Robust high-throughput kinetic analysis of apoptosis with real-time high-content live-cell imaging.

abstract：:Japanese encephalitis virus (JEV), which is a causative agent of sporadic encephalitis, harbours itself inside the neural stem/progenitor cells. It is a well-known fact that JEV infects neural stem/progenitor cells and decreases their proliferation capacity. With mass spectrometry-based quantitative proteomic study, i...

journal_title：Cell death & disease

authors： Mukherjee S,Singh N,Sengupta N,Fatima M,Seth P,Mahadevan A,Shankar SK,Bhattacharyya A,Basu A

更新日期：2017-01-19 00:00:00

abstract：:Mitochondrial ferritin (FtMt) is a mitochondrially localized protein possessing ferroxidase activity and the ability to store iron. FtMt overexpression in cultured cells protects against oxidative damage by sequestering redox-active, intracellular iron. Here, we found that acute exhaustive exercise significantly incre...

journal_title：Cell death & disease

authors： Wu W,Chang S,Wu Q,Xu Z,Wang P,Li Y,Yu P,Gao G,Shi Z,Duan X,Chang YZ

更新日期：2016-11-17 00:00:00

abstract：:Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis. However, the underlying molecular mechanisms of N...

journal_title：Cell death & disease

authors： Zhang LQ,Van Haandel L,Xiong M,Huang P,Heruth DP,Bi C,Gaedigk R,Jiang X,Li DY,Wyckoff G,Grigoryev DN,Gao L,Li L,Wu M,Leeder JS,Ye SQ

更新日期：2017-03-23 00:00:00

abstract：:Members of the transforming growth factor-β (TGF-β) superfamily participate in numerous biological phenomena in multiple tissues, including in cell proliferation, differentiation, and migration. TGF-β superfamily proteins therefore have prominent roles in wound healing, fibrosis, bone formation, and carcinogenesis. Ho...

journal_title：Cell death & disease

authors： Goto K,Tong KI,Ikura J,Okada H

更新日期：2011-12-01 00:00:00

abstract：:Histone deacetylases (HDACs) are epigenetic regulators that are important for the control of various pathophysiological events. We found that HDAC inhibitors completely abolished transforming growth factor-β1 (TGF-β1)-induced apoptosis in AML-12 and primary mouse hepatocytes. Expression of a dominant-negative mutant o...

journal_title：Cell death & disease

authors： Lei WW,Zhang KH,Pan XC,Wang DM,Hu Y,Yang YN,Song JG

更新日期：2010-05-20 00:00:00

abstract：:Global cerebral ischemia/reperfusion (I/R) facilitates the activation of procaspase-3 and promotes apoptosis in hippocampus. But the mechanisms have remained uncharacterized. Protein S-nitrosylation and denitrosylation is an important reversible posttranslational modification, which is a common mechanism in signal tra...

journal_title：Cell death & disease

authors： Sun N,Hao JR,Li XY,Yin XH,Zong YY,Zhang GY,Gao C

更新日期：2013-08-15 00:00:00

abstract：:Chronic psychological stress has been demonstrated to play an important role in several severe diseases, but whether it affects disease therapy or not remains unclear. Mesenchymal stem cells (MSCs) have been demonstrated to have therapeutic potentials in treating tissue injury based on their multidifferentiation poten...

journal_title：Cell death & disease

authors： Yang X,Han ZP,Zhang SS,Zhu PX,Hao C,Fan TT,Yang Y,Li L,Shi YF,Wei LX

更新日期：2014-06-26 00:00:00

abstract：:Noncoding RNAs plays an important role in hepatocellular carcinoma (HCC). Here, we show that miR-124 was downregulated in HCC tissues and that the ectopic expression of miR-124 inhibited the proliferation and migration of HCC cells. We proposed that aquaporin 3 (AQP3) is a direct target of miR-124. AQP3 was upregulate...

journal_title：Cell death & disease

authors： Chen G,Shi Y,Liu M,Sun J

更新日期：2018-02-07 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Han X,Shi H,Sun Y,Shang C,Luan T,Wang D,Ba X,Zeng X

更新日期：2019-09-05 00:00:00

abstract：:Since publication of this paper, the authors have noticed that there were errors in Fig. 2A (the GAPDH of Mel-CV, Mel-CV.S, Mel-RMu and Mel-RMu.S), Fig. 2C (the GAPDH of Mel-CV.S and Mel-RMu.S), Fig. 3F (the GAPDH of Mel-CV.S and Mel-RMu.S), Fig. 3J(the GAPDH of Mel-RMu.S), Fig. 5C (the ERK1/2 of patient#3(post)), and...

