当前位置： SCI文献检索 > Cell Death & Disease期刊下所有文献 > Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.

Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.

Abstract：

:Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis. However, the underlying molecular mechanisms of NAMPT in these physiological and pathological processes are not fully understood. Here, we provide experimental evidence that a Nampt gene homozygous knockout (Nampt-/-) resulted in lethality at an early stage of mouse embryonic development and death within 5-10 days in adult mice accompanied by a 25.24±2.22% body weight loss, after the tamoxifen induction of NamptF/F × Cre mice. These results substantiate that Nampt is an essential gene for life. In Nampt-/- mice versus Nampt+/+ mice, biochemical assays indicated that liver and intestinal tissue NAD levels were decreased significantly; histological examination showed that mouse intestinal villi were atrophic and disrupted, and visceral fat was depleted; mass spectrometry detected unusual higher serum polyunsaturated fatty acid containing triglycerides. RNA-seq analyses of both mouse and human pediatric liver transcriptomes have convergently revealed that NAMPT is involved in key basic cellular functions such as transcription, translation, cell signaling, and fundamental metabolism. Notably, the expression of all eight enzymes in the tricarboxylic acid cycle were decreased significantly in the Nampt-/- mice. These findings prompt us to posit that adult Nampt-/- mouse lethality is a result of a short supply of ATP from compromised intestinal absorption of nutrients from digested food, which leads to the exhaustion of body fat stores.

journal_name

Cell Death Dis

journal_title

Cell death & disease

authors

Zhang LQ,Van Haandel L,Xiong M,Huang P,Heruth DP,Bi C,Gaedigk R,Jiang X,Li DY,Wyckoff G,Grigoryev DN,Gao L,Li L,Wu M,Leeder JS,Ye SQ

doi

10.1038/cddis.2017.132

subject

Has Abstract

pub_date

2017-03-23 00:00:00

pages

e2705

issue

3

issn

2041-4889

pii

cddis2017132

journal_volume

8

pub_type

杂志文章

相关文献

Cell Death & Disease文献大全
  • CD10-/ALDH- cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy.

    abstract：:It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the relationship between CS...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.379

    authors： Ffrench B,Gasch C,Hokamp K,Spillane C,Blackshields G,Mahgoub TM,Bates M,Kehoe L,Mooney A,Doyle R,Doyle B,O'Donnell D,Gleeson N,Hennessy BT,Stordal B,O'Riain C,Lambkin H,O'Toole S,O'Leary JJ,Gallagher MF

    更新日期：2017-10-19 00:00:00

  • Neutral lipids as early biomarkers of cellular fate: the case of α-synuclein overexpression.

    abstract：:α-synuclein (α-syn) accumulation and aggregation is a common pathological factor found in synucleinopathies, a group of neurodegenerative disorders that includes Parkinson´s disease (PD). It has been proposed that lipid dyshomeostasis is responsible for the occurrence of PD-related processes, however, the precise role...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03254-7

    authors： Alza NP,Conde MA,Scodelaro-Bilbao PG,Salvador GA

    更新日期：2021-01-07 00:00:00

  • A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy.

    abstract：:Abdominal Aortic aneurysm (AAA) is associated with chronic inflammation, cells apoptosis, and impairment of autophagy. BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-κB, as well as regulate autophagy. However, its...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-2326-2

    authors： Wu QY,Cheng Z,Zhou YZ,Zhao Y,Li JM,Zhou XM,Peng HL,Zhang GS,Liao XB,Fu XM

    更新日期：2020-02-18 00:00:00

  • p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo.

    abstract：:Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but often acquire oncogenic gain-of-functions (GOFs). GOF manifests itself in accelerated tumor onset, increased metastasis, increased drug r...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.80

    authors： Alexandrova EM,Mirza SA,Xu S,Schulz-Heddergott R,Marchenko ND,Moll UM

    更新日期：2017-03-09 00:00:00

  • Autoantibody against β1-adrenoceptor promotes the differentiation of natural regulatory T cells from activated CD4+ T cells by up-regulating AMPK-mediated fatty acid oxidation.

