Chronic Kidney Disease (CKD): An Observational Study of Etiology, Severity and Burden of Comorbidities.

Abstract:

OBJECTIVES:To study the etiology and burden of comorbidities across stages of chronic kidney disease (CKD). METHODS:Children, 2-16 y of age with CKD Stages II- IV were recruited over 12 mo. The etiology, clinical presentation and severity of complications were studied. RESULTS:Among 78 children [Stage II (n = 21), Stage III (n = 26), Stage IV (n = 31)], congenital anomalies of the kidney and urinary tract (CAKUT) was the commonest etiology and 28 were newly diagnosed in Stage III /IV. High prevalence of comorbidities was observed with growth retardation (65%), hypertension (59%), hyperphosphatemia (32%), vitamin D deficiency (92%), dyslipidemia (64%), left ventricular hypertrophy (45%) and hyperparathyroidism (56%). While most comorbidities correlated with the estimated glomerular filtration rate and severity of CKD, hypertension, vitamin D deficiency and cardiovascular morbidity were prevalent even in early stages. CONCLUSIONS:CAKUT was the commonest cause of CKD. Late detection and high prevalence of comorbidities even in early stages of CKD were observed.

journal_name

Indian J Pediatr

authors

Kamath N,Iyengar AA

doi

10.1007/s12098-017-2413-2

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

822-825

issue

11

eissn

0019-5456

issn

0973-7693

pii

10.1007/s12098-017-2413-2

journal_volume

84

pub_type

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