Abstract:
OBJECTIVE:Fractures of the thoracolumbar spine can cause pain, long-term reductions in quality of life (QOL), and neural deficits. The aim of this study was to investigate the effects of methylene blue (MB) on preventing postoperative pain and improving QOL in patients with throracolumbar fractures undergoing posterior pedicle screw fixation. METHODS:Fifty patients underwent standard posterior pedicular screw fixation for stabilization of the thoracolumbar fractures: 25 received 1ml of MB solution at a concentration of 0.5% and 25 received normal saline on the soft tissue around fusion site. Primary outcomes were the control of pain, evaluated at 48h, 2 and 6 months after surgery with the use of a visual analog scale (VAS), and the improvement of QOL, assessed 2 and 6 months postoperatively by means of Oswestry Disability Index (ODI) questionnaire. RESULTS:The mean VAS scores for pain were significantly lower in the MB group compared with the control group at 2 months (1.30±0.45 vs. 2.60±1.19, P<0.001) and 6 months (1.17±0.37 vs. 1.60±0.87; P=0.028) after treatment. At 2 months after the surgery, the mean ODI score was significantly lower in the MB-treated patients than the control group (20.4±10.92 vs. 34.8±15.11; P=0.001). The ODI score in the MB-treated patients was better than the control group at 6 months after the surgery (12.2±11.66 vs. 20.8±11.14; P=0.016). CONCLUSION:A single dose of MB on the soft tissue around fusion site shows promising results in terms of safety, reduction of postoperative pain, and functional results when compared with placebo 6 months after surgery.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Farrokhi MR,Yazdanpanah H,Gholami M,Farrokhi F,Mesbahi ARdoi
10.1016/j.clineuro.2016.08.018subject
Has Abstractpub_date
2016-11-01 00:00:00pages
6-12eissn
0303-8467issn
1872-6968pii
S0303-8467(16)30302-Xjournal_volume
150pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Little information is available on Asian patients over 80 years with stroke. We aimed to investigate characteristics of the very elderly ischemic stroke hospitalized patients in China. METHODS:We prospectively enrolled consecutive patients with acute ischemic stroke from March, 2002 to October, 2008 into th...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2011.01.005
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abstract::Hypothalamic hamartomas (HH) are rare, non-neoplastic heterotopic tissues which contains normal neurons and glia including oligodendrocytes and fibrillary astrocytes but in an abnormal distribution. They arise from the floor of the third ventricle, tuber cinereum, or mammillary bodies. Estimated incidence ranges from ...
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abstract::Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetically heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) ...
journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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doi:10.1016/j.clineuro.2008.08.006
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abstract::We reviewed computerized tomograms (CT) for basal ganglia and dentate nucleus calcifications in 79 patients with Parkinson's disease (PD), 54 patients with Alzheimer's disease (AD) and 109 controls aged 50 or more. When it was determined, no patient had disturbances in calcium metabolism. We found: (1) 30 subjects out...
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-09-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00