    abstract：:Therapeutic adoptive transfer of natural regulatory T cells (nTreg, CD4+ CD25+ Foxp3+ T cells) or in vivo selective expansion of nTreg cells has been demonstrated to improve the cardiac function in various cardiovascular disease models. The differentiation of nTreg cells is mediated by catecholamines via β1-adrenergic...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1209-2

    authors： Xu W,Wu Y,Wang L,Bai Y,Du Y,Li Y,Cao N,Zhao Y,Zhang Y,Liu H

    更新日期：2019-02-15 00:00:00

  • Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity.

    abstract：:Many cancer therapies are being developed for the induction of durable anti-tumor immunity, especially for malignant tumors. The activation of antigen-presenting cells (APCs), including macrophages and dendritic cells (DCs), can bridge innate and adaptive immune responses against tumors. However, APCs have an immunosu...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1459-7

    authors： He K,Jia S,Lou Y,Liu P,Xu LX

    更新日期：2019-03-04 00:00:00

  • Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids.

    abstract：:Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) poses a serious threat to the world's public health yet without a cure. Certain JEV-infected neural cells express a subset of previously identified intrinsic antiviral interferon stimulated genes (ISGs), indicating brain cells retain autonomous ant...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0763-y

    authors： Zhang B,He Y,Xu Y,Mo F,Mi T,Shen QS,Li C,Li Y,Liu J,Wu Y,Chen G,Zhu W,Qin C,Hu B,Zhou G

    更新日期：2018-06-18 00:00:00

  • RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4.

    abstract：:Long noncoding RNAs (lncRNAs) have been reported to be involved in a variety of human diseases, including cancers. However, their mechanisms have not yet been fully elucidated. We investigated lncRNA changes that may be associated with pancreatic cancer (PC) by analyzing published microarray data, and identified AGAP2...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1384-9

    authors： Hui B,Ji H,Xu Y,Wang J,Ma Z,Zhang C,Wang K,Zhou Y

    更新日期：2019-02-27 00:00:00

  • BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis.

    abstract：:TAF6δ is a pro-apoptotic splice variant of the RNA polymerase II general transcription factor, TAF6, that can dictate life vs. death decisions in animal cells. TAF6δ stands out from classical pro-apoptotic proteins because it is encoded by a gene that is essential at the cellular level, and because it functions as a c...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-017-0115-3

    authors： Delannoy A,Wilhelm E,Eilebrecht S,Alvarado-Cuevas EM,Benecke AG,Bell B

    更新日期：2018-01-22 00:00:00

  • The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

    abstract：:B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated apoptosis. We have investigated the structure and function of the least characterized Bcl-2 family member, Bcl-B, solving the crystal structure of a Bcl-B:Bim complex to 1.9 Å resolution. Bcl-B is distinguished from other Bcl-2 family ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2012.178

    authors： Rautureau GJ,Yabal M,Yang H,Huang DC,Kvansakul M,Hinds MG

    更新日期：2012-12-13 00:00:00

  • EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation.

    abstract：:Psoriasis is characterized by keratinocyte hyperproliferation. While significant progress has been made in understanding the molecular mechanism regulating the proliferation of keratinocytes, little is known about the epigenetic factors that control this process. EZH2 and EZH2 mediated trimethylation of histone H3 lys...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03028-1

    authors： Zhang T,Yang L,Ke Y,Lei J,Shen S,Shao S,Zhang C,Zhu Z,Dang E,Wang G

    更新日期：2020-10-03 00:00:00

  • Concomitant deletion of HRAS and NRAS leads to pulmonary immaturity, respiratory failure and neonatal death in mice.

    abstract：:We reported previously that adult (HRAS-/-; NRAS-/-) double knockout (DKO) mice showed no obvious external phenotype although lower-than-expected numbers of weaned DKO animals were consistently tallied after crossing NRAS-KO and HRAS-KO mice kept on mixed genetic backgrounds. Using mouse strains kept on pure C57Bl/6 b...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-2075-2

    authors： Fuentes-Mateos R,Jimeno D,Gómez C,Calzada N,Fernández-Medarde A,Santos E

    更新日期：2019-11-04 00:00:00

  • Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis.

    abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with poor survival. It is urgent to search for new efficient drugs with good stability and safety for clinical therapy. This study aims to identify potential anticancer drugs from a compound library consisting of 429 natural products....

