Abstract：
OBJECTIVE:To assess Ankle-Foot-Orthosis (AFO) requirement and ambulation in Duchenne Muscular Dystrophy (DMD) patients seen over a period of 4 y at a multi-disciplinary Neuromuscular disorders clinic (NMD). METHODS:A study was conducted in university quaternary research hospital with DMD patients confirmed by MLPA (multiplex ligation - dependent probe amplification) method and were evaluated between January 2012 and December 2015. Their ambulatory status, detailed neurological and functional status were recorded. Requirement of AFOs was determined and provided. RESULTS:In total 126 DMD children reported to the NMD clinic. Mean age at presentation was 7.6 y (range 2 to12 y, SD 2.1). Mean duration of illness at first evaluation was 3.4 y (range 0.5 to 10 y, SD 2.0). AFO's were advised at a mean age of 8.5 y (range 7 to 12 y, SD 1.8). Fifty-nine patients were advised AFO as resting or walking splint. At last follow-up 113 patients were still ambulatory whereas 13 had become wheel chair bound. Out of 59 patients, 48 were still wearing AFOs and the remaining discontinued AFOs for various reasons. CONCLUSIONS:Children with DMD require wearing of AFOs as resting or walking splint, mostly in first or early second decade of life. As there is some gap between onset of clinical signs and requirement of orthosis, follow-up preferably at a multidisciplinary clinic at regular intervals is desirable for timely intervention in the form of AFOs or other splints to prolong ambulatory status in these patients.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Gupta A,Nalini A,Arya SP,Vengalil S,Khanna M,Krishnan R,Taly ABdoi
10.1007/s12098-016-2251-7subject
Has Abstractpub_date
2017-03-01 00:00:00pages
211-215issue
3eissn
0019-5456issn
0973-7693pii
10.1007/s12098-016-2251-7journal_volume
84pub_type
杂志文章abstract：:India currently has an infant mortality rate (IMR) of 73 and aims to reach 60 per 1000 live births by 2000 A.D. The "at risk" approach which has been traditionally used for Maternal and Child Health services could help to reduce costs. The main objective of the study was to identity socio-demographic "risk factors" at...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02859456
更新日期：2000-06-01 00:00:00
abstract：:Mutations in the gamma-aminobutyric acid type A receptor (GABRG2) gene have been associated with generalized epilepsy, childhood absence epilepsy and febrile seizures. In the present study the authors investigated the association of polymorphism of the GABRG2 with simple febrile seizures (FS) in Egyptian children. Pol...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0564-0
更新日期：2012-11-01 00:00:00
abstract：:Since the classic description of this disease by Harold Hirschsprung's. In 1886 just over a century ago, there has been a marked evolution in the diagnostic modalities, understanding of the pathophysiology, unraveling of genetic association and the treatment approach of this disease. Recent research on the molecular b...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02758486
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVES:To review the literature for justification of thoracoscopic management of blebs in children. METHODS:PubMed database was reviewed for articles in English, Portuguese and Spanish using the key words "thoracoscopy", "bleb" and "child". Data was collected for age, gender, type of surgery performed, operating t...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-017-2485-z
更新日期：2018-04-01 00:00:00
abstract：:HIV infection has profound effects on a patient's nutritional status because it can modulate appetite, nutrient absorption and basal metabolic rate. In addition, HIV infection can lead to the depletion of a variety of vitamins and micronutrients including vitamins A, D, B2, B6, B12, L-carnitine, iron, zinc and seleniu...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02730805
更新日期：1996-09-01 00:00:00
abstract：:In patients with Mycoplasma pneumonia extrapulmonary manifestations such as encephalitis, meningitis, cerebellar and brain stem involvement, cranial nerve lesions, peripheral neuropathy, polymyositis have been observed. We report a 16-year-old girl with M. pneumonia infection, acute behavioral changes and coma. Treatm...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02859473
更新日期：2000-06-01 00:00:00
abstract：:Various blood indices vary in a newborn as compared to older child or adult. It depends on the gestational age, day of life, maternal factors, mode of delivery and site of blood collection. Hemoglobin, HCT & MCV tend to be higher in newborns. They further increase in first 2 days of life. Reticulocytosis and presence ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02731037
