Abstract：
:The objective of the study was to identify differences in treatment strategies for anti-NMDA receptor encephalitis based on specialty of treating physicians, geographic location, and years in practice. We conducted an anonymous worldwide electronic survey through the Practice Current section of Neurology® Clinical Practice to appraise differences in decisions about first- and second-line treatment and timing for initiation of second-line treatment for anti-NMDA receptor encephalitis. 399 participants answered all questions of the survey and were included in the analysis. 261 (65%) were adult neurologists, 86 (22%) were neurologists treating children, and 52 (13%) were pediatric rheumatologists. 179 (45%) responders practiced in the US. The majority agreed on the use of steroids and/or IVIg for first-line therapy and rituximab alone as second line. Differences in initial treatment regimen based on specialty included increased use of plasma exchange by adult neurologists (27%) and rituximab by pediatric rheumatologists (29%) (χ 2(4) = 27.43, p < 0.001). Trainees opted for plasma exchange (35%) and junior faculty picked rituximab (15%) more as part of first line (χ 2(4) = 13.37, p = 0.010). There was greater usage of anti-metabolites for second-line therapy outside of the US (15%) (χ 2(4) = 11.67, p = 0.020). US physicians also utilized second-line treatment earlier than their mostly European counterparts (14 vs. 23% used later than 2 weeks; χ 2(1) = 4.96, p = 0.026). Although treatment patterns were similar, differences observed across specialties and geographic locations may guide the development of consensus-driven guidelines by multi-disciplinary task forces. These guidelines may promote treatment trials of immunomodulators in autoimmune encephalitides.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Bartolini L,Muscal Edoi
10.1007/s00415-017-8407-1subject
Has Abstractpub_date
2017-04-01 00:00:00pages
647-653issue
4eissn
0340-5354issn
1432-1459pii
10.1007/s00415-017-8407-1journal_volume
264pub_type
杂志文章abstract：:Ischaemic stroke, the most common type of stroke, is classified into three main subtypes: large-vessel disease, lacunar or small-vessel disease, and cardioembolic; two further subtypes include a determined aetiology of "other" and cryptogenic. Although a substantial amount of literature exists concerning current guide...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-010-5667-4
更新日期：2010-11-01 00:00:00
abstract：:A 23-year-old woman had progressive right hemiparesis followed by spontaneous clinical remission. The clinical profile and multifocal contrast-enhancing CT lesions in the periventricular region of the cerebrum favored the diagnosis of an acute demyelinating process. Serial examinations showed resolution of CT abnormal...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313759
更新日期：1982-01-01 00:00:00
abstract：:Vertigo is frequently associated with migraine, and sometimes it is the cardinal symptom. This type of migraine is called "vestibular migraine", "migrainous vertigo", or "migraine-associated vertigo". Earlier findings on effective prophylactic medication for such migraine attacks and their clinical features are few an...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-0111-3
更新日期：2009-03-01 00:00:00
abstract：:Sera from 23 patients with acute Guillain Barré syndrome (GBS), 15 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and from 40 age-matched blood donors were analysed for antibodies to acidic glycosphingolipids from human brain and peripheral nerve. Antibodies to ganglioside LM1, the majo...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00315684
更新日期：1991-04-01 00:00:00
abstract：:Cluster headache (CH) is characterized by attacks of severe, strictly unilateral pain that is orbital, supraorbital, temporal, or any combination of these, lasts 15-180 min, and occurs from once every other day to eight times a day. The pain is associated with ipsilateral conjunctival injection, lacrimation, nasal con...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-018-9007-4
更新日期：2019-05-01 00:00:00
abstract：:Cobrotoxin-binding protein was isolated by affinity chromatography from human thymoma which had been surgically removed from patients with myasthenia gravis. The protein was composed of polypeptides with a molecular mass of 40, 51, 65, and 74 kilodaltons as determined by polyacrylamide gel electrophoresis in the prese...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00618251
更新日期：1987-05-01 00:00:00
abstract：:Cognitive deficits mainly involving visuospatial functions have been defined in patients with bilateral and even unilateral vestibular loss (UVL). We compared the cognitive test results of 21 patients with acute UVL with age- and education-matched healthy controls. The diagnosis of UVL was based on the clinical findin...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09829-w
