Abstract:
:Silk suture material is primarily composed of silk fibroin and regarded as a non-resorbable material. It is slowly degraded by proteolysis when it is implanted into the body. 4-Hexylresorcinol (4HR) is a well-known antiseptic. In this study, the biodegradability of 4HR-incorporated silk sutures were compared to that of untreated silk sutures and polyglactin 910 sutures, a commercially available resorbable suture. 4HR-incorporated silk sutures exhibited anti-microbial properties. Matrix metalloproteinase (MMP) can digest a wide spectrum of proteins. 4HR increased MMP-2, -3, and -9 expression in RAW264.7 cells. MMP-2, -3, and -9 were able to digest not only silk fibroin but also silk sutures. Consequently, 59.5% of the 4HR-incorporated silk suture material remained at 11 weeks after grafting, which was similar to that of polyglactin 910 degradation (56.4% remained). The residual amount of bare silk suture material at 11 weeks after grafting was 91.5%. The expression levels of MMP-2, -3 and -9 were high in the 4HR-incorporated silk suture-implanted site 12 weeks after implantation. In conclusion, 4HR-treated silk sutures exhibited anti-microbial properties and a similar level of bio-degradation to polyglactin 910 sutures and induced higher expression of MMP-2, -3, and -9 in macrophages.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jo YY,Kweon H,Kim DW,Kim MK,Kim SG,Kim JY,Chae WS,Hong SP,Park YH,Lee SY,Choi JYdoi
10.1038/srep42441subject
Has Abstractpub_date
2017-02-13 00:00:00pages
42441issn
2045-2322pii
srep42441journal_volume
7pub_type
杂志文章abstract::Circadian clocks keep time via ~ 24 h transcriptional feedback loops. In Drosophila, CLOCK-CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback loop components whose transcriptional status varies over a circadian cycle. Although changes in the state of activators and repressors has been cha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75009-5
更新日期:2020-10-21 00:00:00
abstract::The possibility of producing transgenic cloned buffalos by nuclear transfer of fetal fibroblasts expressing enhanced green fluorescent protein (EGFP) was explored in this study. When buffalo fetal fibroblasts (BFFs) isolated from a male buffalo fetus were transfected with pEGFP-N1 (EGFP is driven by CMV and Neo is dri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25120-5
更新日期:2018-05-03 00:00:00
abstract::Experimental evidence has shown that some of the human endogenous hormones significantly affect drug efficacy. Since hormone status varies with individual physiological states, it is essential to understand the interplay of hormones and drugs for precision medicine. Here, we developed an in silico method to predict in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16855-8
更新日期:2017-11-30 00:00:00
abstract::Controlled ovarian stimulation by exogenous gonadotrophins is a key procedure during the in vitro fertilization cycle to obtain a sufficient number of oocytes in humans. Previous studies demonstrated that repeated superovulation had deleterious effects on the ovaries. However, whether repeated superovulation adversely...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31368
更新日期:2016-10-04 00:00:00
abstract::Congenital glaucoma (CG) is a heterogeneous, inherited and severe optical neuropathy that originates from maldevelopment of the anterior segment of the eye. To identify new disease genes, we performed whole-exome sequencing of 26 unrelated CG patients. In one patient we identified two rare, recessive and hypermorphic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46175
更新日期:2017-04-11 00:00:00
abstract::Animal models are indispensible to investigate the pathogenesis and treatments of non-alcoholic fatty liver diseases (NAFLD). Altered cholesterol metabolism has been implicated into the pathogenesis of NAFLD. Here, using high fat, cholesterol and cholate diet (HFHC), we generated a novel tree shrew (Tupaia belangeri c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15970
更新日期:2015-11-02 00:00:00
abstract::To improve estimates of the long-term response of the marine carbon system to climate change a better understanding of the seasonal and interannual variability is needed. We use high-frequency multi-year data at three locations identified as climate change hotspots: two sites located close to South Pacific boundary cu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44109-2
更新日期:2019-05-20 00:00:00
abstract::The Sigma-1 receptor (S1R) is known to play a protective role in the central nervous system including the retina. A major barrier for understanding the underlying mechanism is an ambiguity of S1R subcellular localizations. We thus conducted the first electron microscopy (EM) study of S1R subcellular distribution in th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10689
更新日期:2015-06-02 00:00:00
abstract::In this paper, we present the first realization of an elastic metamaterial allowing independent tuning of negative density and stiffness for elastic waves propagating along a designated direction. In electromagnetic (or acoustic) metamaterials, it is now possible to tune permittivity (bulk modulus) and permeability (d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23630
更新日期:2016-03-23 00:00:00
abstract::Emergence of multiple drug resistant strains of pathogenic bacteria calls for new initiatives to combat infectious diseases. Gold nanoparticles (AuNPs), because of their non-toxic nature and size/shape dependent optical properties, offer interesting possibility. Here we report the antibacterial efficacy of AuNPs of di...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09357-0
更新日期:2017-08-29 00:00:00
abstract::The benefits that physical exercise confers on cardiovascular health are well known, whereas the notion that physical exercise can also improve cognitive performance has only recently begun to be explored and has thus far yielded only controversial results. In the present study, we used a sample of young male subjects...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25440
更新日期:2016-05-05 00:00:00
abstract::Nowadays, various collaborations are creating immense machines to try to track and understand the origin of high-energy cosmic particles (e.g., IceCube, ANTARES, Baikal-GVD, P-ONE). The detection mechanism of these sophisticated experiments relies mainly on an optical signal generated by the passage of charged particl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68954-8
更新日期:2020-07-24 00:00:00
abstract::Tracking animal behavior by video is one of the most common tasks in the life sciences. Although commercial software exists for executing this task, they often present enormous cost to the researcher and can entail purchasing hardware that is expensive and lacks adaptability. Additionally, the underlying code is often...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56408-9
更新日期:2019-12-27 00:00:00
