The bioactivated interfacial behavior of the fluoridated hydroxyapatite-coated mg-zn alloy in cell culture environments.

Abstract:

:A partially fluorine substituted hydroxyapatite- (FHA-) coated Mg-Zn alloy was prepared to investigate the interfacial behavior of degradable Mg-based biomaterials with degradable bioactive coatings in a cell culture environment. Peaks from the results of X-ray diffraction (XRD) were characterized and compared before and after cell culture. It was found that Ca-P, including poorly crystalline ion-substituted Ca-deficient HA (CDHA), was formed in greater amounts on the interface of coated samples compared with the uncoated ones. A thermodynamic mechanism for Ca-P formation on biodegradable Mg alloys in a cell culture environment is proposed. Combined with improved cell calcification, the-FHA coated Mg alloys have the ability to promote CDHA formation, as expected thermodynamically. It is suggested that the specific cell culture environment and the bone-like FHA coatings together facilitate the observed behavior. Moreover, cell culture environment probably increased the biomineralization to a detectable level by affecting the kinetics of apatite formation.

journal_name

Bioinorg Chem Appl

authors

Li J,Cao L,Song Y,Zhang S,Zhao C,Zhang F,Zhang X

doi

10.1155/2011/192671

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

192671

eissn

1565-3633

issn

1687-479X

journal_volume

2011

pub_type

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