:00
abstract::The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen using the C. elegans...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39756
更新日期:2018-11-21 00:00:00
abstract::A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured axons. DLK/Wnd is ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14048
更新日期:2016-06-07 00:00:00
abstract::Cardiac conduction defects decrease life expectancy in myotonic dystrophy type 1 (DM1), a CTG repeat disorder involving misbalance between two RNA binding factors, MBNL1 and CELF1. However, how DM1 condition translates into conduction disorders remains poorly understood. Here we simulated MBNL1 and CELF1 misbalance in...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51114
更新日期:2019-12-12 00:00:00
abstract::Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic development in humans. We use high-resolution X-ray crystallography and computational methods to delineate the mechanism of the homotrimeric RND-type proton/drug a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03145
更新日期:2014-09-19 00:00:00
abstract::Animals host multi-species microbial communities (microbiomes) whose properties may result from inter-species interactions; however, current understanding of host-microbiome interactions derives mostly from studies in which elucidation of microbe-microbe interactions is difficult. In exploring how Drosophila melanogas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18855
更新日期:2017-01-09 00:00:00
abstract::The incubation period for typhoid, polio, measles, leukemia and many other diseases follows a right-skewed, approximately lognormal distribution. Although this pattern was discovered more than sixty years ago, it remains an open question to explain its ubiquity. Here, we propose an explanation based on evolutionary dy...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30212
更新日期:2017-12-21 00:00:00
abstract::Human pluripotent stem cell (hPSC)-derived neural organoids display unprecedented emergent properties. Yet in contrast to the singular neuroepithelial tube from which the entire central nervous system (CNS) develops in vivo, current organoid protocols yield tissues with multiple neuroepithelial units, a.k.a. neural ro...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37549
更新日期:2018-10-29 00:00:00
abstract::Two-component systems (TCS) are protein machineries that enable cells to respond to input signals. Histidine kinases (HK) are the sensory component, transferring information toward downstream response regulators (RR). HKs transfer phosphoryl groups to their specific RRs, but also dephosphorylate them, overall ensuring...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21422
更新日期:2016-12-12 00:00:00
abstract::Prion diseases are caused by PrPSc, a self-replicating pathologically misfolded protein that exerts toxicity predominantly in the brain. The administration of PrPSc causes a robust, reproducible and specific disease manifestation. Here, we have applied a combination of translating ribosome affinity purification and ri...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62911
更新日期:2020-09-22 00:00:00
abstract::SUMO1-conjugation of proteins at neuronal synapses is considered to be a major post-translational regulatory process in nerve cell and synapse function, but the published evidence for SUMO1-conjugation at synapses is contradictory. We employed multiple genetic mouse models for stringently controlled biochemical and im...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26338
更新日期:2017-06-09 00:00:00
abstract::Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown. We have generated a murine model with conditional deletion of WT1 in the lateral plate mesoderm, using the G2 enhancer of the Gata4 gene as a driver. 80% of G2-Gata4(Cre);...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.16009
更新日期:2016-09-19 00:00:00