Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence.

Abstract:

:The dopamine transporter (DAT) plays a crucial role in the pathogenesis of alcohol dependence (AD) and major depression (MD), and males have more risk factors for the development of AD. However, imaging studies on brain DAT availability in males with AD comorbid with MD (AD/MD) are limited, and the association of DAT availability with cognitive function and depressive scores in patients with AD/MD has not been analyzed. Hence, this study examined the relationship between brain DAT availability, cognitive function, and depressive symptoms in different subgroups of males with AD.Single-photon emission computed tomography imaging with Tc-TRODAT-1 as a ligand was used to measure striatal DAT availability in 49 patients with AD (28 pure AD and 21 AD/MD) and 24 age- and sex-matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and 17-item Hamilton Depression Rating Scale were used to assess neurocognitive function and depressive scores, respectively. Patients with AD showed a significant reduction of DAT availability in 3 brain regions (P < 0.001), and this reduction was more pronounced in the patients with pure AD compared to healthy controls. The patients with AD showed significantly poorer performance on the WCST, but only in the control group was DAT availability significantly negatively correlated with total errors and perseverative errors (P < 0.001).These preliminary findings suggest that DAT availability is associated with neurocognitive function, and incongruent reduction of DAT may play a pathophysiological role in different subgroups of AD. In addition, decreased DAT availability may be associated with the severity of depressive symptoms in patients with AD/MD.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Yen CH,Shih MC,Cheng CY,Ma KH,Lu RB,Huang SY

doi

10.1097/MD.0000000000004048

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

e4048

issue

33

eissn

0025-7974

issn

1536-5964

pii

00005792-201608160-00002

journal_volume

95

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Laparoscopic hepatectomy for elderly patients: Major findings based on a systematic review and meta-analysis.

    abstract:BACKGROUND:As the general population continues to age, there is an increase need for surgical management of elderly patients. Compared to open hepatectomy (OH), laparoscopic hepatectomy (LH) offers earlier mobilization, less blood loss, and shorter postoperative hospital stay. However, whether these advantages of LH ov...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000011703

    authors: Chen K,Pan Y,Maher H,Zhang B,Zheng XY

    更新日期:2018-07-01 00:00:00

  • Risk Factors for Diabetes Mellitus in Chronic Pancreatitis: A Cohort of 2,011 Patients.

    abstract::Diabetes mellitus (DM) is a common complication of chronic pancreatitis (CP) and increases the mortality. The identification of risk factors for DM development may contribute to the early detection and potential risk reduction of DM in patients with CP.Patients with CP admitted to Changhai Hospital (Shanghai, China) f...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003251

    authors: Pan J,Xin L,Wang D,Liao Z,Lin JH,Li BR,Du TT,Ye B,Zou WB,Chen H,Ji JT,Zheng ZH,Hu LH,Li ZS

    更新日期:2016-04-01 00:00:00

  • Association Between Obesity and Falls Among Korean Adults: A Population-Based Cross-Sectional Study.

    abstract::The objective of this study was to evaluate the association between falls and obesity using Asian body mass index (BMI) classifications. Using the data from the Korean community health survey in 2011, a total of 229,226 participants ranging from 19 to 106 years old were included in this study. The BMI groups were clas...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003130

    authors: Kim SY,Kim MS,Sim S,Park B,Choi HG

    更新日期:2016-03-01 00:00:00

  • Healthcare access for autistic adults: A systematic review.

    abstract:BACKGROUND:People with autism spectrum disorder (ASD) have an increased susceptibility for many chronic health conditions compared with their peers. An increasing number of adolescents are transitioning from pediatric to adult healthcare services. Thus, being able to access appropriate healthcare services that can not ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020899

    authors: Calleja S,Islam FMA,Kingsley J,McDonald R

    更新日期:2020-07-17 00:00:00

  • Molecular profiling of the colon cancer in South-Eastern Romania: Results from the MERCUR study.

    abstract:ABSTRACT:Colorectal cancer is a heterogeneous disease with multiple epigenetic alterations and different molecular features. The molecular classification is based on 2 major distinct pathways: microsatellite stable pathway and the microsatellite instability pathway. Molecular profiling of colorectal cancer provides imp...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000024062

    authors: Popescu RC,Tocia C,Brînzan C,Cozaru GC,Deacu M,Dumitru A,Leopa N,Mitroi AF,Nicolau A,Dumitru E

    更新日期:2021-01-08 00:00:00

  • Chinese medicine treatment of mastitis in COVID-19 patients: A protocol for systematic review.