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:To determine pulmonary function abnormalities in children with Sickle Cell Disease (SCD) from Western India. METHODS:In this cross sectional study conducted at Surat, Gujarat, India; equal number of age and gender matched children i.e., 99 in the age group of 6-18 y was recruited in case (children with SCD) ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-016-2065-7
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVES:To study the duration of the peripheral venous catheter access and the effect of variables such as intravenous fluid, medications and blood products on the life span of the catheter in authors' pediatric intensive care unit. METHODS:All peripheral intravenous lines established in sick children aged 1 mo to ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1430-7
更新日期：2014-12-01 00:00:00
abstract：:Systemic hypertension is not usually a complication following repair of total anomalous pulmonary venous connection (TAPVC). We report an infant with supracardiac TAPVC with hypertensive crises post-operatively resulting in pulmonary edema. We feel this might have been related to the pre-operative hemodynamics as desc...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0150-x
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVES:To study the etiology and burden of comorbidities across stages of chronic kidney disease (CKD). METHODS:Children, 2-16 y of age with CKD Stages II- IV were recruited over 12 mo. The etiology, clinical presentation and severity of complications were studied. RESULTS:Among 78 children [Stage II (n = 21), St...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-017-2413-2
更新日期：2017-11-01 00:00:00
abstract：:Approximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, the majority of childhood TB cases a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-018-02846-8
更新日期：2019-08-01 00:00:00
abstract：:Thirty patients below the age of 15 years (range 8-1/2 to 15 years, mean 11.8 years) have been studied for the severity of rheumatic mitral regurgitation. Moderately severe to severe pulmonary venous hypertension was found in 76.6% and pulmonary arterial hypertension in 60%. Left ventricular volumes could be calculate...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02832994
更新日期：1992-09-01 00:00:00
abstract：:Functional follicular ovarian cysts are frequently reported in girls with peripheral precocious puberty (PP). These cysts are usually self-limiting and resolve spontaneously. Several drugs like antiestrogens (tamoxifen) and new aromatase inhibitors are seldom used for treatment. Here we report a girl with peripheral P...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0190-2
更新日期：2009-09-01 00:00:00
abstract：:Fever with rashes is one of the commonest clinical problems a general practitioner or pediatrician has to face in day-to-day clinical practice. It can be a mild viral illness or a life-threatening illness like meningococcemia or Dengue hemorrhagic fever or it can be one with a lifelong consequence like Kawasaki diseas...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-017-2459-1
更新日期：2018-07-01 00:00:00
abstract：:Surgical treatment for congenital heart disease has become available over the last five decades. Palliative procedures have been designed to improve physiologic abnormalities, for example systemic artery (or venous) to pulmonary artery shunts of various types to increase the pulmonary blood flow, pulmonary artery cons...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02820180
更新日期：1991-09-01 00:00:00
abstract：OBJECTIVES:To compare early child care practices at home as possible risk factors among children between 2 and 6 y of age with autism and a control group of normal children without any symptom of autism, presenting at the well-baby/immunization clinic. METHODS:This case control study was undertaken at the autism clini...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1602-5
更新日期：2014-12-01 00:00:00
abstract：:The combination of arthrogryposis multiplex congenita and osteogenesis imperfecta is extremely rare. This combination is named Bruck syndrome. A 34 week male baby weighing 1.7 kg at birth was noted to have multiple flexion contractures and pterygia at elbows, wrists and knees, in addition to right foot talipes equinov...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02731745
更新日期：2005-05-01 00:00:00
abstract：:Hypocalcemia is a rare, but reversible, cause of congestive heart failure. We report a 4-month-old boy diagnosed as dilated cardiomyopathy who had prolonged QoTc with low blood levels of calcium, normal phosphate, elevated alkaline phosphatase and findings suggestive of rickets. In view of non response to calcium and ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723209
