Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells.

abstract：:Across phyla, the ribosomes-the central molecular machines for translation of genetic information-exhibit an overall preserved architecture and a conserved functional core. The natural heterogeneity of the ribosome periodically phases a debate on their functional specialization and the tissue-specific variations of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amirbeigiarab S,Kiani P,Velazquez Sanchez A,Krisp C,Kazantsev A,Fester L,Schlüter H,Ignatova Z

更新日期：2019-11-05 00:00:00

abstract：:Throughout time, operational laws and concepts from complex systems have been employed to quantitatively model important aspects and interactions in nature and society. Nevertheless, it remains enigmatic and challenging, yet inspiring, to predict the actual interdependencies that comprise the structure of such systems...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stavroglou SK,Pantelous AA,Stanley HE,Zuev KM

更新日期：2020-04-07 00:00:00

abstract：:Microtubules (MTs) are hollow cytoskeletal filaments assembled from αβ-tubulin heterodimers. Tau, an unstructured protein found in neuronal axons, binds to MTs and regulates their dynamics. Aberrant Tau behavior is associated with neurodegenerative dementias, including Alzheimer's. Here, we report on a direct force me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung PJ,Choi MC,Miller HP,Feinstein HE,Raviv U,Li Y,Wilson L,Feinstein SC,Safinya CR

更新日期：2015-11-24 00:00:00

abstract：:Ethylenediaminetetraacetate and other divalent-cation-complexing agents greatly stimulate the cellular binding of DNA molecules to competent pneumococci, while the appearance of genetic transformants and nuclease-resistant DNA binding are completely inhibited. Based on this finding, we developed an experimental system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seto H,Tomasz A

更新日期：1974-04-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) causes growth arrest in most cell types. TGF-beta induces hypophosphorylation of retinoblastoma susceptibility gene 1 product (RB), which sequesters E2F factors needed for progression into S phase of the cell cycle, thereby leading to cell cycle arrest at G1. It is possible, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li JM,Hu PP,Shen X,Yu Y,Wang XF

更新日期：1997-05-13 00:00:00

abstract：:Recent observations suggest that p53 mutations are responsible not only for growth of primary tumors but also for their dissemination. However, mechanisms involved in p53-mediated control of cell motility and invasion remain poorly understood. By using the primary ovarian surface epithelium cell culture, we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CI,Matoso A,Corney DC,Flesken-Nikitin A,Körner S,Wang W,Boccaccio C,Thorgeirsson SS,Comoglio PM,Hermeking H,Nikitin AY

更新日期：2011-08-23 00:00:00

abstract：:Protein aggregation plays a critical role in the pathogenesis of neurodegenerative diseases, and the mechanism of its progression is poorly understood. Here, we examine the structural and dynamic characteristics of transiently evolving protein aggregates under ambient conditions by directly probing protein surface wat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pavlova A,Cheng CY,Kinnebrew M,Lew J,Dahlquist FW,Han S

更新日期：2016-01-12 00:00:00

abstract：:Rhomboid domain-containing protein 3 (Rhbdd3), which belongs to a family of proteins with rhomboid domain, is widely expressed in immune cells; however, the roles of the Rhbdd members, including Rhbdd3, in immunity remain unknown. Natural killer (NK) cells are critical for host immune defense and also can mediate infl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Liu S,Xia M,Xu S,Wang C,Bao Y,Jiang M,Wu Y,Xu T,Cao X

更新日期：2013-05-07 00:00:00

abstract：:A method is described for the production of hybridoma cell lines secreting antibodies directed against the polyoma virus tumor antigens (T-Ags). Ten cloned lines have been established by this procedure and designated alpha Py Cl and C4, with activities against all three T-Ags; alpha Py LT1, -4 and -7, with activities ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dilworth SM,Griffin BE

更新日期：1982-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-regulated gene expression is stimulated independently by the cellular trans-activator NF-kappa B and the viral protein Tat. Noncytotoxic concentrations of the drug pentoxifylline (PTX) inhibited interaction of NF-kappa B with its motif and the stim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biswas DK,Ahlers CM,Dezube BJ,Pardee AB