    abstract:BACKGROUND:Assessing the effectiveness and safety of Chinese medicine for the mastitis in COVID-19 patients is the main purpose of this systematic review protocol. METHODS:The following electronic databases will be searched from inception to April 2020: MEDLINE, Ovid, EMBASE, the Cochrane Library, the Allied and Compl...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021656

    authors: Wen D,Shi Y,Zhang X,Lv G

    更新日期:2020-08-28 00:00:00

  • Long term follow-up in a patient with prune-belly syndrome - a care compliant case report.

    abstract:RATIONALE:Malformative uropathies represent a major cause of Chronic Kidney Disease (CKD) in children. Genitourinary system is the most frequent and sever affected in Prune-Belly syndrome cases. That is why the findings of early diagnosis and vigilant monitoring for these situations remain a major challenge for the med...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016745

    authors: Cornel A,Duicu C,Delean D,Bulata B,Starcea M

    更新日期:2019-08-01 00:00:00

  • Microhardness distribution of the tibial diaphysis and test site selection for reference point indentation technique.

    abstract::Indentation hardness test is a good in vitro method of bone quality assessment. The purpose of this study is to explore the distribution characteristics of bone tissue microhardness in tibial diaphysis and provide theoretical support for the test site selection of the reference point indentation technique.Three fresh ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016523

    authors: Wang J,Yin B,Liu G,Li S,Zhang X,Hu Z,Wu W,Zhang Y

    更新日期:2019-07-01 00:00:00

  • Treatment of atrial fibrillation with third-degree atrioventricular block by pacing His bundle and left bundle branch: Case report.

    abstract:INTRODUCTION:Substantial advances in cardiac pacing technology have been developed in the past decades. However, efforts to improve pacing technology to achieve physiological electrical activity, such as with cardiac resynchronization therapy, are underway. Permanent His bundle pacing, which directly stimulates the His...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021097

    authors: Zhang D,Huang X

    更新日期:2020-08-14 00:00:00

  • Associations of daily sleep duration and dietary macronutrient consumption with obesity and dyslipidemia in Koreans: A cross-sectional study.

    abstract::Daily sleep duration is known to be associated with obesity and dyslipidemia.This study was performed to examine the interactions between daily sleep duration and the risks of obesity and dyslipidemia according to dietary macronutrient consumption in 14,680 Korean adults using the 5th Korean National Health and Nutrit...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005360

    authors: Doo H,Chun H,Doo M

    更新日期:2016-11-01 00:00:00

  • Association between the A46G polymorphism (rs1042713) in the β2-adrenergic receptor gene and essential hypertension susceptibility in the Chinese population: A PRISMA-compliant meta-analysis.

    abstract:BACKGROUND:Recently, many studies have been conducted to investigate the relationship between the A46G polymorphism in the β2-adrenergic receptor (ADRB2) gene and essential hypertension risk in the Chinese population. However, the results of previous studies were conflicting. OBJECTIVES:The present study aimed to inve...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000023164

    authors: Yan L,Wang H,Liu P,Wang M,Chen J,Zhao X

    更新日期:2020-11-13 00:00:00

  • The effect of platelet-rich plasma on reducing blood loss after total knee arthroplasty: A systematic review and meta-analysis.

    abstract:BACKGROUND:Efficacy and safety of platelet-rich plasma (PRP) compared with control for preventing postoperative bleeding after total knee arthroplasty (TKA) is controversial. We performed a meta-analysis of randomized controlled trials (RCTs) to determine whether PRP might reduce blood loss and improve function followi...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000007262

    authors: Ma J,Sun J,Guo W,Li Z,Wang B,Wang W

    更新日期:2017-06-01 00:00:00

  • CTLA-4 methylation regulates the pathogenesis of myasthenia gravis and the expression of related cytokines.

    abstract:BACKGROUND:Myasthenia gravis (MG) is a progressive autoimmune disease that occurs as a result of the failure of neuromuscular transmission and is characterized by muscle weakness. There has been evidence on the correlations between the genetic predisposition of cytotoxic T lymphocyte and the antigen-4 (CTLA-4) and MG. ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010620

    authors: Fang TK,Yan CJ,Du J

    更新日期:2018-05-01 00:00:00

  • Metallic artifact reduction by evaluation of the additional value of iterative reconstruction algorithms in hip prosthesis computed tomography imaging.

