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Association between atrial fibrillation and volumetric magnetic resonance imaging brain measures: Framingham Offspring Study.

Abstract：

BACKGROUND:The increased risk of stroke and cognitive impairment associated with atrial fibrillation (AF) is well documented. However, there is a paucity of research investigating the relations between AF and brain morphology. OBJECTIVE:The purpose of this study was to investigate the association between AF and brain volume measures on magnetic resonance imaging (MRI). METHODS:The study sample included stroke- and dementia-free participants who attended the Framingham Heart Study offspring cohort 7th examination cycle (1999-2005) and underwent contemporaneous MRI. We examined the association between prevalent AF and brain volume measures (total cerebral volume, frontal lobe volume, temporal lobe volume, temporal horn volume, hippocampal volume, and white matter hyperintensity volume) with linear regression. We first adjusted models for age and sex, and then for vascular risk factors and APOE4. RESULTS:We studied 2144 individuals (mean age 61.8 ± 9.3 years; 54% women); 73 participants (3.4%) had prevalent AF at the time of MRI. In age- and sex-adjusted models, AF was inversely associated with total cerebral brain volume, frontal brain volume, and temporal brain volume. After further adjustment for vascular risk factors and APOE4, AF remained associated with frontal brain volume. CONCLUSION:After accounting for vascular risk factor burden, prevalent AF was associated with lobar indexes of vascular brain aging but not with expected white matter changes.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Piers RJ,Nishtala A,Preis SR,DeCarli C,Wolf PA,Benjamin EJ,Au R

doi

10.1016/j.hrthm.2016.07.004

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

2020-4

issue

10

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(16)30505-7

journal_volume

13

pub_type

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