更新日期：1993-12-01 00:00:00

abstract：:The neuronal nucleus plays a vital role in information processing, but whether it supports computational functions such as paired-pulse facilitation, comparable to synapses, is unclear. Ca(2+)-dependent movement of calmodulin (CaM) to the nucleus is highly responsive to Ca(2+) entry through L-type channels and promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mermelstein PG,Deisseroth K,Dasgupta N,Isaksen AL,Tsien RW

更新日期：2001-12-18 00:00:00

abstract：:The canonical function of the human telomerase protein (hTERT) is to synthesize telomeric DNA, but it has other biological activities, including enhancing cell proliferation, decreasing apoptosis, regulating DNA damage responses, and increasing cellular proliferative lifespan. The mechanistic relationships among these...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukherjee S,Firpo EJ,Wang Y,Roberts JM

更新日期：2011-12-13 00:00:00

abstract：:Previous studies have failed to detect an interaction between monomeric soluble CD4 (sCD4) and class II major histocompatibility complex (MHC) proteins, suggesting that oligomerization of CD4 on the cell surface may be required to form a stable class II MHC binding site. To test this possibility, we transfected the F4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakihama T,Smolyar A,Reinherz EL

更新日期：1995-07-03 00:00:00

abstract：:The interplay of human actions and natural processes over varied spatial and temporal scales can result in abrupt transitions between contrasting land surface states. Understanding these transitions is a key goal of sustainability science because they can represent abrupt losses of natural capital. This paper recogniz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Streeter R,Dugmore AJ

更新日期：2013-04-09 00:00:00

abstract：:The interaction of the NH2-terminal DNA-binding domain of lac repressor with synthetic oligo[d(AT)] was studied by a photo-CIDNP technique (CIDNP is chemically induced dynamic nuclear polarization). Three of the four tyrosines of the NH2-terminal region were found to be accessible to the photosensitive dye. The corres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buck F,Rüterjans H,Kaptein R,Beyreuther K

更新日期：1980-09-01 00:00:00

abstract：:It is becoming common practice to partition glass-forming liquids into two classes based on the dependence of the shear viscosity η on temperature T. In an Arrhenius plot, ln η vs 1/T, a strong liquid shows linear behavior whereas a fragile liquid exhibits an upward curvature [super-Arrhenius (SA) behavior], a situati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallamace F,Branca C,Corsaro C,Leone N,Spooren J,Chen SH,Stanley HE

更新日期：2010-12-28 00:00:00

abstract：:Recently, we described a recurrent variant translocation, t(11;17)(q23;q21), in acute promyelocytic leukemia (APL) which juxtaposes PLZF, a gene encoding a zinc finger protein, to RARA, encoding retinoic acid receptor alpha (RAR alpha). We have now cloned cDNAs encoding PLZF-RAR alpha chimeric proteins and studied the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Guidez F,Rousselot P,Agadir A,Chen SJ,Wang ZY,Degos L,Zelent A,Waxman S,Chomienne C

更新日期：1994-02-01 00:00:00

abstract：:The eukaryote endomembrane system contains a class of H(+)-pumping ATPase (H(+)-ATPases) of the vacuolar type (V-ATPases) that are responsible for the acidification of organelles. Their action is critical to numerous physiological processes, but the regulatory mechanisms that may control activity are not yet fully und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davies JM,Hunt I,Sanders D

更新日期：1994-08-30 00:00:00

abstract：:A translocation involving human chromosome 10, band q24, in a subset of T-cell acute leukemias disrupts a region surrounding the putative oncogene HOX11, which encodes a protein with a homeodomain. The HOX11 protein binds to a specific DNA sequence, it localizes to the cell nucleus, and it transactivates transcription...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dear TN,Sanchez-Garcia I,Rabbitts TH

更新日期：1993-05-15 00:00:00

abstract：:IFN-gamma is well known as the signature cytokine of CD4+ T helper 1, CD8+, and natural killer cells, but recent studies demonstrate that antigen-presenting cells, in particular dendritic cells (DCs), are another potent source for this proinflammatory cytokine. T-bet, a transcription factor that controls IFN-gamma exp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lugo-Villarino G,Maldonado-Lopez R,Possemato R,Penaranda C,Glimcher LH

