Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.

abstract：:Regeneration of appendages is frequent among invertebrates as well as some vertebrates. However, in mammals this has been largely relegated to digit tip regeneration, as found in mice and humans. The regenerated structures are formed from a mound of undifferentiated cells called a blastema, found just below the site o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehoczky JA,Robert B,Tabin CJ

更新日期：2011-12-20 00:00:00

abstract：:To date, numerous inhibitors of the human immunodeficiency virus type 1 protease have been reported, but few have been studied extensively in humans, primarily as a consequence of poor oral bioavailability in animal models. L-735,524 represents a class of human immunodeficiency virus type 1 protease inhibitors, termed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vacca JP,Dorsey BD,Schleif WA,Levin RB,McDaniel SL,Darke PL,Zugay J,Quintero JC,Blahy OM,Roth E

更新日期：1994-04-26 00:00:00

abstract：:Cyanogen bromide fragments were isolated from the heavy chains of three human IgG myeloma proteins of the V(H)III subgroup, sequenced by an automated method, and localized to the variable region. Inspection of these sequences, together with corresponding stretches from both human and animal proteins (studied in other ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kehoe JM,Capra JD

更新日期：1971-09-01 00:00:00

abstract：:Saccharomyces cerevisiae Hop2 and Mnd1 are abundant meiosisspecific chromosomal proteins, and mutations in the corresponding genes lead to defects in meiotic recombination and in homologous chromosome interactions during mid-prophase. Analysis of various double mutants suggests that HOP2, MND1, and DMC1 act in the sam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YK,Leng CH,Olivares H,Lee MH,Chang YC,Kung WM,Ti SC,Lo YH,Wang AH,Chang CS,Bishop DK,Hsueh YP,Wang TF

更新日期：2004-07-20 00:00:00

abstract：:Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of voltage-activated sodium (Nav) channels. We discovered a mutation in an intracellular loop of rNav1.2a (G1079C), which results in a higher apparent affinity for exter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosmans F,Milescu M,Swartz KJ

更新日期：2011-12-13 00:00:00

abstract：:We report the cloning and expression of a cDNA encoding human sterol carrier protein 2 (SCP2). The 1.3-kilobase (kb) cDNA contains an open reading frame which encompasses a 143-amino acid sequence which is 89% identical to the rat SCP2 amino acid sequence. The deduced amino acid sequence of the polypeptide reveals a 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto R,Kallen CB,Babalola GO,Rennert H,Billheimer JT,Strauss JF 3rd

更新日期：1991-01-15 00:00:00

abstract：:When the Mn(2+) and Ca(2+) ions normally present in concanavalin A are removed, the protein becomes incapable of binding saccharides. To explore the structural differences between the native and demetallized forms and their effects on the saccharide-binding properties of the protein, we have refined and compared the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeke GN Jr,Becker JW,Edelman GM

更新日期：1978-05-01 00:00:00

abstract：:The specific ornithine decarboxylase inhibitor alpha-difluoromethylornithine, when given to adult rats in vivo for 5 wk, resulted in a decrease in peripheral blood cell elements in normal rats and a marked suppression of marrow recovery in rats with chemotherapy-induced marrow hypoplasia. In normal rats, alpha-difluor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luk GD,Sharkis SJ,Abeloff MD,McCann PP,Sjoerdsma A,Baylin SB

更新日期：1983-08-01 00:00:00

abstract：:When either the homologous RNA (avian myeloblastosis virus RNA) or a heterologous RNA (poliovirus RNA) was used as a template, the anticomplementary DNA synthesized in vitro by avian myeloblastosis virus reverse transcriptase (RNA-directed DNA nucleotidyltransferase, EC 2.7.7.7) was primed by fragments of the original...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Myers JC,Dobkin C,Spiegelman S

更新日期：1980-03-01 00:00:00

abstract：:Toll-like receptors (TLRs) are expressed on innate immune cells and trigger inflammation upon detection of pathogens and host tissue injury. TLR-mediated proinflammatory-signaling pathways are counteracted by partially characterized anti-inflammatory mechanisms that prevent exaggerated inflammation and host tissue dam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou J,Wu R,High AA,Slaughter CA,Finkelstein D,Rehg JE,Redecke V,Häcker H

更新日期：2011-11-01 00:00:00

abstract：:Oocyte endowment dwindles away during prepubertal and adult life until menopause occurs, and apoptosis has been identified as a central mechanism responsible for oocyte elimination. A few recent reports suggest that uncontrolled inflammation may adversely affect ovarian reserve. We tested the possible role of the proi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uri-Belapolsky S,Shaish A,Eliyahu E,Grossman H,Levi M,Chuderland D,Ninio-Many L,Hasky N,Shashar D,Almog T,Kandel-Kfir M,Harats D,Shalgi R,Kamari Y