更新日期：2020-12-01 00:00:00
abstract：:Recent studies have shown that cerebrospinal fluid (CSF) levels of α-synuclein (α-syn) are highly elevated in patients with Creutzfeldt-Jakob disease (CJD) compared to controls. However, the diagnostic value of CSF α-syn in CJD has not been established. To confirm whether CSF α-syn is increased in CJD and is a useful ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7334-7
更新日期：2014-06-01 00:00:00
abstract：CONTEXT:Polyneuropathy is a common disease and is more prevalent (at least 3 %) in elderly people. However, routine neurological examination of healthy elderly people may show distal sensory loss and absent tendon reflexes, which can obscure the distinction from polyneuropathy. OBJECTIVE:To investigate the relation be...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析
doi：10.1007/s00415-005-0064-0
更新日期：2006-05-01 00:00:00
abstract：:Acid maltase deficiency is described in non-identical adult twins. The onset of the disease can be traced into late infancy; the clinical picture is one of severe muscular dystrophy; respiratory insuficiency was the cause of death in one case. The autopsy showed the central nervous system, heart and liver to be spared...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313272
更新日期：1976-08-06 00:00:00
abstract：BACKGROUND:Multiple sclerosis (MS) notably affects adults of working age. For persons with MS (PwMS), being employed enhances their quality of life and it may be regarded as an indicator of overall functioning. Thus, ensuring work participation in PwMS is of general public health interest. OBJECTIVE:To examine relevan...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09973-3
更新日期：2020-10-01 00:00:00
abstract：:In a fatal case of neuroleptic malignant syndrome, a muscle sample taken within 1 h of death showed acute myopathic features with absence of muscle glycogen and neutral lipid. These features suggest that hyperpyrexia in this syndrome may be caused by heat production from uncoupled phosphorylation in muscle and imply t...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00718024
更新日期：1987-12-01 00:00:00
abstract：BACKGROUND:An upper motor neuron (UMN) lesion in amyotrophic lateral sclerosis (ALS) is often difficult to identify because clinical signs may be discrete or masked by severe simultaneous LMN lesions. We compared the diagnostic sensitivity of transcranial magnetic stimulation (TMS) to cranial muscles and limb muscles i...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150170068
更新日期：2001-10-01 00:00:00
abstract：:Forty-four patients (mean age 66, SD 8 years) with either clinical evidence of a focal lacunar syndrome (n = 36) or with disorders of memory or gait (n = 8) in the presence of a lacunar infarct on CT were studied for cognitive functioning and for the presence of white matter lesions on MRI. MR images were assessed by ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF02444014
更新日期：1996-02-01 00:00:00
abstract：:A double-blind, placebo-controlled multicentre study was carried out to evaluate the efficacy and tolerability of 100, 200 and 300 mg sumatriptan, a selective 5-hydroxytryptamine (5-HT)1-like receptor agonist, given in an oral dispersible form in the acute treatment of migraine attacks. A total of 1130 patients were r...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF01642909
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Volume loss in the deep gray matter (DGM) has been reported in patients with multiple sclerosis (MS) already at early stages of the disease and is thought to progress throughout the disease course. OBJECTIVE:To investigate the impact and predictive value of volume loss in DGM and thalamic subnuclei on disab...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09740-4
更新日期：2020-05-01 00:00:00
abstract：:A low dietary intake of unsaturated fatty acids has been found in male patients with stroke as compared with controls in Italy, and a high consumption of meat has been associated with an increased risk of stroke in Australia. We present a case-control study, comparing the unsaturated and saturated fatty acids content ...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s004150050102
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVES:The mechanisms of early neurologic deterioration (END) and prevention strategies for END are not completely understood. The aim of this study was to investigate the association between CYP2C19*2 variants and END, and the effectiveness of antiplatelet therapy for prevention of END according to CYP2C19*2 genot...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00415-018-8998-1