更新日期：2003-06-24 00:00:00

abstract：:The self-assembled heterocapsule 1.2, which is formed by the hydrogen bonds of tetra(4-pyridyl)-cavitand 1 and tetrakis(4-hydroxyphenyl)-cavitand 2, encapsulates 1 molecule of guests such as 1,4-diacetoxybenzene 3a, 1,4-diacetoxy-2,5-dimethylbenzene 3b, 1,4-diacetoxy-2,5-dialkoxybenzenes (3c, OCH(3); 3d, OC(2)H(5); 3e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitagawa H,Kobori Y,Yamanaka M,Yoza K,Kobayashi K

更新日期：2009-06-30 00:00:00

abstract：:We introduce a polynomial C(mu)[Z; q, t], depending on a set of variables Z = z(1), z(2),..., a partition mu, and two extra parameters q, t. The definition of C(mu) involves a pair of statistics (maj(sigma, mu), inv(sigma, mu)) on words sigma of positive integers, and the coefficients of the z(i) are manifestly in N[q...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haglund J

更新日期：2004-11-16 00:00:00

abstract：:The ten-eleven translocation (TET) family of methylcytosine dioxygenases initiates demethylation of DNA and is associated with tumorigenesis in many cancers; however, the mechanism is mostly unknown. Here we identify upstream activators and downstream effectors of TET1 in breast cancer using human breast cancer cells ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun M,Song CX,Huang H,Frankenberger CA,Sankarasharma D,Gomes S,Chen P,Chen J,Chada KK,He C,Rosner MR

更新日期：2013-06-11 00:00:00

abstract：:The results of physicochemical studies of mammalian metallothioneins are summarized and used to propose a model of the protein. The primary structures of all mammalian metallothioneins are very homologous; there are 38 invariant residues and 20 of them are cysteines. The results of UV and CD optical studies indicated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boulanger Y,Goodman CM,Forte CP,Fesik SW,Armitage IM

更新日期：1983-03-01 00:00:00

abstract：:DNA sequences in Neurospora crassa that code for ribosomal RNA have been isolated in a highly purified state by DNA-RNA hybridization. About 100 separate ribosomal RNA genes exist in each nucleus. These genes are composed of repeated sequences that are present about 100 times per nucleus. The individual members of thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chattopadhyay SK,Kohne DE,Dutta SK

更新日期：1972-11-01 00:00:00

abstract：:For decades, scientists have debated whether supercooled liquids stop flowing below a glass transition temperature [Formula: see text] or whether motion continues to slow gradually down to zero temperature. Answering this question is challenging because human time scales set a limit on the largest measurable viscosity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jadhao V,Robbins MO

更新日期：2017-07-25 00:00:00

abstract：:Several authors have considered Markov processes defined by the motion of a particle on a fixed line with a random velocity(1, 6, 8, 10) or a random diffusivity.(5, 12) A "random evolution" is a natural but apparently new generalization of this notion. In this note we hope to show that this concept leads to simple and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griego RJ,Hersh R

更新日期：1969-02-01 00:00:00

abstract：:We describe a procedure for predicting the tertiary folds of alpha-helical proteins from their primary sequences. The central component of the procedure is a method for predicting interhelical contacts that is based on a helix-packing model. Instead of predicting the individual contacts, our method attempts to identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Hou J,Kim SH

更新日期：2002-03-19 00:00:00

abstract：:The ability to identify sequences in a randomly encoded polypeptide library that are capable of acquiring unique and stably folded structures would be valuable in the examination of protein-folding issues. The quality control system of the yeast secretory pathway prevents the release of incompletely folded polypeptide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagihara Y,Kim PS

更新日期：2002-05-14 00:00:00

abstract：:Neurons in the cochlear nuclei of duck embryos become responsive to tonal stimuli in an orderly spatial and temporal sequence. Cells responding to lower frequencies are recorded before those responding to higher frequencies. Auditory neurons are spatially arranged according to their characteristic frequencies, indicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Konishi M

更新日期：1973-06-01 00:00:00