Abstract:
:Recent developments in the understanding of the molecular control of iron homeostasis provided novel insights into the mechanisms responsible for normal iron balance. However in chronic anemias associated with iron overload, such mechanisms are no longer sufficient to offer protection from iron toxicity, and iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic damage. Today, long-term deferoxamine (DFO) therapy is an integral part of the management of thalassemia and other transfusion-dependent anemias, with a major impact on well-being and survival. However, the high cost and rigorous requirements of DFO therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Within recent years more than one thousand candidate compounds have been screened in animal models. The most outstanding of these compounds include deferiprone (L1); pyridoxal isonicotinoyl hydrazone (PIH) and; bishydroxy- phenyl thiazole. Deferiprone has been used extensively as a substitute for DFO in clinical trials involving hundreds of patients. However, L1 treatment alone fails to achieve a negative iron balance in a substantial proportion of subjects. Deferiprone is less effective than DFO and its potential hepatotoxicity is an issue of current controversy. A new orally effective iron chelator should not necessarily be regarded as one displacing the presently accepted and highly effective parenteral drug DFO. Rather, it could be employed to extend the scope of iron chelating strategies in a manner analogous with the combined use of medications in the management of other conditions such as hypertension or diabetes. Coadministration or alternating use of DFO and a suitable oral chelator may allow a decrease in dosage of both drugs and improve compliance by decreasing the demand on tedious parenteral drug administration. Combined use of DFO and L1 has already been shown to result in successful depletion of iron stores in patients previously failing to respond to single drug therapy, and to lead to improved compliance with treatment. It may also result in a "shuttle effect" between weak intracellular chelators and powerful extracellular chelators or exploit the entero-hepatic cycle to promote fecal iron excretion. All of these innovative ways of chelator usage are now awaiting evaluation in experimental models and in the clinical setting.
journal_name
Bioinorg Chem Appljournal_title
Bioinorganic chemistry and applicationsauthors
Hershko C,Abrahamov A,Konijn AM,Breuer W,Cabantchik IZ,Pootrakul P,Link Gdoi
10.1155/S1565363303000128subject
Has Abstractpub_date
2003-01-01 00:00:00pages
151-68eissn
1565-3633issn
1687-479Xpub_type
杂志文章abstract::This paper describes some physical, structural, and biological properties of gypsum bioceramics doped with various amounts of strontium ions (0.19-2.23 wt%) and compares these properties with those of a pure gypsum as control. Strontium-doped gypsum (gypsum:Sr) was obtained by mixing calcium sulfate hemihydrate powder...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2012/976495
更新日期:2012-01-01 00:00:00
abstract::Platelet activation has been reported to play a major role in arterial thrombosis, cancer metastasis, and progression. Recently, we developed a novel Ir(III)-based compound, [Ir(Cp∗)1-(2-pyridyl)-3-(4-dimethylaminophenyl)imidazo[1,5-a]pyridine Cl]BF4 or Ir-6 and assessed its effectiveness as an antiplatelet drug. Ir-6...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2018/8291393
更新日期:2018-05-02 00:00:00
abstract::1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO3}n (1), {[Ag(bpa)2]CF3SO3.H2O}n (2) and {[Ag(bpe)]CF3SO3}n (3). In complexes 1-3, the corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2020/3812050
更新日期:2020-04-14 00:00:00
abstract::A number of penta- and hexacoordinated organotin(IV) complexes and tetracoordinated tin(II) complexes of compositions Me2SnCl[RCOC:CON(C6H5)N:CCH3] (where R = - CH(3), -p-ClC(6)H(4), and -C(6)H(5)), Me2Sn[RCOC:CON(C6H5)N:CCH3]2 (where R = -CH(3), and -C(6)H(5)), and Sn(II) [RCOC:CON(C6H5)N:CCH3]2 (where R = -p-ClC(6)H...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/BCA/2006/60140
更新日期:2006-01-01 00:00:00
abstract::Four pyrazolone derivatives and their corresponding silver complexes were synthesized and characterized. Based on elemental analysis, 1 : 2 (M : L) molar ratio was suggested for all inspected complexes. 1H, 13C NMR, mass, UV-Vis, TGA, and IR were the spectral tools used for describing the formulae. Moreover, XRD patte...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2018/2727619
更新日期:2018-05-14 00:00:00
abstract::Antifertility and histopathological investigations were carried out on reproductive organs of male albino rats induced by tetraazamacrocyclic complexes of iron(II). The complexes were synthesized by the template condensation of 1,2-diaminoethane, 1,3-diaminopropane with succinic acid and phthalic acid in 2 : 2 molar r...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/BCA/2006/17316
