Abstract:
:This review is to summarize recent developments in the field of mycobacteriology since the diagnosis of tuberculosis remains elusive in spite of our best efforts and great scientific advances. Progress has been made in further improving upon the age old, time tested traditional techniques like microscopy (Auramine-Rhodamine Fluorescent staining and peptide nucleic acids), culture and sensitivity techniques (solid, liquid, radiometric, and non-radiometric systems) that still remain as the gold standard for its diagnosis. Development of rapid methods [(high performance liquid chromatography, thin layer chromatography, RNA sequencing and polymerase chain reaction (PCR), nucleic acid sequence based amplification assay (NASBA), Transcription mediated assay (TMA) and Ligase chain reaction (LCR)] have paved the way for its rapid detection and treatment. It is interesting to see the role of molecular assays appearing more often in literature now. The molecular amplification systems (PCR, NASBA, TMA, LCR) besides identifying Mycobacterium tuberculosis (MTB) as well as non-tuberculous mycobacteria (NTM), directly from the sample can also identify Rifampin (rpoB gene)/Isoniazide (katG gene) resistant strain. Molecular assays have been found useful particularly in smear positive sputum with high sensitivity and specificity whereas variable sensitivity for sputum negative and extra pulmonary specimens has been observed. Representative specimen and its quality affect the performance of these assays. Emphasis should given to proper collection and transportation of the representative specimen for appropriate evaluation.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Wattal Ckeywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
S11-9eissn
0019-5456issn
0973-7693journal_volume
69 Suppl 1pub_type
杂志文章abstract:OBJECTIVES:To screen for variants in the MC4R and LEP genes in 46 patients with clinical suspicion of non-syndromic early onset severe obesity (NEOSO). METHODS:Children with early onset obesity satisfying WHO criteria of obesity were studied. The MC4R and LEP genes were sequenced using a PCR amplicon based NGS on Illu...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-019-03129-6
更新日期:2020-02-01 00:00:00
abstract::Celiac disease may present as a cryptogenic liver disorder being found in 5-10 % of patients with a persistent and cryptogenetic elevation of serum aminotransferase activity. In fact, a wide spectrum of liver injuries in children and adults may be related to CD and in particular: (1) a mild parenchymal damage characte...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02790391
更新日期:2006-09-01 00:00:00
abstract::Bone marrow transplantations have a definite role in treatment of leukemias and lymphomas. In acute myeloid leukemia and CML an allogeneic transplant using an HLA identical donor certainly provides a far superior survival than chemotherapy. Patients with Ph' chromosome need to be transplanted in first remission if a s...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02751432
更新日期:1993-07-01 00:00:00
abstract::Laboratory investigations are an integral part of evaluation of a child with rheumatic disease. In rheumatic diseases markers of inflammation like CRP and erythrocyte sedimentation are usually raised. In addition, various autoantibodies like anti-nuclear antibody, rheumatoid factor, anti-neutrophil cytoplasmic antibod...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723714
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVE:To assess the trends and outcomes in referrals of 'phimosis for circumcision' to a tertiary care pediatric surgical department. METHODS:This is a prospective study of 100 consecutive children of presumed phimosis referred for circumcision. They were assessed and classified by the senior author as having eith...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-009-0120-3
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:To compare early child care practices at home as possible risk factors among children between 2 and 6 y of age with autism and a control group of normal children without any symptom of autism, presenting at the well-baby/immunization clinic. METHODS:This case control study was undertaken at the autism clini...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1602-5
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of an MRI-specific play therapy intervention on the need for sedation in young children. METHODS:All children in the age group of 4-10 y, who were advised an MRI scan over a period of one year were randomized. Exclusion criteria included children with neurodevelopmental disorder...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12098-015-1917-x
更新日期:2016-03-01 00:00:00
abstract::A 5-year-old child presented with the second episode of meningitis when we started investigating her to find a cause for recurrent episode of meningitis. During this she suffered from a third attack after which she was diagnosed as having isolated C(3) deficiency. She was put on penicillin prophylaxis and vaccinated a...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-009-0036-y
更新日期:2009-01-01 00:00:00
abstract::Other investigators have found that in adults the Serum-Ascites Albumin Gradient (SAAG) to be 1.1 g/dl or greater in the presence of portal hypertension (PTHN) and less than that in its absence. We sought to determine the correlation between the level of SAAG and the complications of PTHN, manifested by the presence o...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723242
更新日期:2001-06-01 00:00:00
abstract::Till forty years ago infants and children with hydrocephalus had a bleak future. Most of them used to die. Those who survived lived with mental retardation, spasticity and blindness. With the advent of an effective shunting device in 1957, a new era was ushered in the history of hydrocephalus. Today an infant with hyd...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1997-11-01 00:00:00
abstract::Multiple choice questions have come to occupy a prominent place in the evaluation system of medical education. However the framing of multiple choice questions and their effective use need further clarification in the Indian context. This paper outlines some of the steps that may be adopted for streamlining the prepar...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02749710
更新日期:1989-01-01 00:00:00
abstract::A 29 day old male infant presented with a history of fever, cough, increasing respiratory distress and abdominal distension from the 10th day of life. Examination revealed failure to thrive, marked tachypnea, pallor, hepatosplenomegaly and harsh vesicular breath sounds. Chest skiagram showed extensive broncho-pneumoni...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02752376
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To find out the incidence and natural history of IgMN in India. METHODS:Renal biopsies of children ≤12 y age of last 6 y were retrospectively evaluated. Their clinical and biochemical presentation were correlated. Patients with systemic diseases/disorders were excluded from the study. RESULTS:Immunoglobulin...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-012-0693-0
