Abstract:
BACKGROUND:The extent of left atrial (LA) late gadolinium enhancement (LGE), as a surrogate for fibrosis, has been associated with atrial fibrillation (AF) recurrence after catheter ablation. Furthermore, there is ex vivo evidence that islands of fibrosis may anchor fibrillatory rotors. OBJECTIVE:The purpose of this study was to examine the anatomical association of AF rotors with LA and right atrial (RA) LGE on cardiac magnetic resonance. METHODS:The cohort included 9 patients with persistent AF (mean age 61.1 ± 9.7 years) who underwent LGE cardiac magnetic resonance before AF ablation using the focal impulse and rotor modulation system. The extent of LA and RA LGE was quantified globally and in each of the 7 sectors: LA posterior/inferior wall, anterior wall, roof, left and right pulmonary vein antra, and RA lateral and septal regions. The multivariable association of rotor incidence with global and per sector LGE extent was examined using multivariable Bernoulli logistic regression estimated by generalized estimating equations. RESULTS:The mean RA and LA volumes were 113.2 ± 37.31 and 143.03 ± 58.25 mL, respectively. The mean RA and LA LGE burden was 17.2% ± 11.0% and 17.4% ± 14.4%, respectively. A total of 18 LA rotors and 9 RA rotors were identified in all patients. No univariable or multivariable association was observed between global or per sector LGE extent and focal impulse and rotor modulation rotor incidence. CONCLUSION:In this cohort of patients, there was no association between AF rotor incidence and the global or regional extent of RA and LA LGE.
journal_name
Heart Rhythmjournal_title
Heart rhythmauthors
Chrispin J,Gucuk Ipek E,Zahid S,Prakosa A,Habibi M,Spragg D,Marine JE,Ashikaga H,Rickard J,Trayanova NA,Zimmerman SL,Zipunnikov V,Berger RD,Calkins H,Nazarian Sdoi
10.1016/j.hrthm.2015.11.011subject
Has Abstractpub_date
2016-03-01 00:00:00pages
654-60issue
3eissn
1547-5271issn
1556-3871pii
S1547-5271(15)01397-1journal_volume
13pub_type
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