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Whipple's disease and the central nervous system. A case report and a review of the literature.

Abstract：

:A 65-year-old man was suffering from recurrent manic psychosis accompanied by weight loss. He also had a history of pleural effusion, aspecific migratory non-deforming seronegative polyarthritis, sensorineural hearing loss and semicircular canal paresis. Whipple's disease (WD) had been diagnosed at the age of 63 years. On admission to hospital) he had weight loss, diarrhoea in combination with an organic brain syndrome, hemiparesis and ophthalmoplegia, including internuclear ophthalmoplegia (INO). A clinical diagnosis of central nervous system (CNS) WD was made. MRI revealed a thalamus lesion that halved in size during sulfamethoxazole-trimethoprim treatment. The organic brain syndrome and ophthalmoplegia diminished also, as did the cerebrospinal fluid (CSF) IgG level. A review of CNS WD is presented and implications for treatment are discussed.

journal_name

Clin Neurol Neurosurg

journal_title

Clinical neurology and neurosurgery

authors

Verhagen WI,Huygen PL,Dalman JE,Schuurmans MM

doi

10.1016/0303-8467(96)00035-2

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

299-304

issue

4

eissn

0303-8467

issn

1872-6968

pii

0303846796000352

journal_volume

98

pub_type

杂志文章,评审

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