Abstract:
:The complex [ReOCl(3)pq] (1) (where pq = 2-(2'pyridyl)quinoxaline) has been synthesized and fully characterized by UV-Vis, FTIR, 1 and 2D NMR, and cyclic voltammetry (CV). The DNA-binding properties of the complex 1 as well as of the compounds [ReOCl(3)bpy] (2), [ReOCl(3)phen] (3), and pq (4) were investigated by UV-spectrophotometric (melting curves), CV (cyclic voltammetry), and viscosity measurements. Experimental data suggest that complex 1 intercalates into the DNA base pairs. Upon irradiation, complex 1 was found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II. The mechanism of the DNA cleavage by complex 1 was also investigated.
journal_name
Bioinorg Chem Appljournal_title
Bioinorganic chemistry and applicationsauthors
Mitsopoulou CA,Dagas Cdoi
10.1155/2010/973742subject
Has Abstractpub_date
2010-01-01 00:00:00pages
973742eissn
1565-3633issn
1687-479Xpub_type
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