In Vivo Radionuclide Generators for Diagnostics and Therapy.

Abstract:

:In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therapeutic short-lived α-emitter 212Bi. Often, as in the case of 81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.

journal_name

Bioinorg Chem Appl

authors

Edem PE,Fonslet J,Kjær A,Herth M,Severin G

doi

10.1155/2016/6148357

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

6148357

eissn

1565-3633

issn

1687-479X

journal_volume

2016

pub_type

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