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-2730-7

    authors： Hong P,Liu QW,Xie Y,Zhang QH,Liao L,He QY,Li B,Xu WW

    更新日期：2020-07-13 00:00:00

  • Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity.

    abstract：:The development of nephrotoxicity largely limits the clinical use of chemotherapy. MiRNAs are able to target various genes and involved in the regulation of diverse cellular processes, including cell apoptosis and death. Our study showed that miR-181a expression was significantly increased after 5-fluorouracil (5-FU) ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0677-8

    authors： Liu XY,Zhang FR,Shang JY,Liu YY,Lv XF,Yuan JN,Zhang TT,Li K,Lin XC,Liu X,Lei Q,Fu XD,Zhou JG,Liang SJ

    更新日期：2018-05-23 00:00:00

  • Amino-acid transporters in T-cell activation and differentiation.

    abstract：:T-cell-mediated immune responses aim to protect mammals against cancers and infections, and are also involved in the pathogenesis of various inflammatory or autoimmune diseases. Cellular uptake and the utilization of nutrients is closely related to the T-cell fate decision and function. Research in this area has yield...

    journal_title：Cell death & disease

    pub_type： 杂志文章,评审

    doi：10.1038/cddis.2016.222

    authors： Ren W,Liu G,Yin J,Tan B,Wu G,Bazer FW,Peng Y,Yin Y

    更新日期：2017-03-02 00:00:00

  • IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b.

    abstract：:Bone marrow mesenchymal stem cells (MSCs) have demonstrated therapeutic effects for colitis through immunomodulation and anti-inflammation. However, whether MSC-derived exosomes possessed the similar function remains unclear. In present study, exosomes were isolated from control and IFN-γ-primed MSCs and was verified ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02788-0

    authors： Yang R,Huang H,Cui S,Zhou Y,Zhang T,Zhou Y

    更新日期：2020-07-30 00:00:00

  • Axotomy induces axonogenesis in hippocampal neurons through STAT3.

    abstract：:After axotomy of embryonic hippocampal neurons in vitro, some of the axotomized axons lose their identity, and new axons arise and grow. This axotomy-induced axonogenesis requires importin, suggesting that some injury-induced signals are transported via axons to elicit axonogenesis after axotomy. In this study, we sho...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2011.59

    authors： Ohara R,Fujita Y,Hata K,Nakagawa M,Yamashita T

    更新日期：2011-06-23 00:00:00

  • MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion.

    abstract：:Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer's disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.243

    authors： Chen X,Jiang XM,Zhao LJ,Sun LL,Yan ML,Tian Y,Zhang S,Duan MJ,Zhao HM,Li WR,Hao YY,Wang LB,Xiong QJ,Ai J

    更新日期：2017-06-01 00:00:00

  • Correction: C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis.

    abstract：:The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information. ...

    journal_title：Cell death & disease

    pub_type： 已发布勘误

    doi：10.1038/s41419-018-0834-0

    authors： Jiang Q,Wang F,Shi L,Zhao X,Gong M,Liu W,Song C,Li Q,Chen Y,Wu H,Han D

    更新日期：2018-07-16 00:00:00

  • LncRNA UCA1 promotes tumor metastasis by inducing miR-203/ZEB2 axis in gastric cancer.

    abstract：:Increasing studies showed that long-noncoding RNAs (lncRNAs) play important roles in the biological processes, including cancer initiation and progression. However, little is known about the exact role and regulation mechanism of lncRNA UCA1 during the progression of gastric cancer (GC). In this study, we found that U...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1170-0

    authors： Gong P,Qiao F,Wu H,Cui H,Li Y,Zheng Y,Zhou M,Fan H

    更新日期：2018-11-21 00:00:00

  • Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells.

    abstract：:Mitochondrial reactive oxygen species (mtROS) homeostasis plays an essential role in preventing oxidative injury in endothelial cells, an initial step in atherogenesis. Resveratrol (RSV) possesses a variety of cardioprotective activities, however, little is known regarding the effects of RSV on mtROS homeostasis in en...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2014.530

    authors： Zhou X,Chen M,Zeng X,Yang J,Deng H,Yi L,Mi MT

    更新日期：2014-12-18 00:00:00

  • Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems.

    abstract：:Intrinsic apoptosis relies on the ability of the BCL-2 family to induce the formation of pores on the outer mitochondrial membrane. Previous studies have shown that both BAX and BAK are essential during murine embryogenesis, and reports in human cancer cell lines identified non-canonical roles for BAX and BAK in mitoc...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03002-x

    authors： Joshi P,Bodnya C,Rasmussen ML,Romero-Morales AI,Bright A,Gama V

    更新日期：2020-09-25 00:00:00

  • CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship.