    abstract::To evaluate iterative metal artifact reduction (iMAR) technique in images data of hip prosthesis on computed tomography (CT) and the added value of advanced modeled iterative reconstruction (ADMIRE) compared with standard filtered back projection (FBP).Twenty-eight patients addressed to CT examinations for hip prosthe...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014341

    authors: Neroladaki A,Martin SP,Bagetakos I,Botsikas D,Hamard M,Montet X,Boudabbous S

    更新日期:2019-02-01 00:00:00

  • Impact of diabetes mellitus and chronic liver disease on the incidence of dementia and all-cause mortality among patients with dementia.

    abstract::This study investigated the effects of the presence of type 2 diabetes mellitus (T2D) and/or chronic liver disease (CLD) on the incidence and prognosis of dementia during a 10-year period in Korea using a nationwide population-based dataset from the Korea National Health Insurance Service.To assess the impact of T2D a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008753

    authors: Kim HM,Lee YH,Han K,Lee BW,Kang ES,Kim J,Cha BS

    更新日期:2017-11-01 00:00:00

  • Association between paced QRS duration and atrial fibrillation after permanent pacemaker implantation: A retrospective observational cohort study.

    abstract::Right ventricular pacing often results in prolonged QRS duration (QRSd) as the result of right ventricular stimulation, and atrial fibrillation (AF) may result. The association of pacing-induced prolonged QRSd and AF in patients with permanent pacemakers is unknown.We selected 180 consecutive patients who underwent pa...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009839

    authors: Xing F,Jiang J,Hu X,Feng C,He J,Dong Y,Ma Y,Tang A

    更新日期:2018-02-01 00:00:00

  • High prevalence of sleep disorders and behavioral and psychological symptoms of dementia in late-onset Alzheimer disease: A study in Eastern China.

    abstract::Alzheimer disease (AD) is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly. Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors for AD patients. Sleep di...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018405

    authors: Zhou G,Liu S,Yu X,Zhao X,Ma L,Shan P

    更新日期:2019-12-01 00:00:00

  • Blood pressure reverse-dipping is associated with early formation of carotid plaque in senior hypertensive patients.

    abstract::Nocturnal variations in blood pressure (BP) were associated with carotid intima-media thickness. However, the precise relationship between circadian variations of BP and carotid plaques remains unknown. Therefore, the prognostic value of reverse-dipper pattern of BP for carotid plaque was investigated. In this cross-s...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000604

    authors: Yan B,Peng L,Han D,Sun L,Dong Q,Yang P,Zheng F,Ong H,Zeng L,Wang G

    更新日期:2015-03-01 00:00:00

  • X-linked agammaglobulinemia: an analysis of 96 patients.

    abstract::We have defined the clinical presentation and course of X-linked agammaglobulinemia (X-LA) by means of a multi-center retrospective survey of 96 patients. Infections were the most common presenting feature of patients with X-LA. The most frequent infections involved the upper respiratory tract (75%), lower respiratory...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Lederman HM,Winkelstein JA

    更新日期:1985-05-01 00:00:00

  • Vitamin D Deficiency Strongly Predicts Adverse Medical Outcome Across Different Medical Inpatient Populations: Results From a Prospective Study.

    abstract::Vitamin D deficiency has been associated with several adverse outcomes mainly in the outpatient setting. The objective of this study was to examine the prevalence of vitamin D deficiency and its association with risk of adverse clinical outcomes in a large prospective cohort of medical inpatients.We collected clinical...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003533

    authors: Graedel L,Merker M,Felder S,Kutz A,Haubitz S,Faessler L,Kaeslin M,Huber A,Mueller B,Schuetz P

    更新日期:2016-05-01 00:00:00

  • Interventions to improve physical performances of older people with cancer before complex medico-surgical procedures: Protocol for an umbrella review of systematic reviews and meta-analyses.

    abstract:BACKGROUND:Current demographics lead increasing older cancer patients to undergo complex medico-surgical procedures, with substantial risk of decompensations and deconditioning. The Prehabilitation & Rehabilitation in Oncology: Adaptation to Disease and Accompaniment of Patients' Trajectories (PROADAPT) project is curr...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021780

    authors: Falandry C,Stefani L,Andre L,Granger M,Barbavara C,Habchi H,Bourgeois C,Cure H,Passot G,Gilbert T,PROADAPT working group.

