Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer.

abstract：:Low-dimensional semiconductor structurers formed on a substrate surface at pre-defined locations and with nano-precision placement is of vital interest. The potential of tailoring their electrical and optical properties will revolutionize the next generation of optoelectronic devices. Traditionally, highly aligned sel...

journal_title：Scientific reports

authors： Dushaq G,Rasras M

更新日期：2019-10-02 00:00:00

abstract：:This anatomical study sought to investigate the morphological characteristics and biomechanical properties of the oblique popliteal ligament (OPL). Embalmed cadaveric knees were used for the study. The OPL and its surrounding structures were dissected; its morphology was carefully observed, analyzed and measured; its ...

journal_title：Scientific reports

authors： Wu XD,Yu JH,Zou T,Wang W,LaPrade RF,Huang W,Sun SQ

更新日期：2017-02-16 00:00:00

abstract：:Silicon nanocrystals offer huge advantages compared to other semi-conductor quantum dots as they are made from an abundant, non-toxic material and are compatible with silicon devices. Besides, among a wealth of extraordinary properties ranging from catalysis to nanomedicine, metal nanoparticles are known to increase t...

journal_title：Scientific reports

authors： Goffard J,Gérard D,Miska P,Baudrion AL,Deturche R,Plain J

更新日期：2013-01-01 00:00:00

abstract：:Mammalian parental genomes contribute differently to early embryonic development. Before activation of the zygotic genome, the maternal genome provides all transcripts and proteins required for the transition from a highly specialized oocyte to a pluripotent embryo. Depletion of these maternally-encoded transcripts fr...

journal_title：Scientific reports

authors： Mahadevan S,Sathappan V,Utama B,Lorenzo I,Kaskar K,Van den Veyver IB

更新日期：2017-03-20 00:00:00

abstract：:Anatase TiO2 nanoparticles with exposed {001} facets were synthesized from Ti powder via a sequential hydrothermal reaction process. At the first-step hydrothermal reaction, H-titanate nanowires were obtained in NaOH solution with Ti powder, and at second-step hydrothermal reaction, anatase TiO2 nanoparticles with exp...

journal_title：Scientific reports

authors： Chu L,Qin Z,Yang J,Li X

更新日期：2015-07-20 00:00:00

abstract：:Responses of ecosystems to human-induced stress vary in space and time, because both stressors and ecosystem vulnerabilities vary in space and time. Presently, ecosystem impact assessments mainly take into account variation in stressors, without considering variation in ecosystem vulnerability. We developed a method t...

journal_title：Scientific reports

authors： Zijp MC,Huijbregts MAJ,Schipper AM,Mulder C,Posthuma L

更新日期：2017-08-24 00:00:00

abstract：:Quartz is a common phase in high-silica igneous rocks and is resistant to post-eruptive alteration, thus offering a reliable record of magmatic processes in silicic magma systems. Here we employ the 75 ka Toba super-eruption as a case study to show that quartz can resolve late-stage temporal changes in magmatic δ18O v...

journal_title：Scientific reports

authors： Budd DA,Troll VR,Deegan FM,Jolis EM,Smith VC,Whitehouse MJ,Harris C,Freda C,Hilton DR,Halldórsson SA,Bindeman IN

更新日期：2017-01-25 00:00:00

abstract：:Glaucoma is a leading cause of irreversible vision loss predicted to affect more than 100 million people by 2040. Intraocular pressure (IOP) reduction prevents development of glaucoma and vision loss from glaucoma. Glaucoma surgeries reduce IOP by facilitating aqueous humor outflow through a vent fashioned from the wa...

journal_title：Scientific reports

authors： Parikh KS,Josyula A,Omiadze R,Ahn JY,Ha Y,Ensign LM,Hanes J,Pitha I

更新日期：2020-07-31 00:00:00

abstract：:Mt. Spurr is the largest active volcano in Alaska of high explosive potential. The most recent activity, including two recent magmatic eruptions in 1953 and 1992, has occurred via the flanking Crater Peak. From 2004 to 2006, strong seismicity, gas flux, and heating were observed in the summit area, which had remained ...

journal_title：Scientific reports

authors： Koulakov I,Smirnov SZ,Gladkov V,Kasatkina E,West M,El Khrepy S,Al-Arifi N

更新日期：2018-11-30 00:00:00

abstract：:As the magnetic storage density increases in commercial products, e.g. the hard disc drives, a full understanding of dynamic magnetism in nanometer resolution underpins the development of next-generation products. Magnetic force microscopy (MFM) is well suited to exploring ferromagnetic domain structures. However, ato...