abstract::Dynamic Nuclear Polarization (DNP) has been introduced to overcome the sensitivity limitations of nuclear magnetic resonance (NMR) spectroscopy also of supported lipid bilayers. When investigated by solid-state NMR techniques the approach typically involves doping the samples with biradicals and their investigation at...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20895
更新日期:2016-02-15 00:00:00
abstract::Early admission to the neurosciences intensive care unit (NSICU) is associated with improved patient outcomes. Natural language processing offers new possibilities for mining free text in electronic health record data. We sought to develop a machine learning model using both tabular and free text data to identify pati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-80985-3
更新日期:2021-01-14 00:00:00
abstract::Ovarian tissue cryopreservation is considered as a useful option to preserve fertility for cancer patients. This study purposed to evaluate the change of telomere length and senescence markers during human ovarian tissue cryopreservation. Ovarian tissues were obtained from women who underwent benign ovarian surgery in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81973-3
更新日期:2021-01-26 00:00:00
abstract::This study presents a modular-based implementation of augmented reality to provide an immersive experience in learning or teaching the planning phase, control system, and machining parameters of a fully automated work cell. The architecture of the system consists of three code modules that can operate independently or...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27380
更新日期:2016-06-07 00:00:00
abstract::Most neuronal types have a well-identified electrical phenotype. It is now admitted that a same phenotype can be produced using multiple biophysical solutions defined by ion channel expression levels. This argues that systems-level approaches are necessary to understand electrical phenotype genesis and stability. Midb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31765-z
更新日期:2018-09-11 00:00:00
abstract::High-resolution spectroscopy in the 1-10 μm region has never been fully tackled for the lack of widely-tunable and practical light sources. Indeed, all solutions proposed thus far suffer from at least one of three issues: they are feasible only in a narrow spectral range; the power available for spectroscopy is limite...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12891-6
更新日期:2017-10-06 00:00:00
abstract::Anxiety-related bias in the recognition memory based on trait anxiety has induced some studies. Their results, however, were conflicting. In fact, anxious differences not only differed from personality traits but also from different anxiety mood levels. We explored the emotional memory bias in both trait and state anx...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34289-8
更新日期:2018-11-01 00:00:00
abstract::A major challenge in current exome sequencing in autosomal recessive (AR) families is the lack of an effective method to prioritize single-nucleotide variants (SNVs). AR families are generally too small for linkage analysis, and length of homozygous regions is unreliable for identification of causative variants. Vario...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12028
更新日期:2015-07-06 00:00:00
abstract::Sugarcane (Saccharum spp. hybrids) is a potential lignocellulosic feedstock for biofuel production due to its exceptional biomass accumulation ability, high convertible carbohydrate content and a favorable energy input/output ratio. Genetic modification of biofuel traits to improve biomass conversion requires an under...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30033-4
更新日期:2018-08-02 00:00:00
abstract::Advanced electron microscopy technologies have made it possible to perform precise double-slit interference experiments. We used a 1.2-MV field emission electron microscope providing coherent electron waves and a direct detection camera system enabling single-electron detections at a sub-second exposure time. We devel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19380-4
更新日期:2018-01-17 00:00:00
abstract::The combustion of candles exhibits a variety of dynamical behaviors. Binding several candles together will result in flickering of candle flames, which is generally described as a nonlinear oscillator. The impact on the frequency of the flame by several factors, such as the arrangement, the number and the asymmetry of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36754-w
更新日期:2019-01-23 00:00:00
abstract::Protein aggregation is a common biological phenomenon, observed in different physiological and pathological conditions. Decreased protein solubility and a tendency to aggregate is also observed during physiological aging but the causes are currently unknown. Herein we performed a biophysical separation of aging-relate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19311
更新日期:2016-01-18 00:00:00
abstract::In many cancers, the establishment of a patient's future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the 'pathological response' to a given therapy. However, histopathological assessment of pathological response remains subjective. Here we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36814
更新日期:2016-11-14 00:00:00
abstract::People mimic each other's actions and postures during everyday interactions. It is widely believed this mimicry acts as a social glue, leading to increased rapport. We present two studies using virtual reality to rigorously test this hypothesis. In Study 1, 50 participants interacted with two avatars who either mimick...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35295
更新日期:2016-10-14 00:00:00
abstract::Chicken anemia virus (CAV) is an important pathogen that causes severe immunosuppression in young chickens. We have characterized 13 CAVs isolated from different commercial farms in southern China between 2011 and 2012. We discovered 92 variable residues compared to 37 other CAV complete genome sequences from other pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03519
更新日期:2013-12-17 00:00:00
abstract::A significant advantage of a graphene biosensor is that it inherently represents a continuum of independent and aligned sensor-units. We demonstrate a nanoscale version of a micro-physiometer - a device that measures cellular metabolic activity from the local acidification rate. Graphene functions as a matrix of indep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06865
更新日期:2014-10-31 00:00:00
abstract::Restless Legs syndrome (RLS) is a common sleep disorder for which the genetic contribution remains poorly explained. In 2007, the first large scale genome wide association study (GWAS) identified three genomic regions associated with RLS. MEIS1, BTBD9 and MAP2K5/SKOR1 are the only known genes located within these loci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30665-6
更新日期:2018-08-15 00:00:00