    更新日期:2020-09-25 00:00:00

  • Fentanyl-based intravenous patient-controlled analgesia with low dose of ketamine is not inferior to thoracic epidural analgesia for acute post-thoracotomy pain following video-assisted thoracic surgery: A randomized controlled study.

    abstract:BACKGROUND:Thoracic epidural analgesia is the preferred method for postoperative analgesia following thoracic surgery. However, intravenous patient-controlled analgesia (IVPCA) may be an effective alternative. This study was conducted because few scientific reports exist comparing fentanyl-based IVPCA including a low d...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000016403

    authors: Tseng WC,Lin WL,Lai HC,Huang TW,Chen PH,Wu ZF

    更新日期:2019-07-01 00:00:00

  • Efficacy and safety of spironolactone in the heart failure with mid-range ejection fraction and heart failure with preserved ejection fraction: A meta-analysis of randomized clinical trials.

    abstract:BACKGROUND:Recent studies have shown the efficacy for using spironolactone to treat heart failure with reduced ejection fraction (HFrEF), but the efficacy of spironolactone for heart failure with mid-range ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF) is unclear. This meta-analys...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000014967

    authors: Xiang Y,Shi W,Li Z,Yang Y,Wang SY,Xiang R,Feng P,Wen L,Huang W

    更新日期:2019-03-01 00:00:00

  • Application effect of lattice laser in facial rejuvenation: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Various techniques have been applied in facial rejuvenation and lattice laser is the most accepted. However, the application effect of lattice laser in facial rejuvenation is unclear. This study aims to evaluate the application effect of lattice laser in facial rejuvenation. METHODS:Randomized controlled tr...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021814

    authors: Yan D,Huang Z,Zhang A,Li S,Xiao Y

    更新日期:2020-08-21 00:00:00

  • Gout increases risk of fracture: A nationwide population-based cohort study.

    abstract::There is still debate on whether high uric acid increases bone mineral density (BMD) against osteoporotic fracture or bone resorption caused by gout inflammation. This study aimed to evaluate whether gout offers a protective effect on bone health or not. We conducted a nationwide population-based retrospective cohort ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004669

    authors: Tzeng HE,Lin CC,Wang IK,Huang PH,Tsai CH

    更新日期:2016-08-01 00:00:00

  • Effective treatment of narcolepsy-like symptoms with high-frequency repetitive transcranial magnetic stimulation: A case report.

    abstract:RATIONALE:Narcolepsy is a rare sleep disorder with disrupted sleep-architecture. Clinical management of narcolepsy lies dominantly on symptom-driven pharmacotherapy. The treatment role of repetitive transcranial magnetic stimulation (rTMS) for narcolepsy remains unexplored. PATIENT CONCERNS:In this paper, we present a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008645

    authors: Lai JB,Han MM,Xu Y,Hu SH

    更新日期:2017-11-01 00:00:00

  • Assessment of mental health among nursing staff at different levels.

    abstract::To assess the mental health of nurses and to find the post responsibility and psychological status of clinical nurses.A total of 447 nursing staff at different levels in a teaching hospital was assessed by nursing post responsibility scale and mental symptom checklist (SCL-90) then compared with each other. The study ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019049

    authors: Du ML,Deng WX,Sun W,Chien CW,Tung TH,Zou XC

    更新日期:2020-02-01 00:00:00

  • Isolated metastasis of hepatocellular carcinoma in the right ventricle: A case report.

    abstract::Metastatic hepatocellular carcinoma (HCC) of the right ventricle is very rare and difficult to diagnosis.A 79-year-old man who underwent right hemi-hepatectomy for HCC was admitted to our hospital for chest pain, severe dyspnea, and orthopnea. The echocardiogram showed a tumor located in the right ventricle. A biopsy ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005544

    authors: Kim SB,Shin YC,Kwon SU

    更新日期:2016-12-01 00:00:00

  • The genetic association between EGF A61G polymorphism (rs4444903) and risk of colorectal cancer: An update meta-analysis and trial sequential analysis.

    abstract:BACKGROUND:Colorectal cancer was a complex disease with multiple causative factors including genetic and environmental factors, as well as the interaction of the 2 factors. Relationship between epidermal growth factor (EGF) A61G polymorphism and colorectal cancer risk has been widely investigated previously, whereas re...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014007

    authors: Zhu Y,Chen Z,Jiang H,Lu B

    更新日期:2019-01-01 00:00:00

  • Direct medical costs of hospitalizations for cardiovascular diseases in Shanghai, China: trends and projections.

    abstract::Few studies in China have focused on direct expenditures for cardiovascular diseases (CVDs), making cost trends for CVDs uncertain. Epidemic modeling and forecasting may be essential for health workers and policy makers to reduce the cost burden of CVDs.To develop a time series model using Box-Jenkins methodology for ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000837

    authors: Wang S,Petzold M,Cao J,Zhang Y,Wang W

    更新日期:2015-05-01 00:00:00