journal_title：Scientific reports

authors： Li Z,Li X,Dong D,Liu D,Saito H,Ishio S

更新日期：2014-07-11 00:00:00

abstract：:An enormous amount of tumor sequencing data has been generated through large scale sequencing efforts. The functional consequences of the majority of mutations identified by such projects remain an open, unexplored question. This problem is particularly complicated in the case of rare mutations where frequency of occu...

journal_title：Scientific reports

authors： Katigbak A,Cencic R,Robert F,Sénécha P,Scuoppo C,Pelletier J

更新日期：2016-12-16 00:00:00

abstract：:The presenilin 1 (PSEN1) L271V mutation causes early-onset familial Alzheimer's disease by disrupting the alternative splicing of the PSEN1 gene, producing some transcripts harboring the L271V point mutation and other transcripts lacking exon 8 (PS1(∆exon8)). We previously reported that PS1 L271V increased amyloid bet...

journal_title：Scientific reports

authors： Brautigam H,Moreno CL,Steele JW,Bogush A,Dickstein DL,Kwok JB,Schofield PR,Thinakaran G,Mathews PM,Hof PR,Gandy S,Ehrlich ME

更新日期：2015-11-26 00:00:00

abstract：:Vitamin D and parathyroid hormone (PTH) regulate mineral metabolism and are required to maintain calcium levels. Vitamin D deficiency is common, particularly during pregnancy, and has been associated with hypertensive disorders of pregnancy. We sought to determine whether maternal 25(OH)D, PTH and calcium concentratio...

journal_title：Scientific reports

authors： Santorelli G,Whitelaw D,Farrar D,West J,Lawlor DA

更新日期：2019-02-04 00:00:00

abstract：:There has been much interest in understanding collective dynamics in networks of brain regions due to their role in behavior and cognitive function. Here we show that a simple, homogeneous system of densely connected oscillators, representing the aggregate activity of local brain regions, can exhibit a rich variety of...

journal_title：Scientific reports

authors： Singh R,Menon SN,Sinha S

更新日期：2016-02-26 00:00:00

abstract：:Evaluation of the effect of different parameters for designing a non-viral vector in gene delivery systems has great importance. In this manner, 2D crystals, precisely layered double hydroxides, have attracted the attention of scientists due to their significant adjustability and low-toxicity and low-cost preparation ...

journal_title：Scientific reports

authors： Rabiee N,Bagherzadeh M,Ghadiri AM,Salehi G,Fatahi Y,Dinarvand R

更新日期：2020-11-26 00:00:00

abstract：:Fresh produce vegetables are colonized by different bacterial species, some of which are antagonistic to microbes that cause postharvest losses. However, no comprehensive assessment of the diversity and composition of bacteria inhabiting surfaces of fresh pepper plants grown under different conditions has been conduct...

journal_title：Scientific reports

authors： Mamphogoro TP,Maboko MM,Babalola OO,Aiyegoro OA

更新日期：2020-05-22 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Cabrera-Cruz SA,Smolinsky JA,Buler JJ

更新日期：2018-03-14 00:00:00

abstract：:Transient hepatic steatosis upon liver resection supposes functional relationships between lipid metabolism and liver regeneration. Repin1 has been suggested as candidate gene for obesity and dyslipidemia by regulating key genes of lipid metabolism and lipid storage. Herein, we characterized the regenerative potential...

journal_title：Scientific reports

authors： Abshagen K,Degenhardt B,Liebig M,Wendt A,Genz B,Schaeper U,Stumvoll M,Hofmann U,Frank M,Vollmar B,Klöting N

更新日期：2018-11-15 00:00:00

abstract：:Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Sp...

journal_title：Scientific reports

authors： Ledet MM,Harman RM,Fan JC,Schmitt-Matzen E,Diaz-Rubio ME,Zhang S,Van de Walle GR

更新日期：2020-11-25 00:00:00

abstract：:Antibody phage display has been pivotal in the quest to generate human monoclonal antibodies for biomedical and research applications. Target antigen preparation is a main bottleneck associated with the panning process. This includes production complexity, downstream purification, quality and yield. In many instances,...

journal_title：Scientific reports

authors： Lim CC,Woo PCY,Lim TS

更新日期：2019-04-15 00:00:00

abstract：:A facile one-pot two-stage photochemical synthesis of aromatic azoxy compounds and imines has been developed by coupling the selective reduction of nitroaromatic compounds with the selective oxidation of amines in an aqueous solution. In the first stage (light illumination, Ar atmosphere), the light excited nitroaroma...