更新日期：2014-08-26 00:00:00

abstract：:In early brain development, ascending thalamocortical axons (TCAs) navigate through the ventral telencephalon (VTel) to reach their target regions in the young cerebral cortex. Descending, deep-layer cortical axons subsequently target appropriate thalamic and subcortical target regions. However, precisely how and when...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robichaux MA,Chenaux G,Ho HY,Soskis MJ,Dravis C,Kwan KY,Šestan N,Greenberg ME,Henkemeyer M,Cowan CW

更新日期：2014-02-11 00:00:00

abstract：:Incorporation of 2-acyl spin-labeled lecithin into the phosphatidylcholine protein from bovine liver results in an immobilization of the spin-label at the methyl and the carboxyl terminal end of the acyl chain. The nitroxide group on the protein-bound lecithin molecule is not accessible to ascorbate. This suggests tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devaux PF,Moonen P,Bienvenue A,Wirtz KW

更新日期：1977-05-01 00:00:00

abstract：:To investigate the molecular basis of the voltage sensor that triggers excitation-contraction (EC) coupling, the four-domain pore subunit of the dihydropyridine receptor (DHPR) was cut in the cytoplasmic linker between domains II and III. cDNAs for the I-II domain (alpha1S 1-670) and the III-IV domain (alpha1S 701-187...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahern CA,Arikkath J,Vallejo P,Gurnett CA,Powers PA,Campbell KP,Coronado R

更新日期：2001-06-05 00:00:00

abstract：:In diabetes, the death of insulin-producing beta-cells by apoptosis leads to insulin deficiency. The lower prevalence of diabetes in females suggests that female sex steroids protect from beta-cell injury. Consistent with this hypothesis, 17beta-estradiol (estradiol) manifests antidiabetic actions in humans and rodent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le May C,Chu K,Hu M,Ortega CS,Simpson ER,Korach KS,Tsai MJ,Mauvais-Jarvis F

更新日期：2006-06-13 00:00:00

abstract：:IL-2-PE40 is a chimeric protein composed of human interleukin 2 (IL-2) genetically fused to the amino terminus of a modified form of Pseudomonas exotoxin lacking its cell recognition domain. IL-2-PE40, which is extremely cytotoxic to IL-2 receptor-positive cells, was examined for its ability to prevent graft rejection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lorberboum-Galski H,Barrett LV,Kirkman RL,Ogata M,Willingham MC,FitzGerald DJ,Pastan I

更新日期：1989-02-01 00:00:00

abstract：:Cajal-Retzius (CR) cells are early-generated transient neurons and are important in the regulation of cortical neuronal migration and cortical laminar formation. Molecular entities characterizing the CR cell identity, however, remain largely elusive. We purified mouse cortical CR cells expressing GFP to homogeneity by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamazaki H,Sekiguchi M,Takamatsu M,Tanabe Y,Nakanishi S

更新日期：2004-10-05 00:00:00

abstract：:Canonical Wnt signaling has been implicated in an AP axis polarizing mechanism in most animals, despite limited evidence from arthropods. In the long-germ insect, Drosophila, Wnt signaling is not required for global AP patterning, but in short-germ insects including Tribolium castaneum, loss of Wnt signaling affects d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu J,Posnien N,Bolognesi R,Fischer TD,Rayl P,Oberhofer G,Kitzmann P,Brown SJ,Bucher G

更新日期：2012-05-15 00:00:00

abstract：:A study was made of the effects of di- and trivalent cations on homomeric rho 1-type gamma-aminobutyrate (GABA rho 1) receptors expressed in Xenopus oocytes after injection of mRNA coding for the GABA rho 1 subunit. GABA elicited large currents with a Kd approximately 1 microM. The properties of these GABA rho 1 recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calvo DJ,Vazquez AE,Miledi R

更新日期：1994-12-20 00:00:00

abstract：:Sands from various geographic locations reduce N(2) from the air to NH(3) and traces of N(2)H(4) on exposure to sunlight. This N(2) photofixation occurs under sterile conditions on the surface of finely dispersed titanium minerals such as rutile, utilizing reducing equivalents generated through the photolysis of chemi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schrauzer GN,Strampach N,Hui LN,Palmer MR,Salehi J