    abstract：:The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic transcription factor NF-κB. Recently, missense mutations in CARMA2sh have been shown to cause...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.51

    authors： Scudiero I,Mazzone P,D'Andrea LE,Ferravante A,Zotti T,Telesio G,De Rubis G,Reale C,Pizzulo M,Muralitharan S,Vito P,Stilo R

    更新日期：2017-02-23 00:00:00

  • Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion.

    abstract：:The mitochondrial permeability transition pore (mPTP) plays a critical role in the pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although the pore structure is still unresolved, the mechanism through which cyclophilin D (CypD) regulates mPTP opening is the subject of intensive studies...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02864-5

    authors： Hurst S,Gonnot F,Dia M,Crola Da Silva C,Gomez L,Sheu SS

    更新日期：2020-08-19 00:00:00

  • MicroRNA-194 reciprocally stimulates osteogenesis and inhibits adipogenesis via regulating COUP-TFII expression.

    abstract：:Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells (MSCs) in processes which are tightly controlled by various growth factors, signaling molecules, transcriptional factors and microRNAs. Recently, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) was identified as a ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2014.485

    authors： Jeong BC,Kang IH,Hwang YC,Kim SH,Koh JT

    更新日期：2014-11-20 00:00:00

  • Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants.

    abstract：:Plant-derived dietary antioxidants have attracted considerable interest in recent past for their chemopreventive and cancer therapeutic abilities in animal models. Thymoquinone (TQ) is the major bioactive constituent of volatile oil of Nigella sativa and has been shown to exert various pharmacological properties, such...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2013.172

    authors： Zubair H,Khan HY,Sohail A,Azim S,Ullah MF,Ahmad A,Sarkar FH,Hadi SM

    更新日期：2013-06-06 00:00:00

  • Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke.

    abstract：:Endothelium (EC) is a key component of blood-brain barrier (BBB), and has an important position in the neurovascular unit. Its dysfunction and death after cerebral ischemic/reperfusion (I/R) injury not only promote evolution of neuroinflammation and brain edema, but also increase the risk of intracerebral hemorrhage o...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1716-9

    authors： Chen AQ,Fang Z,Chen XL,Yang S,Zhou YF,Mao L,Xia YP,Jin HJ,Li YN,You MF,Wang XX,Lei H,He QW,Hu B

    更新日期：2019-06-20 00:00:00

  • miR-302 regulates pluripotency, teratoma formation and differentiation in stem cells via an AKT1/OCT4-dependent manner.

    abstract：:Pluripotency makes human pluripotent stem cells (hPSCs) promising for regenerative medicine, but the teratoma formation has been considered to be a major obstacle for their clinical applications. Here, we determined that the downregulation of miR-302 suppresses the teratoma formation, hampers the self-renewal and plur...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.383

    authors： Li HL,Wei JF,Fan LY,Wang SH,Zhu L,Li TP,Lin G,Sun Y,Sun ZJ,Ding J,Liang XL,Li J,Han Q,Zhao RC

    更新日期：2016-01-28 00:00:00

  • Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1.

    abstract：:The acquisition of MDR1-mediated chemoresistance poses a major obstacle to the success of conventional chemotherapeutic agents. HSF1 is also involved in chemoresistance, and several studies have demonstrated the relationship between HSF1 and MDR1 but without any consistent results. Paclitaxel- and doxorubicin-resistan...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-2600-3

    authors： Mun GI,Choi E,Lee Y,Lee YS

    更新日期：2020-05-26 00:00:00

  • Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.

    abstract：:Although numerous pathogenic changes within the mitochondrial respiratory chain (RC) have been associated with an elevated occurrence of apoptosis within the affected tissues, the mechanistic insight into how mitochondrial dysfunction initiates apoptotic cell death is still unknown. In this study, we show that the spe...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.62

    authors： Schüll S,Günther SD,Brodesser S,Seeger JM,Tosetti B,Wiegmann K,Pongratz C,Diaz F,Witt A,Andree M,Brinkmann K,Krönke M,Wiesner RJ,Kashkar H

    更新日期：2015-03-12 00:00:00