Abstract:
:IL-2-PE40 is a chimeric protein composed of human interleukin 2 (IL-2) genetically fused to the amino terminus of a modified form of Pseudomonas exotoxin lacking its cell recognition domain. IL-2-PE40, which is extremely cytotoxic to IL-2 receptor-positive cells, was examined for its ability to prevent graft rejection in mice in which activation of T cells is prominent. We demonstrate that intraperitoneally administered IL-2-PE40 specifically and significantly prolongs the survival of vascularized heart allografts in mice. The chimeric toxin, IL-2-PE40, offers an alternative approach to the treatment of autoimmune diseases and transplant rejection in humans.
journal_name
Proc Natl Acad Sci U S Aauthors
Lorberboum-Galski H,Barrett LV,Kirkman RL,Ogata M,Willingham MC,FitzGerald DJ,Pastan Idoi
10.1073/pnas.86.3.1008subject
Has Abstractpub_date
1989-02-01 00:00:00pages
1008-12issue
3eissn
0027-8424issn
1091-6490journal_volume
86pub_type
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更新日期:2004-02-17 00:00:00
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