更新日期：2018-10-01 00:00:00
abstract：:Non motor symptoms (NMS) of PD are a key determinant of health, quality of life and societal cost of PD. Contrary to common perception, many NMS of PD occur early in PD and some may even predate the diagnosis of PD which is based on motor signs. These include olfactory deficit, sleep problems such as REM behaviour dis...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-008-5006-1
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Studies provide inconclusive results on the question whether loss of mental wellbeing is actually associated with decline in physical function in amyotrophic lateral sclerosis (ALS). The purpose of this study was to determine predictors of mental wellbeing in ALS. METHODS:In total, n = 330 ALS patients were...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10027-x
更新日期：2020-12-01 00:00:00
abstract：:Stiff-person syndrome (SPS) is a rare condition of progressive muscular rigidity and spasm, frequently accompanied by other autoimmune conditions, an association which has been further strengthened by the discovery of anti-GAD antibodies and the response of SPS to immunotherapies. Intravenous immunoglobulin (IVIg) is ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6015-z
更新日期：2011-10-01 00:00:00
abstract：:Corticobasal degeneration (CBD) was first described by Rebeiz et al. in 1967, and was called corticodentatonigral degeneration with neuronal achromasia [1]. Since then, our knowledge of the clinical features and underlying tau pathology has grown tremendously. Clinical antemortem diagnosis of CBD pathology remains cha...
journal_title：Journal of neurology
pub_type： 历史文章,杂志文章
doi：10.1007/s00415-017-8644-3
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Spinocerebellar ataxias (SCAs) are rare dominantly inherited neurodegenerative disorders that lead to severe disability and premature death. OBJECTIVE:To better characterize the natural history of the most common SCAs, SCA1, SCA2, SCA3 and SCA6, we performed a meta-analysis of literature to determine diseas...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-09815-2
更新日期：2020-04-07 00:00:00
abstract：:Unlike most neurodegenerative disorders, individuals at risk from Huntington's disease can be identified prior to the onset of clinical signs of the disease by virtue of it being an autosomal dominant condition. This provides the hypothetical opportunity to delay disease onset and/or slow down the progression of the d...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-015-7700-0
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:Determine toxicity and efficacy of autologous hematopoietic stem cell transplantation (HSCT) for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who are dependent on intravenous immunoglobulins or plasmapheresis. METHODS:Unselected peripheral blood stem cells were re-infused on...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10010-6
更新日期：2020-11-01 00:00:00
abstract：:Extra- and intraneural ganglionic cysts rarely involved peripheral nerves. They are found in the neighbourhood of large joints. Intraneural cysts prefer the deep peroneal nerve and cause intermittent pain and severe nerve damage. The ulnar nerve is affected most often at the wrist. There are different types of distal ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314606
更新日期：1975-06-09 00:00:00
abstract：:Stavudine (2',3'-didehydro-3'deoxythymidine) is a pyrimidine analogue that may be of great value in combination antiretroviral therapy (ART) for treating patients infected with human immunodeficiency virus type 1 (HIV-1). We assessed potential neurotoxic side effects by comparing peripheral nerve function in patients ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050336
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:An optimal management of vascular risk factors, associated with antithrombotic drugs and carotid surgery when appropriate, reduces the risk of a new vascular event after stroke. Although secondary prevention is not optimal in many patients in practice, the question of whether there is an improv...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0591-8
更新日期：2005-01-01 00:00:00
abstract：:A 37-year-old man presented with an acute amnestic syndrome of Korsakoff's type and an upper brain-stem oculomotor syndrome. After a moderate improvement with steroid therapy, he developed progressive behavioural changes due to a frontal lobe syndrome, in addition to motor and visual impairment. Memory performance was...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00315338
更新日期：1991-09-01 00:00:00
abstract：OBJECTIVE:Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8790-2
更新日期：2018-05-01 00:00:00