更新日期:2006-01-01 00:00:00
abstract::The antineoplastic potential of a stable monomeric Au(II) complex with hematoporphyrin IX (Hp), namely [Au(II)Hp(-2H).(H(2)O)(2)], was investigated in a panel of tumor cell lines. The complex exhibits strong cytotoxicity, whereby the leukaemia- and lymphoma-derived cell lines are more sensitive, with IC(50) values com...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2008/367471
更新日期:2008-01-01 00:00:00
abstract::Changes in the expression of microRNAs can affect cancer cells' viability and behavior and the impact on cancer treatment. In this study, the expression of miR-155-5p, miR-203a-3p, and miR-223-3p in the MCF7 cancer cell line was studied when exposed to ZnO nanoparticles synthesized through a green route. Mentioned ZnO...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2020/8817110
更新日期:2020-11-20 00:00:00
abstract::The toxicity mechanisms of mercury and tin organic derivatives are still under debate. Generally the presence of organic moieties in their molecules makes these compounds lipophilic and membrane active species. The recent results suggest that Hg and Sn compounds deplete HS-groups in proteins, glutathione and glutathio...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/S1565363304000068
更新日期:2004-01-01 00:00:00
abstract::The thermodynamic equilibria of nickel(II) with N,N'-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N'-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25°C and an ionic strength of 0.15 mol dm(-3) by glass electrode potenti...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2014/863612
更新日期:2014-01-01 00:00:00
abstract::Stable, six coordinated Bu(2)SnLA type complexes have been prepared [where LH = RCOC:C(OH)N(C(6) H(5))N:CCH(3); R = -4-F-C(6)H(4)-(L(1)H), R = -4-Cl-C(6)H(4)-(L(2)H), R= -4-Br-C(6)H(4)-(L(3)H), R=-CF(3)(L(4)H) and AH = C(O)C(6) H(4) C(O)NCHR'COOH; R'= -H(A(1)H), -CH(3)(A(2)H), -CH(CH(3))(2)(A(3)H)] by the interaction ...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/BCA.2005.201
更新日期:2005-01-01 00:00:00
abstract::The zinc(II) complex (C2H6NS)2Zn·ZnCl2 was synthesized with 2-aminoethanethiol hydrochloride and zinc sulfate heptahydrate as the raw materials in aqueous solution. The composition and structure of the complex were characterized by elemental analysis, infrared spectra, single crystal X-ray diffraction, and thermogravi...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2016/2691253
更新日期:2016-01-01 00:00:00
abstract::Mn peroxidase has been purified to homogeneity from the culture filtrate of a new fungal strain Fomes durissimus MTCC-1173 using concentration by ultrafiltration and anion exchange chromatography on diethylaminoethyl (DEAE) cellulose. The molecular mass of the purified enzyme has been found to be 42.0 kDa using SDS-PA...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2011/260802
更新日期:2011-01-01 00:00:00
abstract::It is important to develop functional transmucosal implant surfaces that reduce the number of initially adhering bacteria and they need to be modified to improve the anti-bacterial performance. Commercially pure Ti sheets were anodized in an electrolyte containing ethylene glycol, distilled water and ammonium fluoride...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2014/829496
更新日期:2014-01-01 00:00:00
abstract::The chemical design of metal complexes of the type [Cu(phen)(antib)](+) (where antib is a quinolone or a fluoroquinolone) has been carried out in an approach to better understand how the coordination of their components affect the activity of quinolones. The ability of [Cu(phen)(nal)](+) to interact with DNA in vivo a...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/S1565363303000025
更新日期:2003-01-01 00:00:00
abstract::A partially fluorine substituted hydroxyapatite- (FHA-) coated Mg-Zn alloy was prepared to investigate the interfacial behavior of degradable Mg-based biomaterials with degradable bioactive coatings in a cell culture environment. Peaks from the results of X-ray diffraction (XRD) were characterized and compared before ...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2011/192671
更新日期:2011-01-01 00:00:00
abstract::The N- and C-terminal blocked hexapeptide Ac-Leu-Ala-His-Tyr-Asn-Lys-amide (LAHYNK) representing the 80-85 fragment of histone H2B was synthesized and its interactions with Cu(II) and Ni(II) ions were studied by potentiometric, UV-Vis, CD, EPR, and NMR spectroscopic techniques in solution. Our data reveal that the imi...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2008/257038
更新日期:2008-01-01 00:00:00
abstract::Heterobimetallic complexes of Zn(II) and Sn(IV) with sarcosine have been synthesized at room temperature under stirring conditions by the reaction of sarcosine and zinc acetate in 2 : 1 molar ratio followed by the stepwise addition of CS2 and organotin(IV) halides, where R = Me, n-Bu, and Ph. The complexes were charac...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2013/351262