更新日期:2012-08-01 00:00:00
abstract::India currently has an infant mortality rate (IMR) of 73 and aims to reach 60 per 1000 live births by 2000 A.D. The "at risk" approach which has been traditionally used for Maternal and Child Health services could help to reduce costs. The main objective of the study was to identity socio-demographic "risk factors" at...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02859456
更新日期:2000-06-01 00:00:00
abstract::Psychosocial and mental health problems are quite prevalent among adolescent worldwide, some data reporting up to 20% of adolescents having such problems. A number of risk factors, familial, individual and societal, have been indentified as contributing to these problems in adolescents. There are also many factors, su...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723793
更新日期:2003-10-01 00:00:00
abstract::Iron overload is a serious and potentially fatal condition that results from multiple blood transfusions required over a long period of time to treat certain types of anemias such as, that caused by beta-thalassemia, sickle cell disease and myelodysplastic syndrome. Deferoxamine, which has been used since four decades...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-010-0030-4
更新日期:2010-02-01 00:00:00
abstract::The clinical disappearance of the murmur of rheumatic mitral regurgitation after period of time has been documented by many researchers. However no studies have related the disappearance of the murmur with the functional or anatomical state of the mitral valve. This study was done to elucidate the mitral valve status ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02825126
更新日期:1995-11-01 00:00:00
abstract::There is increased interest in the surgical management of epilepsy in children in the last decade or two. The plasticity of the developing brain and realization of the deleterious effects of uncontrolled seizures on the brain have prompted earlier surgery where indicated. All patients with uncontrolled partial seizure...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::Allergic rhinitis (AR) and asthma are common respiratory allergic disorders which are increasing globally more in developed countries. Although much has been written about childhood asthma and guidelines published by various international and national fora, not much information is available on AR. This is most common ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02734233
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:Acute respiratory infection is a leading cause of morbidity and mortality in under five children in developing countries. Hence, the present study was undertaken to identify various modifiable risk factors for acute lower respiratory tract infections (ALRI) in children aged 1 mth to 5 yr. METHODS:104 ALRI ca...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-007-0081-3
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To study the prevalence of celiac disease in Indian children with Down syndrome and evaluate its clinical and laboratory predictors. METHODS:Prevalence of celiac disease (CD) was assessed in 100 patients with Down syndrome (DS) attending pediatric genetic clinic at All India Institute of Medical Sciences,in ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-012-0838-1
更新日期:2013-02-01 00:00:00
abstract::Functional abdominal pain (FAP) is one of the most common functional gastrointestinal disorders (FGIDs) of childhood. Only a minority of patients with FAP seek medical attention, often presenting to the primary care physician while symptoms are still evolving. The bio-psychosocial model of treatment not only aims to a...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-016-2111-5
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To measure the economic output/input ratios for the various options of prevention of rheumatic fever/rheumatic heart disease (RF/RHD) and check the viability of primary prevention vis-à-vis secondary and tertiary preventions. METHODS:Cost accounting of the various prevention options was calculated for each v...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-007-0094-y
更新日期:2007-06-01 00:00:00
abstract::High dose vitamin A (HDVA) concentrate began to be distributed in India in 1970 as a short-term, stop-gap approach to reduce clinical signs of vitamin A deficiency. As this problem declined globally, the purpose of distributing them changed to the reduction of young child mortality. However, their impact on this has a...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-018-02851-x
更新日期:2019-06-01 00:00:00
abstract::The clinical presentation of pseudohypoaldosteronism (PHA) mimics congenital adrenal hyperplasia (CAH). Poor response of the dehydration and electrolyte abnormalities to steroid therapy should make one suspect PHA. The treatment is supportive in the form of salt replacement and sodium resonium. We report a case of PHA...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02758269
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Screen for Child Anxiety Related Emotional Disorders (SCARED), a measure found useful in different settings and cultures has not been validated in the subcontinent. This study validated this measure for identifying Anxiety Disorder (AD) among adolescents in an Indian community context. METHODS:Five hundred a...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-013-1233-2
更新日期:2013-11-01 00:00:00
abstract::Anti-fungal agents are classified under two major headings, systematic and topical agents. Only systematic anti-fungal agents will be discussed in this chapter. Since the discovery in 1955, amphotericin B has been the cornerstone of anti-fungal treatment. It is active against most species of fungi. However, Candida lu...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02752281
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the presentation, treatment and outcome of testicular tumors in undescended testes (UDT) in boys below 5 y of age. METHODS:Case records of boys below 5 y of age, diagnosed to have germ cell tumors (GCT) in the UDT were reviewed. RESULTS:Seven children in the age range of 05-54 mo (mean 26 mo) we...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1667-1
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:To find out various life stressors of adolescents, coping strategies adopted by them and the impact of stress on adolescent mental health. METHODS:A descriptive, cross sectional study was conducted in the schools in south zone of Delhi, capital city of the country. Data was collected on 360 adolescents betwe...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-015-1710-x
更新日期:2015-09-01 00:00:00
abstract::Locked-in syndrome is characterized by upper motor neuron quadriplegia, paralysis of lower cranial nerves, bilateral horizontal gaze palsy and anarthria, with preserved consciousness. It is due to a ventral pontine lesion following a basilar artery occlusion. We report the first Indian case report of locked-in syndrom...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-009-0200-4
更新日期:2009-10-01 00:00:00