journal_title：Cell death & disease

authors： Lei FX,Jin L,Liu XY,Lai F,Yan XG,Farrelly M,Guo ST,Zhao XH,Zhang XD

更新日期：2019-03-05 00:00:00

abstract：:Neonatal jaundice is prevalent among newborns and can lead to severe neurological deficits, particularly sensorimotor dysfunction. Previous studies have shown that bilirubin (BIL) enhances the intrinsic excitability of central neurons and this can potentially contribute to their overexcitation, Ca2+ overload, and neur...

journal_title：Cell death & disease

authors： Shi HS,Lai K,Yin XL,Liang M,Ye HB,Shi HB,Wang LY,Yin SK

更新日期：2019-10-10 00:00:00

abstract：:The oncogenic human papillomavirus (HPV) E6/E7 proteins are essential for the onset and maintenance of HPV-associated malignancies. Here, we report that activation of the cellular ubiquitin-proteasome system (UPS) by the omega-3 fatty acid, docosahexaenoic acid (DHA), leads to proteasome-mediated degradation of E6/E7 ...

journal_title：Cell death & disease

authors： Jing K,Shin S,Jeong S,Kim S,Song KS,Park JH,Heo JY,Seo KS,Park SK,Kweon GR,Wu T,Park JI,Lim K

更新日期：2014-11-13 00:00:00

abstract：:Pyroptosis is a highly inflammatory form of programmed cell death that is caused by infection with intracellular pathogens and activation of canonical or noncanonical inflammasomes. The purinergic receptor P2X7 is activated by the noncanonical inflammasome and contributes essentially to pyroptotic cell death. The Ca2+...

journal_title：Cell death & disease

authors： Ousingsawat J,Wanitchakool P,Schreiber R,Kunzelmann K

更新日期：2018-02-20 00:00:00

abstract：:Our recent study identified a list of differentially expressed microRNAs (miRNAs) in human prostate cancer (PCa) tissues compared to adjacent benign prostate tissues. In the current study, to identify the crucial miRNA-mRNA regulatory biomodule involved into prostate carcinogenesis based on the previous miRNA expressi...

journal_title：Cell death & disease

authors： Zhang Y,Jiang F,He H,Ye J,Mao X,Guo Q,Wu SL,Zhong W,Wu CL,Lin N

更新日期：2018-02-21 00:00:00

abstract：:The nuclear localization signal (NLS) in kinesin-14 KIFC1 is associated with nuclear importins and Ran gradient, but detailed mechanism remains unknown. In this study, we found that KIFC1 proteins have specific transport characteristics during cell cycle. In the absence of KIFC1, cell cycle kinetics decrease significa...

journal_title：Cell death & disease

authors： Wei YL,Yang WX

更新日期：2019-05-24 00:00:00

abstract：:GATA3 has emerged as a prominent transcription factor required for maintaining mammary-gland homeostasis. GATA3 loss is associated with aggressive breast cancer development, but the mechanism by which breast cancer is affected by the loss of GATA3 function remains unclear. Here, we report that GATA3 expression is posi...

journal_title：Cell death & disease

authors： Yu W,Huang W,Yang Y,Qiu R,Zeng Y,Hou Y,Sun G,Shi H,Leng S,Feng D,Chen Y,Wang S,Teng X,Yu H,Wang Y

更新日期：2019-11-04 00:00:00

abstract：:Current practices for the therapy of chondrosarcoma, including wide-margin surgical resection and chemotherapy, are less than satisfactory. Recently, emerging evidence has demonstrated that long non-coding RNAs (lncRNAs) have an essential role in the initiation and progression of tumors. As a typical lncRNA, HOTAIR is...

journal_title：Cell death & disease

authors： Bao X,Ren T,Huang Y,Sun K,Wang S,Liu K,Zheng B,Guo W

更新日期：2017-02-09 00:00:00

abstract：:In the healthcare sector, phytocompounds are known to be beneficial by contributing or alleviating a variety of diseases. Studies have demonstrated the progressive effects of phytocompounds on immune-related diseases and to exhibit anticancer effects. Graviola tree is an evergreen tree with its extracts (leafs and see...

journal_title：Cell death & disease

authors： Yiallouris A,Patrikios I,Johnson EO,Sereti E,Dimas K,De Ford C,Fedosova NU,Graier WF,Sokratous K,Kyriakou K,Stephanou A

更新日期：2018-07-09 00:00:00

abstract：:Bladder cancer (BCa) is the one of the most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates that DLK1-DIO3 genomic region especially the miRNA cluster in this region is involved in several pathologic processes and various cancers, and miR-323a-3p is a member of ...

journal_title：Cell death & disease

authors： Li J,Xu X,Meng S,Liang Z,Wang X,Xu M,Wang S,Li S,Zhu Y,Xie B,Lin Y,Zheng X,Liu B,Xie L