journal_title：Scientific reports

authors： Tan H,Liu X,Su J,Wang Y,Gu X,Yang D,Waclawik ER,Zhu H,Zheng Z

更新日期：2019-02-04 00:00:00

abstract：:A number of studies have shown that visible and near infrared spectroscopy (VIS-NIRS) offers a rapid on-site measurement tool for the determination of total contaminant concentration of petroleum hydrocarbons compounds (PHC), heavy metals and metalloids (HM) in soil. However none of them have yet assessed the feasibil...

journal_title：Scientific reports

authors： Cipullo S,Nawar S,Mouazen AM,Campo-Moreno P,Coulon F

更新日期：2019-03-14 00:00:00

abstract：:Microbial secondary metabolites are valuable resources for novel drug discovery. In particular, actinomycetes expressed a range of antibiotics against a spectrum of bacteria. In genus level, strain Allosalinactinospora lopnorensis CA15-2(T) is the first new actinomycete isolated from the Lop Nor region, China. Antimic...

journal_title：Scientific reports

authors： Huang C,Leung RK,Guo M,Tuo L,Guo L,Yew WW,Lou I,Lee SMY,Sun C

更新日期：2016-02-11 00:00:00

abstract：:An increasing number of industrial applications need superstrength steels. It is known that refined grains and nanoscale precipitates can increase strength. The hardest martensitic steel reported to date is C0.8 steel, whose nanohardness can reach 11.9 GPa through incremental interstitial solid solution strengthening....

journal_title：Scientific reports

authors： Yu H,Yan M,Lu C,Tieu AK,Li H,Zhu Q,Godbole A,Li J,Su L,Kong C

更新日期：2016-11-28 00:00:00

abstract：:In a standard semiconductor laser, electrons and holes recombine via stimulated emission to emit coherent light, in a process that is far from thermal equilibrium. Exciton-polariton condensates-sharing the same basic device structure as a semiconductor laser, consisting of quantum wells coupled to a microcavity-have b...

journal_title：Scientific reports

authors： Horikiri T,Yamaguchi M,Kamide K,Matsuo Y,Byrnes T,Ishida N,Löffler A,Höfling S,Shikano Y,Ogawa T,Forchel A,Yamamoto Y

更新日期：2016-05-19 00:00:00

abstract：:Histone methylation is thought to control the regulation of genetic program and the dysregulation of it has been found to be closely associated with cancer. JMJD3 has been identified as an H3K27 demethylase and its role in cancer development is context specific. The role of JMJD3 in gastric cancer (GC) has not been ex...

journal_title：Scientific reports

authors： Xu Z,Xia Y,Xiao Z,Jia Y,Li L,Jin Y,Zhao Q,Wan L,Yi T,Yu Y,Wen Q,Zhu Y,Qin B,Zhang F,Shen J

更新日期：2019-01-29 00:00:00

abstract：:Combined neutron scattering and diffusion nuclear magnetic resonance experiments have been used to reveal significant interregional asymmetries (lateralization) in bovine brain hemispheres in terms of myelin arrangement and water dynamics at micron to atomic scales. Thicker myelin sheaths were found in the left hemisp...

journal_title：Scientific reports

authors： Natali F,Dolce C,Peters J,Stelletta C,Demé B,Ollivier J,Leduc G,Cupane A,Barbier EL

更新日期：2019-10-11 00:00:00

abstract：:The gene separation anxiety (san) encodes Naa50/San, a N-terminal acetyltransferase required for chromosome segregation during mitosis. Although highly conserved among higher eukaryotes, the mitotic function of this enzyme is still poorly understood. Naa50/San was originally proposed to be required for centromeric sis...

journal_title：Scientific reports

authors： Ribeiro AL,Silva RD,Foyn H,Tiago MN,Rathore OS,Arnesen T,Martinho RG

更新日期：2016-12-20 00:00:00

abstract：:Change in body composition with skeletal muscle wasting, a major component of pulmonary cachexia, is associated with mortality in chronic obstructive pulmonary disease and cancer. However, its relevance in interstitial lung diseases (ILDs) remains unclear. We hypothesized changes in body composition would be associate...

journal_title：Scientific reports

authors： Suzuki Y,Yoshimura K,Enomoto Y,Yasui H,Hozumi H,Karayama M,Furuhashi K,Enomoto N,Fujisawa T,Nakamura Y,Inui N,Suda T

更新日期：2018-09-19 00:00:00

abstract：:PC4, a well-known general transcription cofactor, has multiple functions in transcription and DNA repair. Residue W89, is engaged in stacking interactions with DNA in PC4, but substituted by tyrosine in some PC4 orthologous proteins. In order to understand the consequences and reveal the molecular details of this subs...

journal_title：Scientific reports

authors： Huang J,Zhao Y,Liu H,Huang D,Cheng X,Zhao W,Taylor IA,Liu J,Peng YL

更新日期：2015-03-05 00:00:00