更新日期：1983-06-01 00:00:00

abstract：:Infection is a major complication of implantable medical devices, which provide a scaffold for biofilm formation, thereby reducing susceptibility to antibiotics and complicating treatment. Hematogenous implant-related infections following bacteremia are particularly problematic because they can occur at any time in a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Cheng LI,Helfer DR,Ashbaugh AG,Miller RJ,Tzomides AJ,Thompson JM,Ortines RV,Tsai AS,Liu H,Dillen CA,Archer NK,Cohen TS,Tkaczyk C,Stover CK,Sellman BR,Miller LS

更新日期：2017-06-27 00:00:00

abstract：:Developmental and physiological responses are regulated by light throughout the entire life cycle of higher plants. To sense changes in the light environment, plants have developed various photoreceptors, including the red/far-red light-absorbing phytochromes and blue light-absorbing cryptochromes. A wide variety of p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bognár LK,Hall A,Adám E,Thain SC,Nagy F,Millar AJ

更新日期：1999-12-07 00:00:00

abstract：:Ecosystem restoration aims to restore biodiversity and valuable functions that have been degraded or lost. The Coral Triangle is a hotspot for marine biodiversity held in its coral reefs, seagrass meadows, and mangrove forests, all of which are in global decline. These coastal ecosystems support valuable fisheries and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams SL,Ambo-Rappe R,Sur C,Abbott JM,Limbong SR

更新日期：2017-11-07 00:00:00

abstract：:Buffering variability in morphogen distribution is essential for reproducible patterning. A theoretically proposed class of mechanisms, termed "distal pinning," achieves robustness by combining local sensing of morphogen levels with global modulation of gradient spread. Here, we demonstrate a critical role for morphog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rahimi N,Carmon S,Averbukh I,Khajouei F,Sinha S,Schejter ED,Barkai N,Shilo BZ

更新日期：2020-01-21 00:00:00

abstract：:Endothelial cells (EC) play a central role in inflammatory immune responses and efficiently induce effector functions in T cells, despite lacking the classical costimulatory ligands CD80 and CD86. By using the mAb HIL-131 we now demonstrate that human inducible costimulator-ligand (ICOS-L), a molecule related to CD80/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khayyamian S,Hutloff A,Büchner K,Gräfe M,Henn V,Kroczek RA,Mages HW

更新日期：2002-04-30 00:00:00

abstract：:Transcription initiation in eukaryotes is controlled by nucleoprotein complexes formed through cooperative interactions among multiple transcription regulatory proteins. These complexes may be assembled via stochastic collisions or defined pathways. We investigated the dynamics of Fos-Jun-NFAT1 complexes by using a mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramirez-Carrozzi VR,Kerppola TK

更新日期：2001-04-24 00:00:00

abstract：:Although peroxynitrite is harmful to the host, the beneficial effects of peroxynitrite are less well understood. We explored the role of peroxynitrite in the host immune response to Coxsackievirus infection. Peroxynitrite inhibits viral replication in vitro, in part by inhibiting viral RNA entry into the host cell. Ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padalko E,Ohnishi T,Matsushita K,Sun H,Fox-Talbot K,Bao C,Baldwin WM 3rd,Lowenstein CJ

更新日期：2004-08-10 00:00:00

abstract：:A 43-kDa peripheral membrane protein is known to copurify with acetylcholine receptor (AcChoR)-rich membranes isolated from the electric organ of Torpedo californica. Immunoelectron microscopy and crosslinking studies have demonstrated that this 43-kDa protein is closely associated with the cytoplasmic domain(s) of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burden SJ

更新日期：1985-12-01 00:00:00

abstract：:Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant neuronal protein that can adopt different conformations and biological properties. Recently, aSyn pathology was shown to spread between neurons in a prion-like manner. Pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Villar-Piqué A,Lopes da Fonseca T,Sant'Anna R,Szegö ÉM,Fonseca-Ornelas L,Pinho R,Carija A,Gerhardt E,Masaracchia C,Abad Gonzalez E,Rossetti G,Carloni P,Fernández CO,Foguel D,Milosevic I,Zweckstetter M,Ventura S,Outeiro

更新日期：2016-10-18 00:00:00

abstract：:New neurons are generated in adult mammalians and may contribute to repairing the brain after injury. Here, we show that the number of new neurons in the dentate gyrus of adult rats increased in cerebral ischemic stroke and correlated with activation of the cAMP-response-element-binding protein (CREB). Inhibition of e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu DY,Lau L,Liu SH,Wei JS,Lu YM

更新日期：2004-06-22 00:00:00