更新日期：2001-03-01 00:00:00
abstract：:Pediatric soft tissue sarcomas (STS) are a heterogeneous group of malignant tumors constituting about 7% of all cancer cases. Rhabdomyosarcomas (RMS) constitute about half of all soft tissue sarcomas in children, the rest being constituted by non- rhabdomyosarcoma soft tissue sarcomas (NRSTS). Most RMS present in youn...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-011-0560-4
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVES:To evaluate if cardiac dysfunctions are important in assessing the outcome in newborns with Bronchopulmonary Dysplasia (BPD), by evaluating cardiac functions with N-terminal prohormone of brain natriüretic peptide (NT-proBNP) levels, M-mode and tissue doppler echocardiography at 6-12 mo of age. METHODS:Twen...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-013-0994-y
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To present evaluation of a quality improvement program for Accredited Social Health Activists (ASHAs). METHODS:This community intervention trial was conducted in Ballabgarh, India during 2012-2014 with two Primary Health Center (PHC) areas being the intervention areas and two PHC areas being non-intervention...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03012-4
更新日期：2019-11-01 00:00:00
abstract：:A detailed information on a total of 448 consecutive Nepali births which occurred between January 1, 1985 and December 31, 1994 was collected from the birth registers of the Khasi-Jaintia Presbetyrian Synod Hospital of Shillong, Meghalaya. After the exclusion of still and twin births, and the cases of missing informat...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02760471
更新日期：2000-07-01 00:00:00
abstract：:Harlequin fetus is the severe form of congenital ichthyosis. There are very few reports of babies with this condition surviving the first few weeks of life. We treated two siblings who lived for 22 months and six weeks respectively. We started treatment with oral etretinate every early in their lives and achieved good...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02752311
更新日期：1998-03-01 00:00:00
abstract：:Diabetic ketoacidosis is the most common endocrine emergency in children and frequently it is the initial presentation of insulin dependent diabetes mellitus. Despite sophisticated technology and our improved understanding of the pathophysiology of this disease, the mortality from intracranial complications remains co...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02795773
更新日期：1997-01-01 00:00:00
abstract：:Advances in diagnosis and treatment along with improved supportive care have contributed to the current survival rates for pediatric malignancies. Recent concept of a truly "cured child" in pediatric oncology envisages not only a biological cure of the disease but a child on par with peers in growth and development ph...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723807
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:To investigate obesogenic co-causing factors, promoting rise of weight in children, associated to local differences in India. METHODS:Overall 1,680 children, aged 3-11 and balanced by gender, were recruited in school contexts distributed in seven major Indian cities. All children were weighted and measured i...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1550-0
更新日期：2014-09-01 00:00:00
abstract：:Recurrent Guillain-Barre Syndrome is a rare condition. IVIg and plasmapheresis are costly therapies and may not be affordable. We report a 6-yr-old boy in whom two severe episodes of Guillain-Barre Syndrome were successfully treated by exchange transfusion. Possible explanation for its effectiveness is discussed with ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-007-0122-y
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:To determine the safety and efficacy of off label usage of Recombinant activated factor VII (rFVIIa) in children with severe bleeding in non-hemophiliac children with diverse etiologies like leukemia, post hematopoietic stem cell transplantation, dengue shock syndrome and Glanzmann thrombasthenia. METHOD:Med...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0364-6
更新日期：2011-08-01 00:00:00
abstract：:Resistance to antimicrobial agents, which was recognized more than 50 years, continues to be a major cause of increased morbidity, mortality and health care cost. Overuse of antibiotics is considered the major contributing factor; however, poor implementation of infection control measures, prolonged hospitalization, a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02724275
更新日期：2004-03-01 00:00:00