更新日期:2013-01-01 00:00:00
abstract::The novel diphenyltin(IV) compound [Ph(2)(HyFoSc)Sn] (2), where H(2)HyFoSc (1) is 3-hydroxy-2-formylpyridine semicarbazone, was prepared and characterized by vibrational and NMR ((1)H, (13)C) spectroscopy. The structure of [Ph(2)(HyFoSc)Sn] was confirmed by single-crystal X-ray crystallography. The doubly deprotonated...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2010/718606
更新日期:2010-01-01 00:00:00
abstract::In this study, we describe novel gallium(III), germanium(IV), and hafnium(IV) folate complexes, including their synthesis and analyses. The synthesized folate complexes were also subject to thermal analysis (TGA) to better examine their thermal degradation and kinetic properties. The folate complexes had high stabilit...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2020/6678688
更新日期:2020-12-18 00:00:00
abstract::The influences of chondroitin sulfate C (C6S) on size, aggregation, sedimentation, and Zeta potential of sub-micron calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD) crystallites with mean sizes of about 330 nm were investigated using an X-ray diffractometer, nanoparticle size Zeta potential analyz...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2013/360142
更新日期:2013-01-01 00:00:00
abstract::Dry films of platinum chemotherapeutic drugs covalently bound to plasmid DNA (Pt-DNA) represent a useful experimental model to investigate direct effects of radiation on DNA in close proximity to platinum chemotherapeutic agents, a situation of considerable relevance to understand the mechanisms underlying concomitant...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2012/923914
更新日期:2012-01-01 00:00:00
abstract::The Rieske iron-sulfur protein, one of the catalytic subunits of the cytochrome bc(1) complex, is involved in electron transfer at the level of the inner membrane of yeast mitochondria. The Rieske iron-sulfur protein is encoded by nuclear DNA and, after being synthesized in the cytosol, is imported into mitochondria w...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2011/363941
更新日期:2011-01-01 00:00:00
abstract::Terpolymer of 2-amino-6-nitro-benzothiazole-ethylenediamine-formaldehyde (BEF) has been synthesized and characterized by elemental analysis and various spectral techniques like FTIR, UV-Visible, and (1)H and (13)C-NMR. The terpolymer metal complexes were prepared with Cu(2+), Ni(2+), and Zn(2+) metal ions using BEF te...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2014/764085
更新日期:2014-01-01 00:00:00
abstract::The synthetic, spectroscopic, and biological studies of sixteen ring-substituted 4-phenylthiosemicarbazones and 4-nitrophenyl-thiosemicarbazones of anisaldehyde, 4-chlorobenzaldehyde, 4-fluorobenzaldehyde, and vanillin with ruthenium(III) and rhodium(III) chlorides are reported here. Their structures were determined o...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2007/68374
更新日期:2007-01-01 00:00:00
abstract::DNA binding and photocleavage characteristics of a series of mixed ligand complexes of the type [M(bpy)(2)qbdp](PF(6))(n).xH(2)O (where M = Co(III) or Ni(II), bpy = 2.2'-bipryidine, qbdp = Quinolino[3,2-b]benzodiazepine, n = 3 or 2 and x = 5 or 2) have been investigated. The DNA binding property of the complexes with ...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2007/36497
更新日期:2007-01-01 00:00:00
abstract::The highly water-soluble ruthenium complex [Ru(H(2)L)Cl(2)](2)H(2)o, in which H(4)L is the sequestering ligand trans-l, 2-cyclohexanediamminetetraacetic acid (cdta) has been synthesized, structurally characterized and its properties studied. The X-ray crystallographic study shows that the chelating coordinated ligand ...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/S1565363304000160
更新日期:2004-01-01 00:00:00
abstract::New complexes of manganese(II) corresponding to [{(ArO)2PS2}2Mn] and [{(ArO)2PS2}2Mn.nL] (Ar = o-, m-, p-CH3C6H4 and p-Cl-m-CH3C6H3; n = 1, L = N2C12H8, N2C10H8; n = 2, L = NC5H5, P(C6H5)3) have been synthesized and characterized by microelemental analyses (C, H, and N), magnetic susceptibility, molar conductance, the...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2013/261731
更新日期:2013-01-01 00:00:00
abstract::The complex [ReOCl(3)pq] (1) (where pq = 2-(2'pyridyl)quinoxaline) has been synthesized and fully characterized by UV-Vis, FTIR, 1 and 2D NMR, and cyclic voltammetry (CV). The DNA-binding properties of the complex 1 as well as of the compounds [ReOCl(3)bpy] (2), [ReOCl(3)phen] (3), and pq (4) were investigated by UV-s...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2010/973742
更新日期:2010-01-01 00:00:00
abstract::Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CH3OH)]·CH3OH (1), [Ni(naph-L-phe)(phen)(CH3OH)] (2), and [Ni(o-van-L-phe)(phen)(CH3OH)]·5CH3OH (3) (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde...
journal_title:Bioinorganic chemistry and applications
pub_type: 杂志文章
doi:10.1155/2018/8478152
更新日期:2018-07-05 00:00:00