更新日期：2017-08-24 00:00:00

abstract：:Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but often acquire oncogenic gain-of-functions (GOFs). GOF manifests itself in accelerated tumor onset, increased metastasis, increased drug r...

journal_title：Cell death & disease

authors： Alexandrova EM,Mirza SA,Xu S,Schulz-Heddergott R,Marchenko ND,Moll UM

更新日期：2017-03-09 00:00:00

abstract：:B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. Bax is latent and monomeric in the cytosol but transforms into its lethal, mitochondria-embedded oligomeric form in response to cell stress, leading to the rele...

journal_title：Cell death & disease

authors： Xu XP,Zhai D,Kim E,Swift M,Reed JC,Volkmann N,Hanein D

更新日期：2013-06-20 00:00:00

abstract：:Protein acetylation has a crucial role in energy metabolism. Here we performed the first large-scale profiling of acetylome in rat islets, showing that almost all enzymes in core metabolic pathways related to insulin secretion were acetylated. Label-free quantitative acetylome of islets in response to high glucose rev...

journal_title：Cell death & disease

authors： Zhang Y,Zhou F,Bai M,Liu Y,Zhang L,Zhu Q,Bi Y,Ning G,Zhou L,Wang X

更新日期：2019-01-25 00:00:00

abstract：:Previous studies have shown that miR-203 is a skin-specific microRNA (miRNA) with a profound role in skin cell differentiation. However, emerging microarray and deep sequencing data revealed that miR-203 is also expressed in embryonic skeletal muscle and myoblasts. In this study, we found that miR-203 was transiently ...

journal_title：Cell death & disease

authors： Luo W,Wu H,Ye Y,Li Z,Hao S,Kong L,Zheng X,Lin S,Nie Q,Zhang X

更新日期：2014-07-17 00:00:00

abstract：:Synapsin I is a phosphoprotein that coats the cytoplasmic side of synaptic vesicles and regulates their trafficking within nerve terminals. Autoantibodies against Syn I have been described in sera and cerebrospinal fluids of patients with numerous neurological diseases, including limbic encephalitis and clinically iso...

journal_title：Cell death & disease

authors： Rocchi A,Sacchetti S,De Fusco A,Giovedi S,Parisi B,Cesca F,Höltje M,Ruprecht K,Ahnert-Hilger G,Benfenati F

更新日期：2019-11-14 00:00:00

abstract：:We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X(L) and MCL1 anti-apoptotic activity, using combined computational and experimental approaches. We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-X(L) expres...

journal_title：Cell death & disease

authors： Denoyelle C,Lambert B,Meryet-Figuière M,Vigneron N,Brotin E,Lecerf C,Abeilard E,Giffard F,Louis MH,Gauduchon P,Juin P,Poulain L

更新日期：2014-10-09 00:00:00

abstract：:DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoan Leishmania. We show that genetic inactivation of DDX3 leads ...

journal_title：Cell death & disease

authors： Padmanabhan PK,Zghidi-Abouzid O,Samant M,Dumas C,Aguiar BG,Estaquier J,Papadopoulou B

更新日期：2016-10-13 00:00:00

abstract：:Inflammation plays an important role in hypertensive cardiac injury. The endoplasmic reticulum (ER) stress pathway is involved in the inflammatory response. However, the role of ER stress in elevated angiotensin II (Ang II)-induced cardiac injury remains unclear. In this study, we investigated the role of ER stress in...

journal_title：Cell death & disease

authors： Li TT,Jia LX,Zhang WM,Li XY,Zhang J,Li YL,Li HH,Qi YF,Du J

更新日期：2016-06-09 00:00:00

abstract：:Primary liver cancer (PLC) may be mainly classified as the following four types: hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), hepatoblastoma (HB), and combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (cHCC-ICC). The majority of PLC develops in the background of tumor micr...

journal_title：Cell death & disease

authors： Wang G,Wang Q,Liang N,Xue H,Yang T,Chen X,Qiu Z,Zeng C,Sun T,Yuan W,Liu C,Chen Z,He X

更新日期：2020-05-04 00:00:00

abstract：:Protein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, we report the first ...

journal_title：Cell death & disease

authors： Bessa C,Soares J,Raimundo L,Loureiro JB,Gomes C,Reis F,Soares ML,Santos D,Dureja C,Chaudhuri SR,Lopez-Haber C,Kazanietz MG,Gonçalves J,Simões MF,Rijo P,Saraiva L

更新日期：2018-01-18 00:00:00

abstract：:Following publication of this article, it was brought to our attention that there was a typo in the References (reference number 43) whereby the first author's name was misspelled. The correct citation is provided below. We apologize for the inconvenience. ...

journal_title：Cell death & disease

authors： Wang LH,Baker NE

更新日期：2019-10-22 00:00:00